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1. 发明申请

US20070163282A1 Ice-making system for refrigeration appliance 有权
标题翻译：制冷设备制冰系统
公开(公告)号：US20070163282A1
公开(公告)日：2007-07-19
申请号：US11331732
申请日：2006-01-13
申请人： Robert Cushman , David Hall , James Scoville , James Holland , Andrea Bertolaccini , Stefano Zuccolo , Enrico Favretti , Huang Hsin
发明人： Robert Cushman , David Hall , James Scoville , James Holland , Andrea Bertolaccini , Stefano Zuccolo , Enrico Favretti , Huang Hsin
IPC分类号： F25C1/22 , F25D11/02
CPC分类号： F25D17/065 , F25C1/08 , F25C2400/10 , F25D2317/061 , F25D2317/0666 , F25D2317/067 , F25D2323/021
摘要： An ice-making system is adapted to operate within a section of a refrigeration appliance where the ice-making system and the ice made in the ice-making system are exposed to a temperature greater than zero degrees Centigrade. When installed in the fresh food compartment of a refrigerator that also has a freezer section compartment, the refrigeration system furnishes a cooling effect to the freezer compartment sufficient to maintain the freezer compartment at a temperature of zero degrees or less and separately furnish to the ice-making unit a cooling effect sufficient to freeze water for making ice in the ice-making unit of the ice-making system. The ice-making system can include a reservoir that is operatively associated with the ice-making unit of the ice-making system for delivering water to the ice-making unit and for receiving water returned from the ice-making unit.
摘要翻译：制冰系统适于在制冷系统的一部分内操作，其中制冰系统和制冰系统中制成的冰暴露于大于零摄氏度的温度。当安装在还具有冷冻室隔室的冰箱的新鲜食物室中时，制冷系统对冷冻室提供足够的冷却效果，足以将冷冻室保持在零度或更小的温度，并且分别向冰 - 使得制冷单元具有足以在制冰系统的制冰单元中冷冻用于制冰的冷却效果。制冰系统可以包括与制冰系统的制冰单元可操作地相关联的储存器，用于将水输送到制冰单元并用于接收从制冰单元返回的水。

2. 发明申请

US20060204051A1 Method and system for managing account information 有权
标题翻译：用于管理帐户信息的方法和系统
公开(公告)号：US20060204051A1
公开(公告)日：2006-09-14
申请号：US11373551
申请日：2006-03-10
申请人： James Holland
发明人： James Holland
IPC分类号： G06K9/00
CPC分类号： G06Q20/02 , G06Q20/227 , G06Q20/40 , G06Q20/4014 , G06Q20/42 , G06Q20/425 , G06Q40/04 , G07C9/00039 , G07C9/00087
摘要： A method and system for authenticating the identity of a consumer is disclosed. After the consumer is authenticated by a trusted third party, the consumer designates accounts that the consumer wishes to “lock.” When a party requests access to that account, the consumer is notified through the consumer's phone and asked to input a PIN. If the consumer provides the PIN, the requestor is granted access to the consumer's account without requiring further input from the consumer. If the party authorizing the transaction in this “two-factor” authentication does not possess both the phone and the consumer's PIN, or that party elects not to provide the PIN, the request will not be authenticated.
摘要翻译：公开了一种用于认证消费者身份的方法和系统。在消费者被可靠的第三方认证之后，消费者指定消费者希望“锁定”的帐户。当一方请求访问该帐户时，消费者将通过消费者的电话进行通知，并要求输入PIN。如果消费者提供PIN，则请求者被授予访问消费者帐户的权限，而不需要消费者的进一步输入。如果在“双因素”认证中授权交易的一方不具有电话和消费者的PIN，或者该方不选择提供PIN，则该请求将不被认证。

