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1. 发明授权

US4531943A Catheter with soft deformable tip 失效
标题翻译：导管与软变形尖端
公开(公告)号：US4531943A
公开(公告)日：1985-07-30
申请号：US520996
申请日：1983-08-08
申请人： Robert A. Van Tassel , Mark A. Rydell , Gilmore T. Schjeldahl
发明人： Robert A. Van Tassel , Mark A. Rydell , Gilmore T. Schjeldahl
IPC分类号： A61M25/04 , A61F2/958 , A61M25/00 , A61N1/05
CPC分类号： A61M25/0069 , A61M25/1011 , A61N1/056
摘要： A catheter for insertion in a body orifice or blood vessel comprising an elongated tubular body with a soft, symmetrically deformable member on the distal end thereof for decreasing the likelihood of injury to body tissue upon the insertion and removal thereof. In one embodiment, the tip member comprises a toroidally shaped inflatable and non-distensible expandable "balloon" mounted on the end of the otherwise relatively rigid tip of the catheter. The catheter has a lumen extending the length thereof and communicating with the tip member whereby a fluid may be introduced to control the size, shape and firmness of the tip member. In a second embodiment, the soft deformable tip member comprises an annular plastic or rubber sleeve surrounding the otherwise rigid tip of the catheter and normally extending there beyond by a predetermined distance. The thickness or composition of the sleeve is varied about a circumferential ring so as to provide a preferred location for the collapse of the sleeve.
摘要翻译：用于插入体孔或血管中的导管，其包括在其远端上具有软的对称可变形构件的细长管状体，用于减少在插入和移除身体组织时损伤身体组织的可能性。在一个实施例中，尖端构件包括安装在导管的另外相对刚性的尖端的端部上的环形形状的可膨胀且不可扩张的可膨胀“可膨胀”气囊。导管具有延伸其长度并与尖端构件连通的内腔，由此可以引入流体以控制尖端构件的尺寸，形状和坚固度。在第二实施例中，软可变形尖端构件包括环形塑料或橡胶套筒，其环绕导管的其它刚性末端，并且通常在其上延伸超过预定距离。套筒的厚度或组成围绕圆周环变化，以提供用于套筒塌陷的优选位置。

2. 发明授权

US5855559A Hemostatic agent delivery device having built-in pressure sensor 失效
标题翻译：止血剂输送装置，内置压力传感器
公开(公告)号：US5855559A
公开(公告)日：1999-01-05
申请号：US800047
申请日：1997-02-14
申请人： Robert A. Van Tassel , Robert S. Schwartz , David Holms , Mark A. Rydell
发明人： Robert A. Van Tassel , Robert S. Schwartz , David Holms , Mark A. Rydell
IPC分类号： A61B17/00 , A61B5/00
CPC分类号： A61B17/00491 , A61B17/0057 , A61B2017/00495 , A61B2017/00672
摘要： An instrument for achieving rapid hemostasis at the conclusion of a catheterization procedure comprising a hemostatic agent injection device for use with a conventional introducer sheath used to gain access to the blood vessel. The injection device includes an elongated tubular member having ejection ports proximate its distal end. A hub member is located on the proximal end of the tubular member and includes an elongated groove or track located in its surface with a transparent cover. The enclosed track is in fluid communication with the lumen extending through the tubular member. After the catheterization procedure, the instrument is inserted into the introducer sheath. Blood flows into the lumen of the device and into the enclosed track. The leading edge of the blood pulsates within the enclosed track, clearly indicating that the ports are located in the blood vessel and subjected to variations in blood pressure. The instrument and introducer sheath are then slowly retracted as a unit in the puncture wound. The blood flow will stop pulsating in the enclosed track when the ports have exited the blood vessel wall. A hemostatic agent is then injected by the instrument adjacent the vessel wall.
摘要翻译：一种用于在导尿术程序结束时实现快速止血的仪器，其包括用于与用于进入血管的通道的常规导引鞘一起使用的止血剂注射装置。注射装置包括细长管状构件，其具有靠近其远端的排出口。毂构件位于管状构件的近端上并且包括位于其表面中的具有透明盖的细长凹槽或轨道。封闭的轨道与延伸穿过管状构件的内腔流体连通。导管术后，将仪器插入导引鞘内。血液流入设备的内腔并进入封闭的轨道。血液的前缘在封闭的轨道内脉动，清楚地表明端口位于血管中并经受血压变化。然后将仪器和引导器护套作为穿刺伤口中的单元缓慢缩回。当港口离开血管壁时，血液流动将停止在封闭轨道中的脉动。然后通过仪器在血管壁附近注射止血剂。

