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1. 发明授权

US4939101A Method of making direct bonded wafers having a void free interface 失效
标题翻译：制造具有无空隙界面的直接接合晶片的方法
公开(公告)号：US4939101A
公开(公告)日：1990-07-03
申请号：US240332
申请日：1988-09-06
申请人： Robert D. Black , Stephen D. Arthur , Robert S. Gilmore , Homer H. Glascock, II
发明人： Robert D. Black , Stephen D. Arthur , Robert S. Gilmore , Homer H. Glascock, II
IPC分类号： H01L21/20 , H01L21/762
CPC分类号： H01L21/76251 , H01L21/2007 , Y10S148/012 , Y10S228/903
摘要： Wafers which are direct bonded to each other in accordance with prior art processes suffer from voids at their bonded interface. Annealing such composite structures at high temperature and high pressure (for silicon wafers preferably about 1,100.degree. C. and 15,000 psi) eliminates all voids which are not a result of the presence of a particle on one of the wafers at the time of mating.
摘要翻译：根据现有技术方法直接接合的晶片在其键合界面处具有空隙。在高温和高压下退火这种复合结构（对于优选约1100℃和15,000psi的硅晶片）消除了在配合时不是在其中一个晶片上存在颗粒的所有空隙。

2. 发明授权

US09655772B2 Systems, devices and methods for caloric vestibular stimulation having an impedance monitor and/or temperature sensor 有权
公开(公告)号：US09655772B2
公开(公告)日：2017-05-23
申请号：US13525817
申请日：2012-06-18
申请人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
发明人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
IPC分类号： A61B1/00 , A61F7/12 , A61F7/00 , A61B18/00 , A61F7/02
CPC分类号： A61F7/12 , A61B2018/00875 , A61F7/007 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/0296 , A61N1/36036 , A61N2/002 , A61N2/006
摘要： An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.

3. 发明申请

US20110161012A1 READERS AND COMPUTER PROGRAM PRODUCTS THAT COOPERATE WITH SINGLE-USE EXTERNAL DOSIMETERS FOR USE IN RADIATION THERAPIES 审中-公开
标题翻译：与单次使用外用药剂配合用于放射治疗的读者和计算机程序产品
公开(公告)号：US20110161012A1
公开(公告)日：2011-06-30
申请号：US13041906
申请日：2011-03-07
申请人： Robert D. Black , Gregory Glenwood Mann , Steven R. Widener , Phillip M. Lehman
发明人： Robert D. Black , Gregory Glenwood Mann , Steven R. Widener , Phillip M. Lehman
IPC分类号： G01T1/02 , G06F19/00
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive means onto the skin of a patient to evaluate the radiation dose delivered during a treatment session. The sensor patches are configured to be minimally obtrusive and operate without the use of externally extending power cords or lead wires.
摘要翻译：方法，系统，装置和计算机程序产品包括将具有粘合剂的一次性辐射传感器贴片定位到患者的皮肤上，以评估在治疗期间递送的辐射剂量。传感器贴片配置为最低限度地突出，并且不使用外部扩展的电源线或引线进行操作。

4. 发明授权

US07966054B2 Disposable single-use external dosimeters for detecting radiation in fluoroscopy and other medical procedures/therapies 有权
标题翻译：一次性一次性外用剂量计，用于检测荧光透视和其他医疗程序/治疗中的辐射
公开(公告)号：US07966054B2
公开(公告)日：2011-06-21
申请号：US10865430
申请日：2004-06-10
申请人： Robert D. Black , Steven R. Widener , John Carroll , Gregory Glenwood Mann , Phillip M. Lehman
发明人： Robert D. Black , Steven R. Widener , John Carroll , Gregory Glenwood Mann , Phillip M. Lehman
IPC分类号： A61B5/05
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive onto the skin of a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The sensor patches are configured to be relatively unobtrusive and operate during radiation without the use of externally extending power cords or lead wires.
摘要翻译：方法，系统，设备和计算机程序产品包括将具有粘合剂的单次使用的辐射传感器贴片定位在患者的皮肤上，以评估在医疗过程或治疗期间递送的辐射剂量。传感器贴片被配置为相对不引人注意并且在辐射期间操作，而不使用外部延伸的电源线或引线。

