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1. 发明授权

US08686375B2 Molecule mass detection via field emission of electrons from membranes 有权
标题翻译：通过电子从膜发射的分子质量检测
公开(公告)号：US08686375B2
公开(公告)日：2014-04-01
申请号：US13625731
申请日：2012-09-24
申请人： Robert H. Blick , Lloyd M. Smith , Michael Westphall , Hua Qin
发明人： Robert H. Blick , Lloyd M. Smith , Michael Westphall , Hua Qin
IPC分类号： G01T1/00
CPC分类号： G01N23/00 , H01J47/001 , H01J49/025
摘要： An active detector and methods for detecting molecules, including large molecules such as proteins and oligonucleotides, at or near room temperature based on the generation of electrons via field emission (FE) and/or secondary electron emission (SEE). The detector comprises a semiconductor membrane having an external surface that is contacted by one or more molecules, and an internal surface having a thin metallic layer or other type of electron emitting layer. The kinetic energy of molecules contacting the semiconductor membrane is transferred through the membrane and induces the emission of electrons from the emitting layer. An electron detector, which optionally includes means for electron amplification, is positioned to detect the emitted electrons.
摘要翻译：基于通过场发射（FE）和/或二次电子发射（SEE）产生电子，在室温或室温下检测分子（包括大分子如蛋白质和寡核苷酸）的主动检测器和方法。检测器包括具有与一个或多个分子接触的外表面的半导体膜和具有薄金属层或其它类型的电子发射层的内表面。接触半导体膜的分子的动能通过膜转移并诱导从发射层发射电子。可选地包括用于电子放大的装置的电子检测器被定位成检测发射的电子。

2. 发明授权

US07884324B2 Nanopillar arrays for electron emission 有权
标题翻译：用于电子发射的纳米柱阵列
公开(公告)号：US07884324B2
公开(公告)日：2011-02-08
申请号：US12130103
申请日：2008-05-30
申请人： Robert H. Blick , Michael S. Westphall , Hua Qin , Lloyd M. Smith
发明人： Robert H. Blick , Michael S. Westphall , Hua Qin , Lloyd M. Smith
IPC分类号： G01N23/00 , G01N13/10 , H01J49/08
CPC分类号： H01J1/32 , H01J29/023 , H01J43/246 , Y10S977/762
摘要： The present invention provides systems, devices, device components and structures for modulating the intensity and/or energies of electrons, including a beam of incident electrons. In some embodiments, for example, the present invention provides nano-structured semiconductor membrane structures capable of generating secondary electron emission. Nano-structured semiconductor membranes of this aspect of the present invention include membranes having an array of nanopillar structures capable of providing electron emission for amplification, filtering and/or detection of incident radiation, for example secondary electron emission and/or field emission. Nano-structured semiconductor membranes of the present invention are useful as converters wherein interaction of incident primary electrons and nanopillars of the nanopillar array generates secondary emission. Nano-structured semiconductor membranes of this aspect of the present invention are also useful as directed charge amplifiers wherein secondary emission from a nanopillar array provides gain functionality for increasing the intensity of radiation comprising incident electrons.
摘要翻译：本发明提供了用于调制包括入射电子束的电子的强度和/或能量的系统，装置，器件组件和结构。在一些实施例中，例如，本发明提供能够产生二次电子发射的纳米结构的半导体膜结构。本发明该方面的纳米结构半导体膜包括具有能够提供用于放射，滤波和/或检测入射辐射的电子发射的纳米柱结构阵列的膜，例如二次电子发射和/或场发射。本发明的纳米结构半导体膜可用作其中纳米柱阵列的入射一次电子和纳米柱的相互作用产生二次发射的转换器。本发明该方面的纳米结构半导体膜也可用作定向电荷放大器，其中来自纳米柱阵列的二次发射提供了用于增加包括入射电子的辐射强度的增益功能。

