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1. 发明申请

US20070269376A1 Method for Determining Dosage for an Oral Killed Vaccine 审中-公开
标题翻译：确定口服杀灭疫苗剂量的方法
公开(公告)号：US20070269376A1
公开(公告)日：2007-11-22
申请号：US11573890
申请日：2005-08-17
申请人： Robert Clancy , Phillip Comans , Gerald Pang
发明人： Robert Clancy , Phillip Comans , Gerald Pang
IPC分类号： A61K39/02 , A61K39/00 , A61K39/085 , A61K39/104 , A61K39/108 , A61K39/118 , A61P31/00 , A61P37/00
CPC分类号： A61K39/104 , A61K39/02 , A61K2039/521 , A61K2039/542 , A61K2039/545
摘要： There is disclosed a method for determining an administration regimen for an oral killed vaccine for use in immunising individuals in a population against an infection or disease. The method comprise administering the oral killed vaccine to one or more individuals in a population and identifying an indicative dosaging level of the vaccine which induces a reduction in immune system responsiveness to the vaccine in the one or more individuals. A further dosaging level that elicits an immune response in one or more individuals of the population without inducing the reduction in immune system responsiveness to the vaccine is then determined.
摘要翻译：公开了一种用于确定口服灭活疫苗的给药方案的方法，所述口服灭活疫苗用于免疫群体中针对感染或疾病的个体。该方法包括将口服灭活的疫苗施用于群体中的一个或多个个体，并鉴定诱导在一个或多个个体中对疫苗的免疫系统反应性降低的疫苗的指示剂量水平。然后确定在群体的一个或多个个体中引起免疫应答的另一剂量水平，而不诱导免疫系统对疫苗的响应性降低。

2. 发明授权

US07858073B2 Oral killed vaccines and method for providing same 有权
标题翻译：口服杀死疫苗及其提供方法
公开(公告)号：US07858073B2
公开(公告)日：2010-12-28
申请号：US11573889
申请日：2005-08-17
申请人： Robert Clancy , Phillip Comans , Gerald Pang
发明人： Robert Clancy , Phillip Comans , Gerald Pang
IPC分类号： A61K49/00 , A61K39/02 , A61K39/108
CPC分类号： A61K39/104 , A61K39/085 , A61K39/102 , A61K2039/521 , A61K2039/57 , G01N33/5047 , G01N33/505 , G01N33/6863 , G01N33/6869
摘要： There is described a method for selecting microbial isolates for use in oral killed vaccines against abnormal microbial colonization of mucosal surfaces by the microbes. The method comprises evaluating capacity of a plurality of different isolates of a microbe to activate antigen responsive cells to provide activation data for each microbial isolate, and the effectiveness of the isolates in reducing infection of a mucosal surface by the microbe to provide clearance data for each microbial isolate. An isolate, the activation data and clearance data for which correlate and is optimal for generating mucosal immunity against the microbe compared to the, or each, other of the isolates, or an isolate the activation data for which is optimal and a further isolate the clearance data for which is optimal, compared to the, or each, other of the isolates, respectively, is then selected for use in the vaccine. There is also described a method for providing an oral killed vaccine against abnormal microbial colonization of a mucosal surface, comprising evaluating the capacity of a plurality of different isolates of a microbe to induce expression of IL-10 and IL-12 in antigen responsive cells. At least one isolate is selected that induces optimal expression of IL-12 relative to IL-10 compared to the, or each, other of the isolates, respectively, for use in the vaccine.
摘要翻译：描述了用于选择微生物分离物的方法，所述微生物分离物用于通过微生物对粘膜表面的异常微生物定居的口服杀死疫苗。该方法包括评估微生物的多个不同分离物的活性以激活抗原反应性细胞以提供每种微生物分离物的活化数据的能力，以及分离物在微生物中减少粘膜表面感染的有效性以提供每种微生物的清除数据微生物分离物。分离物，活化数据和清除数据，其相对于和最适于产生对微生物的粘膜免疫相对于或每个其他分离物相关并且是最佳的，或其活化数据为最佳的分离物，并进一步分离清除然后选择与其分离的或每个其他分离物相比较优化的数据用于疫苗。还描述了一种用于提供针对粘膜表面的异常微生物定居的口服杀死疫苗的方法，其包括评价多个不同的微生物分离物在抗原应答细胞中诱导IL-10和IL-12表达的能力。选择至少一种分离物，其分别诱导用于疫苗的IL-12相对于IL-10的最佳表达，或分别与其他分离物相分离。

