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1. 发明授权

US07367341B2 Methods and devices for selective disruption of fatty tissue by controlled cooling 有权
标题翻译：通过受控冷却选择性破坏脂肪组织的方法和装置
公开(公告)号：US07367341B2
公开(公告)日：2008-05-06
申请号：US10391221
申请日：2003-03-17
申请人： Richard Rox Anderson , Dieter Manstein
发明人： Richard Rox Anderson , Dieter Manstein
IPC分类号： A61B19/00
CPC分类号： A61F7/00 , A61B5/415 , A61B5/6804 , A61B18/02 , A61B2018/0237 , A61B2018/0262 , A61F7/10 , A61F2007/0054 , A61F2007/0056 , A61F2007/0075 , A61F2007/0082 , A61F2007/0094 , A61F2007/0096 , A61F2007/0239 , A61F2007/029 , A61H23/00
摘要： The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.
摘要翻译：本发明涉及用于通过受控冷却选择性破坏富含脂质细胞的方法。本发明还涉及一种用于实施通过受控冷却选择性破坏富含脂质细胞的方法的装置。

2. 发明授权

US08915948B2 Method and apparatus for photothermal treatment of tissue at depth 有权
标题翻译：深层组织光热处理方法及装置
公开(公告)号：US08915948B2
公开(公告)日：2014-12-23
申请号：US12032004
申请日：2008-02-15
申请人： Gregory B. Altshuler , Andrei V. Erofeev , Henry Zenzie , Richard Rox Anderson , Dieter Manstein , James Burke, III , Andrew Radl , Michael Z. Smirnov
发明人： Gregory B. Altshuler , Andrei V. Erofeev , Henry Zenzie , Richard Rox Anderson , Dieter Manstein , James Burke, III , Andrew Radl , Michael Z. Smirnov
IPC分类号： A61N5/06 , A61B5/00 , A61B18/20 , A61N7/00 , A61B18/00 , A61N1/32 , A61B18/14
CPC分类号： A61N5/0625 , A61B5/6843 , A61B18/14 , A61B18/203 , A61B2018/00005 , A61B2018/00011 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61N1/20 , A61N1/32 , A61N1/328 , A61N1/36 , A61N5/0613 , A61N5/0616 , A61N7/00 , A61N2005/0659 , A61N2007/0008 , A61N2007/0034
摘要： The present invention provides method and apparatus for treating tissue in a region at depth by applying optical radiation thereto of a wavelength able to reach the depth of the region and of a selected relatively low power for a duration sufficient for the radiation to effect the desired treatment while concurrently cooling tissue above the selected region to protect such tissue. Treatment may be enhanced by applying mechanical, acoustic or electrical stimulation to the region.
摘要翻译：本发明提供了通过向其施加能够达到该区域的深度的波长并且选择相对较低的功率持续足以使辐射实现所需治疗的持续时间的光辐射来治疗深度区域中的组织的方法和装置同时同时冷却选定区域上方的组织以保护这种组织。可以通过对该区域施加机械，声学或电刺激来增强治疗。

3. 发明申请

US20140303697A1 METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE 有权
标题翻译：皮肤组织轻度治疗的方法和装置
公开(公告)号：US20140303697A1
公开(公告)日：2014-10-09
申请号：US14358359
申请日：2012-11-16
申请人： Richard Rox Anderson , Dieter Manstein , Henry HL Chan , Joseph Ting
发明人： Richard Rox Anderson , Dieter Manstein , Henry HL Chan , Joseph Ting
IPC分类号： A61F7/00
CPC分类号： A61F7/0085 , A61B18/02 , A61B2018/00452 , A61B2018/0047 , A61B2018/00791 , A61B2018/00875 , A61B2018/0237 , A61B2018/0262 , A61F7/007 , A61F2007/0052 , A61F2007/0056 , A61F2007/0075 , A61F2007/0094 , A61F2007/0095
摘要： Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about −5 degrees Celsius for a duration of about one minute or less, using a plurality of cooled contact surfaces, each having a width between about 2 mm and about 20 mm. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surfaces.
摘要翻译：提供了可以提供靠近皮肤表面的皮肤组织的冷却和/或冷冻以产生皮肤中减轻或减少色素沉着的外观的美容方法和装置。使用多个冷却的接触表面，其宽度可以在约2mm至约20mm之间，将皮肤冷却至约-5摄氏度的温度约1分钟或更短的时间。可以提供冷却装置以从被处理的皮肤组织提供受控的热量去除。可以可选地提供传感器以检测靠近冷却表面的组织的冷冻。

