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1. 发明申请

US20110286953A1 WHITENING AGENT, ANTI-AGING AGENT, AND ANTI-OXIDANT AGENT 审中-公开
标题翻译：白化剂，抗老化剂和抗氧化剂
公开(公告)号：US20110286953A1
公开(公告)日：2011-11-24
申请号：US13138378
申请日：2010-02-03
申请人： Rikako Suzuki , Kiyotaka Hasegawa , Kiyoshi Sato , Tokiya Yokoi , Ken Kusakari
发明人： Rikako Suzuki , Kiyotaka Hasegawa , Kiyoshi Sato , Tokiya Yokoi , Ken Kusakari
IPC分类号： A61K8/97 , A61Q19/08 , A61Q19/02 , A61K36/12 , A61Q19/00
CPC分类号： A61K8/97 , A61K36/11 , A61Q19/02 , A61Q19/08
摘要： [Problem] To provide a whitening agent having a superior skin whitening activity, and having a superior effect in lightening and whitening pigmentation, aging spots, freckles, chloasma, or the like after sunburn, and an antioxidant agent and an anti-aging agent having a superior free radical scavenging ability for preventing and controlling aging in the skin and skin diseases caused by active oxygen (free radicals), and having a high level of safety.[Means for Solving the Problem] An extract of Psilotum spp., the family Psilotaceae, the genus Psilotum is contained.
摘要翻译：本发明提供一种具有优异的皮肤美白活性的美白剂，并且在晒斑后的减轻和增白色素沉着，老化斑，雀斑，黄褐斑等具有优异的作用，以及抗氧化剂和抗老化剂，其具有具有优异的自由基清除能力，用于预防和控制由活性氧（自由基）引起的皮肤和皮肤疾病的老化，并具有高度的安全性。 [解决问题的手段]包含Psilotum spp。，Psilotaceae，Psilotum属的提取物。

2. 发明申请

US20120141400A1 EXTERNAL SKIN PREPARATION, WHITENER, ANTIOXIDANT AND ANTI-AGING AGENT 审中-公开
标题翻译：外用皮肤制剂，白蛋白，抗氧化剂和抗老化剂
公开(公告)号：US20120141400A1
公开(公告)日：2012-06-07
申请号：US13261178
申请日：2010-08-03
申请人： Rikako Suzuki , Kiyotaka Hasegawa , Kiyoshi Sato , Ken Kusakari , Tokiya Yokoi
发明人： Rikako Suzuki , Kiyotaka Hasegawa , Kiyoshi Sato , Ken Kusakari , Tokiya Yokoi
IPC分类号： A61K8/97 , A61Q19/08 , A61P17/18 , A61Q19/02
CPC分类号： A61K36/185 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： Provided are a whitener having superior whitening action and superior skin lightening and whitening effects against pigment deposition, age spots, freckles, liver spots and the like, and an antioxidant and anti-aging agent having superior free radical capturing abilities that prevent and/or inhibit skin aging and skin diseases caused by active oxygen (free radicals). The whitener, antioxidant and anti-aging agent contain an extract from Polyalthia longifolia.
摘要翻译：本发明提供一种具有优异的美白作用和对颜料沉积，老年斑，雀斑，肝斑等具有优异的皮肤增白和美白效果的美白剂，以及具有优异的自由基捕获能力的抗氧化剂和抗老化剂，其防止和/或抑制皮肤老化和皮肤疾病引起的活性氧（自由基）。增白剂，抗氧化剂和抗老化剂含有来自Polyalthia longifolia的提取物。

