专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06573110B1 Combinatorial chemistry system and method of use 失效
标题翻译：组合化学体系和使用方法
公开(公告)号：US06573110B1
公开(公告)日：2003-06-03
申请号：US09674900
申请日：1999-12-15
申请人： Robert J. Hessler , Robert Braun , Nicholas Winograd
发明人： Robert J. Hessler , Robert Braun , Nicholas Winograd
IPC分类号： G01N33545
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00459 , B01J2219/00468 , B01J2219/005 , B01J2219/00702 , B01L3/5085 , B01L2200/0647 , B01L2300/0893 , C40B40/00 , Y10T436/11 , Y10T436/24
摘要： A combinatorial chemistry system allows for the dual processing of different molecules coated on a library of beads. The system includes beads coated with different molecules on each bead, a bead holder, screening equipment and characterization equipment. Molecules on the beads are both screened and characterized simultaneously.
摘要翻译：组合化学系统允许涂覆在磁珠库上的不同分子的双重加工。该系统包括在每个珠粒上涂覆有不同分子的珠子，珠子保持器，筛选设备和表征设备。珠子上的分子同时进行筛选和表征。

2. 发明授权

US5834195A Method for identifying members of combinatorial libraries 失效
标题翻译：识别组合库成员的方法
公开(公告)号：US5834195A
公开(公告)日：1998-11-10
申请号：US718428
申请日：1996-12-18
申请人： Stephen J. Benkovic , Nicholas Winograd , Christopher L. Brummel , Irene N. W. Lee
发明人： Stephen J. Benkovic , Nicholas Winograd , Christopher L. Brummel , Irene N. W. Lee
IPC分类号： C07D487/04 , C07H21/00 , C07K1/04 , G01N33/53 , C12Q1/68
CPC分类号： C07H21/00 , C07K1/047 , B01J2219/00702 , Y10T436/24
摘要： A method to determine the molecular weights of femtomole or smaller quantities of small molecules, such as peptides, oligonucleotides, or heterocyclics, covalently attached to polystyrene beads on a grid, is presented using imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS). The determination is made possible by selectively clipping the bond linking the small molecule to the bead, followed directly by a TOF-SIMS assay of the bead on the grid. The method can be applied to large numbers of polystyrene beads having different small molecules attached thereto for direct characterization of massive combinatorial libraries.
摘要翻译： PCT No.PCT / US95 / 03355 Sec。 371日期：1996年12月18日 102（e）日期1996年12月18日PCT提交1995年3月23日PCT公布。公开号WO95 / 25737 日期1995年9月28日使用成像飞行时间二次离子来确定飞甲托或分子量较小的小分子如分子量，如肽，寡核苷酸或杂环的共价连接到网格上的聚苯乙烯珠粒的方法质谱（TOF-SIMS）。通过选择性地剪切将小分子连接到珠粒上的键，然后直接通过网格上的珠粒的TOF-SIMS测定来确定。该方法可以应用于大量具有连接到其上的不同小分子的聚苯乙烯珠，用于大规模组合文库的直接表征。

3. 发明授权

US06432716B1 Method to identify a surface-bound molecule 有权
公开(公告)号：US06432716B1
公开(公告)日：2002-08-13
申请号：US09051216
申请日：1998-12-18
申请人： Nicholas Winograd , Donald E. Riederer , Reema Chatterjee
发明人： Nicholas Winograd , Donald E. Riederer , Reema Chatterjee
IPC分类号： G01N3300
摘要： The present invention relates to a method of identifying a molecule of a molecule-substrate complex, wherein the molecule is covalently attached directly to a substrate or indirectly by means of a linking moiety, comprising: (a) bombarding the molecule-substrate complex with energized particles to cleave the molecule from the molecule-substrate complex; and (b) determining the molecular weight of the cleaved molecule by means of mass spectrometry. The inventive method may further comprise irradiating the cleaved molecule with photons.

4. 发明授权

US5272338A Molecular imaging system 失效
标题翻译：分子成像系统
公开(公告)号：US5272338A
公开(公告)日：1993-12-21
申请号：US887201
申请日：1992-05-21
申请人： Nicholas Winograd , Stephen J. Benkovic
发明人： Nicholas Winograd , Stephen J. Benkovic
IPC分类号： G01N23/225 , G01Q90/00 , H01J37/256 , H01J37/252
CPC分类号： G01N23/2258 , H01J37/256 , H01J49/0004 , H01J49/0463 , H01J49/162 , G01N2223/073 , H01J2237/2533
摘要： An ion-beam based system enables quantitative analysis and visualization of a sample with atomic and molecular specificity. The system comprises a liquid metal ion source that directs a tightly focused beam of ions at the sample, the beam having an ion density that is insufficient to materially change the surface properties of the sample. A controller connected to the liquid metal ion source gates on the ion beam for a period of time that is sufficient to enable the ion source to achieve a tight focus of the beam at the sample and for further scanning the ion beam across the sample. A laser beam is positioned over the sample and has a wavelength that resonantly ionizes components of the sample that are liberated by action of the scanned ion beam. A detector measures the liberated ionized components and is connected to a display system that provides an image of the distribution of the species on surface of the sample.
摘要翻译：基于离子束的系统能够对原子和分子特异性的样品进行定量分析和可视化。该系统包括液体金属离子源，其将紧密聚焦的离子束引导到样品处，所述束的离子密度不足以实质上改变样品的表面性质。连接到离子束上的液体金属离子源栅极的控制器一段时间足以使得离子源能够在样品处实现光束的紧密聚焦，并进一步扫描穿过样品的离子束。激光束定位在样品上方，并具有通过扫描离子束的作用而使样品的分量共振电离的波长。检测器测量释放的电离组分并连接到显示系统，其提供物质在样品表面上的分布的图像。

5. 发明授权

US4022950A Reversible photogalvanic cells for the conversion of solar radiation into electricity 失效
标题翻译：用于将太阳辐射转化为电能的可逆光电池
公开(公告)号：US4022950A
公开(公告)日：1977-05-10
申请号：US649090
申请日：1976-01-14
申请人： Francis K. Fong , Nicholas Winograd
发明人： Francis K. Fong , Nicholas Winograd
IPC分类号： H01G9/20 , H01M14/00 , H01M6/30
CPC分类号： H01M14/005 , H01G9/20
摘要： A device to convert solar energy into electricity, making use of the reversible photogalvanic principle. This principle is based on the spontaneous light and dark reactions between two electrochemical half cells constructed from a reversible electrochemical reaction. The device uses photosensitizers that operate in a broad band infrared spectral region.The specific photosensitizer used is chlorophyll a coated on a platinum electrode suspended in an ionic salt solution on one side of the cell and a platinum electrode is also suspended on the other side of the half cell in a hydroquinone solution, and the electrodes are electrically connected, these solutions are interconnected by a salt bridge which permits the flow of cation charge reversibly between said first and second half cells upon on-off light irradiation of the chlorophyll coated electrode.
摘要翻译：将太阳能转化为电力的设备，利用可逆的光电原理。该原理基于由可逆电化学反应构建的两个电化学半电池之间的自发光和暗反应。该装置使用在宽带红外光谱区域中操作的光敏剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式