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1. 发明授权

US5492672A Sterilization apparatus and method for multicomponent sterilant 失效
公开(公告)号：US5492672A
公开(公告)日：1996-02-20
申请号：US279688
申请日：1994-07-25
申请人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
发明人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
IPC分类号： A61C19/00 , A61B1/12 , A61C1/00 , A61L2/06 , A61L2/20 , A61L2/24
CPC分类号： A61L2/208 , A61L2/20 , A61L2/24 , A61C1/0076 , A61C19/002 , A61L2202/122 , A61L2202/24
摘要： The present invention provides a sterilization process particularly well suited for sterilizing instruments and other devices having long narrow lumens. Apparatus in which the process can be practiced is also provided. The process uses a multicomponent sterilant vapor wherein one component is water. The lumened instruments are fluidly connected to the exhaust manifold of the sterilizer. A deep vacuum is drawn in the sterilization chamber followed by the injection of pulses of the sterilant vapor until a higher, but still subatmospheric pressure level is reached. When the pressure level reaches a predetermined subatmospheric level, a flow-through sterilization phase begins. It includes successive alternating periods of sterilant flow and the discontinuance of such flow. During sterilant flow periods, there are sterilant injection pulses where the sterilant flows through the chamber and the lumened instruments to exhaust. Each such flow period is followed by a hold period. Following the sterilization phase, there are one or more aeration steps to remove sterilant from the chamber.

2. 发明授权

US4909999A Flow-through vapor phase sterilization system 失效
标题翻译：流通气相灭菌系统
公开(公告)号：US4909999A
公开(公告)日：1990-03-20
申请号：US323187
申请日：1989-03-13
申请人： Arthur L. Cummings , Robert W. Childers , Thaddeus J. Mielnik, Jr.
发明人： Arthur L. Cummings , Robert W. Childers , Thaddeus J. Mielnik, Jr.
IPC分类号： A61L2/24
CPC分类号： A61L2/24
摘要： The present invention provides a flow-through system for use with at least one sealable pressure or nonpressure container. The system can be used to selectively sterilize, humidify and aerate the container and can be integrally or releasably attached to the container. The system includes at least one liquid reservoir for holding a sterilant, such as an aqueous solution of hydrogen peroxide. A second liquid reservoir for holding water for humidification may be provided. The system also includes a unit which houses a heater for vaporizing incoming liquid and optionally heating incoming air and a converter for converting selected vapors to a form suitable for disposal. A vacuum motor draws air from the container to reduce pressure therein so that air from an air supply is drawn through an air filter into the heater and into the container. A substantial portion of the withdrawn air from the container is diverted to the converter. The reduced pressure in the container may be sufficient for urging liquid from the reservoir to the heater where the liquid is vaporized and carried by the stream of air into the container. Alternatively, a remaining portion of withdrawn air may be used to exert pressure within the liquid reservoir to urge the liquid to the heater. Valves are provided to selectively control liquid flow to the heater.
摘要翻译：本发明提供了一种用于至少一个可密封的压力或非压力容器的流通系统。该系统可以用于选择性地消毒，加湿和充气容器，并且可以一体地或可释放地附接到容器。该系统包括用于保持灭菌剂的至少一个液体储存器，例如过氧化氢水溶液。可以提供用于保持用于加湿的水的第二液体储存器。该系统还包括容纳用于蒸发进入的液体和可选地加热进入的空气的加热器的单元和用于将选定的蒸气转换成适于处置的形式的转换器。真空马达从容器中抽出空气以减少其中的压力，使得来自空气源的空气通过空气过滤器被抽入加热器并进入容器。来自容器的取出空气的大部分被转移到转换器。容器中的减压可能足以将液体从储存器推送到加热器，其中液体被气体蒸发并由空气流携带到容器中。或者，可以使用剩余部分的抽出空气来在液体储存器内施加压力以将液体推向加热器。提供阀以选择性地控制流向加热器的液体流。

