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1. 发明申请

US20090047221A1 COMPOUNDS AND COMPOSITIONS USEFUL IN THE TREATMENT OF NEOPLASIA 审中-公开
标题翻译：化合物和组合物用于治疗NEOPLASIA
公开(公告)号：US20090047221A1
公开(公告)日：2009-02-19
申请号：US11718314
申请日：2004-10-31
申请人： Allen McClay , David Waugh , Paul Armstrong , Zoica Delbederi , Catherine Higgins , Hendrik Van Den Berg , Patrick Johnston , William Watters , Kelly McGarel , Timothy Mils
发明人： Allen McClay , David Waugh , Paul Armstrong , Zoica Delbederi , Catherine Higgins , Hendrik Van Den Berg , Patrick Johnston , William Watters , Kelly McGarel , Timothy Mils
IPC分类号： A61K9/68 , C07D405/10 , A61K31/4178 , A61P35/00 , A61K31/7048 , C12N5/06 , C07D311/76 , G01N33/566 , A61K31/437 , A61K31/4375 , A61K33/24 , A61K31/704
CPC分类号： C07D493/04 , C07D311/76
摘要： There is described compounds for use in therapy, said compounds being defined by Formula (1): There is also described an anti-proliferative composition comprising one or more compounds according to Formula (1), and a method of treatment of neoplasia comprising the administration of such a compound or composition.
摘要翻译：描述了用于治疗的化合物，所述化合物由式（1）定义：还描述了包含一种或多种根据式（1）的化合物的抗增殖组合物，以及治疗包含给药的肿瘤的方法的这种化合物或组合物。

2. 发明授权

US08791582B2 Integrated circuit package with voltage distributor 有权
标题翻译：具有电压分配器的集成电路封装
公开(公告)号：US08791582B2
公开(公告)日：2014-07-29
申请号：US12844922
申请日：2010-07-28
申请人： Chu-Chung Lee , Kian Leong Chin , Kevin J. Hess , Patrick Johnston , Tu-Anh N. Tran , Heng Keong Yip
发明人： Chu-Chung Lee , Kian Leong Chin , Kevin J. Hess , Patrick Johnston , Tu-Anh N. Tran , Heng Keong Yip
IPC分类号： H01L23/48
CPC分类号： H01L24/81 , H01L21/56 , H01L23/62 , H01L24/11 , H01L24/16 , H01L24/32 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/73 , H01L24/85 , H01L2224/0401 , H01L2224/04042 , H01L2224/05553 , H01L2224/16225 , H01L2224/32225 , H01L2224/32245 , H01L2224/45124 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48227 , H01L2224/48247 , H01L2224/48464 , H01L2224/4911 , H01L2224/49171 , H01L2224/49175 , H01L2224/73265 , H01L2224/85203 , H01L2224/85205 , H01L2924/01079 , H01L2924/14 , H01L2924/15311 , H01L2924/181 , H01L2924/19043 , H01L2924/19104 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： An integrated circuit package includes a semiconductor die attached to a package support. The die has a plurality of peripheral bond pads along a periphery of the die and a first bond pad on an interior portion of the die wherein the first bond pad is a power supply bond pad. A conductive distributor is over the die and within a perimeter of the die and has a first opening. The plurality of bond pads are located between the perimeter of the die and a perimeter of the conductive distributor. The first bond pad is in the first opening. A first bond wire is connected between the first bond pad and the conductive distributor. A second bond wire is connected between a first peripheral bond pad of the plurality of peripheral bond pads and the conductive distributor.
摘要翻译：集成电路封装包括附接到封装支撑件的半导体管芯。所述管芯具有沿着所述管芯的周边的多个外围接合焊盘和所述管芯的内部部分上的第一接合焊盘，其中所述第一接合焊盘是电源接合焊盘。导电分布器在模具之上并且在模具的周边内并且具有第一开口。多个接合焊盘位于模具的周边和导电分配器的周边之间。第一个焊盘在第一个开口。第一接合线连接在第一接合焊盘和导电分布器之间。第二接合线连接在多个外围接合焊盘的第一外围接合焊盘和导电分布器之间。

