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1. 发明授权

US09028829B2 Uniform field magnetization and targeting of therapeutic formulations 有权
标题翻译：均匀场磁化和靶向治疗剂型
公开(公告)号：US09028829B2
公开(公告)日：2015-05-12
申请号：US12653465
申请日：2009-12-15
申请人： Robert J. Levy , Michael Chorny , Vladimir Muzykantov , Elizabeth Hood
发明人： Robert J. Levy , Michael Chorny , Vladimir Muzykantov , Elizabeth Hood
IPC分类号： A61K39/44 , A61N2/10 , A61M31/00 , A61K9/50 , A61K9/51 , A61K47/42 , A61K47/48 , A61K48/00 , A61L31/16 , C12N15/11 , C12N15/86
CPC分类号： A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K47/42 , A61K47/59 , A61K47/645 , A61K47/6455 , A61K47/6849 , A61K47/6921 , A61K47/6937 , A61K48/0008 , A61K48/0041 , A61K48/0083 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2300/624 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.
摘要翻译：提供了用于治疗颗粒的磁性靶向的系统和方法。治疗性颗粒包含一种或多种磁性或可磁化材料和至少一种治疗剂。使用能够磁化可磁化材料的均匀磁场来特异性地靶向治疗颗粒，并且可以将其靶向到身体中的特定位置，或者可以被靶向用于捕获，容纳和移除。治疗性颗粒可以包含抗氧化酶，并且可以靶向细胞以保护细胞免受氧化损伤。

2. 发明申请

US20100260780A1 Uniform field magnetization and targeting of therapeutic formulations 有权
标题翻译：均匀场磁化和靶向治疗剂型
公开(公告)号：US20100260780A1
公开(公告)日：2010-10-14
申请号：US12653465
申请日：2009-12-15
申请人： Robert J. Levy , Michael Chorny , Vladimir Muzykantov , Elizabeth Hood
发明人： Robert J. Levy , Michael Chorny , Vladimir Muzykantov , Elizabeth Hood
IPC分类号： A61K39/44 , A61N2/10 , A61F2/82 , A61M31/00 , A61K38/44 , A61P43/00 , C12N13/00
CPC分类号： A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K47/42 , A61K47/59 , A61K47/645 , A61K47/6455 , A61K47/6849 , A61K47/6921 , A61K47/6937 , A61K48/0008 , A61K48/0041 , A61K48/0083 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2300/624 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.
摘要翻译：提供了用于治疗颗粒的磁性靶向的系统和方法。治疗性颗粒包含一种或多种磁性或可磁化材料和至少一种治疗剂。使用能够磁化可磁化材料的均匀磁场来特异性地靶向治疗颗粒，并且可以将其靶向到身体中的特定位置，或者可以被靶向用于捕获，容纳和移除。治疗性颗粒可以包含抗氧化酶，并且可以靶向细胞以保护细胞免受氧化损伤。

3. 发明申请

US20130156792A9 Uniform field magnetization and targeting of therapeutic formulations 有权
公开(公告)号：US20130156792A9
公开(公告)日：2013-06-20
申请号：US12653465
申请日：2009-12-15
申请人： Robert J. Levy , Michael Chorny , Vladimir Muzykantov , Elizabeth Hood
发明人： Robert J. Levy , Michael Chorny , Vladimir Muzykantov , Elizabeth Hood
IPC分类号： A61K39/44 , A61F2/82 , C12N13/00 , A61K38/44 , A61P43/00 , A61N2/10 , A61M31/00
CPC分类号： A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K47/42 , A61K47/59 , A61K47/645 , A61K47/6455 , A61K47/6849 , A61K47/6921 , A61K47/6937 , A61K48/0008 , A61K48/0041 , A61K48/0083 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2300/624 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.

4. 发明授权

US09694103B2 Photochemical activation of surfaces for attaching biomaterial 有权
公开(公告)号：US09694103B2
公开(公告)日：2017-07-04
申请号：US13606672
申请日：2012-09-07
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
IPC分类号： A61K9/00 , A61L27/16 , C08F126/02 , C08F120/06 , A61L27/54 , A61L27/50 , A61K31/765 , A61K31/785 , C07K17/02 , C08F226/02 , C08J7/18 , C08F271/02 , C08F290/00 , C08F291/00 , C08G63/91 , C08L75/04 , C07K17/06
CPC分类号： A61L27/16 , A61K31/765 , A61K31/785 , A61L27/50 , A61L27/54 , A61L2400/18 , B01J2219/00637 , B01J2219/00648 , C07K17/02 , C07K17/06 , C08F8/10 , C08F8/32 , C08F8/34 , C08F120/06 , C08F126/02 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08G63/91 , C08J7/18 , C08L75/04
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

5. 发明授权

US09233163B2 Hydrolytically releasable prodrugs for sustained release nanoparticle formulations 有权
标题翻译：用于缓释纳米颗粒制剂的水解可释放的前药
公开(公告)号：US09233163B2
公开(公告)日：2016-01-12
申请号：US13976776
申请日：2011-12-28
申请人： Ivan Alferiev , Michael Chorny , Robert J. Levy
发明人： Ivan Alferiev , Michael Chorny , Robert J. Levy
IPC分类号： A61K47/48 , C08B37/02
CPC分类号： A61K47/48123 , A61K47/551 , A61K47/554 , A61K47/645 , C08B37/0021
摘要： A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.
摘要翻译：根据式（I）的前药，其中R2是药物的残基，所述药物具有形成COOR 2基团的羟基; Z是O或NH; m为0或1; 并且R3是包含亲油基团或聚合物残基的有机部分，条件是如果聚合物是羧甲基葡聚糖，则Z为0。一种系统包括多个磁性纳米颗粒，包括如上所述的前体药物，能够产生支架和/或磁性纳米颗粒的暂时磁化的支架和均匀磁场源。用药物治疗医学病症的方法包括向需要该药物的患者施用如上所述的前药，该前药能够在施用步骤后释放患者的药物。

