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1. 发明申请

US20200060814A1 ENGINEERED TISSUE PROSTHESIS 审中-公开
公开(公告)号：US20200060814A1
公开(公告)日：2020-02-27
申请号：US16466023
申请日：2017-12-04
申请人： Richard F. MURPHY , Kemal SCHANKERELI , Michael L. DAVIS , Vascudyne, LLC.
发明人： Richard F. Murphy , Kemal Schankereli , Michael L. Davis
IPC分类号： A61F2/24 , A61L27/36
摘要： The present invention is medical device and method for treating venous valve failure or insufficiency. The device is a prosthesis that includes an engineered tissue valve supported by a frame or stent.

2. 发明授权

US09211361B2 Thin collagen tissue for medical device applications 有权
标题翻译：用于医疗器械应用的薄胶原组织
公开(公告)号：US09211361B2
公开(公告)日：2015-12-15
申请号：US12724311
申请日：2010-03-15
申请人： Kemal Schankereli
发明人： Kemal Schankereli
IPC分类号： A61F2/24 , A61L27/36 , A61K35/34
CPC分类号： A61L27/3604 , A61K35/34 , Y10S623/922
摘要： This invention relates to processes of preparing heterogeneous graft material from animal tissue. Specifically, the invention relates to the preparation of animal tissue, in which the tissue is cleaned and chemically cross-linked using both vaporized and liquid cross-linking agents, resulting in improved physical properties such as thin tissue and lowered antigenicity, thereby increasing the ease of delivering the tissue during surgery and decreasing the risk of post-surgical complication, respectively.
摘要翻译：本发明涉及从动物组织制备异种移植材料的方法。具体地，本发明涉及动物组织的制备，其中使用蒸发和液体交联剂将组织清洁和化学交联，导致改善的物理性质如薄组织和降低的抗原性，从而增加容易度分别在手术期间输送组织并降低手术后并发症的风险。

3. 发明申请

US20140214159A1 PROSTHETIC VALVES AND RELATED INVENTIONS 有权
标题翻译：前驱阀和相关发明
公开(公告)号：US20140214159A1
公开(公告)日：2014-07-31
申请号：US14237023
申请日：2012-08-13
申请人： Robert Vidlund , Kemal Schankereli , Lucian Lozonschi , Georg Lutter
发明人： Robert Vidlund , Kemal Schankereli , Lucian Lozonschi , Georg Lutter
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B2017/0404 , A61F2/2409 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/2457 , A61F2210/0004 , A61F2210/0014 , A61F2220/0008 , A61F2220/005 , A61F2220/0058 , A61F2220/0091 , A61F2230/0013 , A61F2230/0034 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0091 , A61F2310/00023 , A61F2310/00077 , A61L27/34 , A61L27/3625 , A61L27/3629 , A61L33/0011 , A61L2400/16 , A61L2430/20 , C08L67/04
摘要： This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
摘要翻译：本发明涉及一种可压缩瓣膜置换假体的设计和功能，可以使用经导管输送系统部署到搏动的心脏而不需要体外循环。所讨论的设计重点是通过微创方式部署装置，并且作为一个例子考虑了一种微创外科手术，优选利用用于瓣膜引入的肋间或副脊柱空间。为了实现这一点，阀以这样的方式形成，使得其可以被压缩以配合在输送系统内，并且二次从输送系统喷射到诸如二尖瓣或三尖瓣的目标瓣膜的环中。