5. 发明授权

US07897927B2 Readers that cooperate with single-use internal dosimeters for detecting radiation in medical procedures/therapies 失效
标题翻译：与一次性内部剂量计配合使用以在医疗程序/疗法中检测辐射的读者
公开(公告)号：US07897927B2
公开(公告)日：2011-03-01
申请号：US12354461
申请日：2009-01-15
申请人： Robert D. Black , Steven R. Widener , John Carroll , Gregory Glenwood Mann , Phillip M. Lehman
发明人： Robert D. Black , Steven R. Widener , John Carroll , Gregory Glenwood Mann , Phillip M. Lehman
IPC分类号： G01T1/02
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation internal dosimeters with MOSFETs into a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The MOSFETs can be unpowered during irradiation.
摘要翻译：方法，系统，设备和计算机程序产品包括将具有MOSFET的单次使用辐射内部剂量计定位到患者中以评估在医疗过程或治疗期间递送的辐射剂量。 MOSFET在照射过程中可以无功。

6. 发明申请

US20090180962A1 IN VIVO FLUORESCENCE SENSORS, SYSTEMS, AND RELATED METHODS OPERATING IN CONJUNCTION WITH FLUORESCENT ANALYTES 有权
标题翻译：荧光荧光传感器，系统和相关方法与荧光分析仪相结合
公开(公告)号：US20090180962A1
公开(公告)日：2009-07-16
申请号：US12389012
申请日：2009-02-19
申请人： Robert D. Black , Natasha Bolick
发明人： Robert D. Black , Natasha Bolick
IPC分类号： A61B10/00
CPC分类号： A61K49/0041 , A61B5/0002 , A61B5/0071 , A61B5/0084 , A61B5/417 , A61K49/0058
摘要： Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification.In particular embodiments, the intensity of the excitation signals emitted to the localized tissue can be varied in a predetermined manner to generate optical profiling data of the response of the tissue proximate the sensor.
摘要翻译：方法，系统，装置和计算机程序产品包括：（i）向受试者施用荧光分析物; （ii）在期望的监测周期内从植入的传感器重复地发射激发光; （iii）使用输出激发光的植入传感器检测响应于激发光的荧光强度; 和（iv）使用与检测到的荧光强度相关联的数据来执行以下至少之一中的至少一个：（a）计算在植入的传感器位置附近接收的分析物的浓度或剂量; （b）评估荧光分析物的药效学或药代动力学活性; （c）确认Ab附着于肿瘤部位; （d）监测非目标地点，以确认其不会受到治疗的不当影响; （e）监测细胞特性的变化; （f）使用计算的剂量或浓度数据来调整或定制施用于受试者的分析物的治疗量; （g）确定目标部位的胶束浓度，然后根据确认刺激毒素释放; 和（h）监测由基因治疗修饰产生的蛋白质的表达。在特定实施例中，发射到局部组织的激发信号的强度可以以预定的方式变化，以产生靠近传感器的组织的响应的光学剖面数据。

7. 发明授权

US07510699B2 In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes 有权
标题翻译：体内荧光传感器，系统和与荧光分析物结合操作的相关方法
公开(公告)号：US07510699B2
公开(公告)日：2009-03-31
申请号：US10779907
申请日：2004-02-17
申请人： Robert D. Black , Natasha Bolick
发明人： Robert D. Black , Natasha Bolick
IPC分类号： A61B5/00
CPC分类号： A61K49/0041 , A61B5/0002 , A61B5/0071 , A61B5/0084 , A61B5/417 , A61K49/0058
摘要： Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification.In particular embodiments, the intensity of the excitation signals emitted to the localized tissue can be varied in a predetermined manner to generate optical profiling data of the response of the tissue proximate the sensor.
摘要翻译：方法，系统，装置和计算机程序产品包括：（i）向受试者施用荧光分析物; （ii）在期望的监测周期内从植入的传感器重复地发射激发光; （iii）使用输出激发光的植入传感器检测响应于激发光的荧光强度; 和（iv）使用与检测到的荧光强度相关联的数据来执行以下至少之一中的至少一个：（a）计算在植入的传感器位置附近接收的分析物的浓度或剂量; （b）评估荧光分析物的药效学或药代动力学活性; （c）确认Ab附着于肿瘤部位; （d）监测非目标地点，以确认其不会受到治疗的不当影响; （e）监测细胞特性的变化; （f）使用计算的剂量或浓度数据来调整或定制施用于受试者的分析物的治疗量; （g）确定目标部位的胶束浓度，然后根据确认刺激毒素释放; 和（h）监测由基因治疗修饰产生的蛋白质的表达。在特定实施例中，发射到局部组织的激发信号的强度可以以预定的方式变化，以产生靠近传感器的组织的响应的光学剖面数据。

