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1. 发明授权

US08180454B2 Fitting a neural prosthesis using impedance and electrode height 有权
标题翻译：使用阻抗和电极高度拟合神经假体
公开(公告)号：US08180454B2
公开(公告)日：2012-05-15
申请号：US11607201
申请日：2006-12-01
申请人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/18
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。

2. 发明申请

US20080294223A1 Fitting a Neural Prosthesis Using Impedance and Electrode Height 有权
标题翻译：使用阻抗和电极高度拟合神经假体
公开(公告)号：US20080294223A1
公开(公告)日：2008-11-27
申请号：US11925285
申请日：2007-10-26
申请人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。

3. 发明授权

US08190267B2 Fitting a neural prosthesis using impedance and electrode height 有权
公开(公告)号：US08190267B2
公开(公告)日：2012-05-29
申请号：US11925285
申请日：2007-10-26
申请人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.

4. 发明申请

US20070191911A1 Fitting a neural prosthesis using impedance and electrode height 有权
标题翻译：使用阻抗和电极高度拟合神经假体
公开(公告)号：US20070191911A1
公开(公告)日：2007-08-16
申请号：US11607201
申请日：2006-12-01
申请人： Robert Greenberg , Ione Fine , Arup Roy , Matthew McMahon , Mark Humayun , James Weiland , Alan Horsager , Dao Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert Greenberg , Ione Fine , Arup Roy , Matthew McMahon , Mark Humayun , James Weiland , Alan Horsager , Dao Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/18
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。

5. 发明授权

US08244364B2 Apparatus and method for electrical stimulation of human retina 有权
标题翻译：人类视网膜电刺激的装置和方法
公开(公告)号：US08244364B2
公开(公告)日：2012-08-14
申请号：US11926054
申请日：2007-10-28
申请人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
发明人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
IPC分类号： A61N1/08
CPC分类号： A61N1/36046
摘要： An apparatus and method for retinal stimulation are shown. The method comprises varied parameters, including frequency, pulse width, and pattern of pulse trains to determine a stimulation pattern and visual perception threshold.
摘要翻译：显示视网膜刺激的装置和方法。该方法包括各种参数，包括脉冲序列的频率，脉冲宽度和模式，以确定刺激模式和视觉感知阈值。

6. 发明授权

US08457754B2 Apparatus and method for electrical stimulation of human neurons 有权
标题翻译：电刺激人类神经元的装置和方法
公开(公告)号：US08457754B2
公开(公告)日：2013-06-04
申请号：US11952051
申请日：2007-12-06
申请人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
发明人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
IPC分类号： A61N1/08
CPC分类号： A61N1/36046
摘要： An apparatus and method for retinal stimulation are shown. The method comprises varied parameters, including frequency, pulse width, and pattern of pulse trains to determine a stimulation pattern and neural perception threshold, and creating a model based on the neural perception thresholds to optimize patterns of neural stimulation.
摘要翻译：显示视网膜刺激的装置和方法。该方法包括各种参数，包括频率，脉冲宽度和脉冲序列模式，以确定刺激模式和神经感知阈值，并创建基于神经感知阈值的模型以优化神经刺激模式。

7. 发明授权

US08311634B2 Apparatus and method for electrical stimulation of human retina 有权
公开(公告)号：US08311634B2
公开(公告)日：2012-11-13
申请号：US11818373
申请日：2007-06-14
申请人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
发明人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
IPC分类号： A61N1/08
CPC分类号： A61N1/36046
摘要： An apparatus and method for retinal stimulation are shown. The method comprises varied parameters, including frequency, pulse width, and pattern of pulse trains to determine a stimulation pattern and visual perception threshold.

8. 发明申请

US20080125832A1 APPARATUS AND METHOD FOR ELECTRICAL STIMULATION OF HUMAN NEURONS 有权
标题翻译：人类神经电刺激的装置和方法
公开(公告)号：US20080125832A1
公开(公告)日：2008-05-29
申请号：US11952051
申请日：2007-12-06
申请人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
发明人： Alan Matthew Horsager , Scott H. Greenwald , Mark S. Humayun , Matthew J. McMahon , Ione Fine , Robert J. Greenberg , Geoffrey M. Boynton
IPC分类号： A61N1/04
CPC分类号： A61N1/36046
摘要： An apparatus and method for retinal stimulation are shown. The method comprises varied parameters, including frequency, pulse width, and pattern of pulse trains to determine a stimulation pattern and neural perception threshold, and creating a model based on the neural perception thresholds to optimize patterns of neural stimulation.
摘要翻译：显示视网膜刺激的装置和方法。该方法包括各种参数，包括频率，脉冲宽度和脉冲序列模式，以确定刺激模式和神经感知阈值，并创建基于神经感知阈值的模型以优化神经刺激模式。

9. 发明授权

US09078739B2 Fitting of brightness in a visual prosthesis 有权
标题翻译：在视觉假体中配合亮度
公开(公告)号：US09078739B2
公开(公告)日：2015-07-14
申请号：US12879979
申请日：2010-09-10
申请人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
发明人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
IPC分类号： A61N1/36 , A61N1/05 , A61F9/08
CPC分类号： A61F9/08 , A61N1/36046
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. The perceptual response to electrical neural stimulation varies from patient to patient and The response to electrical neural stimulation varies from patient to patient and the relationship between current and perceived brightness is often non-linear. It is necessary to determine this relationship to fit the prosthesis settings for each patient. It is advantageous to map the perceptual responses to stimuli. The method of mapping of the present invention is to provide a plurality of stimuli that vary in current, voltage, pulse duration, frequency, or some other dimension; measuring and recording the response to those stimuli; deriving a formula or equation describing the map from the individual points; storing the formula; and using that formula to map future stimulation.
摘要翻译：本发明是一种将电极阵列自动调整为单个患者的神经特征的方法。对电神经刺激的感知反应因患者而异，并且对电神经刺激的响应因患者而异，并且电流和感知亮度之间的关系通常是非线性的。需要确定这种关系以适应每个患者的假体设置。将感知反应映射到刺激是有利的。本发明的映射方法是提供在电流，电压，脉冲持续时间，频率或某些其他维度上变化的多个刺激; 测量和记录对这些刺激的反应; 从各个点得出描述地图的公式或方程; 存储公式; 并使用该公式来映射未来的刺激。

10. 发明申请

US20120330377A1 Visual Prosthesis Fitting 审中-公开
标题翻译：视觉假体拟合
公开(公告)号：US20120330377A1
公开(公告)日：2012-12-27
申请号：US13590011
申请日：2012-08-20
申请人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
发明人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
IPC分类号： A61F9/08 , A61N1/372
摘要： The present invention is a fitting system with a graphical interface with specific interface screens for specific functions. Methods and devices for fitting a visual prosthesis are described. In one of the methods, threshold levels and maximum levels for the electrodes of the prosthesis are determined and a map of brightness to electrode stimulation levels is later formed. A fitting system for a visual prosthesis is also discussed, together with a computer-operated system having a graphical user interface showing visual prosthesis diagnostic screens and visual prosthesis configuration screens.
摘要翻译：本发明是具有特定功能的特定接口屏幕的图形界面的拟合系统。描述了用于装配视觉假体的方法和装置。在其中一种方法中，确定假体电极的阈值水平和最大水平，并且稍后形成亮度与电极刺激水平的图。还讨论了用于视觉假体的装配系统，以及具有显示视觉假体诊断屏幕和视觉假体配置屏幕的图形用户界面的计算机操作系统。

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