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1. 发明授权

US06685722B1 Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
标题翻译：止血导管和治疗中风和其他小血管血栓栓塞障碍的方法
公开(公告)号：US06685722B1
公开(公告)日：2004-02-03
申请号：US09437530
申请日：1999-11-10
申请人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti
发明人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti
IPC分类号： A61M2900
CPC分类号： A61B17/22032 , A61B17/135 , A61B17/221 , A61B2017/22034 , A61B2017/22044 , A61B2017/22077 , A61B2017/22084 , A61B2017/22094 , A61B2017/2212 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/008 , A61F2230/0091 , A61M2025/0042 , A61M2025/0183
摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.
摘要翻译：用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

2. 发明申请

US20140135803A9 Embolectomy Catheters And Methods For Treating Stroke And Other Small Vessel Thromboembolic Disorders 失效
公开(公告)号：US20140135803A9
公开(公告)日：2014-05-15
申请号：US12709408
申请日：2010-02-19
申请人： Robert F. Rosenbluth , George R. Green, JR. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti , Teresa L. Halverson , Maricela D. Walker , Robert Pecor
发明人： Robert F. Rosenbluth , George R. Green, JR. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti , Teresa L. Halverson , Maricela D. Walker , Robert Pecor
IPC分类号： A61B17/22 , A61F2/01
CPC分类号： A61B17/22032 , A61B17/135 , A61B17/221 , A61B2017/22034 , A61B2017/22044 , A61B2017/22077 , A61B2017/22084 , A61B2017/22094 , A61B2017/2212 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/008 , A61F2230/0091 , A61M2025/0042 , A61M2025/0183
摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

3. 发明授权

US07691121B2 Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
标题翻译：止血导管和治疗中风和其他小血管血栓栓塞障碍的方法
公开(公告)号：US07691121B2
公开(公告)日：2010-04-06
申请号：US10730860
申请日：2003-12-09
申请人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti
发明人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti
IPC分类号： A61M29/00
CPC分类号： A61B17/22032 , A61B17/135 , A61B17/221 , A61B2017/22034 , A61B2017/22044 , A61B2017/22077 , A61B2017/22084 , A61B2017/22094 , A61B2017/2212 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/008 , A61F2230/0091 , A61M2025/0042 , A61M2025/0183
摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may included a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.
摘要翻译：用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。凝块移除装置可以包括设计成防止血块从其中通过的可展开的线窝。输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

4. 发明授权

US08100935B2 Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
标题翻译：止血导管和治疗中风和其他小血管血栓栓塞障碍的方法
公开(公告)号：US08100935B2
公开(公告)日：2012-01-24
申请号：US11773601
申请日：2007-07-05
申请人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti
发明人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti
IPC分类号： A61M29/00
CPC分类号： A61B17/22032 , A61B17/135 , A61B17/221 , A61B2017/22034 , A61B2017/22044 , A61B2017/22077 , A61B2017/22084 , A61B2017/22094 , A61B2017/2212 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/008 , A61F2230/0091 , A61M2025/0042 , A61M2025/0183
摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.
摘要翻译：用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

5. 发明授权

US08784441B2 Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 失效
标题翻译：止血导管和治疗中风和其他小血管血栓栓塞障碍的方法
公开(公告)号：US08784441B2
公开(公告)日：2014-07-22
申请号：US12709408
申请日：2010-02-19
申请人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti , Teresa L. Halverson , Maricela D. Walker , Robert Pecor
发明人： Robert F. Rosenbluth , George R. Green, Jr. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti , Teresa L. Halverson , Maricela D. Walker , Robert Pecor
IPC分类号： A61B17/22
CPC分类号： A61B17/22032 , A61B17/135 , A61B17/221 , A61B2017/22034 , A61B2017/22044 , A61B2017/22077 , A61B2017/22084 , A61B2017/22094 , A61B2017/2212 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/008 , A61F2230/0091 , A61M2025/0042 , A61M2025/0183
摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.
摘要翻译：用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

6. 发明申请

US20100145371A1 Embolectomy Catheters And Methods For Treating Stroke And Other Small Vessel Thromboembolic Disorders 失效
标题翻译：用于治疗中风和其他小血管栓塞性疾病的结肠切除术导管和方法
公开(公告)号：US20100145371A1
公开(公告)日：2010-06-10
申请号：US12709408
申请日：2010-02-19
申请人： Robert F. Rosenbluth , George R. Green, JR. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti , Teresa L. Halverson , Maricela D. Walker , Robert Pecor
发明人： Robert F. Rosenbluth , George R. Green, JR. , Brian J. Cox , Thomas R. Sternweiler , Sean L. Chow , Richard R. Monetti , Teresa L. Halverson , Maricela D. Walker , Robert Pecor
IPC分类号： A61B17/22 , A61F2/01
CPC分类号： A61B17/22032 , A61B17/135 , A61B17/221 , A61B2017/22034 , A61B2017/22044 , A61B2017/22077 , A61B2017/22084 , A61B2017/22094 , A61B2017/2212 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/008 , A61F2230/0091 , A61M2025/0042 , A61M2025/0183
摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.
摘要翻译：用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

