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1. 发明申请

US20090018141A1 KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH 失效
标题翻译：激酶抑制剂，其组合物及其使用方法
公开(公告)号：US20090018141A1
公开(公告)日：2009-01-15
申请号：US12135575
申请日：2008-06-09
申请人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
发明人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
IPC分类号： A61K31/496 , A61K31/17 , C07C275/40 , A61K31/404 , C07D209/42 , C07D403/12 , C12N9/99 , A61P3/10 , A61K31/444 , C07D401/12 , A61K31/495 , C07D241/04
CPC分类号： C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。

2. 发明授权

US08765802B2 Kinase inhibitors, compositions thereof, and methods of use therewith 失效
标题翻译：激酶抑制剂，其组合物及其使用方法
公开(公告)号：US08765802B2
公开(公告)日：2014-07-01
申请号：US12135575
申请日：2008-06-09
申请人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
发明人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self
IPC分类号： A61K31/40 , C07D209/42
CPC分类号： C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。

3. 发明授权

US5576690A Combined audible and visual signaling device 失效
标题翻译：组合的听觉和视觉信号装置
公开(公告)号：US5576690A
公开(公告)日：1996-11-19
申请号：US511914
申请日：1995-08-07
申请人： David Waugh , Leslie M. Orloff
发明人： David Waugh , Leslie M. Orloff
IPC分类号： G08B1/08 , G08B7/06 , G09B1/08
CPC分类号： G08B1/08 , G08B7/06
摘要： Push button controlled wireless transmitters send digitally encoded signals to a plug-in receiver/signaling device. The receiver/signaling device has a microprocessor suitably programmed to respond to signals from a transmitter bearing the discrete address of the receiver, and to decode a transmitter identification code. Thereupon the microprocessor supplies an audio output circuit with signals to simulate selectively mechanical front or back door chimes, and supplies signals to energize a strobe lamp to emit bursts of multiple flashes, the number of flashes in a burst identifying the specific transmitter, whereby a person with a hearing deficiency is informed as to which transmitter is being actuated.
摘要翻译：按钮控制的无线发射器将数字编码的信号发送到插入式接收器/信号装置。接收器/信令装置具有适当编程的微处理器来响应来自承载接收机的离散地址的发射机的信号，并对发射机识别码进行解码。因此，微处理器为音频输出电路提供信号以模拟选择性地机械的前门铃或后门铃，并且提供信号以激励频闪灯以发射多次闪光的突发，突发中的闪烁次数识别特定的发射器，由此一个人通知听觉不足，说明哪个发射机被启动。

4. 发明申请

US20090047221A1 COMPOUNDS AND COMPOSITIONS USEFUL IN THE TREATMENT OF NEOPLASIA 审中-公开
标题翻译：化合物和组合物用于治疗NEOPLASIA
公开(公告)号：US20090047221A1
公开(公告)日：2009-02-19
申请号：US11718314
申请日：2004-10-31
申请人： Allen McClay , David Waugh , Paul Armstrong , Zoica Delbederi , Catherine Higgins , Hendrik Van Den Berg , Patrick Johnston , William Watters , Kelly McGarel , Timothy Mils
发明人： Allen McClay , David Waugh , Paul Armstrong , Zoica Delbederi , Catherine Higgins , Hendrik Van Den Berg , Patrick Johnston , William Watters , Kelly McGarel , Timothy Mils
IPC分类号： A61K9/68 , C07D405/10 , A61K31/4178 , A61P35/00 , A61K31/7048 , C12N5/06 , C07D311/76 , G01N33/566 , A61K31/437 , A61K31/4375 , A61K33/24 , A61K31/704
CPC分类号： C07D493/04 , C07D311/76
摘要： There is described compounds for use in therapy, said compounds being defined by Formula (1): There is also described an anti-proliferative composition comprising one or more compounds according to Formula (1), and a method of treatment of neoplasia comprising the administration of such a compound or composition.
摘要翻译：描述了用于治疗的化合物，所述化合物由式（1）定义：还描述了包含一种或多种根据式（1）的化合物的抗增殖组合物，以及治疗包含给药的肿瘤的方法的这种化合物或组合物。

5. 发明申请

US20150371563A1 Supplemental Label 审中-公开
标题翻译：补充标签
公开(公告)号：US20150371563A1
公开(公告)日：2015-12-24
申请号：US14310931
申请日：2014-06-20
申请人： David Waugh
发明人： David Waugh
IPC分类号： G09F3/02
CPC分类号： G09F3/02 , G09F3/10 , G09F2003/0201 , G09F2003/0202 , G09F2003/0214 , G09F2003/0239 , G09F2003/0241 , G09F2003/0257 , G09F2003/0267 , G09F2003/0269 , Y10T428/1476 , Y10T428/1481
摘要： A sheet having a supplemental label according to an embodiment includes a presentation portion having a print receptive front face and a coupling portion coupled to the presentation portion. The coupling portion is a transparent composite film made of an upper film, a repositional adhesive, a release agent, another layer of film, and an adhesive which is joined to a substrate such as paper or other print receptive media.
摘要翻译：根据实施例的具有补充标签的片材包括呈现部分，其具有打印接收前面和耦合到呈现部分的联接部分。耦合部分是由上膜，再定位粘合剂，脱模剂，另一层膜以及粘合到诸如纸或其它印刷容纳介质的基底上的粘合剂构成的透明复合膜。

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