3. 发明授权

US5556607A Sterilization apparatus and method for multicomponent sterilant 失效
标题翻译：多组分灭菌剂灭菌装置及方法
公开(公告)号：US5556607A
公开(公告)日：1996-09-17
申请号：US530577
申请日：1995-09-19
申请人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
发明人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
IPC分类号： A61C19/00 , A61B1/12 , A61C1/00 , A61L2/06 , A61L2/20 , A61L2/24 , A61L9/00
CPC分类号： A61L2/208 , A61L2/20 , A61L2/24 , A61C1/0076 , A61C19/002 , A61L2202/122 , A61L2202/24
摘要： The present invention provides a sterilization process particularly well suited for sterilizing instruments and other devices having long narrow lumens. Apparatus in which the process can be practiced is also provided. The process uses a multicomponent sterilant vapor wherein one component is water. The lumened instruments are fluidly connected to the exhaust manifold of the sterilizer. A deep vacuum is drawn in the sterilization chamber followed by the injection of pulses of the sterilant vapor until a higher, but still subatmospheric pressure level is reached. When the pressure level reaches a predetermined subatmospheric level, a flow-through sterilization phase begins. It includes successive alternating periods of sterilant flow and the discontinuance of such flow. During sterilant flow periods, there are sterilant injection pulses where the sterilant flows through the chamber and the lumened instruments to exhaust. Each such flow period is followed by a hold period. Following the sterilization phase, there are one or more aeration steps to remove sterilant from the chamber.
摘要翻译：本发明提供了一种特别适用于消毒器具和其他具有较长腔体的器具的灭菌方法。还提供了可以实施该方法的装置。该方法使用多组分灭菌剂蒸气，其中一种组分是水。流明的仪器与灭菌器的排气歧管流体连接。在灭菌室中抽取深度真空，然后注入灭菌剂蒸气的脉冲，直到达到较高但仍低于大气压的压力水平。当压力水平达到预定的低于大气压水平时，开始流通灭菌阶段。它包括连续的交替周期的灭菌剂流动和这种流动的中断。在灭菌剂流动期间，灭菌剂喷射脉冲，其中消毒剂流过腔室，并且流明的仪器排出。每个这样的流动周期之后是保持期。灭菌阶段之后，有一个或多个曝气步骤从室中除去灭菌剂。

4. 发明授权

US5232095A Shipping apparatus with diagonally rotatably mounted contents 失效
标题翻译：具有对角可旋转安装内容物的装运装置
公开(公告)号：US5232095A
公开(公告)日：1993-08-03
申请号：US686097
申请日：1991-04-16
申请人： Robert W. Childers , Thaddeus J. Mielnik
发明人： Robert W. Childers , Thaddeus J. Mielnik
IPC分类号： B65D81/02
CPC分类号： B65D81/02
摘要： An apparatus for shipping goods which must be maintained in a predetermined orientation is provided. A closable outer container has a shaft passing through it along an axis. A weighted closable inner container is rotatably mounted about this axis so that it may freely rotate within the outer container while always assuming a predetermined orientation.
摘要翻译：提供了必须保持在预定方位上的用于运输货物的装置。一个可关闭的外部容器具有沿轴线穿过它的轴。加重的可关闭的内部容器围绕该轴线可旋转地安装，使得其可以在外部容器内自由旋转，同时始终采取预定取向。

5. 发明授权

US09283312B2 Dialysis system and method for cassette-based pumping and valving 有权
标题翻译：用于基于盒式泵送和阀门的透析系统和方法
公开(公告)号：US09283312B2
公开(公告)日：2016-03-15
申请号：US12987738
申请日：2011-01-10
申请人： Robert W. Childers , Richard Avoy , John Booras , Joseph H. Bowman, Jr. , Paul Grippo , Andrew D. Hopping , David Howard , Jeffrey W. Jerrell , Benjamin Kellam , Brian Lauman , Sherwin Shang , David Vescovi , Tahua Yang , Alex Yu
发明人： Robert W. Childers , Richard Avoy , John Booras , Joseph H. Bowman, Jr. , Paul Grippo , Andrew D. Hopping , David Howard , Jeffrey W. Jerrell , Benjamin Kellam , Brian Lauman , Sherwin Shang , David Vescovi , Tahua Yang , Alex Yu
IPC分类号： A61M1/28 , A61M1/16
CPC分类号： A61M1/281 , A61M1/16 , A61M1/1696 , A61M1/28 , A61M1/284 , A61M2205/122
摘要： A peritoneal dialysis system includes a disposable cassette including a flexible sheet; a hardware unit including (i) at least one pump actuator and piston head moved by the pump actuator, (ii) at least one valve actuator, (iii) at least one sensor, and (iv) a disposable cassette interface for interfacing with the disposable cassette, the disposable cassette interface including: (a) at least one pump aperture, the at least one piston head moveable out of and retractable into the at least one pump aperture to move a corresponding pumping portion of the flexible sheet of the disposable cassette, the piston head moving within a vacuum chamber, the vacuum chamber enabling a vacuum to be pulled around the piston head to the flexible sheet of the disposable cassette; (b) at least one valve aperture, at least a portion of the at least one valve actuator located in the valve aperture to move a valve portion of the flexible sheet of the disposable cassette; and (c) at least one sensor aperture, the at least one sensor located in the at least one sensor aperture, the at least one sensor operable with a sensor portion of the flexible sheet of the disposable cassette.
摘要翻译：腹膜透析系统包括：包括柔性片的一次性盒; 硬件单元包括（i）由泵致动器移动的至少一个泵致动器和活塞头，（ii）至少一个阀致动器，（iii）至少一个传感器，以及（iv）一次性盒接口，用于与所述一次性盒式接口包括：（a）至少一个泵孔，所述至少一个活塞头可移动到所述至少一个泵孔中并可缩回到所述至少一个泵孔中，以移动所述一次性盒的柔性片的相应的泵送部分所述活塞头在真空室内移动，所述真空室能够使所述活塞头周围的真空被拉到所述一次性盒的柔性片; （b）至少一个阀孔，所述至少一个阀致动器的至少一部分位于阀孔中，以移动一次性盒的柔性片的阀部分; 和（c）至少一个传感器孔，所述至少一个传感器位于所述至少一个传感器孔中，所述至少一个传感器可与一次性盒的柔性片的传感器部分一起操作。