3. 发明申请

US20100129603A1 RETRO-PERCUSSIVE TECHNIQUE FOR CREATING NANOSCALE HOLES 有权
标题翻译：用于创造纳米孔的革命性技术
公开(公告)号：US20100129603A1
公开(公告)日：2010-05-27
申请号：US12277900
申请日：2008-11-25
申请人： Robert H. Blick , Minrui Yu , Hua Qin , Hyun-Seok Kim
发明人： Robert H. Blick , Minrui Yu , Hua Qin , Hyun-Seok Kim
IPC分类号： B32B3/10 , B29C35/08
CPC分类号： B23K26/389 , Y10T428/24273 , Y10T428/24281
摘要： A method of forming extremely small pores in glass or a similar substrate, useful, for example, in patch clamp applications, that employs a backer plate to contain energy of a laser-induced ablation through the front surface of the substrate so as to create a rear surface shock wave providing a fire polishing of the exit aperture of the pore such as produces improved sealing with cell membranes.
摘要翻译：在玻璃或类似衬底中形成非常小的孔的方法，可用于例如膜片钳应用中，其采用衬底板来包含通过衬底的前表面的激光诱导的消融的能量，从而产生后表面冲击波提供孔的出口孔的火抛光，例如使细胞膜产生改善的密封。

4. 发明申请

US20120141729A1 Retro-Percussive Technique for Creating Nanoscale Holes 审中-公开
标题翻译：复古打击技术创造纳米孔
公开(公告)号：US20120141729A1
公开(公告)日：2012-06-07
申请号：US13310119
申请日：2011-12-02
申请人： Robert H. Blick , Minrui Yu , Hua Qin , Hyun-Seok Kim
发明人： Robert H. Blick , Minrui Yu , Hua Qin , Hyun-Seok Kim
IPC分类号： B32B3/10
CPC分类号： B23K26/389 , Y10T428/24273 , Y10T428/24281
摘要： A method of forming extremely small pores in glass or a similar substrate, useful, for example, in patch clamp applications, that employs a backer plate to contain energy of a laser-induced ablation through the front surface of the substrate so as to create a rear surface shock wave providing a fire polishing of the exit aperture of the pore such as produces improved sealing with cell membranes.
摘要翻译：在玻璃或类似衬底中形成非常小的孔的方法，可用于例如膜片钳应用中，其采用衬底板来包含通过衬底的前表面的激光诱导的消融的能量，从而产生后表面冲击波提供孔的出口孔的火抛光，例如使细胞膜产生改善的密封。

5. 发明授权

US08217665B2 Radio-frequency ion channel probe 有权
标题翻译：射频离子通道探头
公开(公告)号：US08217665B2
公开(公告)日：2012-07-10
申请号：US12277837
申请日：2008-11-25
申请人： Robert H. Blick , Hua Qin
发明人： Robert H. Blick , Hua Qin
IPC分类号： G01R27/26 , A61K9/127
CPC分类号： G01N33/6872 , G01N33/48728
摘要： A patch-clamp system employs a high-frequency characterization of cell wall membranes. Changes in the frequency response of a tank circuit incorporating the cell wall membrane impedance provides highly sensitive and highly time-resolved measurements of ion channel activity.
摘要翻译：膜片钳系统采用细胞壁膜的高频表征。结合细胞壁膜阻抗的储能电路的频率响应的变化提供离子通道活性的高灵敏度和高度时间分辨的测量。

6. 发明授权

US08092739B2 Retro-percussive technique for creating nanoscale holes 有权
标题翻译：用于创建纳米尺度孔的复古打击技术
公开(公告)号：US08092739B2
公开(公告)日：2012-01-10
申请号：US12277900
申请日：2008-11-25
申请人： Robert H. Blick , Minrui Yu , Hua Qin , Hyun-Seok Kim
发明人： Robert H. Blick , Minrui Yu , Hua Qin , Hyun-Seok Kim
IPC分类号： B29C35/08
CPC分类号： B23K26/389 , Y10T428/24273 , Y10T428/24281
摘要： A method of forming extremely small pores in glass or a similar substrate, useful, for example, in patch clamp applications, that employs a backer plate to contain energy of a laser-induced ablation through the front surface of the substrate so as to create a rear surface shock wave providing a fire polishing of the exit aperture of the pore such as produces improved sealing with cell membranes.
摘要翻译：在玻璃或类似衬底中形成非常小的孔的方法，可用于例如膜片钳应用中，其采用衬底板来包含通过衬底的前表面的激光诱导的消融的能量，从而产生后表面冲击波提供孔的出口孔的火抛光，例如使细胞膜产生改善的密封。