3. 发明授权

US06193670B1 Hemostatic agent delivery device having built-in pressure sensor 失效
标题翻译：止血剂输送装置，内置压力传感器
公开(公告)号：US06193670B1
公开(公告)日：2001-02-27
申请号：US09218482
申请日：1998-12-22
申请人： Robert A. Van Tassel , Robert S. Schwartz , David Holmes , Mark A. Rydell
发明人： Robert A. Van Tassel , Robert S. Schwartz , David Holmes , Mark A. Rydell
IPC分类号： A61B500
CPC分类号： A61B17/00491 , A61B17/0057 , A61B2017/00495
摘要： An instrument for achieving rapid hemostasis at the conclusion of a catheterization procedure comprising a hemostatic agent injection device for use with a conventional introducer sheath used to gain access to the blood vessel. The injection device includes an elongated tubular member having ejection ports proximate its distal end. A hub member includes an elongated groove or track located in its surface with a transparent cover. The enclosed track is sealed from the lumen extending through the tubular member with a compliant membrane and filled with a predetermined amount of fluid. After the catheterization procedure, the device is inserted into the introducer sheath. Blood flows into the lumen of the device and pulsates against the compliant membrane. The fluid in the track pulsates within the enclosed track, clearly indicating that the ports are located in the blood vessel and subjected to variations in blood pressure. The instrument and introducer sheath are then slowly retracted as a unit in the puncture wound. The blood flow will stop pulsating against the compliant membrane when the ports have exited the blood vessel wall. A hemostatic agent is then injected by the instrument adjacent the vessel wall.
摘要翻译：一种用于在导尿术程序结束时实现快速止血的仪器，其包括用于与用于进入血管的通道的常规导引鞘一起使用的止血剂注射装置。注射装置包括细长管状构件，其具有靠近其远端的排出口。轮毂构件包括位于其表面上的具有透明盖的细长凹槽或轨道。封闭的轨道与通过管状构件延伸的管腔与柔性膜密封并填充预定量的流体。在导管插入术后，将装置插入导引鞘。血液流入装置的内腔并与柔顺膜搏动。轨道中的流体在封闭轨道内脉动，清楚地表明端口位于血管中并经受血压变化。然后将仪器和引导器护套作为穿刺伤口中的单元缓慢缩回。当端口离开血管壁时，血流将停止脉动抵抗柔顺膜。然后通过仪器在血管壁附近注射止血剂。

4. 发明授权

US09005173B2 Skin abrasion system and method 有权
标题翻译：皮肤磨损系统和方法
公开(公告)号：US09005173B2
公开(公告)日：2015-04-14
申请号：US13241734
申请日：2011-09-23
申请人： Brian D. Zelickson , David A. Kist , Mark A. Rydell
发明人： Brian D. Zelickson , David A. Kist , Mark A. Rydell
IPC分类号： A61M35/00 , A61B17/50 , A61H1/00 , A61H7/00 , A45D26/00 , A45D44/00 , A61B17/54 , A61K8/02 , A61Q9/04 , A61B17/00 , A61B17/32 , A61B19/00
CPC分类号： A45D26/0004 , A45D44/00 , A61B17/54 , A61B2017/00128 , A61B2017/00132 , A61B2017/00199 , A61B2017/00464 , A61B2017/00473 , A61B2017/00477 , A61B2017/00734 , A61B2017/00761 , A61B2017/320008 , A61B2017/320076 , A61B2017/320078 , A61B2090/065 , A61K8/0208 , A61Q9/04
摘要： A system and method for rejuvenating skin through ablation using a handheld device (200) having a removable treatment component (213) with an abrasive material on one surface of the component which surface is on a portion of the treatment component (213) configured to conform to a skin surface. The system further includes application of other elements to facilitate skin recovery and rejuvenation processes.
摘要翻译：一种用于通过消融来恢复皮肤的系统和方法，所述手持式装置（200）具有可移除处理部件（213），所述手术装置在所述部件的一个表面上具有研磨材料，该表面位于所述处理部件（213）的被配置为符合到皮肤表面。该系统还包括应用其他元素以促进皮肤恢复和复原过程。