3. 发明申请

US20120025401A1 INTEGRATED CIRCUIT PACKAGE WITH VOLTAGE DISTRIBUTOR 有权
标题翻译：具有电压分配器的集成电路封装
公开(公告)号：US20120025401A1
公开(公告)日：2012-02-02
申请号：US12844922
申请日：2010-07-28
申请人： CHU-CHUNG LEE , Kian Leong Chin , Kevin J. Hess , Patrick Johnston , Tu-Anh N. Tran , Heng Keong Yip
发明人： CHU-CHUNG LEE , Kian Leong Chin , Kevin J. Hess , Patrick Johnston , Tu-Anh N. Tran , Heng Keong Yip
IPC分类号： H01L23/488 , H01L21/768
CPC分类号： H01L24/81 , H01L21/56 , H01L23/62 , H01L24/11 , H01L24/16 , H01L24/32 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/73 , H01L24/85 , H01L2224/0401 , H01L2224/04042 , H01L2224/05553 , H01L2224/16225 , H01L2224/32225 , H01L2224/32245 , H01L2224/45124 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48227 , H01L2224/48247 , H01L2224/48464 , H01L2224/4911 , H01L2224/49171 , H01L2224/49175 , H01L2224/73265 , H01L2224/85203 , H01L2224/85205 , H01L2924/01079 , H01L2924/14 , H01L2924/15311 , H01L2924/181 , H01L2924/19043 , H01L2924/19104 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： An integrated circuit package includes a semiconductor die attached to a package support. The die has a plurality of peripheral bond pads along a periphery of the die and a first bond pad on an interior portion of the die wherein the first bond pad is a power supply bond pad. A conductive distributor is over the die and within a perimeter of the die and has a first opening. The plurality of bond pads are located between the perimeter of the die and a perimeter of the conductive distributor. The first bond pad is in the first opening. A first bond wire is connected between the first bond pad and the conductive distributor. A second bond wire is connected between a first peripheral bond pad of the plurality of peripheral bond pads and the conductive distributor.
摘要翻译：集成电路封装包括附接到封装支撑件的半导体管芯。所述管芯具有沿所述管芯的周边的多个外围接合焊盘和所述管芯的内部部分上的第一接合焊盘，其中所述第一接合焊盘是电源接合焊盘。导电分布器在模具之上并且在模具的周边内并且具有第一开口。多个接合焊盘位于模具的周边和导电分配器的周边之间。第一个焊盘在第一个开口。第一接合线连接在第一接合焊盘和导电分布器之间。第二接合线连接在多个外围接合焊盘的第一外围接合焊盘和导电分布器之间。

4. 发明申请

US20060083738A1 Treatment of cancer by the use of anti fas antibody 审中-公开
标题翻译：通过使用抗fas抗体治疗癌症
公开(公告)号：US20060083738A1
公开(公告)日：2006-04-20
申请号：US10514604
申请日：2003-05-16
申请人： Patrick Johnston , Daniel Longley
发明人： Patrick Johnston , Daniel Longley
IPC分类号： A61K48/00 , A61K39/395 , A61K31/704 , A61K31/337 , A61K31/28
CPC分类号： C07K16/2878 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/704 , A61K33/24 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： The present invention provides a method of killing cancer cells and method of treatment of cancer comprising administration of a therapeutically effective amount of a) a specific binding member which binds to a cell death receptor or a nucleic acid encoding said binding member and (b) a chemotherapeutic agent. The binding member pereferably binds to a Fas receptor. Also described are medicaments for use in treating cancer.
摘要翻译：本发明提供了杀死癌细胞的方法和治疗癌症的方法，包括给予治疗有效量的a）与细胞死亡受体或编码所述结合成员的核酸结合的特异性结合成员，和（b）化疗剂。结合成员优先地结合Fas受体。还描述了用于治疗癌症的药物。

