专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5756688A MR imaging compositions and methods 失效
标题翻译： MR成像组合物和方法
公开(公告)号：US5756688A
公开(公告)日：1998-05-26
申请号：US121133
申请日：1993-09-14
申请人： Robert A. Snow , David L. Ladd , John L. Toner , K. Robert Hollister
发明人： Robert A. Snow , David L. Ladd , John L. Toner , K. Robert Hollister
IPC分类号： G01R33/28 , A61B5/055 , A61K49/00 , A61K49/06 , A61K49/12 , C08G65/32 , C08G65/48 , C08G69/40 , A61B5/05 , A61K33/40 , G01N24/00 , G01N31/00
CPC分类号： A61K49/128
摘要： This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.
摘要翻译：本发明提供了可用于MR成像的组合物，其包含包含与聚（环氧烷）部分连接的螯合剂残基的单元的聚合物，所述聚合物具有与其相关的参与性金属离子。

2. 发明授权

US5932188A Therapeutic and diagnostic imaging compositions and methods 失效
标题翻译：治疗和诊断成像组合物和方法
公开(公告)号：US5932188A
公开(公告)日：1999-08-03
申请号：US963125
申请日：1997-10-28
申请人： Robert A. Snow , David L. Ladd , John L. Toner
发明人： Robert A. Snow , David L. Ladd , John L. Toner
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/04 , C08G65/34 , C08G65/48 , C08G69/40 , A61B5/055 , C07F5/00
CPC分类号： A61K47/48215 , A61K47/48192 , A61K47/48207 , A61K51/0497 , A61K2123/00
摘要： This invention provides therapeutic and diagnostic imaging compositions and methods featuring a polymer comprising units containing a poly(alkylene oxide) moiety linked to the residue of a chelating agent, said polymer having a cytotoxic agent associated therewith.
摘要翻译：本发明提供治疗和诊断成像组合物和方法，其特征在于包含含有与螯合剂残基连接的聚（环氧烷）部分的单元的聚合物，所述聚合物具有与其相关的细胞毒性剂。

3. 发明授权

US5817292A MR imaging compositions and methods 失效
标题翻译： MR成像组合物和方法
公开(公告)号：US5817292A
公开(公告)日：1998-10-06
申请号：US960746
申请日：1992-10-14
申请人： Robert A. Snow , David L. Ladd , John L. Toner
发明人： Robert A. Snow , David L. Ladd , John L. Toner
IPC分类号： A61K49/06 , A61K49/12 , A61K49/00
CPC分类号： A61K49/128
摘要： This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.
摘要翻译：本发明提供了可用于MR成像的组合物，其包含包含与聚（环氧烷）部分连接的螯合剂残基的单元的聚合物，所述聚合物具有与其相关的参与性金属离子。

4. 发明授权

US5730968A Segmented chelating polymers as imaging and therapeutic agents 失效
标题翻译：分段螯合聚合物作为成像和治疗剂
公开(公告)号：US5730968A
公开(公告)日：1998-03-24
申请号：US221714
申请日：1994-03-31
申请人： Dennis E. Butterfield , Dennis K. Fujii , David L. Ladd , Robert A. Snow , Julia S. Tan , John L. Toner
发明人： Dennis E. Butterfield , Dennis K. Fujii , David L. Ladd , Robert A. Snow , Julia S. Tan , John L. Toner
IPC分类号： A61K47/48 , A61K51/00 , C08G65/32 , C08G65/329 , A61K31/77 , A61K49/00 , C08G65/48
CPC分类号： C08G65/329 , Y10S530/815 , Y10S530/816
摘要： A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said composition having a molecular weight of at least 4,500; ##STR1## wherein: Z is a chelating residue; Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L; L represents an amide linkage; E.sup.(b) is one or more counterions each having a charge of b; b is an integer from 1, 2 and 3; n is an integer selected from the group 1, 2, 3 and 4; w is zero or an integer from 1 to 5; M.sup.(+a) is a cation, having a charge of +a; a is an integer from 1 to 4; r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M.sup.(+a) can be the same or different cation; d is the total charge on the chelating residue and is an integer from 0 to 10; d+.SIGMA.(b.multidot.w)+.SIGMA.(a.multidot.r)=O; and R is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C.sub.1 -C.sub.4 alkyl, aryl containing 6 to 24 carbon atoms, C.sub.2 -C.sub.5 alkanoyloxyl and C.sub.1 -C.sub.4 alkoxy, or R is an immunoreactive group or cytotoxic drug linked to Q by a chemical bond or a linking group.
摘要翻译：适用于诊断成像或细胞杀伤剂的组合物，其包含通过酰胺键与聚（环氧烷）部分连接的螯合残基，所述组合物的分子量至少为4,500; 其中：Z是螯合残基; Q是在R和L具有碳末端的二价聚（亚烷基亚氧烷基）部分; L表示酰胺键; E（b）是一个或多个各自具有b的电荷的抗衡离子; b是1,2和3的整数; n是选自1,2,3,4组的整数; w为0或1〜5的整数; M（+ a）为阳离子，电荷为+ a; a是从1到4的整数; r为0或1〜3的整数，条件是当r为2-3时，每个M（+ a）可以是相同或不同的阳离子; d是螯合残基上的总电荷，为0至10的整数; d + SIGMA（bxw）+ SIGMA（axr）= O; 并且R是选自氢，羟基，C 1 -C 4烷基，含有6至24个碳原子的芳基，C 2 -C 5烷酰氧基和C 1 -C 4烷氧基的封端部分，或R是免疫反应性基团或与 Q通过化学键或连接基团。