4. 发明授权

US07942153B2 Method and apparatus for dermatological treatment 有权
标题翻译：皮肤病治疗方法和装置
公开(公告)号：US07942153B2
公开(公告)日：2011-05-17
申请号：US11931232
申请日：2007-10-31
申请人： Dieter Manstein , R. Rox Anderson
发明人： Dieter Manstein , R. Rox Anderson
IPC分类号： A61B19/00
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00452 , A61B2018/0047 , A61B2018/208
摘要： The present invention provides improved methods and apparatus for skin treatment. The apparatus includes multiple sources of optical energy or several blades that are scanned along a region of skin to form micro-line patterns of damaged tissue. The micro-lines are small in at least one dimension, having a width of less than about 1 mm, and the wounded regions promote beneficial results by stimulation of wound healing and tissue remodeling.
摘要翻译：本发明提供了用于皮肤治疗的改进方法和装置。该装置包括沿着皮肤区域扫描的多个光能源或几个叶片，以形成受损组织的微线图案。微细线在至少一个维度上是小的，具有小于约1mm的宽度，受伤的区域通过刺激伤口愈合和组织重塑来促进有益的结果。

5. 发明申请

US20090146086A1 SYSTEM AND APPARATUS FOR DERMATOLOGICAL TREATMENT 有权
标题翻译：用于皮肤治疗的系统和装置
公开(公告)号：US20090146086A1
公开(公告)日：2009-06-11
申请号：US12330252
申请日：2008-12-08
申请人： Dieter Manstein
发明人： Dieter Manstein
IPC分类号： G01J3/10 , G01J1/00
CPC分类号： A61B18/18 , A61B18/203 , A61B2018/00023 , A61B2018/00452 , A61B2018/00458 , A61B2018/0047 , A61B2018/00642 , A61B2018/1807 , A61B2090/065 , A61B2562/0257 , A61N5/0616 , A61N2005/0654 , A61N2005/0656 , A61N2005/0666 , A61N2005/0667
摘要： Exemplary embodiments of system and apparatus can be provided for treating various dermatological and biological conditions using electromagnetic energy in the form of optical radiation. For example, energy can be provided by a chemical reaction, such as by combustion of a fine metallic filament, which can be used to generate a high-intensity pulse of energy without requiring external energy sources. Various parameters of the reactive materials and enclosures can be selected and/or applied to provide a radiation pulse having particular characteristics, including fluence, peak intensity, and radiation wavelength distribution. Various filters may be provided to further modify characteristics of the radiation. Such radiation pulses can be used to irradiate tissue such as skin to obtain various therapeutic or beneficial effects, including improvement in the appearance of pigmented or venous lesions.
摘要翻译：可以提供系统和装置的示例性实施例，以使用光辐射形式的电磁能量来治疗各种皮肤病学和生物学条件。例如，可以通过化学反应（例如通过金属细丝的燃烧）来提供能量，其可用于产生高强度脉冲的能量而不需要外部能量源。可以选择和/或施加反应性材料和外壳的各种参数以提供具有特征，包括通量，峰值强度和辐射波长分布的辐射脉冲。可以提供各种滤光器以进一步修改辐射的特性。这种辐射脉冲可用于照射诸如皮肤的组织以获得各种治疗或有益效果，包括改善着色或静脉损伤的外观。

6. 发明申请

US20060122668A1 Method and apparatus for EMR treatment 审中-公开
公开(公告)号：US20060122668A1
公开(公告)日：2006-06-08
申请号：US11235697
申请日：2005-09-21
申请人： R. Anderson , Gregory Altshuler , Dieter Manstein , Sergey Biruchinsky , Andrei Erofeev
发明人： R. Anderson , Gregory Altshuler , Dieter Manstein , Sergey Biruchinsky , Andrei Erofeev
IPC分类号： A61N5/06
CPC分类号： A61N7/02 , A61B18/20 , A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61B2018/00904
摘要： A method and apparatus are provided for performing a therapeutic treatment on a patient's skin by concentrating applied radiation of at least one selected wavelength at a plurality of selected, three-dimensionally located, treatment portions, which treatment portions are within non-treatment portions. The ratio of treatment portions to the total volume may vary from 0.1% to 90%, but is preferably less than 50%. Various techniques, including wavelength, may be utilized to control the depth to which radiation is concentrated and suitable optical systems may be provided to concentrate applied radiation in parallel or in series for selected combinations of one or more treatment portions.

7. 发明授权

US08840608B2 Methods and devices for selective disruption of fatty tissue by controlled cooling 有权
标题翻译：通过受控冷却选择性破坏脂肪组织的方法和装置
公开(公告)号：US08840608B2
公开(公告)日：2014-09-23
申请号：US11016196
申请日：2004-12-17
申请人： Richard R. Anderson , Dieter Manstein
发明人： Richard R. Anderson , Dieter Manstein
IPC分类号： A61B18/02
CPC分类号： A61F7/00 , A61B5/6804 , A61B8/485 , A61B18/02 , A61B2017/00084 , A61B2090/378 , A61F7/10 , A61F2007/0001 , A61F2007/0056 , A61F2007/0094 , A61F2007/029
摘要： The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.
摘要翻译：本发明涉及用于通过受控冷却选择性破坏富含脂质细胞的方法。本发明还涉及一种用于实施通过受控冷却选择性破坏富含脂质细胞的方法的装置。

