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1. 发明授权

US06283983B1 Percutaneous in-situ coronary bypass method and apparatus 有权
标题翻译：经皮原位冠状动脉搭桥方法及装置
公开(公告)号：US06283983B1
公开(公告)日：2001-09-04
申请号：US09192554
申请日：1998-08-10
申请人： Joshua Makower , Robert S. Schwartz , David R. Holmes , Robert A. Van Tassel
发明人： Joshua Makower , Robert S. Schwartz , David R. Holmes , Robert A. Van Tassel
IPC分类号： A61M2900
CPC分类号： A61B17/11 , A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0057 , A61B17/0643 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0004 , A61M2025/0076 , A61M2025/009 , A61M2025/0096 , A61M2025/018 , A61M2025/1052 , A61M2210/125
摘要： Methods and devices for percutaneous, in situ coronary bypass wherein a tissue puncturing catheter is used to form blood flow paths between an artery and an adjacent vein such that arterial blood will flow through a segment of the adjacent vein, thereby bypassing a lesion in the artery. The tissue puncturing catheter comprises a flexible catheter having a tissue puncturing apparatus such as a sharp tipped member, an electro-surgical apparatus or a laser beam passable therefrom to create the desired blood flow paths between the artery and vein. Stents are provided for facilitating blood flow through the blood flow paths and the segment of the vein used as the bypass conduit. One such stent is specially constructed to carry arterial blood in one direction through the vein segment while allowing venous blood to continue to flow in the opposite direction through that venous segment.
摘要翻译：用于经皮的原位冠状动脉旁路的方法和装置，其中组织穿刺导管用于形成动脉和相邻静脉之间的血流路径，使得动脉血液将流过相邻静脉的一段，从而绕过动脉中的病变。组织穿刺导管包括柔性导管，其具有组织穿刺装置，例如尖锐的尖端构件，电外科手术装置或可从其穿过的激光束，以在动脉和静脉之间产生所需的血流路径。提供了用于促进血液流过血流路径和用作旁路导管的静脉段的支架。一种这样的支架被特别构造成通过静脉段沿一个方向携带动脉血，同时允许静脉血继续沿相反方向流过该静脉段。

2. 发明授权

US08579955B2 Anti-arrhythmia devices and methods of use 失效
公开(公告)号：US08579955B2
公开(公告)日：2013-11-12
申请号：US11551670
申请日：2006-10-20
申请人： Robert S. Schwartz , Robert A. Van Tassel , David R. Holmes, Jr.
发明人： Robert S. Schwartz , Robert A. Van Tassel , David R. Holmes, Jr.
IPC分类号： A61F2/82
CPC分类号： A61M29/02 , A61F2/07 , A61F2/24 , A61F2/2481 , A61F2/2487 , A61F2/82 , A61F2/848 , A61F2/90 , A61F2002/821 , A61F2002/8483 , A61F2220/0016 , A61M29/00
摘要： An apparatus and method of use are disclosed for treating, preventing and terminating arrhythmias. In particular, the apparatus is implantable within or on various tissues and structures and is used to prevent or block conduction of aberrant impulses. A variety of methods of the present invention may be used to attack arrhythmias by short-circuiting impulses, inducing fibrosis, ablating tissue or inducing inflammation. In addition, the device and methods may also be used to treat aneurysms. The device may also be used to treat hypertension, and to function as a blood pressure regulator.

3. 发明申请

US20090210050A1 Implantable Device For Promoting Repair Of A Body Lumen 审中-公开
标题翻译：用于促进身体内腔修复的植入式装置
公开(公告)号：US20090210050A1
公开(公告)日：2009-08-20
申请号：US12429803
申请日：2009-04-24
申请人： Robert A. Van Tassel , David R. Holmes, JR. , Robert S. Schwartz
发明人： Robert A. Van Tassel , David R. Holmes, JR. , Robert S. Schwartz
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/028 , A61B5/6862 , A61B5/6876 , A61F2/0077 , A61F2/91 , A61L31/14
摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
摘要翻译：提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长细胞以有组织的模式。或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