5. 发明授权

US6017522A Segmented chelating polymers as imaging and therapeutic agents 失效
标题翻译：分段螯合聚合物作为成像和治疗剂
公开(公告)号：US6017522A
公开(公告)日：2000-01-25
申请号：US845421
申请日：1997-04-25
申请人： Dennis E. Butterfield , Dennis K. Fujii , David L. Ladd , Robert A. Snow , Julia S. Tan , John L. Toner
发明人： Dennis E. Butterfield , Dennis K. Fujii , David L. Ladd , Robert A. Snow , Julia S. Tan , John L. Toner
IPC分类号： A61K47/48 , A61K51/00 , C08G65/32 , C08G65/329 , A61K31/77 , A61K49/00 , C08G65/48
CPC分类号： C08G65/329 , Y10S530/815 , Y10S530/816
摘要： A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said compisition having a molecular weight of at least 4,500; ##STR1## wherein: Z is a chelating residue;Q is a divalent poly(alkylene oxidylene) moiety having a carbon terminus at R and at L;L represents an amide linkage;E.sup.(b) is one or more counterions each having a charge of b;b is an integer from 1, 2 and 3;n is an integer selected from the group 1, 2, 3 and 4;w is zero or an integer from 1 to 5;M.sup.(+a) is a cation, having a charge of +a;a is an integer from 1 to 4;r is 0 or an integer from 1 to 3, provided that when r is 2-3, each M.sup.(+a) can be the same or different cation;d is the total charge on the chelating residue and is an integer from 0 to 10;d+.SIGMA.(b.multidot.w)+.SIGMA.(a.multidot.r)=O; andR is a capping moiety chosen from the group consisting of hydrogen, hydroxyl, C.sub.1 -C.sub.4 alkyl, aryl containing 6 to 24 carbon atoms, C.sub.2 -C.sub.5 alkanoyloxyl and C.sub.1 -C.sub.4 alkoxy, or R is an immunoreactive group or cytotoxic drug linked to Q by a chemical bond or a linking group.
摘要翻译：适合用于诊断成像的组合物或作为细胞杀伤剂的组合物，其包含通过酰胺键与聚（环氧烷）部分连接的螯合残基，所述制剂具有至少4,500的分子量; 其中：Z是螯合残基; Q是在R和L具有碳末端的二价聚（亚烷基亚氧烷基）部分; L表示酰胺键; E（b）是一个或多个各自具有b的电荷的抗衡离子; b是1,2和3的整数; n是选自1,2,3,4组的整数; w为0或1〜5的整数; M（+ a）为阳离子，电荷为+ a; a是从1到4的整数; r为0或1〜3的整数，条件是当r为2-3时，每个M（+ a）可以是相同或不同的阳离子; d是螯合残基上的总电荷，为0至10的整数; d + SIGMA（bxw）+ SIGMA（axr）= O; 并且R是选自氢，羟基，C 1 -C 4烷基，含有6至24个碳原子的芳基，C 2 -C 5烷酰氧基和C 1 -C 4烷氧基的封端部分，或R是免疫反应性基团或与 Q通过化学键或连接基团。

6. 发明授权

US5583206A Chelating polymers 失效
标题翻译：螯合聚合物
公开(公告)号：US5583206A
公开(公告)日：1996-12-10
申请号：US348197
申请日：1994-11-28
申请人： Robert A. Snow , David L. Ladd , John L. Toner
发明人： Robert A. Snow , David L. Ladd , John L. Toner
IPC分类号： A61K49/00 , A61K31/80 , A61K51/00 , A61P35/00 , C08G65/332 , C08G65/48 , C09K3/00 , C09K3/16 , C07F5/00
CPC分类号： C08G65/3324
摘要： In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation thereof. The polymer is particularly useful in therapeutic and diagnostic imaging compositions and as an antistatic agent.
摘要翻译：根据本发明，提供了包含与聚（环氧烷）部分连接的螯合剂残基的单元的聚合物及其制备方法。聚合物特别可用于治疗和诊断成像组合物和抗静电剂。