3. 发明授权

US08399420B2 Azacytidine analogues and uses thereof 失效
标题翻译：氮杂胞苷类似物及其用途
公开(公告)号：US08399420B2
公开(公告)日：2013-03-19
申请号：US12238054
申请日：2008-09-25
申请人： Lewis Silverman , James Holland , Marit Liland Sandvold , Finn Myhren , Ole Henrik Eriksen
发明人： Lewis Silverman , James Holland , Marit Liland Sandvold , Finn Myhren , Ole Henrik Eriksen
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07D405/14 , A61K31/53 , A61K31/706 , C07H19/12
摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3—(CH2)n—(CH═CH—CH2)m—CH═CH—(CH2)k—; k is an integer from 0 to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
摘要翻译：本发明涉及如下式（I）化合物：其中R是H，R 5 C（O），R 5 CH 2 OC（O）或R 5 CH 2 NHC（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H，R5C（O），R5CH2OC（O）或R5CH2NHC（O），条件是R和R4不同时为H; 并且R 5具有通式：CH 3 - （CH 2）n - （CH = CH-CH 2）m -CH = CH-（CH 2）k - ; k是0至7的整数; m为0〜2的整数; n为0〜10的整数，或其药学盐。还公开了制备和使用这些化合物的方法。

4. 发明授权

US08158605B2 Azacytidine analogues and uses thereof 有权
标题翻译：氮杂胞苷类似物及其用途
公开(公告)号：US08158605B2
公开(公告)日：2012-04-17
申请号：US12238125
申请日：2008-09-25
申请人： Lewis Silverman , James Holland
发明人： Lewis Silverman , James Holland
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07D405/14 , A61K31/53 , A61K31/706 , C07H19/12
摘要： The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H or R5C(O), provided that R and R4 are not simultaneously H; and R5 is a C3-C26 alkenyl, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
摘要翻译：本发明涉及如下式（I）化合物：其中R为H，R 5 C（O）; R1是交叉虚线表示连接R1与式（I）分子形成的键的位置。 R2和R3独立地是OH或H，条件是R2和R3不同时为OH; R4是H或R5C（O），条件是R和R4不同时为H; R5为C3-C26烯基或其药物盐。还公开了制备和使用这些化合物的方法。

5. 发明授权

US06040146A Detection of mammary tumor virus-like sequences in human breast cancer 失效
标题翻译：人乳腺癌乳腺肿瘤病毒样序列的检测
公开(公告)号：US06040146A
公开(公告)日：2000-03-21
申请号：US745892
申请日：1996-11-08
申请人： Beatriz Pogo , James Holland
发明人： Beatriz Pogo , James Holland
IPC分类号： G01N33/53 , C07H21/00 , C07H21/04 , C07K7/08 , C07K9/00 , C07K14/15 , C07K14/47 , C07K16/10 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/569 , G01N33/574 , C07K16/30
CPC分类号： C07K14/005 , C12Q1/6886 , G01N33/57415 , C12N2740/12022 , Y10S436/813
摘要： The present invention relates to materials and methods for diagnosing breast cancer in humans. It is based, at least in part, on the discovery that a substantial percentage of human breast cancer tissue samples contained nucleic acid sequences corresponding to a portion of the mouse mammary tumor virus env gene. In contrast, such sequences were absent in almost all other human tissues tested.
摘要翻译：本发明涉及用于诊断人类乳腺癌的材料和方法。至少部分地基于以下发现，即相当大部分的人乳腺癌组织样本含有对应于小鼠乳腺肿瘤病毒env基因的一部分的核酸序列。相比之下，几乎所有其他测试的人体组织中都没有这样的序列。

6. 发明申请

US20220086466A1 ENHANCED REAL-TIME VISUAL QUALITY METRIC GENERATION FOR VIDEO CODING 有权
公开(公告)号：US20220086466A1
公开(公告)日：2022-03-17
申请号：US17457062
申请日：2021-12-01
申请人： James Holland , Muhammad Hamdan , Atthar Mohammed , Venkata Prasad , Dmitry Ryzhov
发明人： James Holland , Muhammad Hamdan , Atthar Mohammed , Venkata Prasad , Dmitry Ryzhov
IPC分类号： H04N19/196 , H04N19/172 , H04N19/176 , H04N19/159 , H04N19/146
摘要： This disclosure describes systems, methods, and devices related to generating visual quality metrics for encoded video frames. A method may include generating respective first visual quality metrics for pixels of an encoded video frame; generating respective second visual quality metrics for the pixels, the respective first visual quality metrics and the respective second visual quality metrics indicative of estimated human perceptions of the encoded video frame; generating a pixel block-based weight for the respective first visual quality metrics; generating a frame-based weight for the respective second visual quality metrics; and generating, based on the respective first visual quality metrics, the pixel block-based weight, the respective second visual quality metrics, and the frame-based weight, a human visual score indicative of a visual quality of the encoded video frame.