6. 发明授权

US09084877B2 Magnetic targeting device, system and method 有权
标题翻译：磁性靶向装置，系统及方法
公开(公告)号：US09084877B2
公开(公告)日：2015-07-21
申请号：US13883054
申请日：2011-10-27
申请人： Robert J. Levy , Michael Chorny , Ilia Fishbein
发明人： Robert J. Levy , Michael Chorny , Ilia Fishbein
IPC分类号： A61N2/00 , A61K9/50 , A61K9/51 , A61L29/14 , A61M25/10
CPC分类号： A61N2/00 , A61K9/0009 , A61K9/5094 , A61K9/5115 , A61L29/14 , A61L29/18 , A61M25/10
摘要： A treatment system includes a magnetic targeting catheter and a plurality of MNP. The MNP may include one or more magnetic field-responsive agents and one or more therapeutic agents. The catheter may include an inner shaft having at least one lumen and a fluid delivery balloon adapted to administer a fluid from the inner shaft into a space surrounding the catheter. An expandable mesh formed of a magnetizable material may surround the fluid delivery balloon. The catheter may further include one or more occlusion balloons for controlling blood flow through a vessel in which the catheter is placed. A method of treating a medical condition may include advancing a magnetic targeting catheter to a site, deploying an expandable mesh connected to the catheter, applying a magnetic field to the mesh and depositing a plurality of MNP or cells loaded with MNP near the mesh.
摘要翻译：治疗系统包括磁性靶向导管和多个MNP。 MNP可以包括一种或多种磁场响应剂和一种或多种治疗剂。导管可以包括具有至少一个内腔的内轴和适于将流体从内轴施加到围绕导管的空间的流体输送球囊。由可磁化材料形成的可膨胀网可围绕流体输送球囊。导管还可以包括一个或多个阻塞气囊，用于控制通过其中放置导管的血管的血流。治疗医疗状况的方法可以包括将磁性靶向导管推进到位置，展开连接到导管的可扩张网，向网状物施加磁场并且在网格附近沉积多个MNP或装载有MNP的细胞。

7. 发明授权

US08562505B2 Uniform field magnetization and targeting of therapeutic formulations 有权
公开(公告)号：US08562505B2
公开(公告)日：2013-10-22
申请号：US12150864
申请日：2008-05-01
申请人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
发明人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
IPC分类号： A61N2/10
CPC分类号： A61K41/00 , A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K31/203 , A61K31/337 , A61K31/713 , A61K35/44 , A61K35/761 , A61K47/42 , A61K47/59 , A61K47/6455 , A61K47/6923 , A61K47/6929 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343 , C12N2710/10345
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

8. 发明申请

US20130243862A1 PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL 审中-公开
标题翻译：用于连接生物材料的表面的光化学活化
公开(公告)号：US20130243862A1
公开(公告)日：2013-09-19
申请号：US13606672
申请日：2012-09-07
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
IPC分类号： A61L27/16 , C08F120/06 , A61L27/54 , C08F126/02
CPC分类号： A61L27/16 , A61K31/765 , A61K31/785 , A61L27/50 , A61L27/54 , A61L2400/18 , B01J2219/00637 , B01J2219/00648 , C07K17/02 , C07K17/06 , C08F8/10 , C08F8/32 , C08F8/34 , C08F120/06 , C08F126/02 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08G63/91 , C08J7/18 , C08L75/04
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
摘要翻译：一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上。组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。还提供了将生物材料递送到细胞的方法。

9. 发明授权

US07635734B2 Photochemical activation of surfaces for attaching biomaterial 有权
标题翻译：用于附着生物材料的表面的光化学活化
公开(公告)号：US07635734B2
公开(公告)日：2009-12-22
申请号：US11250877
申请日：2005-10-14
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
IPC分类号： A61K47/48
CPC分类号： C08G63/91 , A61K31/765 , A61K31/785 , A61L27/50 , A61L2400/18 , C07K17/02 , C08F8/10 , C08F8/32 , C08F8/34 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08J7/18 , C08L75/04 , C08F120/06 , C08F126/02
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
摘要翻译：一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上。组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。还提供了将生物材料递送到细胞的方法。

10. 发明申请

US20130296285A1 Design of Hydrolytically Releasable Prodrugs for Sustained Release Nanoparticle Formulations 有权
标题翻译：用于缓释纳米颗粒配方的水解可释放前药的设计
公开(公告)号：US20130296285A1
公开(公告)日：2013-11-07
申请号：US13976776
申请日：2011-12-28
申请人： Ivan Alferiev , Michael Chorny , Robert J. Levy
发明人： Ivan Alferiev , Michael Chorny , Robert J. Levy
IPC分类号： A61K47/48
CPC分类号： A61K47/48123 , A61K47/551 , A61K47/554 , A61K47/645 , C08B37/0021
摘要： A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.
摘要翻译：根据式（I）的前药，其中R2是药物的残基，所述药物具有形成COOR 2基团的羟基; Z是O或NH; m为0或1; 并且R3是包含亲油基团或聚合物残基的有机部分，条件是如果聚合物是羧甲基葡聚糖，则Z为0。一种系统包括多个磁性纳米颗粒，包括如上所述的前体药物，能够产生支架和/或磁性纳米颗粒的暂时磁化的支架和均匀磁场源。用药物治疗医学病症的方法包括向需要该药物的患者施用如上所述的前药，该前药能够在施用步骤后释放患者的药物。

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