3. 发明申请

US20120122951A1 SKIN-WHITENING AGENT AND COSMETIC METHOD FOR WHITENING SKIN 审中-公开
标题翻译：用于白化皮肤的皮肤白化剂和化妆方法
公开(公告)号：US20120122951A1
公开(公告)日：2012-05-17
申请号：US13138787
申请日：2010-03-04
申请人： Rikako Suzuki , Yosuke Tojo , Chieko Mizumoto , Kiyotaka Hasegawa , Yutaka Ashida , Jun-ichi Hosoi , Kiyoshi Sato
发明人： Rikako Suzuki , Yosuke Tojo , Chieko Mizumoto , Kiyotaka Hasegawa , Yutaka Ashida , Jun-ichi Hosoi , Kiyoshi Sato
IPC分类号： A61K31/40 , A61Q19/02 , C07D207/16
CPC分类号： A61K31/401 , A23L33/175 , A23V2002/00 , A61K8/0212 , A61K8/0216 , A61K8/4913 , A61K2800/92 , A61Q19/02 , A23V2200/318
摘要： The development of a skin-whitening agent which has a lower molecular weight, can be synthesized through a fewer steps and can be produced at low cost has been demanded. Thus, it is provided by the present invention a skin-whitening agent including one or more compounds selected from the group consisting of 4-cis-hydroxyproline and its derivative and/or its salt, a skin-whitening composition for external formulation to the skin, a cosmetic composition and a pharmaceutical composition, each of which contains the skin-whitening agent of the invention, and a cosmetic method for whitening the skin, which includes a step of administering one or more compounds selected from the group consisting of 4-cis-hydroxyproline and its derivative and/or its salt. In the skin-whitening agent and the cosmetic method for whitening the skin of the invention, the 4-cis-hydroxyproline may be 4-cis-L-hydroxyproline and/or 4-cis-D-hydroxyproline.
摘要翻译：需要开发具有较低分子量的皮肤增白剂，可以通过较少的步骤合成并且可以以低成本生产。因此，本发明提供一种皮肤增白剂，其包含一种或多种选自4-顺式 - 羟基脯氨酸及其衍生物和/或其盐的化合物，用于皮肤外用制剂的皮肤增白组合物，化妆品组合物和药物组合物，其含有本发明的皮肤增白剂和美白化妆品的方法，其包括给予一种或多种选自4-顺式 - 羟脯氨酸及其衍生物和/或其盐。在本发明的皮肤美白剂和美白化妆品的美白方法中，4-顺式 - 羟基脯氨酸可以是4-顺式-L-羟基脯氨酸和/或4-顺式-D-羟基脯氨酸。

4. 发明申请

US20110171247A1 Novel vascular endothelial growth factor expression inhibitors 审中-公开
标题翻译：新型血管内皮生长因子表达抑制剂
公开(公告)号：US20110171247A1
公开(公告)日：2011-07-14
申请号：US13064350
申请日：2011-03-21
申请人： Kiyotaka Hasegawa , Shinji Inomata , Kenichi Umishio
发明人： Kiyotaka Hasegawa , Shinji Inomata , Kenichi Umishio
IPC分类号： A61K36/185 , A61K8/97 , A61K36/77 , A61K36/8994 , A61K36/05 , A61K36/73 , A61Q19/08 , A61P9/00
CPC分类号： A61Q19/08 , A61K8/97 , A61K36/05 , A61K36/185 , A61K36/28 , A61K36/8994 , A61K2300/00
摘要： The invention provides anti-aging agents, angiogenesis inhibitors and vascular endothelial growth factor (VEGF) expression inhibitors containing one or more galenicals selected from the group consisting of mukurossi peel extract, hazelnut extract, linden extract, coix extract, chlorella extract and tormentilla extract.
摘要翻译：本发明提供了含有一种或多种选自葫芦果皮提取物，榛子提取物，椴树提取物，ix ix提取物，小球藻提取物和折羊毒素提取物的抗衰老剂，血管生成抑制剂和血管内皮生长因子（VEGF）表达抑制剂。

5. 发明授权

US4647732A Digital switch 失效
标题翻译：数字开关
公开(公告)号：US4647732A
公开(公告)日：1987-03-03
申请号：US751923
申请日：1985-07-05
申请人： Sekisuke Yamanaka , Akira Yanase , Kiyotaka Hasegawa , Takahiro Sakakino
发明人： Sekisuke Yamanaka , Akira Yanase , Kiyotaka Hasegawa , Takahiro Sakakino
IPC分类号： H01H19/00 , H01H3/34 , H01H21/80
CPC分类号： H01H19/003
摘要： A digital switch may have an advantageous actuating member including, in addition to pawls for a ratchet mechanism, a pair of main bodies and spring portions integrally formed therewith, whereby the mechanical integrity of the actuating member and smooth operation are assured. The spring portions are interconnected by a mounting plate which is in turn engaged to a casing member. The switch may include an advantageous electro-conductive pattern which is made by insert molding an embossed metallic plate into synthetic resin, whereby the dimensional accuracy of the pattern is assured and the production may be facilitated. Further, the switching element may make use of a set of concentric cams which selectively drive movable contact pieces onto fixed contact pieces according to the step-wise rotation of a ratchet wheel.
摘要翻译：数字开关可以具有有利的致动构件，除了用于棘轮机构的棘爪之外，还包括一对主体和与其一体形成的弹簧部分，由此确保致动构件的机械完整性和平稳的操作。弹簧部分通过安装板相互连接，安装板又与外壳部件接合。开关可以包括通过将压花的金属板嵌入成型为合成树脂而制成的有利的导电图案，由此可以确保图案的尺寸精度并且可以促进生产。此外，开关元件可以利用一组同心凸轮，其根据棘轮的逐步旋转选择性地将可动接触片驱动到固定接触片上。