8. 发明授权

US08274064B2 System and apparatus for dermatological treatment 有权
标题翻译：用于皮肤病治疗的系统和装置
公开(公告)号：US08274064B2
公开(公告)日：2012-09-25
申请号：US12330252
申请日：2008-12-08
申请人： Dieter Manstein
发明人： Dieter Manstein
IPC分类号： A61N5/06
CPC分类号： A61B18/18 , A61B18/203 , A61B2018/00023 , A61B2018/00452 , A61B2018/00458 , A61B2018/0047 , A61B2018/00642 , A61B2018/1807 , A61B2090/065 , A61B2562/0257 , A61N5/0616 , A61N2005/0654 , A61N2005/0656 , A61N2005/0666 , A61N2005/0667
摘要： Exemplary embodiments of system and apparatus can be provided for treating various dermatological and biological conditions using electromagnetic energy in the form of optical radiation. For example, energy can be provided by a chemical reaction, such as by combustion of a fine metallic filament, which can be used to generate a high-intensity pulse of energy without requiring external energy sources. Various parameters of the reactive materials and enclosures can be selected and/or applied to provide a radiation pulse having particular characteristics, including fluence, peak intensity, and radiation wavelength distribution. Various filters may be provided to further modify characteristics of the radiation. Such radiation pulses can be used to irradiate tissue such as skin to obtain various therapeutic or beneficial effects, including improvement in the appearance of pigmented or venous lesions.
摘要翻译：可以提供系统和装置的示例性实施例，以使用光辐射形式的电磁能量来治疗各种皮肤病学和生物学条件。例如，可以通过化学反应（例如通过金属细丝的燃烧）来提供能量，其可用于产生高强度脉冲的能量而不需要外部能量源。可以选择和/或施加反应性材料和外壳的各种参数以提供具有特征，包括通量，峰值强度和辐射波长分布的辐射脉冲。可以提供各种滤光器以进一步修改辐射的特性。这种辐射脉冲可用于照射诸如皮肤的组织以获得各种治疗或有益效果，包括改善着色或静脉损伤的外观。

9. 发明申请

US20110224683A1 METHOD AND APPARATUS FOR SKIN STABILIZATION AND POSITIONING 审中-公开
标题翻译：用于皮肤稳定和定位的方法和装置
公开(公告)号：US20110224683A1
公开(公告)日：2011-09-15
申请号：US12910646
申请日：2010-10-22
申请人： Dieter Manstein
发明人： Dieter Manstein
IPC分类号： A61B19/00
CPC分类号： A61B18/20 , A61B5/150022 , A61B5/150748 , A61B5/15136 , A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/0047 , A61B2018/00577 , A61B2018/2005 , A61H39/02 , A61M37/00 , A61M2037/0007
摘要： Exemplary embodiments of a method, device, and apparatus for positioning an apparatus on a location of a tissue. For example, a substantially rigid film over an area of tissue to be treated can be provided. The film can include a positioning arrangement that facilitates a particular spatial engagement with the apparatus. The exemplary method can further include applying a portion of the film to a portion of a surface of the tissue and positioning the apparatus at the location by the engagement of the film to the apparatus using the feature of the film.
摘要翻译：用于将装置定位在组织的位置上的方法，装置和装置的示例性实施例。例如，可以提供待处理组织区域上的基本上刚性的膜。胶片可以包括便于与装置进行特定的空间接合的定位装置。该示例性方法还可以包括将薄膜的一部分施加到组织表面的一部分，并且通过使用薄膜的特征将薄膜与该装置接合来将该装置定位在该位置。

10. 发明授权

US07351252B2 Method and apparatus for photothermal treatment of tissue at depth 有权
标题翻译：深层组织光热处理方法及装置
公开(公告)号：US07351252B2
公开(公告)日：2008-04-01
申请号：US10465137
申请日：2003-06-19
申请人： Gregory B. Altshuler , Andrei V. Erofeev , Henry H. Zenzie , R. Rox Anderson , Dieter Manstein , James Burke, III , Andrew Radl , Michael Z. Smirnov
发明人： Gregory B. Altshuler , Andrei V. Erofeev , Henry H. Zenzie , R. Rox Anderson , Dieter Manstein , James Burke, III , Andrew Radl , Michael Z. Smirnov
IPC分类号： A61N5/06
CPC分类号： A61B18/203 , A61B18/14 , A61B2018/00005 , A61B2018/00011 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61N1/32 , A61N5/0613 , A61N7/00 , A61N2007/0008
摘要： The present invention provides method and apparatus for treating tissue in a region at depth by applying optical radiation thereto of a wavelength able to reach the depth of the region and of a selected relatively low power for a duration sufficient for the radiation to effect the desired treatment while concurrently cooling tissue above the selected region to protect such tissue. Treatment may be enhanced by applying mechanical, acoustic or electrical stimulation to the region.
摘要翻译：本发明提供了通过向其施加能够达到该区域的深度的波长并且选择相对较低的功率持续足以使辐射实现所需治疗的持续时间的光辐射来治疗深度区域中的组织的方法和装置同时同时冷却选定区域上方的组织以保护这种组织。可以通过对该区域施加机械，声学或电刺激来增强治疗。

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