7. 发明授权

US5539117A 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines 失效
标题翻译： 2-乙酰基-6-氰基吡啶并且它们用作合成低聚-2,6-吡啶的中间体
公开(公告)号：US5539117A
公开(公告)日：1996-07-23
申请号：US277193
申请日：1994-07-19
申请人： Robert A. Snow , Daniel J. Delecki , Chandra R. Shah , K. Robert Hollister
发明人： Robert A. Snow , Daniel J. Delecki , Chandra R. Shah , K. Robert Hollister
IPC分类号： C07D213/84 , C07D405/06 , C07F7/18 , C07D213/22 , C07F7/02
CPC分类号： C07D213/84 , C07D405/06 , C07F7/1856
摘要： The present invention is directed to 2-acetyl-6-cyanopyridine compounds that are useful as intermediates in the synthesis of oligo-2,6-pyridines. The present invention is also directed to new, simpler, less expensive methods for synthesizing such oligopyridines using the novel 2-acetyl-6-cyanopyridine compounds as intermediates.
摘要翻译：本发明涉及可用作合成低聚-2,6-吡啶的中间体的2-乙酰基-6-氰基吡啶化合物。本发明还涉及使用新颖的2-乙酰基-6-氰基吡啶化合物作为中间体合成这种低聚吡啶的新的，更简单的，更便宜的方法。

8. 发明授权

US5350696A 2-acetyl-6-cyanopyridines and their use as intermediates in the synthesis of oligo-2,6-pyridines 失效
标题翻译： 2-乙酰基-6-氰基吡啶并且它们用作合成低聚-2,6-吡啶的中间体
公开(公告)号：US5350696A
公开(公告)日：1994-09-27
申请号：US46221
申请日：1993-04-13
申请人： Robert A. Snow , Daniel J. Delecki , Chandra R. Shah , K. Robert Hollister
发明人： Robert A. Snow , Daniel J. Delecki , Chandra R. Shah , K. Robert Hollister
IPC分类号： C07D213/84 , C07D405/06 , C07F7/18 , C07D405/12
CPC分类号： C07D213/84 , C07D405/06 , C07F7/1856
摘要： The present invention is directed to 2-acetyl-6-cyanopyridine compounds that are useful as intermediates in the synthesis of oligo-2,6-pyridines. The present invention is also directed to new, simpler, less expensive methods for synthesizing such oligopyridines using the novel 2-acetyl-6-cyanopyridine compounds as intermediates.
摘要翻译：本发明涉及可用作合成低聚-2,6-吡啶的中间体的2-乙酰基-6-氰基吡啶化合物。本发明还涉及使用新颖的2-乙酰基-6-氰基吡啶化合物作为中间体合成这种低聚吡啶的新的，更简单的，更便宜的方法。

9. 发明授权

US5532150A Low diol polyalkylene oxide biologically active proteinaceous substances 失效
标题翻译：低二醇聚环氧烷生物活性蛋白质物质
公开(公告)号：US5532150A
公开(公告)日：1996-07-02
申请号：US245999
申请日：1994-05-19
申请人： Robert A. Snow , David L. Ladd , Denton W. Hoyer
发明人： Robert A. Snow , David L. Ladd , Denton W. Hoyer
IPC分类号： A61K38/00 , A61K38/43 , A61K47/48 , A61P9/00 , A61P9/10 , A61P29/00 , C12N9/96
CPC分类号： A61K47/48215 , Y10S514/886
摘要： Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation.
摘要翻译：公开了含有低二醇聚乙二醇的药物组合物，其共价连接到超氧化物上，并且构成组合物的歧化酶过程。还公开了一种治疗与超氧化物阴离子对组织的不良反应（例如缺血事件，再灌注损伤，创伤和炎症）相关的疾病过程的方法。

10. 发明授权

US5707603A Pyridine complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions 失效
标题翻译：吡啶络合剂和靶向免疫反应剂可用于治疗和诊断组合物
公开(公告)号：US5707603A
公开(公告)日：1998-01-13
申请号：US375276
申请日：1995-01-19
申请人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain , Robert A. Snow , Ashis K. Saha , Richard Philion , Clyde W. Shearman , Chandra Shah
发明人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain , Robert A. Snow , Ashis K. Saha , Richard Philion , Clyde W. Shearman , Chandra Shah
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07D213/38 , C07D213/53 , C07D213/61 , C07D213/74 , C07D213/77 , C07D401/14 , C07D403/10 , C07D471/04 , C07D471/14 , C07D471/18 , C07D487/22 , G01N33/534 , A61K51/04 , C07D213/22 , C07F13/00
CPC分类号： C07D213/53 , A61K47/48169 , A61K47/48707 , A61K51/1054 , A61K51/1063 , A61K51/1093 , C07D213/61 , C07D213/77 , C07D471/04
摘要： The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive group covalently bonded to the complexing agent. The present invention also provides novel complexing agents having the structure A-I, as defined in the specification. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.
摘要翻译：本发明提供靶向的放射免疫试剂，其包含金属放射性核素离子，如说明书中所定义的具有结构A-1的络合剂和共价键合到络合剂上的免疫反应性基团。本发明还提供具有本说明书中定义的结构A-1的新型络合剂。靶向放射免疫试剂在治疗和诊断成像组合物和方法中特别有用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式