7. 发明授权

US06375669B1 Apparatus and method for vascular embolization 有权
标题翻译：血管栓塞的装置和方法
公开(公告)号：US06375669B1
公开(公告)日：2002-04-23
申请号：US09471507
申请日：1999-12-23
申请人： Robert F. Rosenbluth , Brian J. Cox , George R. Green, Jr.
发明人： Robert F. Rosenbluth , Brian J. Cox , George R. Green, Jr.
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12163 , A61B17/12186 , A61B17/12195 , A61B2017/1205 , A61B2017/12063
摘要： Apparatus for vascular embolization, deployable through a microcatheter, includes a flexible, elongate deployment tube dimensioned for insertion through the microcatheter, and a filamentous embolic device releasably attached to the distal end of the tube. The embolic device is controllably transformable from a soft, compliant state to a rigid or semi-rigid state. The embolic device may include a polymeric material that is transformable by contact with vascular blood or with a liquid that is cooler than vascular blood, or it may include a metallic material that is transformable by electrolytic corrosion. The embolic device may be a continuous filamentous polymeric extrusion; an elongate microcoil filled with polymeric material; an elongate, multi-segmented chain including polymeric interconnecting portions; or an elongate chain of metal segments that are fused together by electrolytic corrosion. An aneurysm is embolized with this apparatus by deploying a microcatheter so that its distal end is adjacent the aneurysm; deploying the embolic device through the microcatheter and into the aneurysm so that the embolic device forms a web-like mass in the aneurysm; and transforming the embolic device from its soft, compliant state to its rigid or semi-rigid state. The embolic device is advantageously deployed by releasably attaching it to a flexible, elongate deployment tube that is passed through the microcatheter, and then detaching the embolic device from the tube when the embolic device is suitably situated.
摘要翻译：用于通过微导管展开的血管栓塞的装置包括尺寸适于插入通过微导管的柔性细长展开管和可释放地附接到管的远端的丝状栓塞装置。栓塞装置可以从柔软的柔顺状态可控地变形成刚性或半刚性状态。栓塞装置可以包括通过与血管或与血液血液更冷的液体接触可变形的聚合材料，或者它可以包括可通过电解腐蚀转化的金属材料。栓塞装置可以是连续的丝状聚合物挤出物; 填充有聚合物材料的细长的微线圈; 包括聚合物互连部分的细长多段链; 或通过电解腐蚀熔合在一起的金属段的细长链。通过部署微导管使其远端邻近动脉瘤，将动脉瘤栓塞在该装置上; 将栓塞装置通过微导管部署到动脉瘤中，使得栓塞装置在动脉瘤中形成网状质量; 并将栓塞装置从其柔软的柔顺状态转变为刚性或半刚性状态。栓塞装置有利地通过将其可释放地附接到穿过微导管的柔性细长的展开管来展开，然后当栓塞装置适当地定位时将栓塞装置从管中分离出来。

8. 发明授权

US09918720B2 Multiple layer filamentary devices for treatment of vascular defects 有权
公开(公告)号：US09918720B2
公开(公告)日：2018-03-20
申请号：US13439754
申请日：2012-04-04
申请人： Philippe Marchand , Brian J. Cox , Robert F. Rosenbluth , John Nolting , Tan Q. Dinh , Thomas C. Wilder
发明人： Philippe Marchand , Brian J. Cox , Robert F. Rosenbluth , John Nolting , Tan Q. Dinh , Thomas C. Wilder
IPC分类号： A61M29/00 , A61B17/12 , A61B17/00 , A61B17/22
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12118 , A61B17/12172 , A61B17/12177 , A61B2017/00526 , A61B2017/1205 , A61B2017/22067
摘要： Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments may include a permeable shell and inner structure configured to occlude blood flow therethrough.

9. 发明申请

US20120136440A1 Method And Apparatus For Treating Airway Obstruction 审中-公开
标题翻译：用于治疗气道阻塞的方法和装置
公开(公告)号：US20120136440A1
公开(公告)日：2012-05-31
申请号：US13367108
申请日：2012-02-06
申请人： Brian J. Cox , Robert F. Rosenbluth , Dean Schaefer
发明人： Brian J. Cox , Robert F. Rosenbluth , Dean Schaefer
IPC分类号： A61F2/20
CPC分类号： A61F2/90 , A61F2/00 , A61F5/56 , A61F2220/0008 , A61F2220/0016 , A61M16/0465
摘要： Methods and Devices for treating airway openings and breathing disorders including obstructive sleep apnea are disclosed. Structures and methods disclosed herein maintain and preserve airway openings against posterior collapse of the tongue.
摘要翻译：公开了用于治疗气道开口和包括阻塞性睡眠呼吸暂停的呼吸障碍的方法和装置。本文公开的结构和方法维持并保持气道开口以防止舌头的后塌陷。

10. 发明授权

US07483558B2 Vascular embolization with an expansible implant 有权
标题翻译：血管栓塞与可扩展植入物
公开(公告)号：US07483558B2
公开(公告)日：2009-01-27
申请号：US11733697
申请日：2007-04-10
申请人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
发明人： George R. Greene, Jr. , Robert F. Rosenbluth , Brian J. Cox
IPC分类号： G06T7/60 , A61F2/06 , B22C7/02
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
摘要翻译：由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。在进入血管部位时，植入物基本上扩张以填充血管部位。保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。

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