3. 发明申请

US20080112979A1 Oral Killed Vaccines and Method for Providing Same 有权
标题翻译：口服杀灭疫苗及其提供方法
公开(公告)号：US20080112979A1
公开(公告)日：2008-05-15
申请号：US11573889
申请日：2005-08-17
申请人： Robert Clancy , Phillip Comans , Gerald Pang
发明人： Robert Clancy , Phillip Comans , Gerald Pang
IPC分类号： A61K39/02 , G01N33/48 , C12Q1/02
CPC分类号： A61K39/104 , A61K39/085 , A61K39/102 , A61K2039/521 , A61K2039/57 , G01N33/5047 , G01N33/505 , G01N33/6863 , G01N33/6869
摘要： There is described a method for selecting microbial isolates for use in oral killed vaccines against abnormal microbial colonisation of mucosal surfaces by the microbes. The method comprises evaluating capacity of a plurality of different isolates of a microbe to activate antigen responsive cells to provide activation data for each microbial isolate, and the effectiveness of the isolates in reducing infection of a mucosal surface by the microbe to provide clearance data for each microbial isolate. An isolate, the activation data and clearance data for which correlate and is optimal for generating mucosal immunity against the microbe compared to the, or each, other of the isolates, or an isolate the activation data for which is optimal and a further isolate the clearance data for which is optimal, compared to the, or each, other of the isolates, respectively, is then selected for use in the vaccine. There is also described a method for providing an oral killed vaccine against abnormal microbial colonisation of a mucosal surface, comprising evaluating the capacity of a plurality of different isolates of a microbe to induce expression of IL-10 and IL-12 in antigen responsive cells. At least one isolate is selected that induces optimal expression of IL-12 relative to IL-10 compared to the, or each, other of the isolates, respectively, for use in the vaccine.
摘要翻译：描述了用于选择微生物分离物的方法，所述微生物分离物用于通过微生物对粘膜表面的异常微生物定居的口服杀死疫苗。该方法包括评估微生物的多个不同分离物的活性以激活抗原反应性细胞以提供每种微生物分离物的活化数据的能力，以及分离物在微生物中减少粘膜表面感染的有效性以提供每种微生物的清除数据微生物分离物。分离物，活化数据和清除数据，其相对于和最适于产生对微生物的粘膜免疫相对于或每个其他分离物相关并且是最佳的，或者其活化数据为最佳的分离物，并进一步分离清除然后选择与其分离的或每个其他分离物相比较优化的数据用于疫苗。还描述了一种用于提供针对粘膜表面的异常微生物定居的口服杀死疫苗的方法，其包括评价多个不同的微生物分离物在抗原应答细胞中诱导IL-10和IL-12表达的能力。选择至少一种分离物，其分别诱导用于疫苗的IL-12相对于IL-10的最佳表达，或分别与其他分离物相分离。

4. 发明申请

US20050169901A1 Composition and methods afor diagnosis and treatment of cardiovascular disorders 审中-公开
标题翻译：心血管疾病诊断和治疗的组成和方法
公开(公告)号：US20050169901A1
公开(公告)日：2005-08-04
申请号：US10512356
申请日：2003-04-24
申请人： Gerald Pang , Patricia Lynne Conway , Robert Clancy
发明人： Gerald Pang , Patricia Lynne Conway , Robert Clancy
IPC分类号： A61K35/74 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/395 , A61K45/00 , A61P9/10 , C07K16/28 , G01N33/68
CPC分类号： A61K36/03 , A61K35/74 , A61K35/747 , A61K36/062 , A61K45/06 , A61K2039/505 , C07K16/2878 , G01N33/6854 , G01N33/6863 , G01N33/6869 , A61K2300/00
摘要： The present invention relates to methods for diagnosis, prevention and treatment of cardiovascular disorders or associated disorders and, in particular, to the use in such methods of regulating cytokine levels or activity. Compositions and kits suitable for use in the methods are described.
摘要翻译：本发明涉及用于诊断，预防和治疗心血管疾病或相关疾病的方法，特别涉及在这些调节细胞因子水平或活性的方法中的用途。描述适用于该方法的组合物和试剂盒。

5. 发明授权

US07655248B2 Compositions and methods for treatment of candidiasis 有权
标题翻译：用于治疗念珠菌病的组合物和方法
公开(公告)号：US07655248B2
公开(公告)日：2010-02-02
申请号：US10311837
申请日：2001-06-19
申请人： Robert Clancy , Gerald Pang , Elahi Shokrollah
发明人： Robert Clancy , Gerald Pang , Elahi Shokrollah
IPC分类号： A61K39/00 , A01N63/04
CPC分类号： A61K39/0002 , A61K35/747 , A61K2300/00
摘要： The present invention relates to novel oral compositions and vaccines, and in particular to oral vaccines for the prevention or therapy of candidiasis.
摘要翻译：本发明涉及新颖的口服组合物和疫苗，特别涉及用于预防或治疗念珠菌病的口服疫苗。

6. 发明申请

US20060120963A1 Method of identifying therapeutic compounds for a treatment of hepatic disorders 审中-公开
公开(公告)号：US20060120963A1
公开(公告)日：2006-06-08
申请号：US11325456
申请日：2006-01-05
申请人： Robert Clancy , Robert Batey , Gerald Pang
发明人： Robert Clancy , Robert Batey , Gerald Pang
IPC分类号： A61K49/00
CPC分类号： A61K49/0008 , Y10S436/811
摘要： The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in such methods, therapeutic compounds identified using said methods and the use of a Chinese Herb, CH-100, in the treatment of hepatic disorders, particularly alcohol-induced hepatic disorders, are described.

