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1. 发明申请

US20070005399A1 Method and computer program for evaluating the sustainability of a permanent life insurance policy 审中-公开
标题翻译：评估永久人寿保险政策可持续性的方法和计算机程序
公开(公告)号：US20070005399A1
公开(公告)日：2007-01-04
申请号：US11172541
申请日：2005-06-30
申请人： Richard Weber , Chris Hause
发明人： Richard Weber , Chris Hause
IPC分类号： G06Q40/00
CPC分类号： G06Q40/08
摘要： A method and computer program for evaluating the sustainability of a permanent life insurance policy involves helping a user choose a type of insurance policy that is appropriate by asking the user a series of questions relating to the person's risk and management preferences. A confidence factor is determined for an insurance policy's funding premium, wherein the confidence factor indicates a probability that the policy will sustain until a user-selected age, such as the age of one hundred. The confidence factor is determined by applying parameters of the user's policy to one thousand trial illustrations developed using performance information from actual portfolios over the last forty years, and reporting a percentage of the trial illustrations that sustained through age one hundred. If the confidence factor is unacceptably low, the user adjusts the premium and/or an investment allocation scheme to generate a new confidence factor. The confidence factor can be generated for a new policy or for an in-force policy.
摘要翻译：用于评估永久人寿保险政策的可持续性的方法和计算机程序涉及帮助用户选择一种适当的保险单，通过向用户询问与该人的风险和管理偏好相关的一系列问题。确定保险单的资金溢价的置信因子，其中置信因子表示在用户选择的年龄（例如100岁）之前该策略将持续的概率。通过将用户政策的参数应用于使用过去四十年来实际投资组合的绩效信息而开发的一千个试用插图，并报告了百岁以上的试用插图的百分比，来确定置信因子。如果置信因子不可接受地低，则用户调整溢价和/或投资分配方案以产生新的置信因子。可以为新政策或有效政策产生置信因素。

2. 发明申请

US20090155282A1 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 有权
公开(公告)号：US20090155282A1
公开(公告)日：2009-06-18
申请号：US12268352
申请日：2008-11-10
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
IPC分类号： A61K39/395 , C12N5/02 , C07H21/04
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

3. 发明授权

US07135174B2 Antibodies directed to PDGFD and uses thereof 有权
公开(公告)号：US07135174B2
公开(公告)日：2006-11-14
申请号：US10041860
申请日：2002-01-07
申请人： Jose R. F. Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh
发明人： Jose R. F. Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , C07K2317/21 , C07K2317/56
摘要： The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

4. 发明申请

US20060179861A1 Method and apparatus for cooling with coolant at a subambient pressure 有权
标题翻译：在低压下用冷却剂冷却的方法和装置
公开(公告)号：US20060179861A1
公开(公告)日：2006-08-17
申请号：US11058691
申请日：2005-02-15
申请人： Richard Weber , William Wyatt
发明人： Richard Weber , William Wyatt
IPC分类号： F28C1/00 , B63B25/26 , F28D5/00
CPC分类号： B63J2/02 , F25B23/006 , F25B2339/047 , H01Q1/02 , H01Q1/34
摘要： According to one embodiment, an apparatus includes a fluid coolant and structure which reduces a pressure of the fluid coolant through a subambient pressure at which the coolant has a cooling temperature less than a temperature of the heat-generating structure. The apparatus also includes structure that directs a flow of the fluid coolant in the form of a liquid at a subambient pressure in a manner causing the liquid coolant to be brought into thermal communication with the heat-generating structure. The heat from the heat-generating structure causes the liquid coolant to boil and vaporize so that the coolant absorbs heat from the heat-generating structure as the coolant changes state. The structure is configured to circulate the fluid coolant through a flow loop while maintaining the pressure of the fluid coolant within a range having an upper bound less than ambient pressure. The apparatus also includes a first heat exchanger for exchanging heat between the fluid coolant flowing through the loop and a second coolant in an intermediary loop so as to condense the fluid coolant flowing through the loop to a liquid. The apparatus also includes a second heat exchanger for exchanging heat between the second coolant in the intermediary cooling loop and a body of water on which the ship is disposed.
摘要翻译：根据一个实施例，一种装置包括流体冷却剂和结构，其通过冷却剂具有小于发热结构的温度的冷却温度的低于环境压力来降低流体冷却剂的压力。该装置还包括以使液体冷却剂与发热结构热连通的方式将流体冷却剂以液体的形式引导到低于环境压力的结构。来自发热结构的热量导致液体冷却剂沸腾和蒸发，使得当冷却剂改变状态时，冷却剂从发热结构吸收热量。该结构构造成使流体冷却剂循环流动循环，同时将流体冷却剂的压力保持在上限小于环境压力的范围内。该装置还包括第一热交换器，用于在流过环路的流体冷却剂和中间循环中的第二冷却剂之间进行热交换，以将流过环路的流体冷却剂冷凝至液体。该设备还包括第二热交换器，用于在中间冷却回路中的第二冷却剂与船体上设置的水体之间进行热交换。

