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1. 发明申请

US20060179861A1 Method and apparatus for cooling with coolant at a subambient pressure 有权
标题翻译：在低压下用冷却剂冷却的方法和装置
公开(公告)号：US20060179861A1
公开(公告)日：2006-08-17
申请号：US11058691
申请日：2005-02-15
申请人： Richard Weber , William Wyatt
发明人： Richard Weber , William Wyatt
IPC分类号： F28C1/00 , B63B25/26 , F28D5/00
CPC分类号： B63J2/02 , F25B23/006 , F25B2339/047 , H01Q1/02 , H01Q1/34
摘要： According to one embodiment, an apparatus includes a fluid coolant and structure which reduces a pressure of the fluid coolant through a subambient pressure at which the coolant has a cooling temperature less than a temperature of the heat-generating structure. The apparatus also includes structure that directs a flow of the fluid coolant in the form of a liquid at a subambient pressure in a manner causing the liquid coolant to be brought into thermal communication with the heat-generating structure. The heat from the heat-generating structure causes the liquid coolant to boil and vaporize so that the coolant absorbs heat from the heat-generating structure as the coolant changes state. The structure is configured to circulate the fluid coolant through a flow loop while maintaining the pressure of the fluid coolant within a range having an upper bound less than ambient pressure. The apparatus also includes a first heat exchanger for exchanging heat between the fluid coolant flowing through the loop and a second coolant in an intermediary loop so as to condense the fluid coolant flowing through the loop to a liquid. The apparatus also includes a second heat exchanger for exchanging heat between the second coolant in the intermediary cooling loop and a body of water on which the ship is disposed.
摘要翻译：根据一个实施例，一种装置包括流体冷却剂和结构，其通过冷却剂具有小于发热结构的温度的冷却温度的低于环境压力来降低流体冷却剂的压力。该装置还包括以使液体冷却剂与发热结构热连通的方式将流体冷却剂以液体的形式引导到低于环境压力的结构。来自发热结构的热量导致液体冷却剂沸腾和蒸发，使得当冷却剂改变状态时，冷却剂从发热结构吸收热量。该结构构造成使流体冷却剂循环流动循环，同时将流体冷却剂的压力保持在上限小于环境压力的范围内。该装置还包括第一热交换器，用于在流过环路的流体冷却剂和中间循环中的第二冷却剂之间进行热交换，以将流过环路的流体冷却剂冷凝至液体。该设备还包括第二热交换器，用于在中间冷却回路中的第二冷却剂与船体上设置的水体之间进行热交换。

2. 发明申请

US20050092481A1 Method and apparatus for efficient heat exchange in an aircraft or other vehicle 有权
标题翻译：用于飞机或其他车辆中有效热交换的方法和装置
公开(公告)号：US20050092481A1
公开(公告)日：2005-05-05
申请号：US10698269
申请日：2003-10-31
申请人： William Wyatt , James Haws , Richard Weber
发明人： William Wyatt , James Haws , Richard Weber
IPC分类号： F28D7/00 , F28F27/02 , F28F27/00
CPC分类号： F28F27/02 , F28D7/005 , F28D2021/0021
摘要： A heat exchanger extracts heat from a two-phase fluid coolant so that the coolant changes from a vapor state to a liquid state. Two valves have respective inlets which communicate with the coolant in the heat exchanger, and which are physically spaced from each other. Valve control structure responds to the presence of liquid at the inlet to either valve by opening that valve, so that the liquid coolant flows through the valve to a discharge section. A different feature involves a housing with a heat exchanger therein, the heat exchanger having a plurality of coolant conduits that are axially spaced. A flow of air travels axially within the housing, then flows transversely past the conduits to the other side thereof, and then resumes flowing axially on the other side of the conduits.
摘要翻译：热交换器从两相流体冷却剂中提取热量，使得冷却剂从蒸汽状态变为液态。两个阀具有与热交换器中的冷却剂连通并且彼此物理间隔开的各自的入口。阀控制结构通过打开该阀来响应在两个阀的入口处的液体的存在，使得液体冷却剂通过阀流到排出部分。不同的特征涉及其中具有热交换器的壳体，热交换器具有轴向间隔开的多个冷却剂导管。空气流在壳体内轴向移动，然后横向流过管道至其另一侧，然后在导管的另一侧沿轴向流动。