8. 发明授权

US07491942B2 Single-use internal dosimeters for detecting radiation in fluoroscopy and other medical procedures/therapies 有权
标题翻译：用于检测荧光透视和其他医疗程序/治疗中的辐射的一次性内置剂量计
公开(公告)号：US07491942B2
公开(公告)日：2009-02-17
申请号：US10865312
申请日：2004-06-10
申请人： Robert D. Black , Steven R. Widener , John Carroll , Gregory Glenwood Mann , Phillip M. Lehman
发明人： Robert D. Black , Steven R. Widener , John Carroll , Gregory Glenwood Mann , Phillip M. Lehman
IPC分类号： G01T1/02
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation internal dosimeters with MOSFETs into a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The MOSFETs can be unpowered during irradiation.
摘要翻译：方法，系统，设备和计算机程序产品包括将具有MOSFET的单次使用辐射内部剂量计定位到患者中以评估在医疗过程或治疗期间递送的辐射剂量。 MOSFET在照射过程中可以无功。

9. 发明申请

US20080228049A1 Systems, Circuits and Apparatus For In Vivo Detection of Biomolecule Concentrations Using Fluorescent Tags 审中-公开
标题翻译：使用荧光标记体内检测生物分子浓度的系统，电路和装置
公开(公告)号：US20080228049A1
公开(公告)日：2008-09-18
申请号：US12126500
申请日：2008-05-23
申请人： Robert D. Black
发明人： Robert D. Black
IPC分类号： A61B5/1455
CPC分类号： A61B5/0071 , A61B5/0084 , A61K49/0058
摘要： Systems are disclosed wherein labeled binding molecules can be provided in vivo to tissue having biomolecules that specifically bind the labeled binding molecule. A first optical radiation is emitted into the tissue in vivo to excite the labeled binding molecule bound to the biomolecule in vivo. A second optical radiation that is emitted by the excited labeled binding molecule, in response to the excitation thereof, can be detected in vivo. Related telemetric-circuits and apparatus are also disclosed.
摘要翻译：公开了系统，其中标记的结合分子可以在体内提供给具有特异性结合标记的结合分子的生物分子的组织。在体内将第一光辐射发射到组织中以在体内激发与生物分子结合的标记的结合分子。激发的标记结合分子响应于其激发而发射的第二光辐射可以在体内检测。还公开了相关的遥测电路和装置。

10. 发明授权

US4186889A Forage harvester recutter screen 失效
标题翻译：饲料收割机回收机屏幕
公开(公告)号：US4186889A
公开(公告)日：1980-02-05
申请号：US907126
申请日：1978-05-18
申请人： Robert D. Black , John J. Hennen , Jerry L. Krafka
发明人： Robert D. Black , John J. Hennen , Jerry L. Krafka
IPC分类号： A01F29/06 , B26D1/38 , B02C18/22
CPC分类号： B26D1/38 , A01F29/06
摘要： A forage harvester has a cutterhead housing with a rotary reel type cutterhead mounted therein, the cutterhead having a plurality of knives parallel to the cutterhead axis at the cutterhead periphery, the knife edges generating a cylinder as the cutterhead rotates. The cutterhead reduces crop material that is fed into the housing and discharges the reduced material through a discharge opening to a conveying system that conveys the crop material to a crop-receiving vehicle. Removably mounted over the discharge opening is a recutter screen that has an arcuate shape generally concentric with and adjacent to the cutterhead periphery and a plurality of elongated apertures, each aperture having parallel longitudinal edges that extend diagonally relative to the knife cutting edges. The apertures are arranged in two transversely extending rows with the apertures in one row being inclined in one direction from the vertical and the apertures in the adjacent row being inclined in the opposite direction, the opposite angle of inclination of the apertures in the second row counteracting the tendency of the apertures in the first row to move the crop material impelled through the apertures in the direction of inclination. Alternate screens are conventionally provided with different size apertures according to the fineness of cut desired, and the screens are removably mounted in a frame that is adjustable relative to the cutterhead to maintain the optimum minimum clearance between the cutterhead and the recutter screen.
摘要翻译：饲料收割机具有安装在其中的旋转卷轴式刀盘的刀架壳体，刀架在刀盘周边具有平行于刀盘轴线的多个刀具，刀刃在刀架旋转时产生圆柱体。刀架减少送入壳体中的作物材料，并且将还原材料通过排放口排出到输送系统，该输送系统将作物材料输送到作物接收车辆。可移动地安装在排出口上的是一种重排筛，其具有与刀架周边大致同心且相邻的弓形形状，以及多个细长的孔，每个孔具有平行的纵向边缘，该纵向边缘相对于刀刃边缘对角地延伸。孔被布置成两个横向延伸的行，一排中的孔从垂直方向在一个方向上倾斜，并且相邻行中的孔在相反方向上倾斜，第二排中的孔的相反倾斜角抵消第一排中的孔的倾向是使作物沿着倾斜方向通过孔而被推动。传统的屏幕通常根据所要切割的细度而具有不同尺寸的孔，并且屏幕可移除地安装在相对于刀盘可调节的框架中，以保持切割头和再生器屏幕之间的最佳最小间隙。

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