6. 发明申请

US20090220627A1 NOVEL VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION INHIBITORS 审中-公开
标题翻译：新型血管内皮生长因子表达抑制剂
公开(公告)号：US20090220627A1
公开(公告)日：2009-09-03
申请号：US12066876
申请日：2006-09-15
申请人： Kiyotaka Hasegawa , Shinji Inomata , Kenichi Umishio
发明人： Kiyotaka Hasegawa , Shinji Inomata , Kenichi Umishio
IPC分类号： A61K36/00
CPC分类号： A61Q19/08 , A61K8/97 , A61K36/05 , A61K36/185 , A61K36/28 , A61K36/8994 , A61K2300/00
摘要： The invention provides anti-aging agents, angiogenesis inhibitors and vascular endothelial growth factor (VEGF) expression inhibitors containing one or more galenicals selected from the group consisting of mukurossi peel extract, hazelnut extract, linden extract, coix extract, chlorella extract and tormentilla extract.
摘要翻译：本发明提供含有一种或多种选自葫芦果皮提取物，榛子提取物，椴树提取物，ix ix提取物，小球藻提取物和折羊毒素提取物的抗衰老剂，血管生成抑制剂和血管内皮生长因子（VEGF）表达抑制剂。

7. 发明申请

US20130040911A1 ADHESION-PREVENTING MATERIAL 审中-公开
标题翻译：粘合防止材料
公开(公告)号：US20130040911A1
公开(公告)日：2013-02-14
申请号：US13638156
申请日：2010-12-09
申请人： Gilbu Soe , Motonori Aoshima , Toshiki Inoue , Kiyotaka Hasegawa
发明人： Gilbu Soe , Motonori Aoshima , Toshiki Inoue , Kiyotaka Hasegawa
IPC分类号： A61K31/717 , A61P41/00 , C08B15/05
CPC分类号： A61L31/148 , A61L31/048 , C08B11/12 , C08B11/20 , C08J5/18 , C08J2301/28 , C08L1/286 , C08L2205/025 , C08L2205/16 , C08L1/28
摘要： Provided are a novel carboxymethyl cellulose (CMC) structure and a method for producing the same. The CMC structure of the present invention is useful as a medical material and particularly as an adhesion-preventing material, and has good biocompatibility and bioabsorbability and controllable periods of functioning and dissolving, or has both effects for preventing adhesions and wound healing.The CMC structure of the present invention is substantially composed of carboxymethyl celluloses, comprising an acid carboxymethyl cellulose and an alkaline metal carboxymethyl cellulose in a mixed state. The method of production of the present invention comprises subjecting the alkaline metal (or acid) carboxymethyl cellulose structure to an acid (or alkali) treatment, wherein the acid (or alkali) treatment is terminated before the alkaline metal (or acid) carboxymethyl cellulose is fully converted to the acid (or alkaline metal) carboxymethyl cellulose.
摘要翻译：提供了一种新型羧甲基纤维素（CMC）结构及其制备方法。本发明的CMC结构作为医疗用材料，特别是作为防粘连材料是有用的，具有良好的生物相容性和生物吸收性，可控制的功能和溶解时间，或具有防止粘连和伤口愈合的两种效果。本发明的CMC结构基本上由羧甲基纤维素组成，其包含酸性羧甲基纤维素和混合状态的碱金属羧甲基纤维素。本发明的生产方法包括使碱金属（或酸）羧甲基纤维素结构经受酸（或碱）处理，其中酸（或碱）处理在碱金属（或酸）羧甲基纤维素是完全转化为酸（或碱金属）羧甲基纤维素。