3. 发明申请

US20070209782A1 System and method for cooling a server-based data center with sub-ambient cooling 审中-公开
标题翻译：用于冷却基于服务器的数据中心的系统和方法
公开(公告)号：US20070209782A1
公开(公告)日：2007-09-13
申请号：US11371681
申请日：2006-03-08
申请人： William Wyatt , Richard Weber
发明人： William Wyatt , Richard Weber
IPC分类号： F28D15/00
CPC分类号： H05K7/20827 , F28C2001/006 , F28D15/0266 , F28D2021/0019 , F28D2021/0031 , F28F2265/14
摘要： According to one embodiment of the invention, a cooling system for heat-generating structures comprises a plurality of heat exchangers, a structure which directs flow of the fluid coolant substantially in the form of a liquid to each of the plurality of heat exchangers, and a structure which reduces a pressure of the fluid coolant to a pressure at which the fluid coolant has a boiling temperature less than a temperature of the heat-generating structures. Each of the plurality of heat exchangers is in thermal communication with at least one of the heat-generating structures and has an inlet and an outlet. Thermal energy from the heat-generating structure causes the fluid coolant substantially in the form of a liquid to boil and vaporize in each of the plurality of heat exchangers so that the fluid coolant absorbs thermal energy from the heat-generating structure as the fluid coolant changes state.
摘要翻译：根据本发明的一个实施例，一种用于发热结构的冷却系统包括多个热交换器，一种将流体冷却剂基本上以液体形式流向多个热交换器中的每一个的结构，以及结构，其将流体冷却剂的压力降低到流体冷却剂的沸点低于发热结构的温度的压力。多个热交换器中的每个热交换器与发热结构中的至少一个热连通并且具有入口和出口。来自发热结构的热能导致基本上呈液体形式的流体冷却剂在多个热交换器中的每个热交换器中沸腾和汽化，使得流体冷却剂随着流体冷却剂改变而吸收来自发热结构的热能州。

4. 发明申请

US20070119199A1 System and method for electronic chassis and rack mounted electronics with an integrated subambient cooling system 审中-公开
标题翻译：具有集成的低温冷却系统的电子机箱和机架式电子装置的系统和方法
公开(公告)号：US20070119199A1
公开(公告)日：2007-05-31
申请号：US11291041
申请日：2005-11-30
申请人： Richard Weber , Kerrin Rummel , Albert Payton , William Wyatt
发明人： Richard Weber , Kerrin Rummel , Albert Payton , William Wyatt
IPC分类号： F25D23/12
CPC分类号： H05K7/20681 , F28D15/0266 , H01L23/427 , H01L2924/0002 , H05K7/207 , H01L2924/00
摘要： According to one embodiment of the invention, a cooling system for a heat-generating structure that is disposed in an environment having an ambient pressure comprises a fluid coolant and three structures. The first structure allows the heat generating structure to removably couple to the cooling system. The second structure reduces a pressure of the fluid coolant to a subambient pressure at which the fluid coolant has a boiling temperature less than a temperature of the heat-generating structure. The third structure directs a flow of the fluid coolant in the form of a liquid at the subambient pressure in a manner causing the fluid coolant to be brought into thermal communication with the heat-generating structure where heat from the heat-generating structure causes the fluid coolant in the form of the liquid to boil and vaporize so that the fluid coolant absorbs heat from the heat-generating structure as the fluid coolant changes state.
摘要翻译：根据本发明的一个实施例，用于在具有环境压力的环境中设置的发热结构的冷却系统包括流体冷却剂和三个结构。第一结构允许发热结构可移除地耦合到冷却系统。第二结构将流体冷却剂的压力降低到流体冷却剂的沸腾温度低于发热结构的温度的次环境压力。第三结构将流体冷却剂的流动以低于环境压力的液体形式引导，使流体冷却剂与发热结构热连通，其中来自发热结构的热量导致流体以液体形式的冷却剂沸腾和汽化，使得当流体冷却剂改变状态时，流体冷却剂从发热结构吸收热量。

