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1. 发明授权

US11998756B2 Apparatus and methods for determining a property of a tissue 有权
公开(公告)号：US11998756B2
公开(公告)日：2024-06-04
申请号：US15619154
申请日：2017-06-09
申请人： Clinical Laserthermia Systems AB
发明人： Pär H. Henriksson , Karl-Göran Tranberg
IPC分类号： A61N5/06 , A61B17/00 , A61B18/00 , A61B18/20 , A61B18/24
CPC分类号： A61N5/0601 , A61B18/24 , A61B2017/00026 , A61B2017/00084 , A61B2018/00988 , A61B2018/208
摘要： An apparatus for determining a thermal property of tissue includes a base unit with one or more energy source and at least two, preferably detachable, leads. The distal end of each lead, which is introduced into the tissue to be treated, has at least two longitudinally spaced temperature measuring elements to measure surrounding tissue temperature and at least two longitudinally spaced electrode surfaces for applying current to the tissue. Each distal end is also provided with an element which uses energy emitted by the sources of energy to heat up the surrounding tissue. The base unit has computing elements, current generating elements for generating an alternating current, and conductance determining elements for determining the tissue conductance between pairs of electrode surfaces based on the alternating current applied by the current generating elements to the tissue. Methods for using the device and leads for use in the device are also described.

2. 发明申请

US20170021189A1 SYSTEM AND METHOD FOR THERAPY AND DIAGNOSIS COMPRISING OPTICAL COMPONENTS FOR DISTRIBUTION OF RADIATION 有权
标题翻译：用于分布辐射的光学部件的治疗和诊断系统和方法
公开(公告)号：US20170021189A1
公开(公告)日：2017-01-26
申请号：US15283105
申请日：2016-09-30
申请人： SPECTRACURE AB
发明人： Marcelo Soto Thompson , Stefan Andersson Engels , Sune Svanberg
IPC分类号： A61N5/06 , A61B5/00
CPC分类号： A61N5/0601 , A61B5/0071 , A61B5/0084 , A61B2017/00057 , A61B2018/208 , A61N5/062 , A61N2005/0612 , A61N2005/0629 , A61N2005/063 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/0663 , A61N2005/067
摘要： A system and method for interactive therapy and diagnosis of a human or animal comprising at least one first radiation source for emission of a diagnostic radiation, at least one second radiation source for emission of a therapeutic radiation, and at least one radiation conductor adapted to conduct radiation to a tumor site at or in said human or animal. A non-mechanical operation mode selector directs the therapeutic radiation and/or the diagnostic radiation to the tumor site through the radiation conductors. The operation mode selector means is preferably a non-mechanical optical switch and/or an optical combiner. The system may be used for interactive interstitial photodynamic tumor therapy.
摘要翻译：一种用于人或动物的交互式治疗和诊断的系统和方法，包括用于发射诊断辐射的至少一个第一辐射源，用于发射治疗辐射的至少一个第二辐射源，以及适于进行传导的至少一个辐射导体辐射到所述人或动物中或之中的肿瘤部位。非机械操作模式选择器通过辐射导体将治疗辐射和/或诊断辐射引导到肿瘤部位。操作模式选择器装置优选地是非机械光学开关和/或光学组合器。该系统可用于交互式间质性光动力肿瘤治疗。