5. 发明授权

US6029875A Bicycle mounted knapsack 失效
标题翻译：自行车背包
公开(公告)号：US6029875A
公开(公告)日：2000-02-29
申请号：US874715
申请日：1997-06-13
申请人： Patrick Johnston
发明人： Patrick Johnston
IPC分类号： A45C13/36 , A45F3/04 , A45F4/02 , B62J7/00 , B62J7/04 , B62J9/00
CPC分类号： B62J9/001 , A45C13/36 , A45F3/04 , B62J7/00 , B62J7/04 , A45F4/02
摘要： The knapsack has a bottom wall resting against a user's back when supported by shoulder straps. The bottom wall is larger than a bicycle luggage carrier or rack. The knapsack has a frame structure for reinforcing the bottom wall and the side wall of the knapsack so that when the knapsack is placed with the bottom wall horizontally on top of the carrier, loose articles in the knapsack do not cause the bottom wall of the knapsack to sag over the sides of the carrier. The shoulder straps are attached to the bottom wall or sandwiched between the bottom wall and the carrier to prevent the shoulder straps from dangling down and possibly interfering with movement of the bicycle wheels. The knapsack has fastening straps for securing the knapsack to the luggage carrier. In one embodiment, the frame structure is a removable insert for a conventional knapsack.
摘要翻译：背包由背肩支撑时，背包有一个靠在用户背部的底壁。底壁比自行车行李架或架子大。背包具有用于加强背包的底壁和侧壁的框架结构，使得当背包水平放置在托架顶部的背包时，背包中的松散物品不会导致背包的底壁在航空母舰的两侧下垂。肩带被附接到底壁或夹在底壁和托架之间，以防止肩带悬挂并可能干扰自行车车轮的运动。背包具有用于将背包固定到行李架的紧固带。在一个实施例中，框架结构是用于常规背包的可移除插入件。

6. 发明申请

US20140018256A1 METHOD OF DIAGNOSING AUTISM SPECTRUM DISORDER 审中-公开
标题翻译：诊断光谱异常的方法
公开(公告)号：US20140018256A1
公开(公告)日：2014-01-16
申请号：US13981244
申请日：2012-01-23
申请人： Patrick Johnston , David Hardoon , Declan Murphy , John Powell , Christine Ecker
发明人： Patrick Johnston , David Hardoon , Declan Murphy , John Powell , Christine Ecker
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16
摘要： The present invention provides a method for diagnosing an autism spectrum disorder (ASD), or predisposition to develop an ASD, in a subject, which comprises the step of investigating a set of single nucleotide polymorphisms (SNPs) in a sample from the subject, wherein the number of SNPs in the set is such that the method can diagnose ASD with at least 70% accuracy. The invention also provides a kit for diagnosing an ASD, or predisposition to develop an ASD, in a subject, which comprises a plurality of primer pairs or probes capable of investigating such a set of SNPs in a sample from a subject, and a method for making such a kit.
摘要翻译：本发明提供一种用于诊断受试者中的自闭症谱系障碍（ASD）或开发ASD的倾向性的方法，其包括研究来自受试者的样品中的一组单核苷酸多态性（SNP）的步骤，其中组中的SNP数量使得该方法能够以至少70％的准确度来诊断ASD。本发明还提供了一种用于诊断受试者的ASD或ASD发病倾向的试剂盒，其包含能够研究来自受试者的样品中的这样一组SNP的多个引物对或探针，以及用于制作这样一个工具包。

7. 发明申请

US20070286867A1 Combination Therapy 审中-公开
标题翻译：联合治疗
公开(公告)号：US20070286867A1
公开(公告)日：2007-12-13
申请号：US10580662
申请日：2004-11-26
申请人： Patrick Johnston , Daniel Longley
发明人： Patrick Johnston , Daniel Longley
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： The invention provides combination therapies and methods for the treatment of cancers associates with p53 mutations. The method comprises the separate, sequential or simultaneous administration of a therapeutically effective amount of a) a specific binding member, for example CH-11, which binds to a cell death receptor, for example Fas, or a nucleic acid encoding said binding member and b) a chemotherapeutic agent, wherein the chemotherapeutic agent is a topoisomerase inhibitor, for example CPT-1 or a thymidylate synthase inhibitor, for example TDX. Synergistic cytotoxic effects have been demonstrated using such combinations.
摘要翻译：本发明提供了用于治疗与p53突变相关的癌症的组合疗法和方法。该方法包括单独，顺序或同时施用治疗有效量的a）特异性结合成员例如CH-11，其结合细胞死亡受体，例如Fas，或编码所述结合成员的核酸，以及 b）化学治疗剂，其中化学治疗剂是拓扑异构酶抑制剂，例如CPT-1或胸苷酸合酶抑制剂，例如TDX。已经使用这种组合证明了协同细胞毒性作用。