8. 发明申请

US20120165409A1 WRINKLE-IMPROVING AGENT 审中-公开
标题翻译：缠绕剂改性剂
公开(公告)号：US20120165409A1
公开(公告)日：2012-06-28
申请号：US13410612
申请日：2012-03-02
申请人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
发明人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
IPC分类号： A61K31/195 , A61P17/00
CPC分类号： A61K8/44 , A61Q19/08
摘要： A wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.
摘要翻译：具有改善皱纹的效果的皱纹改善剂，即使施用于皮肤也不会引起安全性或疼痛的问题，并且含有作为活性成分的非常安全的物质。发现N-苯甲酰基 - 丙氨酸，其他特定的β-丙氨酸衍生物及其盐具有皱纹改善效果，由此可以提供含有一种或两种以上活性成分的皱纹改善剂的选自由这些特异性＆amp; - 丙氨酸衍生物组成的组的化合物及其盐。

9. 发明申请

US20100035881A1 WRINKLE-IMPROVING AGENT 审中-公开
标题翻译：缠绕剂改性剂
公开(公告)号：US20100035881A1
公开(公告)日：2010-02-11
申请号：US12067267
申请日：2006-09-15
申请人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
发明人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
IPC分类号： A61K8/36 , A61K8/49 , A61K8/42 , A61K8/46 , A61Q19/08
CPC分类号： A61K8/44 , A61Q19/08
摘要： The invention provides a novel wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.
摘要翻译：本发明提供了具有改善皱纹的效果的新型皱纹改善剂，即使施用于皮肤也不会引起安全性或疼痛的问题，并且含有作为活性成分的非常安全的物质。发现N-苯甲酰基-β-丙氨酸，其它特定β-丙氨酸衍生物及其盐具有皱纹改善效果，由此可以提供含有作为活性成分的一种或两种以上化合物的皱纹改善剂选自由这些特异性β-丙氨酸衍生物及其盐组成的组。

10. 发明申请

US20070249915A1 Inhibitors 审中-公开
标题翻译：抑制剂
公开(公告)号：US20070249915A1
公开(公告)日：2007-10-25
申请号：US10574469
申请日：2004-09-30
申请人： Hirofumi Aoki , Tatsuhiro Kodama , Kiyotaka Hasegawa , Kentaro Kajiya , Yumiko Ishimatatsu , Masashi Ogou , Seiichi Yoshida , Jiro Kishimoto , Osamu Moro
发明人： Hirofumi Aoki , Tatsuhiro Kodama , Kiyotaka Hasegawa , Kentaro Kajiya , Yumiko Ishimatatsu , Masashi Ogou , Seiichi Yoshida , Jiro Kishimoto , Osamu Moro
IPC分类号： A61B5/00
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides a skin test method for predicting the formation of spots in the skin. This method judges skin to be susceptible to the formation of spots in the case expression in the epidermis of MCP-2 gene, a polynucleotide capable of hybridizing under highly stringent conditions to mouse AK012157 gene, human FLJ21763 gene or rat S74257 gene, or Mcp9, Mcp10, Isg15, Usp18, Oas12, Gbp2, Gtpi, Ifi47, Igtp, Tgtp, Sprr2A, Krt2-6b, Cdk5rap2, Mef2C, Gsta4, Osf2, Tnc, Igfbp6, Ppicap or Mm. 74656 gene, is increased as compared with normal expression in the epidermis.
摘要翻译：本发明提供一种用于预测皮肤斑点形成的皮肤试验方法。该方法可以判断皮肤易于在MCP-2基因的表皮中表达的斑点形成，该基因是能够在高度严格条件下与小鼠AK012157基因，人FLJ21763基因或大鼠S74257基因或Mcp9基因杂交的多核苷酸， Mcp10，Isg15，Usp18，Oas12，Gbp2，Gtpi，Ifi47，Igtp，Tgtp，Sprr2A，Krt2-6b，Cdk5rap2，Mef2C，Gsta4，Osf2，Tnc，Igfbp6，Ppicap或Mm。 74656基因与表皮正常表达相比增加。

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