3. 发明授权

US09486285B2 Treatment of skin by spatial modulation of thermal heating 有权
标题翻译：通过热加热的空间调制处理皮肤
公开(公告)号：US09486285B2
公开(公告)日：2016-11-08
申请号：US13584440
申请日：2012-08-13
申请人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
发明人： Dilip Y. Paithankar , Jayant D. Bhawalkar , James C. Hsia
IPC分类号： A61B18/18 , A61B18/20 , A61B18/00
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00029 , A61B2018/00452 , A61B2018/00458 , A61B2018/208
摘要： Treating skin can include delivering a beam of radiation to a target region of the skin to cause a zone of thermal injury including a lateral pattern of varying depths of thermal injury distributed along the target region. The lateral pattern includes at least one first sub-zone of a first depth of thermal injury laterally adjacent to at least one second sub-zone of a second depth of thermal injury. The first depth is greater than the second depth. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth extend from a surface of the target region of the skin to form a substantially continuous surface thermal injury. The at least one first sub-zone of the first depth and the at least one second sub-zone of the second depth are substantially heated to at least a critical temperature.
摘要翻译：治疗皮肤可以包括将辐射束传送到皮肤的目标区域，以引起热损伤区域，包括沿着目标区域分布的不同深度的热损伤的横向图案。横向图案包括与第二热损伤深度的至少一个第二子区域相邻的第一热损伤深度的至少一个第一子区域。第一个深度大于第二个深度。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域从皮肤的目标区域的表面延伸以形成基本上连续的表面热损伤。第一深度的至少一个第一子区域和第二深度的至少一个第二子区域基本上被加热至至少临界温度。

4. 发明申请

US20160184019A1 Multiwavelength Surgical Laser 有权
标题翻译：多波长手术激光
公开(公告)号：US20160184019A1
公开(公告)日：2016-06-30
申请号：US14945053
申请日：2015-11-18
申请人： InnovaQuartz LLC
发明人： Stephen E. Griffin
IPC分类号： A61B18/22
CPC分类号： A61B18/20 , A61B18/22 , A61B2018/00547 , A61B2018/00577 , A61B2018/00589 , A61B2018/00601 , A61B2018/00625 , A61B2018/1807 , A61B2018/2015 , A61B2018/2065 , A61B2018/207 , A61B2018/208 , A61B2018/2205 , A61B2018/2244
摘要： A multiwavelength laser-based intense light source is described having applications in incision, excision and ablation of soft tissues with minimal collateral tissue damage. The light source combines the output of a plurality of relatively low power laser sources, emitting radiation in the region of the electromagnetic spectrum bounded by approximately 350 nm to 450 nm, where the combined output may be coupled into a single fiber optic energy delivery device: a standard surgical probe. Spectral and spatial beam combining are used to produce an incoherent light source with relatively low average power at any given wavelength, but with high total power and superior M2 beam quality, targeting multiple chromophores in target tissue and tissue breakdown product chromophores for consistently high and target absorption without indiscriminant char interference throughout a surgical procedure.
摘要翻译：描述了基于多波长激光的强光源，其具有在具有最小侧支组织损伤的软组织的切割，切除和消融中的应用。光源组合多个相对较低功率的激光源的输出，在由约350nm至450nm限定的电磁光谱区域中发射辐射，其中组合输出可耦合到单个光纤能量传递装置中：标准手术探针。光谱和空间光束组合用于产生在任何给定波长下具有相对较低平均功率的非相干光源，但是具有高总功率和优异的M2光束质量，靶向目标组织中的多个发色团和组织分解产物发色团一致地高和目标在整个外科手术过程中吸收没有不分歧的焦虑干扰。