7. 发明授权

US06989278B1 Method of identifying therapeutic compounds for a treatment of hepatic disorders 失效
标题翻译：鉴定用于治疗肝脏疾病的治疗化合物的方法
公开(公告)号：US06989278B1
公开(公告)日：2006-01-24
申请号：US09959970
申请日：2000-05-15
申请人： Robert Clancy , Robert Batey , Gerald Pang
发明人： Robert Clancy , Robert Batey , Gerald Pang
IPC分类号： G01N33/53
CPC分类号： A61K49/0008 , Y10S436/811
摘要： The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in such methods, therapeutic compounds identified using said methods and the use of a Chinese Herb, CH-100, in the treatment of hepatic disorders, particularly alcohol-induced hepatic disorders, are described.
摘要翻译：本发明涉及鉴定用于治疗肝脏疾病，优选酒精诱发的肝炎的潜在治疗化合物的方法。此外，描述了在这些方法中使用哺乳动物，使用所述方法鉴定的治疗化合物和使用中草药CH-100治疗肝脏疾病，特别是酒精诱导的肝脏疾病。

8. 发明申请

US20060216763A1 Methods for predicting and/or diagnosing the risk of gastric cancer 审中-公开
标题翻译：预测和/或诊断胃癌风险的方法
公开(公告)号：US20060216763A1
公开(公告)日：2006-09-28
申请号：US11444062
申请日：2006-05-30
申请人： Robert Clancy , Gerald Pang
发明人： Robert Clancy , Gerald Pang
IPC分类号： G01N33/574 , G01N33/554 , G01N33/569
CPC分类号： G01N33/56911 , G01N33/57446 , G01N33/6869
摘要： The present invention relates to methods of predicting the risk of developing cancer and in particular to a method for diagnosing, and/or predicting the risk of developing gastric cancer in a subject infected with Helicobacter.
摘要翻译：本发明涉及预测发展中的癌症风险的方法，尤其涉及用于诊断和/或预测感染幽门螺杆菌的受试者发生胃癌风险的方法。

9. 发明申请

US20070067574A1 Method and apparatus for managing cache partitioning 有权
标题翻译：用于管理缓存分区的方法和装置
公开(公告)号：US20070067574A1
公开(公告)日：2007-03-22
申请号：US11233575
申请日：2005-09-21
申请人： Brian Stempel , James Dieffenderfer , Jeffrey Bridges , Thomas Sartorius , Rodney Smith , Robert Clancy , Victor Augsburg
发明人： Brian Stempel , James Dieffenderfer , Jeffrey Bridges , Thomas Sartorius , Rodney Smith , Robert Clancy , Victor Augsburg
IPC分类号： G06F12/00
CPC分类号： G06F12/126
摘要： A method of managing cache partitions provides a first pointer for higher priority writes and a second pointer for lower priority writes, and uses the first pointer to delimit the lower priority writes. For example, locked writes have greater priority than unlocked writes, and a first pointer may be used for locked writes, and a second pointer may be used for unlocked writes. The first pointer is advanced responsive to making locked writes, and its advancement thus defines a locked region and an unlocked region. The second pointer is advanced responsive to making unlocked writes. The second pointer also is advanced (or retreated) as needed to prevent it from pointing to locations already traversed by the first pointer. Thus, the pointer delimits the unlocked region and allows the locked region to grow at the expense of the unlocked region.
摘要翻译：管理高速缓存分区的方法提供用于较高优先级写入的第一指针和用于较低优先级写入的第二指针，并且使用第一指针来划分较低优先级的写入。例如，锁定的写入具有比解锁的写入更高的优先级，并且第一指针可以用于锁定的写入，并且第二指针可以用于解锁的写入。响应于锁定写入，第一指针是高级的，并且其进步因此定义了锁定区域和解锁区域。响应于解锁写入，第二个指针是高级的。第二个指针也根据需要进行高级（或撤销），以防止它指向已经被第一个指针所遍历的位置。因此，指针限定未锁定区域，并允许锁定区域以解锁区域为代价而增长。

10. 发明申请

US20050232943A1 Antigenic composition of a Pseudomonas aeruginosa protein 失效
标题翻译：铜绿假单胞菌蛋白质的抗原组成
公开(公告)号：US20050232943A1
公开(公告)日：2005-10-20
申请号：US11158599
申请日：2005-06-22
申请人： Allan Cripps , Jennelle Kyd , Margaret Dunkley , Robert Clancy
发明人： Allan Cripps , Jennelle Kyd , Margaret Dunkley , Robert Clancy
IPC分类号： G01N33/569 , A61K39/00 , A61K39/104 , A61P31/04 , A61P37/00 , C07K14/21 , C07H21/04 , C12N1/21 , C12N15/74 , C12Q1/18
CPC分类号： C07K14/21 , A61K39/00 , Y10S435/975 , Y10S530/825
摘要： A novel antigen from P. aeruginosa is provided. The use of the antigen in detecting/diagnosing P. aeruginosa as well as its use in eliciting an immune response are also provided.
摘要翻译：提供了来自铜绿假单胞菌的新型抗原。还提供了在检测/诊断铜绿假单胞菌中使用抗原以及其在引发免疫应答中的用途。

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