6. 发明授权

US09101716B2 Multi-pass dialysis 有权
标题翻译：多次透析
公开(公告)号：US09101716B2
公开(公告)日：2015-08-11
申请号：US12024828
申请日：2008-02-01
申请人： Robert W. Childers , Anthony J. Simiele, III
发明人： Robert W. Childers , Anthony J. Simiele, III
IPC分类号： A61M37/00 , A61M1/28 , A61M1/16
CPC分类号： A61M1/16 , A61M1/1601 , A61M1/1639 , A61M1/1694 , A61M1/1696 , A61M1/28 , A61M2205/33 , A61M2205/3334 , A61M2205/75
摘要： A system for dialysis is disclosed. The system uses renal failure therapy fluid, such as dialysis fluid, several times before it is discarded. In a home hemodialysis application, the patient's blood is passed through the dialyzer several times, that is, multiple passes through the dialyzer, until the dialysis fluid is saturated or near saturation, with waste products from the patient's blood. In peritoneal dialysis, the dialysate is used at least twice within the patient's peritoneal cavity, i.e., multiple passes, before it is discarded. This has the effect minimizing the amount of dialysate a patient must handle and dispose of in the dialysis process.
摘要翻译：披露了一种透析系统。该系统在丢弃前多次使用肾衰竭治疗液，如透析液等。在家庭血液透析应用中，患者的血液多次通过透析器，即多次通过透析器，直到透析液饱和或接近饱和，患者血液中的废物产生。在腹膜透析中，透析液在被丢弃之前在患者的腹膜腔内使用至少两次，即多遍。这具有使患者在透析过程中必须处理和处置的透析液的量最小化的效果。

7. 发明授权

US09072831B2 Medical fluid pump valve integrity test methods and systems 有权
标题翻译：医用流体泵阀的完整性检测方法和系统
公开(公告)号：US09072831B2
公开(公告)日：2015-07-07
申请号：US13249603
申请日：2011-09-30
申请人： Thomas Kelly , Robert W. Childers , Don Busby , Rodolfo Roger , Waleed Mutasem El Sayyid , Shahid Din
发明人： Thomas Kelly , Robert W. Childers , Don Busby , Rodolfo Roger , Waleed Mutasem El Sayyid , Shahid Din
IPC分类号： A61M37/00 , A61M1/16 , A61M1/34 , A61M1/36 , A61M1/28
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A valve integrity method for a medical fluid pump includes pumping fluid into the medical fluid pump while an outlet valve is closed and an inlet valve is open, closing the inlet valve while the outlet valve is closed, attempting to pump fluid out of the medical fluid pump while the inlet valve and the outlet valve are closed, and determining that at least one of the valves is leaking if a change in medical fluid volume within the medical fluid pump is detected.
摘要翻译：用于医疗流体泵的阀完整性方法包括将流体输送到医用流体泵中，同时出口阀关闭并且入口阀打开，在出口阀关闭时关闭入口阀，试图将流体从医用流体中泵出泵，同时入口阀和出口阀关闭，并且如果检测到医用流体泵内的医用流体体积的变化，则确定至少一个阀是泄漏的。