4. 发明授权

US5728132A Self-sealing vascular access device 失效
标题翻译：自密封血管通路装置
公开(公告)号：US5728132A
公开(公告)日：1998-03-17
申请号：US629022
申请日：1996-04-08
申请人： Robert A. Van Tassel , David R. Holmes , Robert S. Schwartz
发明人： Robert A. Van Tassel , David R. Holmes , Robert S. Schwartz
IPC分类号： A61B17/00 , A61B17/34 , A61M25/08 , A61B17/04
CPC分类号： A61B17/3417 , A61B17/0057 , A61B17/00491 , A61B17/3498
摘要： An instrument for achieving rapid hemostasis at the conclusion of a catheterization procedure comprises a device for injecting a fluid hemostatic agent into a puncture wound that is operatively associated with a conventional introducer sheath component of the introducer used to gain access to a blood vessel using the Seldinger technique. The hemostatic agent injection device includes a tubular member that can be concentrically disposed with a tubular introducer sheath so as to be slidable therealong and where the injection device includes a hemostatic agent inlet port at a proximal end thereof and an ejection port at a distal end, the two ports being interconnected by a lumen. In a first embodiment, the hemostatic agent injection device is adapted to coaxially surround the introducer sheath and in an alternate embodiment, the injection device is coaxially disposed within the lumen of the introducer sheath.
摘要翻译：用于在导管插入术结束时实现快速止血的仪器包括用于将流体止血剂注射到穿刺伤口中的装置，所述穿刺伤口与用于使用所述Seldinger进入血管的导引器的常规导引器鞘部件可操作地相关联技术。止血剂注射装置包括管状构件，该管状构件可以同心地设置有管状导引鞘，以便能够沿着其滑动，并且其中注射装置包括其近端处的止血剂入口和远端的排出口，两个端口由管腔相互连接。在第一实施例中，止血剂注射装置适于同轴地包围导引鞘，并且在替代实施例中，注射装置同轴地设置在导引鞘的内腔中。

5. 发明授权

US06969373B2 Syringe system 失效
标题翻译：注射器系统
公开(公告)号：US06969373B2
公开(公告)日：2005-11-29
申请号：US09967681
申请日：2001-09-28
申请人： Robert S. Schwartz , Robert A. Van Tassel , David R. Holmes
发明人： Robert S. Schwartz , Robert A. Van Tassel , David R. Holmes
IPC分类号： A61B17/00 , A61B17/34 , A61M5/145 , A61M5/158 , A61M5/168 , A61M5/31 , A61M5/32 , A61M25/00 , A61M5/178 , A61M1/00
CPC分类号： A61M5/158 , A61B17/3478 , A61B2017/00247 , A61B2018/00392 , A61M5/14546 , A61M5/16813 , A61M5/3291 , A61M2005/14513 , A61M2005/3123 , A61M2025/0008 , A61M2025/0057 , A61M2025/0079 , A61M2025/0081 , A61M2025/0091
摘要： A medical device is provided having a needle or a catheter, insertable into a living body, which defines a plurality of holes in fluid communication with a central lumen. The holes may be of various patterns located and angled to create a desired injectate cloud pattern when an injectate is forced through the central lumen and through the plurality of holes. One embodiment provides various designs including a moveable sheath or stylet used to selectively occlude one or more of the holes while in use, thereby providing an operating physician a way to manipulate the cloud pattern anytime during the introduction of the injectate. A reducer may be used in conjunction with these needles which provides an increased degree of control when injecting very small quantities of fluid.
摘要翻译：提供具有可插入生物体中的针或导管的医疗装置，其限定与中心腔流体连通的多个孔。当注射剂被迫穿过中心腔并穿过多个孔时，孔可以是各种图案，其定位和成角度以产生期望的注射云图案。一个实施例提供了各种设计，包括用于在使用中选择性地闭塞一个或多个孔的可移动护套或探针，从而为操作医师提供在注射器引入期间随时操作云图案的方式。减速器可以与这些针结合使用，当注射非常少量的流体时，可以提供更高程度的控制。