7. 发明申请

US20070218005A1 NUCLEI DENSITY AND NUCLEI AREA METHODS FOR DETERMINING THE EFFECTS OF A BOTULINUM TOXIN ON MUSCLES 审中-公开
标题翻译：核酸密度和核酸区域确定火鸡毒素对马铃薯的影响的方法
公开(公告)号：US20070218005A1
公开(公告)日：2007-09-20
申请号：US11749427
申请日：2007-05-16
申请人： James Holland , Edward Chow
发明人： James Holland , Edward Chow
IPC分类号： A61K49/00
CPC分类号： G01N33/5014 , A61K49/0004 , G01N33/5088 , G01N2333/33
摘要： Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.
摘要翻译：公开了确定梭菌神经毒素对肌肉的作用的方法。特别地，公开了基于核指数和/或肌肉萎缩量确定神经毒素的效力和/或扩散的方法。这些方法可用于区分两种不同的梭菌神经毒素。在某些实施方案中，神经毒素从肉毒杆菌获得。

8. 外观设计

USD411081S Yogurt spoon 失效
公开(公告)号：USD411081S
公开(公告)日：1999-06-15
申请号：US84723
申请日：1998-03-09
申请人： James Holland
设计人： James Holland

9. 发明申请

US20050019338A1 Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles 失效
标题翻译：用于确定肉毒杆菌毒素对肌肉的影响的核密度和核区域方法
公开(公告)号：US20050019338A1
公开(公告)日：2005-01-27
申请号：US10918845
申请日：2004-08-13
申请人： James Holland , Edward Chow
发明人： James Holland , Edward Chow
IPC分类号： G01N33/15 , A61K49/00 , A61K39/00 , A61K39/08 , A61K39/38
CPC分类号： G01N33/5014 , A61K49/0004 , G01N33/5088 , G01N2333/33
摘要： Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.
摘要翻译：公开了确定梭菌神经毒素对肌肉的作用的方法。特别地，公开了基于核指数和/或肌肉萎缩量确定神经毒素的效力和/或扩散的方法。这些方法可用于区分两种不同的梭菌神经毒素。在某些实施方案中，神经毒素从肉毒杆菌获得。

10. 发明授权

US5686247A Detection of mammary tumor virus env gene-like sequences in human breast cancer 失效
标题翻译：检测人乳腺癌中乳腺肿瘤病毒env基因样序列
公开(公告)号：US5686247A
公开(公告)日：1997-11-11
申请号：US555394
申请日：1995-11-09
申请人： James Holland , Beatriz Pogo
发明人： James Holland , Beatriz Pogo
IPC分类号： G01N33/53 , C07H21/00 , C07H21/04 , C07K7/08 , C07K9/00 , C07K14/15 , C07K14/47 , C07K16/10 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/569 , G01N33/574 , C12Q19/34
CPC分类号： C07K14/005 , C12Q1/6886 , G01N33/57415 , C12N2740/12022 , Y10S436/813
摘要： The present invention relates to materials and methods for diagnosing breast cancer in humans. It is based, at least in part, on the discovery that a substantial percentage of human breast cancer tissue samples contained nucleic acid sequences corresponding to a portion of the mouse mammary tumor env gene. In contrast, such sequences were absent in almost all other human tissues tested.
摘要翻译：本发明涉及用于诊断人类乳腺癌的材料和方法。至少部分地基于这样的发现：大部分人乳腺癌组织样本含有对应于小鼠乳腺肿瘤env基因的一部分的核酸序列。相比之下，几乎所有其他测试的人体组织中都没有这样的序列。

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