7. 发明申请

US20100127716A1 RADIO-FREQUENCY ION CHANNEL PROBE 有权
标题翻译：无线电频道离子通道探头
公开(公告)号：US20100127716A1
公开(公告)日：2010-05-27
申请号：US12277837
申请日：2008-11-25
申请人： Robert H. Blick , Hua Qin
发明人： Robert H. Blick , Hua Qin
IPC分类号： G01R27/00
CPC分类号： G01N33/6872 , G01N33/48728
摘要： A patch-clamp system employs a high-frequency characterization of cell wall membranes. Changes in the frequency response of a tank circuit incorporating the cell wall membrane impedance provides highly sensitive and highly time-resolved measurements of ion channel activity.
摘要翻译：膜片钳系统采用细胞壁膜的高频表征。结合细胞壁膜阻抗的储能电路的频率响应的变化提供离子通道活性的高灵敏度和高度时间分辨的测量。

8. 发明授权

US07776661B2 Nano-electromechanical circuit using co-planar transmission line 有权
标题翻译：使用共面传输线的纳米机电电路
公开(公告)号：US07776661B2
公开(公告)日：2010-08-17
申请号：US11776254
申请日：2007-07-11
申请人： Hua Qin , Hyun Seok Kim , Robert H. Blick
发明人： Hua Qin , Hyun Seok Kim , Robert H. Blick
IPC分类号： H01L21/00
CPC分类号： H03H9/462 , H03H9/02259 , H03H2009/02267 , Y10T29/49002
摘要： A co-planar waveguide structure is integrated with an upwardly extending resonant pillar to produce transfer cells that provide controlled transmission of electricity between adjacent structures of the co-planar waveguide in order to produce easily fabricated electronic devices operating at megahertz and gigahertz speeds for filtration, modulation, rectification, and mixing of high-frequency signals.
摘要翻译：共面波导结构与向上延伸的谐振支柱集成以产生转移电池，其在共面波导的相邻结构之间提供受控的电力传输，以便制造容易制造的以兆赫和千兆赫兹速度进行过滤的电子器件，高频信号的调制，整流和混频。

9. 发明申请

US20090015351A1 NANO-ELECTROMECHANICAL CIRCUIT USING CO-PLANAR TRANSMISSION LINE 有权
标题翻译：使用共面传输线的纳米电子电路
公开(公告)号：US20090015351A1
公开(公告)日：2009-01-15
申请号：US11776254
申请日：2007-07-11
申请人： Hua Qin , Hyun Seok Kim , Robert H. Blick
发明人： Hua Qin , Hyun Seok Kim , Robert H. Blick
IPC分类号： H03H9/00
CPC分类号： H03H9/462 , H03H9/02259 , H03H2009/02267 , Y10T29/49002
摘要： A co-planar waveguide structure is integrated with an upwardly extending resonant pillar to produce transfer cells that provide controlled transmission of electricity between adjacent structures of the co-planar waveguide in order to produce easily fabricated electronic devices operating at megahertz and gigahertz speeds for filtration, modulation, rectification, and mixing of high-frequency signals.
摘要翻译：共面波导结构与向上延伸的谐振支柱集成以产生转移电池，其在共面波导的相邻结构之间提供受控的电力传输，以便制造容易制造的以兆赫和千兆赫兹速度进行过滤的电子器件，高频信号的调制，整流和混频。

10. 发明申请

US20140029634A1 SEMICONDUCTOR MICROTUBE LASERS 有权
公开(公告)号：US20140029634A1
公开(公告)日：2014-01-30
申请号：US13467217
申请日：2012-05-09
申请人： Robert H. Blick , Luke J. Mawst
发明人： Robert H. Blick , Luke J. Mawst
IPC分类号： H01S5/12
CPC分类号： H01S5/1228 , H01S5/041 , H01S5/06 , H01S5/10 , H01S5/1042 , H01S5/1075 , H01S5/12 , H01S5/3201
摘要： Disclosed are semiconductor microtube lasers including a semiconductor multilayer heterostructure. The multilayer heterostructure includes a substantially cylindrical optically active structure capable of light emission when under the influence of an applied electromagnetic field and a substantially cylindrical distributed feedback grating structure configured to provide optical feedback for a selected wavelength of light from the optically active region and to produce lasing action from the microtube when under the influence of an applied electromagnetic field.
摘要翻译：公开了包括半导体多层异质结构的半导体微管激光器。多层异质结构包括基本上圆柱形的光学活性结构，其在施加的电磁场的影响下能够发光，并且基本上为圆柱形的分布反馈光栅结构，其被配置为为来自光学活性区域的所选波长的光提供光学反馈并产生在施加的电磁场的影响下，微管的激光作用。

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