5. 发明申请

US20100106102A1 APPARATUS FOR DELIVERY OF DEVICE AND ANTIMICROBIAL AGENT INTO TRANS-DERMAL CATHETER 有权
标题翻译：用于将装置和抗微生物剂递送到透明导管的装置
公开(公告)号：US20100106102A1
公开(公告)日：2010-04-29
申请号：US12605963
申请日：2009-10-26
申请人： Robert J. Ziebol , William S. Nettekoven , Mark A. Rydell
发明人： Robert J. Ziebol , William S. Nettekoven , Mark A. Rydell
IPC分类号： A61L29/14
CPC分类号： A61M25/01 , A61L2/186 , A61L2202/24 , A61M5/001 , A61M25/0017 , A61M25/0105 , A61M25/0111 , A61M39/165 , A61M39/18 , A61M39/20 , A61M2025/0018 , A61M2025/0019 , A61M2025/0056 , A61M2209/10
摘要： An apparatus for delivery of an elongate member into the lumen of a trans-dermal catheter. In a preferred embodiment, the apparatus comprises a protective sheath configured to at least substantially surround an elongate member; and slidable member configured to travel along the protective sheath, the slidable member operatively coupled to the elongate member; wherein the elongate member is insertable into a lumen of a trans-dermal catheter by moving the slidable member along at least a part of the length of the protective sheath. In another embodiment, the apparatus comprises a protective sheath configured to at least substantially surround an elongate member; a slidable member configured to travel along the protective sheath, the slidable member operatively coupled to the elongate member; and a connecting member positioned on the distal end of the protective sheath, the connecting member configured to lock onto the distal end of a trans-dermal catheter; wherein the elongate member is insertable into the lumen of the trans-dermal catheter by moving the slidable member along at least a part of the length of the protective sheath.
摘要翻译：用于将细长构件递送到经皮导管的内腔中的装置。在优选实施例中，该装置包括被配置为至少基本上围绕细长构件的保护护套; 以及可滑动构件，其构造成沿着所述保护护套行进，所述可滑动构件可操作地联接到所述细长构件; 其中所述细长构件通过沿着所述保护护套的长度的至少一部分移动所述可滑动构件而可插入到经皮导管的内腔中。在另一个实施例中，该装置包括被配置为至少基本上围绕细长构件的保护套; 可滑动构件，其构造成沿着所述保护护套行进，所述可滑动构件可操作地联接到所述细长构件; 以及连接构件，所述连接构件定位在所述保护护套的远端上，所述连接构件构造成锁定在经皮导管的远端上; 其中所述细长构件通过沿着所述保护护套的长度的至少一部分移动所述可滑动构件而可插入所述经皮导管的内腔中。

6. 发明申请

US20100057144A1 RAIL-BASED MODULAR DISC NUCLEUS PROSTHESIS 审中-公开
标题翻译：基于轨道的模块化核心预测
公开(公告)号：US20100057144A1
公开(公告)日：2010-03-04
申请号：US12548225
申请日：2009-08-26
申请人： Jeffrey C. Felt , Mark A. Rydell , Stephen H. Crosbie , John E. Sherman
发明人： Jeffrey C. Felt , Mark A. Rydell , Stephen H. Crosbie , John E. Sherman
IPC分类号： A61B17/56
CPC分类号： A61F2/442 , A61F2/3094 , A61F2/4455 , A61F2/4611 , A61F2002/30014 , A61F2002/30016 , A61F2002/30075 , A61F2002/30166 , A61F2002/30235 , A61F2002/30383 , A61F2002/30387 , A61F2002/30462 , A61F2002/3052 , A61F2002/30561 , A61F2002/30563 , A61F2002/30594 , A61F2002/30604 , A61F2002/30677 , A61F2002/30971 , A61F2002/444 , A61F2002/4627 , A61F2210/0061 , A61F2220/0025 , A61F2220/0075 , A61F2230/0028 , A61F2230/0069 , A61F2250/0018 , A61F2250/0019
摘要： A method and apparatus for repairing a damaged intervertebral disc nucleus in a minimally invasive manner utilizes a modular disc prosthesis preferably comprised of at least three modular segments and at least two rails that operably connect adjacent modular segments. In one embodiment, each modular segment includes a harder inner portion and a softer outer portion. Preferably, the rails operate to slidably connect and interlock adjacent modular segments. A stem portion of the rails that extends outside the periphery of the body of the prosthesis is removable after implantation such that the modular segments form an implanted unitary device that closely mimics the geometry of the disc nucleus cavity.
摘要翻译：用于以微创方式修复损伤的椎间盘细胞核的方法和装置利用模块化椎间盘假体，优选地包括至少三个模块化区段和至少两个可操作地连接相邻模块区段的轨道。在一个实施例中，每个模块化区段包括较硬的内部部分和较软的外部部分。优选地，轨道操作以可滑动地连接和互锁相邻的模块段。在植入之后延伸到假体本体周边之外的轨道的茎部分是可去除的，使得模块化部分形成与模腔细胞核的几何形状紧密相似的植入的整体装置。