5. 发明申请

US20160175049A1 A DEVICE FOR FRACTIONAL LASER-BASED-TREATMENT 审中-公开
标题翻译：一种用于基于激光治疗的器件
公开(公告)号：US20160175049A1
公开(公告)日：2016-06-23
申请号：US14907869
申请日：2014-07-30
申请人： KONINKLIJKE PHILIPS N.V.
发明人： CAECILIA HENDRINA THEODORA CHLON , MARTIN JURNA , ANTONIUS MAARTEN NUIJS , MARIA ANGELINA JOSEPHA GROOTEL-RENSEN , BASTIAAN WILHELMUS MARIA MOESKOPS
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2017/00075 , A61B2018/00452 , A61B2018/0047 , A61B2018/00636 , A61B2018/00642 , A61B2018/00672 , A61B2018/00684 , A61B2018/00702 , A61B2018/20351 , A61B2018/20359 , A61B2018/205547 , A61B2018/208
摘要： The invention provides a treatment device (100) for fractional laser-based skin treatment. The treatment device comprises an emission window (70) comprising an elongated area (75) and a plurality of predefined locations (74) in said elongated area (75), wherein the predefined locations (74) are arranged in an elongated array which extends along a treatment axis (72) of the window (70), and wherein each predefined location (74) in the array is located at a distance from the treatment axis (72), seen in a direction perpendicular to the treatment axis (72), which is smaller than 25% of a maximum distance between two predefined locations (74) in the array, seen in a direction parallel to the treatment axis (72). The treatment device further comprises a treatment generator (80) comprising a treatment laser (20) for emitting laser light (21) towards skin tissue (110) from said plurality of predefined locations (74) in the emission window (70) for generating, in use, laser-based lesions (120) inside the skin tissue (110). The treatment device further comprises a motion sensor (90) for sensing motion of the treatment device relative to the skin surface (105) and a controller (60) for determining a non-zero sequence of at least one of the plurality of predefined locations in the emission window from which laser light is consecutively emitted in dependence on the sensed motion. The controller is configured to activate the treatment generator to generate said non-zero sequence when the sensed motion of the treatment device relative to the skin surface only has a component in a direction parallel to the treatment axis.
摘要翻译：本发明提供了一种用于基于分数激光的皮肤治疗的治疗装置（100）。处理装置包括在所述细长区域（75）中包括细长区域（75）和多个预定位置（74）的发射窗口（70），其中预定位置（74）布置成沿着窗口（70）的处理轴线（72），并且其中阵列中的每个预定位置（74）位于与处理轴线（72）垂直的方向上从处理轴线（72）的一定距离处，其小于在平行于处理轴线（72）的方向上在阵列中的两个预定位置（74）之间的最大距离的25％。治疗装置还包括治疗发生器（80），其包括用于从发射窗（70）中的所述多个预定位置（74）向皮肤组织（110）发射激光（21）的治疗激光器（20）在使用中，在皮肤组织（110）内的基于激光的损伤（120）。治疗装置还包括用于感测治疗装置相对于皮肤表面（105）的运动的运动传感器（90）和用于确定多个预定位置中的至少一个的非零序列的控制器（60）根据感测到的运动，激光依次发射的发射窗口。控制器被配置为当感测到的治疗装置相对于皮肤表面的运动仅在平行于治疗轴线的方向上具有分量时，激活治疗发生器以产生所述非零序列。

6. 发明申请

US20160157935A1 DEVICE AND METHOD FOR NON-INVASIVE TREATMENT OF SKIN USING LASER LIGHT 审中-公开
标题翻译：使用激光照射非皮肤治疗皮肤的装置和方法
公开(公告)号：US20160157935A1
公开(公告)日：2016-06-09
申请号：US14903634
申请日：2014-07-04
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MARTIN JURNA , JONATHAN ALAMBRA PALERO , BABU VARGHESE , MARGARET RUTH HORTON
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/0047 , A61B2018/205545 , A61B2018/208
摘要： An increasing number of non-invasive skin treatment devices are being provided for use by consumers instead of by medical professionals. Such home use raises new concerns, such as safety and treatment efficacy. The invention improves on existing devices and treatment methods. The invention provides a device and method, wherein a light source is configured and arranged to provide a first (31) and a second (32) region of non-zero intensity within a transverse cross-section of a laser light beam (21) having a single higher-order laser beam mode, and a third region (33), disposed between the first (31) and second (32) regions, of lower light intensity than the non-zero light intensity. The first (31) and second (32) regions are configured to create, during use, a lesion in skin tissue in the focal spot of the laser light beam, and the third (33) region is configured to avoid creating in the focal spot, during use, a lesion in skin tissue between the lesions created by the first and second regions. For example, the light source may be configured and arranged to produce laser light in a higher mode, the order being higher than fundamental mode. The intensity pattern of the beam profile, with its regions of substantially differing intensity, is substantially constant along the propagation axis. This provides an area in the skin tissue in the focal spot at the treatment location with substantially no lesions, disposed between areas of lesions.
摘要翻译：越来越多的非侵入性皮肤治疗装置被提供给消费者而不是医疗专业人员使用。这种家庭使用引起了新的担忧，例如安全和治疗功效。本发明改进了现有装置和处理方法。本发明提供了一种装置和方法，其中光源被配置和布置成在激光束（21）的横截面内提供非零强度的第一（31）和第二（32）区域，其具有单个高阶激光束模式，以及设置在第一（31）和第二（32）区域之间的光强度比非零光强度低的第三区域（33）。第一（31）和第二（32）区域被配置为在使用期间在激光束的焦斑中产生皮肤组织中的损伤，并且第三（33）区域被配置为避免在焦点中产生在使用期间，在由第一和第二区域产生的损伤之间的皮肤组织中的损伤。例如，光源可以被配置和布置成产生更高模式的激光，其顺序高于基本模式。沿其传播轴线，其具有基本上不同强度的区域的光束轮廓的强度图案基本上是恒定的。这提供了处于治疗位置的焦点中的皮肤组织中的区域，其基本上没有病变，设置在病变区域之间。