6. 发明授权

US07235096B1 Implantable device for promoting repair of a body lumen 失效
标题翻译：用于促进体腔修复的植入式装置
公开(公告)号：US07235096B1
公开(公告)日：2007-06-26
申请号：US09382275
申请日：1999-08-25
申请人： Robert A. Van Tassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. Van Tassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/028 , A61B5/6862 , A61B5/6876 , A61F2/0077 , A61F2/91 , A61L31/14
摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
摘要翻译：提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长细胞以有组织的模式。或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

7. 发明授权

US08428729B2 Cardiac stimulation apparatus and method for the control of hypertension 有权
标题翻译：心脏刺激装置及控制高血压的方法
公开(公告)号：US08428729B2
公开(公告)日：2013-04-23
申请号：US13281742
申请日：2011-10-26
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
摘要翻译：一种电刺激心肌以改变心脏的射血分布，控制心脏的机械功能并降低观察到的患者血压的方法。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。在一些情况下，在测量的预处理血压超过治疗阈值的情况下，可以以相对于患者的心脏射血周期计时的电刺激来刺激患者的心脏。这是为了在至少两个心室之间或心室内引起不同步，其改变患者的心脏射血分布从预处理的心脏射血分布。这具有从测量的预处理血压降低患者的血压的效果。

8. 发明申请

US20120041502A1 Cardiac Stimulation Apparatus And Method For The Control Of Hypertension 有权
标题翻译：心脏刺激装置及控制高血压的方法
公开(公告)号：US20120041502A1
公开(公告)日：2012-02-16
申请号：US13281742
申请日：2011-10-26
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
摘要翻译：一种电刺激心肌以改变心脏的射血分布，控制心脏的机械功能并降低观察到的患者血压的方法。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。在一些情况下，在测量的预处理血压超过治疗阈值的情况下，可以以相对于患者的心脏射血周期计时的电刺激来刺激患者的心脏。这是为了在至少两个心室之间或在心室内引起不同步，其改变患者的心脏射血分布从预处理的心脏射血分布。这具有从测量的预处理血压降低患者的血压的效果。

9. 发明授权

US08430861B2 Microvascular obstruction detection and therapy 有权
标题翻译：微血管阻塞检测与治疗
公开(公告)号：US08430861B2
公开(公告)日：2013-04-30
申请号：US12376086
申请日：2007-08-01
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61M31/00
CPC分类号： A61M25/007 , A61B5/02007 , A61B5/0215 , A61B5/055 , A61B8/00 , A61B8/06 , A61M25/10 , A61M25/1011 , A61M37/0092 , A61M2025/0002 , A61M2025/0003 , A61M2025/1052
摘要： A method of detecting and treating a microvascular obstruction is provided. In one embodiment, a catheter is provided for both detecting the microvascular obstruction and treating or removing the obstruction.
摘要翻译：提供了检测和治疗微血管阻塞的方法。在一个实施例中，提供了用于检测微血管阻塞物和治疗或去除阻塞物的导管。

10. 发明申请

US20100168649A1 MICROVASCULAR OBSTRUCTION DETECTION AND THERAPY 有权
标题翻译：微血管造影检测和治疗
公开(公告)号：US20100168649A1
公开(公告)日：2010-07-01
申请号：US12376086
申请日：2007-08-01
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61M25/10 , A61B5/055 , A61B8/12 , A61M25/09 , A61N7/00
CPC分类号： A61M25/007 , A61B5/02007 , A61B5/0215 , A61B5/055 , A61B8/00 , A61B8/06 , A61M25/10 , A61M25/1011 , A61M37/0092 , A61M2025/0002 , A61M2025/0003 , A61M2025/1052
摘要： A method of detecting and treating a microvascular obstruction is provided. In one embodiment, a catheter is provided for both detecting the microvascular obstruction and treating or removing the obstruction.
摘要翻译：提供了检测和治疗微血管阻塞的方法。在一个实施例中，提供了用于检测微血管阻塞物和治疗或去除阻塞物的导管。

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