7. 发明授权

US6140452A Biomaterial for in situ tissue repair 失效
标题翻译：用于原位组织修复的生物材料
公开(公告)号：US6140452A
公开(公告)日：2000-10-31
申请号：US195328
申请日：1998-11-18
申请人： Jeffrey C. Felt , Mark A. Rydell , Richard J. Zdrahala , Alexander Arsenyev
发明人： Jeffrey C. Felt , Mark A. Rydell , Richard J. Zdrahala , Alexander Arsenyev
IPC分类号： A61B1/00 , A61B17/00 , A61B17/16 , A61B17/17 , A61B17/88 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2/46 , A61F2/82 , A61L27/18 , A61L29/04 , A61L29/06 , C08G18/10 , C08G18/48 , C08G18/69
CPC分类号： C08G18/4854 , A61B17/17 , A61F2/30756 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61L27/18 , A61L29/041 , A61L29/06 , C08G18/10 , C08G18/69 , A61B1/00165 , A61B17/00234 , A61B17/16 , A61B17/1671 , A61B17/1675 , A61B2017/00535 , A61F2/07 , A61F2/28 , A61F2/30767 , A61F2/3099 , A61F2/32 , A61F2/38 , A61F2/4081 , A61F2/4202 , A61F2/442 , A61F2/82 , A61F2/945 , A61F2002/30016 , A61F2002/30024 , A61F2002/30235 , A61F2002/30583 , A61F2002/30929 , A61F2002/30957 , A61F2002/4233 , A61F2002/4627 , A61F2002/4635 , A61F2210/0085 , A61F2230/0069 , A61F2250/0019 , A61F2250/0021 , A61L2430/38 , B01F2215/0039
摘要： A method, and related composition and apparatus for repairing a tissue site. The method involves the use of a curable polyurethane biomaterial composition having a plurality of parts adapted to be mixed at the time of use in order to provide a flowable composition and to initiate cure. The flowable composition can be delivered using minimally invasive means to a tissue site and there fully cured provide a permanent and biocompatible prosthesis for repair of the tissue site. Further provided are a mold apparatus, e.g., in the form of a balloon or tubular cavity, for receiving a biomaterial composition, and a method for delivering and filling the mold apparatus with a curable composition in situ to provide a prosthesis for tissue repair.
摘要翻译：一种用于修复组织部位的方法和相关组合物和装置。该方法包括使用可固化的聚氨酯生物材料组合物，其具有适于在使用时混合的多个部分，以提供可流动的组合物并开始固化。可流动组合物可以使用微创手段递送到组织部位，并且完全固化提供用于修复组织部位的永久性和生物相容性假体。还提供了一种用于接收生物材料组合物的气球或管状空腔形式的模具装置，以及用于在原位地递送和填充具有可固化组合物的模具装置以提供用于组织修复的假体的方法。