7. 发明授权

US09050116B2 Dermal retraction with intersecting electromagnetic radiation pathways 有权
标题翻译：具有相交电磁辐射通路的皮肤收缩
公开(公告)号：US09050116B2
公开(公告)日：2015-06-09
申请号：US10966794
申请日：2004-10-14
申请人： Gregg S. Homer
发明人： Gregg S. Homer
IPC分类号： A61B19/00 , A61B18/20 , A61N5/067 , A61B18/00
CPC分类号： A61N5/0616 , A61B18/203 , A61B2018/00452 , A61B2018/0047 , A61B2018/208 , A61N1/403 , A61N7/00 , A61N2005/0626 , A61N2005/0665 , A61N2005/067 , A61N2007/0034
摘要： A method and device for stimulating human dermal tissue retraction and collagen and elastin production is provided. One or more lasers or other electromagnetic radiation devices produce at least two output beams (split or independent beams) that can be directed to deliver electromagnetic energy to a desired subsurface depth of dermal tissue, thereby disrupting the same, without causing excessive damage to the adjacent epidermis, subcutaneous fatty tissue, or blood vessels of the skin.
摘要翻译：提供了一种用于刺激人体皮肤组织缩回和胶原蛋白和弹性蛋白生产的方法和装置。一个或多个激光器或其他电磁辐射装置产生至少两个输出光束（分裂或独立的光束），其可以被引导以将电磁能量传递到真皮组织的期望的地下深度，从而破坏它们，而不会对相邻的表皮，皮下脂肪组织或皮肤的血管。

8. 发明申请

US20140081251A1 METHOD AND APARATUS FOR SKIN REDUCTION 审中-公开
标题翻译：用于减少皮肤的方法和用途
公开(公告)号：US20140081251A1
公开(公告)日：2014-03-20
申请号：US14026879
申请日：2013-09-13
申请人： Joseph Giovannoli
发明人： Joseph Giovannoli
IPC分类号： A61B18/20 , A61B17/322
CPC分类号： A61B18/203 , A61B17/322 , A61B2018/00452 , A61B2018/0047 , A61B2018/00601 , A61B2018/00625 , A61B2018/00738 , A61B2018/208
摘要： A method for reducing human or animal tissue includes making a plurality of excisions to collectively form a patch of tissue to be reduced, instead of making a single large excision in the patch. Thus, scarring after healing is less noticeable. The treated regions of tissue may be arranged such that a total area of all removed tissue segments taken in a direction perpendicular to an axis of the patch changes gradually along said axis. The removed regions of tissue may be navicular in shape, and the patches may be navicular in shape in the event an elongated excision is made. The removal of tissue regions can be realized by proper treatment methods such as incisions and laser treatment.
摘要翻译：减少人或动物组织的方法包括制作多个切口以共同形成要减少的组织块，而不是在贴片中进行单次大的切除。因此，愈合后的瘢痕形成不太明显。组织的处理区域可以被布置成使得沿垂直于贴片的轴线的方向截取的所有去除的组织区段的总面积沿所述轴线逐渐变化。去除的组织区域可以是舟形的，并且在进行细长切除的情况下，斑块可以是舟形的。组织区域的去除可以通过适当的治疗方法如切口和激光治疗来实现。