8. 发明申请

US20070270488A1 Treatment and Assays 审中-公开
标题翻译：治疗和分析
公开(公告)号：US20070270488A1
公开(公告)日：2007-11-22
申请号：US10592282
申请日：2005-03-14
申请人： Patrick Johnston , Daniel Longley
发明人： Patrick Johnston , Daniel Longley
IPC分类号： A61K31/282 , A61P35/00 , C12N5/00 , C12Q1/02 , C12Q1/68
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2800/52
摘要： Described is a method to predict response of tumour cells to in vivo treatment with a platinum-based chemotherapeutic agent, the method based on the determination of the expression of one or more of the genes encoding BCRP protein, wherein enhanced expression of said gene correlates with enhanced resistance to the chemotherapeutic agent. Also described are methods of sensitising cancer cells, particularly colorectal cancer cells to treatment.
摘要翻译：描述了一种预测肿瘤细胞对基于铂的化学治疗剂的体内治疗的反应的方法，该方法基于测定一种或多种编码BCRP蛋白的基因的表达，其中所述基因的增强表达与增强对化学治疗剂的抵抗力。还描述了使癌细胞，特别是结肠直肠癌细胞对治疗敏感的方法。

9. 发明授权

US5898217A Semiconductor device including a substrate having clustered interconnects 失效
标题翻译：包括具有聚集互连的衬底的半导体器件
公开(公告)号：US5898217A
公开(公告)日：1999-04-27
申请号：US2610
申请日：1998-01-05
申请人： Patrick Johnston
发明人： Patrick Johnston
IPC分类号： H01L23/498 , H01L23/52 , H01L23/04 , H01L23/48
CPC分类号： H01L23/49822 , H01L23/49838 , H01L24/97 , H01L2224/16 , H01L2224/16235 , H01L2224/97 , H01L2924/01033 , H01L2924/15174 , H01L2924/15311 , H01L2924/15787 , H01L2924/30107
摘要： A semiconductor device (100) including a die (110) electrically connected to a substrate (120), wherein the substrate has a novel interconnect routing structure. The routing structure has a plurality of interconnects (122) including a plurality of intermediate vias (140), including both intermediate vias associated with supply interconnects and signal interconnects, that are clustered together to reduce undesirable mutual loop inductance (L.sub.m) and reduce switching noise (.DELTA.I). A plurality of first printed wires (128a) and a plurality of second printed wires (128b) may incorporated in the substrate for routing of the plurality intermediate vias in cluster form. The substrate may have a plurality of clusters of the intermediate vias.
摘要翻译：一种包括电连接到衬底（120）的管芯（110）的半导体器件（100），其中所述衬底具有新颖的互连布线结构。路由结构具有包括多个中间通孔（140）的多个互连（122），其包括与电源互连和信号互连相关联的两个中间通孔，其聚集在一起以减少不需要的互环电感（Lm）并降低开关噪声（DELTA I）。多个第一印刷线（128a）和多个第二印刷线（128b）可以结合在基板中，用于以簇形式路由多个中间通孔。衬底可以具有多个中间通孔簇。

10. 发明授权

US10150543B2 Method for rigging and controlling a wing sail 有权
公开(公告)号：US10150543B2
公开(公告)日：2018-12-11
申请号：US15025954
申请日：2014-10-01
申请人： Gregory Owen Johnston , Patrick Johnston
发明人： Gregory Owen Johnston , Patrick Johnston
IPC分类号： B63H9/10 , B63H9/08 , B63B15/00 , B63H9/06
摘要： A rigging comprises a mast controllably about a longitudinal axis; a flexible sail comprising a starboard and port flexible sail portions; a plurality of elongated battens which extend a luff and a leach of sail portions; each batten is pivotally connected to a respective outermost part of the respective side of the mast. Rotation of the mast causes the battens connected to one of the sail portions to be compressed along their length and causes the battens connected of the other sail portions to be tensioned along their length so as to change the shape of an aerofoil formed by the sail.

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