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    • 2. 发明申请
    • Single Component Sulfur-based Cathodes For Lithium and Lithium-ion Batteries
    • 用于锂和锂离子电池的单组分硫基阴极
    • US20140205903A1
    • 2014-07-24
    • US13746969
    • 2013-01-22
    • John PopeDan ButtryShannon WhiteRobert Corcoran
    • John PopeDan ButtryShannon WhiteRobert Corcoran
    • H01M4/60
    • H01M4/602H01M4/137H01M10/052H01M10/0525
    • The present invention pertains to the selection of cathode materials. The cathode materials of concern are the conducting polymer or backbone and the redox active species or sulfur species. The selection of the materials is based on the characteristics of the materials relating to the other components of the batteries and to each other. The present invention also pertains to the resultant cathode materials, particularly a selected cathode material of a single component sulfur-based conducting polymer with the sulfur species covalently linked to the conducting polymer, and most particularly a thiophene based polymer with covalently linked sulfur species. The conducting polymers have been covalently-derivatized with sulfides and/or sulfide-containing groups as battery cathode materials. The present invention also pertains to a battery employing the selection method and resultant cathode materials.
    • 本发明涉及阴极材料的选择。 所关注的阴极材料是导电聚合物或主链和氧化还原活性物质或硫物质。 材料的选择是基于与电池的其它部件相关的材料的特性和彼此。 本发明还涉及所得的阴极材料,特别是选择的具有共价连接到导电聚合物上的硫物质的单组分硫基导电聚合物的阴极材料,最特别地是具有共价连接的硫物质的噻吩基聚合物。 导电聚合物已被硫化物和/或含硫化物基团共价衍生化为电池阴极材料。 本发明还涉及采用选择方法和所得阴极材料的电池。
    • 6. 发明申请
    • Methods and compositions for controlled release of drugs
    • 控释药物的方法和组成
    • US20050002895A1
    • 2005-01-06
    • US10859472
    • 2004-06-01
    • Robert Corcoran
    • Robert Corcoran
    • A61K31/4468A61K31/485A61K31/74A61K47/48
    • A61K31/74A61K31/4468A61K31/485A61K47/56A61K47/58A61K47/60
    • This invention provides a method and compositions for the controlled release of drugs that have been attached by means of a covalent bond to a polymer or other moiety that blocks activity of the drug until it has been released. A two-stage process is provided in which an unmasking reaction results in the formation of a chemical group that can then undergo a second reaction to release the drug. In a preferred embodiment, the narcotic analgesic fentanyl covalently attached to an inert polymer by way of its nitrogen through the formation of a quaternary vinylammonium salt, and then released by a sequence involving hydrolysis of an acetal that exposes an alcohol that may then undergo an intramolecular nucleophilic substitution reaction involving displacement of the nitrogen of oxycodone. The rate of this process may be controlled by controlling either or both of the rates of the acetal hydrolysis or the intramolecular substitution reaction, but is preferably controlled by the latter through varying the number of atoms in the chain connecting the alcohol group and the vinylic carbon, as well as by the addition of substituents on that chain. The drug-delivery molecules of this invention are useful for release of amine, alcohol and thiol drugs, including a number of narcotic analgesics, tricyclic amine antidepressants, and many others.
    • 本发明提供了用于通过共价键连接到药物的控制释放的方法和组合物,所述聚合物或其它部分阻断药物的活性直至释放。 提供两阶段方法,其中非掩蔽反应导致形成化学基团,然后可以进行第二次反应以释放药物。 在优选的实施方案中,麻醉止痛芬太尼通过其氮气通过形成季铵乙烯基铵盐共价连接到惰性聚合物上,然后通过涉及水解缩醛的序列释放,所述缩醛暴露出可以经历分子内的醇 涉及羟考酮氮位移的亲核取代反应。 该方法的速率可以通过控制缩醛水解或分子内取代反应的速率来控制,但优选通过改变连接醇基和乙烯基碳的链中的原子数来由后者控制 ,以及通过在该链上加入取代基。 本发明的药物递送分子可用于释放胺,醇和硫醇药物,包括许多麻醉止痛剂,三环胺抗抑郁药和许多其它药物。