9. 发明申请

US20130079852A1 Apparatus And Methods For Determining A Property Of A Tissue 审中-公开
标题翻译：用于确定组织性质的装置和方法
公开(公告)号：US20130079852A1
公开(公告)日：2013-03-28
申请号：US13593427
申请日：2012-08-23
申请人： Pär H. Henriksson , Karl-Göran Tranberg
发明人： Pär H. Henriksson , Karl-Göran Tranberg
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B18/24 , A61B2017/00026 , A61B2017/00084 , A61B2018/00988 , A61B2018/208
摘要： An apparatus for determining a thermal property of tissue includes a base unit with one or more energy source and at least two, preferably detachable, leads. The distal end of each lead, which is introduced into the tissue to be treated, has at least two longitudinally spaced temperature measuring elements to measure surrounding tissue temperature and at least two longitudinally spaced electrode surfaces for applying current to the tissue. Each distal end is also provided with an element which uses energy emitted by the sources of energy to heat up the surrounding tissue. The base unit has computing elements, current generating elements for generating an alternating current, and conductance determining elements for determining the tissue conductance between pairs of electrode surfaces based on the alternating current applied by the current generating elements to the tissue. Methods for using the device and leads for use in the device are also described.
摘要翻译：用于确定组织的热性质的装置包括具有一个或多个能源和至少两个，优选可分离的引线的基座单元。引入待处理组织的每个引线的远端具有至少两个纵向间隔的温度测量元件，以测量周围的组织温度和至少两个纵向间隔开的电极表面，用于向组织施加电流。每个远端还设置有使用由能量源发射的能量来加热周围组织的元件。基本单元具有计算元件，用于产生交流电流的电流产生元件和用于基于由电流产生元件施加到组织的交流电流来确定电极对表面之间的组织电导的电导确定元件。还描述了使用装置和引线在装置中使用的方法。

10. 发明申请

US20130053838A1 INTERVENTIONAL RADIOLOGIC DEVICES AND METHODS FOR EMBEDDED FILTER REMOVAL 审中-公开
标题翻译：传统放射学设备和嵌入式过滤器去除方法
公开(公告)号：US20130053838A1
公开(公告)日：2013-02-28
申请号：US13591056
申请日：2012-08-21
申请人： William T. Kuo
发明人： William T. Kuo
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B2018/00172 , A61B2018/208 , A61B2090/064
摘要： An interventional radiologic device for removal of an embedded filter is provided. The device distinguishes a laser sheath with optical fibers for applying ablation energy to tissue. A removable introducer is movable within the lumen of the laser sheath and has at least two open channels to run wires. One or more sheath detachable modular adapters are used for providing ablation energy, force sensing and/or preventing bleeding. The distal open end of the laser sheath is preferably beveled with an angle up to 45 degrees. In one aspect, the introducer has a bulb-like tip, which fits against the distal end the laser sheath, yet can still be removed from the laser sheath via its proximal end. This device can be inserted over two wires simultaneously thereby allowing insertion over a wire loop configuration used to engage the apex of embedded IVC filters.
摘要翻译：提供了用于去除嵌入式滤波器的介入放射学装置。该装置将激光护套与光纤区分开来，以将消融能量施加到组织。可移除导引器可在激光护套的管腔内移动，并且具有至少两个开放的通道以运行电线。一个或多个护套可拆卸模块化适配器用于提供消融能量，力感测和/或防止出血。激光护套的远端开口端优选以45度的角度倾斜。在一个方面，导引器具有灯泡状尖端，其与激光护套的远端配合，但仍然可以通过其近端从激光护套移除。该装置可以同时插入两根线上，从而允许插入用于接合嵌入式IVC过滤器的顶点的线环配置。

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