5. 发明申请

US20070263356A1 Method and Apparatus for Cooling Electronics with a Coolant at a Subambient Pressure 有权
标题翻译：在低压下用冷却剂冷却电子的方法和装置
公开(公告)号：US20070263356A1
公开(公告)日：2007-11-15
申请号：US11381297
申请日：2006-05-02
申请人： Richard Weber , William Wyatt , Kerrin Rummel
发明人： Richard Weber , William Wyatt , Kerrin Rummel
IPC分类号： H05K7/20
CPC分类号： F25B23/006 , F25B43/00 , F28D15/0266 , F28D2021/0031 , F28F23/00 , H01L2924/0002 , H01Q1/02 , H01L2924/00
摘要： According to one embodiment of the invention, a method is provided for cooling heat-generating structure disposed in an environment having an ambient pressure. The heat-generating structure includes electronics. The method includes providing a coolant, reducing a pressure of the coolant to a subambient pressure at which the coolant has a boiling temperature less than a temperature of the heat-generating structure, and bringing the heat-generating structure and the coolant at the subambient pressure into contact with one another, so that the coolant boils and vaporizes to thereby absorb heat from the heat-generating structure. In a more particular embodiment the coolant is either pure water or pure methanol with an electrical resistivity level of greater than one million Ohms-cm. Further, in another particular embodiment the method includes filtering the coolant to maintain its purity above a particular level.
摘要翻译：根据本发明的一个实施例，提供一种用于冷却设置在具有环境压力的环境中的发热结构的方法。发热结构包括电子产品。该方法包括提供冷却剂，将冷却剂的压力降低到冷却剂的沸腾温度低于发热结构的温度的次环境压力，并使发热结构和冷却剂处于低于环境压力彼此接触，使得冷却剂沸腾并蒸发，从而从发热结构吸收热量。在更具体的实施方案中，冷却剂是纯水或具有大于100万欧姆 - 厘米的电阻率水平的纯甲醇。此外，在另一个具体实施方案中，该方法包括过滤冷却剂以将其纯度保持在特定水平以上。

6. 发明申请

US20090155282A1 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 有权
公开(公告)号：US20090155282A1
公开(公告)日：2009-06-18
申请号：US12268352
申请日：2008-11-10
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
IPC分类号： A61K39/395 , C12N5/02 , C07H21/04
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

7. 发明授权

US07135174B2 Antibodies directed to PDGFD and uses thereof 有权
公开(公告)号：US07135174B2
公开(公告)日：2006-11-14
申请号：US10041860
申请日：2002-01-07
申请人： Jose R. F. Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh
发明人： Jose R. F. Corvalan , Xiao-Chi Jia , Xiao Feng , Xiao-dong Yang , Francine Chen , Gadi Gazit , Richard Weber , Binyam Bezabeh
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , C07K2317/21 , C07K2317/56
摘要： The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

8. 发明申请

US20050059087A1 Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof 有权
标题翻译：针对表皮生长因子受体的缺失突变体的抗体及其用途
公开(公告)号：US20050059087A1
公开(公告)日：2005-03-17
申请号：US10877774
申请日：2004-06-25
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal Kang , Chadwick King , Scott Klakamp , Qiaojuan Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal Kang , Chadwick King , Scott Klakamp , Qiaojuan Su
IPC分类号： A61K39/395 , A61K47/48 , C07K16/22 , C07K16/28 , C07K17/00 , C12N20060101 , C12N5/06 , G01N33/53
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
摘要翻译：本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

9. 发明授权

US5209240A Device for inducing and registering imbalance 失效
标题翻译：用于诱导和记录不平衡的装置
公开(公告)号：US5209240A
公开(公告)日：1993-05-11
申请号：US658334
申请日：1991-02-20
申请人： Sanjeev Jain , John E. Vermette , Richard Weber , Robert J. Doub , Gad Alon , Alan G. Day, III
发明人： Sanjeev Jain , John E. Vermette , Richard Weber , Robert J. Doub , Gad Alon , Alan G. Day, III
IPC分类号： A61B5/103 , G01G19/44
CPC分类号： A61B5/1036 , G01G19/44
摘要： A device is provided for registering and recording induced imbalance in a human subject. A horizontal platform is adapted for controlled, linear displacement in a horizontal plane to induce imbalance. Imbalance and response can be detected and recorded by means of electric contact shoes or other means.
摘要翻译：提供了用于在人类对象中记录和记录诱导的不平衡的装置。水平平台适用于在水平面中受控的线性位移以引起不平衡。可以通过电动接触鞋或其他方式检测和记录不平衡和响应。

10. 发明授权

US4762796A pH control of a process stream 失效
标题翻译：工艺流的pH控制
公开(公告)号：US4762796A
公开(公告)日：1988-08-09
申请号：US308467
申请日：1981-10-05
申请人： Richard Weber , Loren H. Haag
发明人： Richard Weber , Loren H. Haag
IPC分类号： C02F1/66 , B01D53/14 , C02F1/68 , G05D21/02 , G05D21/00 , G05D7/00
CPC分类号： G05D21/02 , B01D53/1412 , B01D53/1425 , B01D53/1468 , Y10T436/12
摘要： The invention features a unique pH control system and method for maintaining the proper pH in a continuous process stream. The system backmixes a sample stream, which decreases the dynamic gain of the control system, and which allows for the ease of adding a controlled amount of reagent or buffer to the process stream on a continuous basis.
摘要翻译：本发明具有独特的pH控制系统和用于在连续工艺流中保持适当pH的方法。系统将混合样品流，这减少了控制系统的动态增益，并且允许在连续的基础上容易地将控制量的试剂或缓冲液添加到工艺流中。

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