8. 发明授权

US09039648B2 Dialysis system with enhanced features 有权
标题翻译：具有增强功能的透析系统
公开(公告)号：US09039648B2
公开(公告)日：2015-05-26
申请号：US12885082
申请日：2010-09-17
申请人： Thomas Kelly , Robert W. Childers , Don Busby , Rodolfo Roger , Waleed Mutasem El Sayyid , Shahid Din
发明人： Thomas Kelly , Robert W. Childers , Don Busby , Rodolfo Roger , Waleed Mutasem El Sayyid , Shahid Din
IPC分类号： A61M37/00 , A61M1/16 , A61M1/34 , A61M1/36 , A61M1/28
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump: first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.
摘要翻译：透析系统包括透析液盒式血液泵; 与血液泵流体连通的透析器：第一和第二透析液体盒式平衡室，每个平衡室具有（i）与透析器流体连通的新鲜透析液隔室和（ii）废透析液室; 透析液体基于盒的新鲜透析液体膜泵，其与所述第一和第二平衡室的新鲜透析液体隔室流体连通; 一透析流体盒式用过的透析流体膜泵，其与所述透析器和所述第一和第二平衡室的废透析液隔室流体连通; 以及与透析器流体连通以进行患者连接的动脉和静脉线，每个动脉和静脉线包括用于电检测患者进入断开的接触。

9. 发明授权

US08882692B2 Hemodialysis system with multiple cassette interference 有权
标题翻译：血液透析系统具有多个盒式干扰
公开(公告)号：US08882692B2
公开(公告)日：2014-11-11
申请号：US13213676
申请日：2011-08-19
申请人： Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
发明人： Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
IPC分类号： A61M1/14 , A61M1/28 , A61M1/16 , A61M1/34
CPC分类号： A61M1/1639 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1635 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/34 , A61M1/3627 , A61M2205/127 , A61M2205/3331 , A61M2205/3368 , A61M2205/502 , Y10T29/49826
摘要： A hemodialysis system for operation with a blood source and a dialysate source, the system including: (i) a first machine portion including a blood pump; (ii) a blood cassette operatively connected to the blood pump such that the blood pump can pump blood through the blood cassette when the blood cassette is in fluid communication with the blood source; (iii) a dialyzer fluidly connected to the blood cassette; (iv) a second machine portion separate from the first machine portion, the second machine portion including a dialysate pump; and (v) a dialysate cassette separate from the blood cassette, the dialysate cassette operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate cassette when the dialysate cassette is in fluid communication with the dialysate source, the dialysate cassette being fluidly connected to the dialyzer.
摘要翻译：一种用于与血液源和透析液源一起操作的血液透析系统，该系统包括：（i）包括血液泵的第一机器部分; （ii）可操作地连接到所述血液泵的血盒，使得当所述血盒与所述血液源流体连通时，所述血泵可以将血液泵送通过所述血盒; （iii）流体地连接到血液盒的透析器; （iv）与第一机器部分分开的第二机器部分，第二机器部分包括透析泵; 和（v）与血液盒分离的透析液盒，所述透析液盒可操作地连接到透析泵，使得当透析液盒与透析液流体连通时透析液泵可以透析透析液，透析液盒流体连接到透析器。

10. 发明授权

US08834719B2 Personal hemodialysis system 有权
标题翻译：个人血液透析系统
公开(公告)号：US08834719B2
公开(公告)日：2014-09-16
申请号：US13330243
申请日：2011-12-19
申请人： Robert W. Childers , Thomas D. Kelly , Rodolfo Roger
发明人： Robert W. Childers , Thomas D. Kelly , Rodolfo Roger
IPC分类号： B01D61/28 , B01D61/30 , A61M1/16 , A61M1/18 , A61M1/28
CPC分类号： A61M1/16 , A61M1/14 , A61M1/1601 , A61M1/1605 , A61M1/1621 , A61M1/1649 , A61M1/166 , A61M1/168 , A61M1/1686 , A61M1/1688 , A61M1/28 , A61M1/281 , A61M1/3465 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3652 , A61M2205/128 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3379 , A61M2205/6036 , B01D61/243 , B01D61/30 , Y10T29/49826 , Y10T137/0396 , Y10T137/87893
摘要： A dialysis machine method includes in an embodiment applying a pneumatic closing pressure to a first valve chamber and arranging a compliance chamber to flex and absorb energy from the pneumatic closing pressure so as to tend to prevent the pneumatic closing pressure from opening an existing closure of a second valve chamber.
摘要翻译：透析机方法包括在一个实施例中将气动关闭压力施加到第一阀室并且布置顺应室以从气动闭合压力弯曲和吸收能量，以便倾向于防止气动闭合压力打开现有的闭合件第二阀室。

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