8. 发明授权

US6079868A Static mixer 失效
标题翻译：静态混合器
公开(公告)号：US6079868A
公开(公告)日：2000-06-27
申请号：US33261
申请日：1998-03-02
申请人： Mark A. Rydell
发明人： Mark A. Rydell
IPC分类号： A61B17/00 , A61F2/30 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2/46 , A61L27/18 , A61L29/04 , B01F5/06 , B01F13/00 , B01F15/00 , C08G18/10 , C08G18/48 , C08G18/69 , B01F15/02 , A61M5/31 , A61M31/00 , B67D5/60
CPC分类号： A61B17/00491 , A61B17/00234 , A61B17/8816 , A61B17/8833 , A61F2/30756 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2/4618 , A61L27/18 , A61L29/041 , B01F13/002 , B01F13/0027 , B01F15/00954 , B01F15/00993 , B01F5/0615 , B01F5/0646 , C08G18/10 , C08G18/4854 , C08G18/69 , A61B17/8822 , A61B17/8827 , A61B2017/00495 , A61B2017/8838 , A61F2/38 , A61F2/4081 , A61F2/4202 , A61F2/442 , A61F2002/30583 , A61F2002/30957 , A61F2002/4233 , A61F2002/4627 , A61F2002/4628 , A61F2002/4635 , A61F2002/465 , A61F2210/0085 , A61L2430/38 , B01F2215/0039
摘要： A device for mixing and delivering a curable biomaterial using minimally invasive techniques. The device provides a mixing path that is configured to contribute a longitudinal distance dimension to the device that is considerably less than the length of the mixing path itself. In so doing, the device can provide improved ergonomic control and single-handed operation in the course of mixing biomaterial components, in order to initiate cure, and delivering the mixed biomaterial through a delivery conduit and to a tissue site in vivo. Optional features of the device include the ability to warm the biomaterial components, to position or retract a protective sheath covering the delivery conduit, and the ability to divert or shunt an initial volume of mixed biomaterial.
摘要翻译：用于使用微创技术混合和递送可固化生物材料的装置。该装置提供了混合路径，该混合路径被配置为向装置贡献远小于混合路径本身的长度的纵向距离尺寸。在这样做时，该装置可以在混合生物材料组件的过程中提供改进的人体工程学控制和单手操作，以便开始固化，并且通过输送管道和体内的组织部位递送混合的生物材料。该装置的可选特征包括加热生物材料部件，定位或缩回覆盖输送导管的保护鞘的能力，以及转移或分流初始体积的混合生物材料的能力。

9. 发明授权

US6042536A Bladder sling 失效
公开(公告)号：US6042536A
公开(公告)日：2000-03-28
申请号：US133596
申请日：1998-08-13
申请人： Claude Tihon , Mark A. Rydell , William P. Ryan
发明人： Claude Tihon , Mark A. Rydell , William P. Ryan
IPC分类号： A61B17/00 , A61B17/02 , A61B17/06 , A61F2/00 , A61F2/02 , A61F5/48
CPC分类号： A61B17/0218 , A61F2/0045 , A61B2017/00805 , A61B2017/0225 , A61B2017/0618
摘要： A sling for supporting the urethra and neck of the bladder to prevent urinary incontinence is disclosed. The sling is designed to provide sufficient support to inhibit the unintended flow of urine, yet stretch in a controlled fashion so that the bladder can be voided at approximate times.

10. 发明授权

US5964751A Light delivery system with blood flushing capability 失效
标题翻译：具有血液冲洗能力的轻型输送系统
公开(公告)号：US5964751A
公开(公告)日：1999-10-12
申请号：US140116
申请日：1998-08-25
申请人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
发明人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
IPC分类号： A61B17/22 , A61B18/22 , A61M1/00 , A61M29/02 , A61B17/36
CPC分类号： A61B17/22 , A61B18/22 , A61B2017/22051 , A61B2018/2261 , A61M1/00 , A61M25/104 , A61M29/02
摘要： A light delivery system for use in irradiating vascular tissue includes a balloon catheter with a working lumen for receiving an optical fiber therein and an inflation/flushing lumen adapted to receive a liquid at a proximal end and leading to a space defined within the balloon member attached to a distal end of the catheter. The balloon member has a pattern of holes or pores in the wall thereof through which the saline may flow when the balloon is inflated, causing any blood or other absorbing substances that may interfere with good radiant energy transmission to be flushed away from the treatment site.
摘要翻译：用于照射血管组织的光输送系统包括球囊导管，其具有用于在其中接收光纤的工作腔，以及适于在近端接收液体并且导致限定在所述球囊构件附近的空间的充气/冲洗腔到导管的远端。气球构件在其壁中具有孔或孔的图案，当气囊膨胀时，盐可以通过该孔或孔流动，导致可能干扰良好的辐射能量传递的任何血液或其它吸收物质从治疗部位冲洗掉。

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