5. 发明申请

US20050092481A1 Method and apparatus for efficient heat exchange in an aircraft or other vehicle 有权
标题翻译：用于飞机或其他车辆中有效热交换的方法和装置
公开(公告)号：US20050092481A1
公开(公告)日：2005-05-05
申请号：US10698269
申请日：2003-10-31
申请人： William Wyatt , James Haws , Richard Weber
发明人： William Wyatt , James Haws , Richard Weber
IPC分类号： F28D7/00 , F28F27/02 , F28F27/00
CPC分类号： F28F27/02 , F28D7/005 , F28D2021/0021
摘要： A heat exchanger extracts heat from a two-phase fluid coolant so that the coolant changes from a vapor state to a liquid state. Two valves have respective inlets which communicate with the coolant in the heat exchanger, and which are physically spaced from each other. Valve control structure responds to the presence of liquid at the inlet to either valve by opening that valve, so that the liquid coolant flows through the valve to a discharge section. A different feature involves a housing with a heat exchanger therein, the heat exchanger having a plurality of coolant conduits that are axially spaced. A flow of air travels axially within the housing, then flows transversely past the conduits to the other side thereof, and then resumes flowing axially on the other side of the conduits.
摘要翻译：热交换器从两相流体冷却剂中提取热量，使得冷却剂从蒸汽状态变为液态。两个阀具有与热交换器中的冷却剂连通并且彼此物理间隔开的各自的入口。阀控制结构通过打开该阀来响应在两个阀的入口处的液体的存在，使得液体冷却剂通过阀流到排出部分。不同的特征涉及其中具有热交换器的壳体，热交换器具有轴向间隔开的多个冷却剂导管。空气流在壳体内轴向移动，然后横向流过管道至其另一侧，然后在导管的另一侧沿轴向流动。

6. 发明申请

US20050059087A1 Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof 有权
标题翻译：针对表皮生长因子受体的缺失突变体的抗体及其用途
公开(公告)号：US20050059087A1
公开(公告)日：2005-03-17
申请号：US10877774
申请日：2004-06-25
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal Kang , Chadwick King , Scott Klakamp , Qiaojuan Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal Kang , Chadwick King , Scott Klakamp , Qiaojuan Su
IPC分类号： A61K39/395 , A61K47/48 , C07K16/22 , C07K16/28 , C07K17/00 , C12N20060101 , C12N5/06 , G01N33/53
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
摘要翻译：本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

7. 发明授权

US5209240A Device for inducing and registering imbalance 失效
标题翻译：用于诱导和记录不平衡的装置
公开(公告)号：US5209240A
公开(公告)日：1993-05-11
申请号：US658334
申请日：1991-02-20
申请人： Sanjeev Jain , John E. Vermette , Richard Weber , Robert J. Doub , Gad Alon , Alan G. Day, III
发明人： Sanjeev Jain , John E. Vermette , Richard Weber , Robert J. Doub , Gad Alon , Alan G. Day, III
IPC分类号： A61B5/103 , G01G19/44
CPC分类号： A61B5/1036 , G01G19/44
摘要： A device is provided for registering and recording induced imbalance in a human subject. A horizontal platform is adapted for controlled, linear displacement in a horizontal plane to induce imbalance. Imbalance and response can be detected and recorded by means of electric contact shoes or other means.
摘要翻译：提供了用于在人类对象中记录和记录诱导的不平衡的装置。水平平台适用于在水平面中受控的线性位移以引起不平衡。可以通过电动接触鞋或其他方式检测和记录不平衡和响应。

8. 发明授权

US4762796A pH control of a process stream 失效
标题翻译：工艺流的pH控制
公开(公告)号：US4762796A
公开(公告)日：1988-08-09
申请号：US308467
申请日：1981-10-05
申请人： Richard Weber , Loren H. Haag
发明人： Richard Weber , Loren H. Haag
IPC分类号： C02F1/66 , B01D53/14 , C02F1/68 , G05D21/02 , G05D21/00 , G05D7/00
CPC分类号： G05D21/02 , B01D53/1412 , B01D53/1425 , B01D53/1468 , Y10T436/12
摘要： The invention features a unique pH control system and method for maintaining the proper pH in a continuous process stream. The system backmixes a sample stream, which decreases the dynamic gain of the control system, and which allows for the ease of adding a controlled amount of reagent or buffer to the process stream on a continuous basis.
摘要翻译：本发明具有独特的pH控制系统和用于在连续工艺流中保持适当pH的方法。系统将混合样品流，这减少了控制系统的动态增益，并且允许在连续的基础上容易地将控制量的试剂或缓冲液添加到工艺流中。

9. 发明授权

US08235410B2 Trailer and towing related technologies 失效
标题翻译：拖车牵引相关技术
公开(公告)号：US08235410B2
公开(公告)日：2012-08-07
申请号：US13028046
申请日：2011-02-15
申请人： Richard Weber , Linda Weber
发明人： Richard Weber , Linda Weber
IPC分类号： B60D1/58
CPC分类号： B60D1/167 , B60D1/1675 , B60D1/18 , Y10T29/49826
摘要： The inventive technology, in embodiments, may be described as an extended trailer hitch receiver tube support apparatus that uses triangulation of key structural components to provide a hitch of comparatively higher strength. Tensionable receiver tube supporters may be used to achieve a triangular lattice support; a vertical member established above a cross member may provide a forward attachment site for the tensionable receiver tube supporters, thereby allowing the transfer of forces from the extended receiver tube to the vertical member, and then back to the vehicle frame (or frame attached component) via tensionable vertical member supporters.
摘要翻译：在实施例中，本发明的技术可以被描述为使用关键结构部件的三角测量来提供相对较高强度的搭接的延伸拖车牵引接收管支撑装置。可以使用张力接收管支撑器来实现三角形格架支撑; 建立在横梁上方的垂直构件可以为可张紧的接收管支撑件提供前向附接位置，从而允许将力从扩展的接收管传递到垂直构件，然后返回到车辆框架（或框架附接部件）通过可张紧的垂直成员支持者。

10. 发明申请

US20090240038A1 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 有权
标题翻译：抗体生长因子受体的遗传突变体的抗体及其用途
公开(公告)号：US20090240038A1
公开(公告)日：2009-09-24
申请号：US12396313
申请日：2009-03-02
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
IPC分类号： C07K16/18
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
摘要翻译：本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

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