4. 发明申请

US20110125105A1 CONDUIT PROTECTOR 审中-公开
标题翻译：电源保护器
公开(公告)号：US20110125105A1
公开(公告)日：2011-05-26
申请号：US12674827
申请日：2008-08-22
申请人： James L. Pokorney , Kemal Schankereli
发明人： James L. Pokorney , Kemal Schankereli
IPC分类号： A61M39/00 , B32B1/08
CPC分类号： A61B17/3421 , A61B17/3431 , A61B17/3468 , A61F2/2493 , Y10T428/13
摘要： A conduit protector for temporarily minimizing the surface friction on an outside surface of an implant includes a curvilinear sheet formed into a generally cylindrical shape having a first axial edge and a second axial edge, a connecting member coupling the first axial edge of the curvilinear sheet to the second axial edge of the curvilinear sheet, and a release member structured for separating the first axial edge of the curvilinear sheet from the second axial edge of the curvilinear sheet. An inside surface of the curvilinear sheet may have an inner diameter approximately equal to an outer diameter of the outside surface of the implant.
摘要翻译：用于临时最小化植入物外表面上的表面摩擦的导管保护器包括形成为具有第一轴向边缘和第二轴向边缘的大致圆柱形形状的曲线片，将曲线片的第一轴向边缘连接到曲线片的第二轴向边缘以及用于将曲线片的第一轴向边缘与曲线片的第二轴向边缘分离的释放构件。曲线片的内表面可以具有大致等于植入物的外表面的外径的内径。

5. 发明申请

US20100210899A1 Method for percutaneous lateral access to the left ventricle for treatment of mitral insufficiency by papillary muscle alignment 审中-公开
标题翻译：经皮外侧进入左心室治疗二尖瓣功能不全的方法
公开(公告)号：US20100210899A1
公开(公告)日：2010-08-19
申请号：US12749487
申请日：2010-03-29
申请人： Kemal Schankereli
发明人： Kemal Schankereli
IPC分类号： A61F2/00
CPC分类号： A61F2/2457 , A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B2017/048 , A61F2/2487
摘要： This invention relates to devices and methods for the therapeutic changing of the geometry of the left ventricle of the human heart. Specifically, the invention relates to the left-ventricular lateral wall introduction of an anchoring device to align the papillary muscles.
摘要翻译：本发明涉及用于治疗改变人心脏左心室几何形状的装置和方法。具体而言，本发明涉及左心室侧壁引入锚定装置以对准乳头肌。

6. 发明申请

US20060089701A1 In situ molded stent and method and system for delivery 审中-公开
标题翻译：原位模制支架及方法及系统用于运输
公开(公告)号：US20060089701A1
公开(公告)日：2006-04-27
申请号：US10973747
申请日：2004-10-26
申请人： Stephen Forsyth , Max Wood , Kemal Schankereli , Kenneth Thurston
发明人： Stephen Forsyth , Max Wood , Kemal Schankereli , Kenneth Thurston
IPC分类号： A61F2/06
CPC分类号： A61F2/82
摘要： A method for forming a stent in situ involves manipulating a delivery system to provide a mold within a lumen of a living body, and injecting a settable, biocompatible phase invertible composition into the mold. After the biocompatible phase invertible composition is set, the delivery system is removed. The stent provides a micro-porous support structure with good tensile strength that is adhesively bound to the lumen. The biocompatible phase invertible composition may be a composition concocted from albumin and collagen, for example, and may be infused with an anti-restenosis agent.
摘要翻译：用于原位形成支架的方法包括操纵输送系统以在活体的内腔内提供模具，以及将可固化的生物相容性相可逆组合物注射到模具中。在设置生物相容性可逆组合物之后，移除递送系统。支架提供具有良好拉伸强度的微孔支撑结构，该结构粘合地结合到内腔。生物相容性相可逆组合物可以是例如从白蛋白和胶原调制的组合物，并且可以注射抗再狭窄剂。

7. 发明申请

US20120179244A1 Device and System for Transcatheter Mitral Valve Replacement 审中-公开
标题翻译：用于经导管二尖瓣置换的装置和系统
公开(公告)号：US20120179244A1
公开(公告)日：2012-07-12
申请号：US13425712
申请日：2012-03-21
申请人： Kemal Schankereli , E. Christopher Orton
发明人： Kemal Schankereli , E. Christopher Orton
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2457 , A61F2/848 , A61F2002/9522 , A61F2210/0014 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0069 , A61F2310/00023
摘要： This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
摘要翻译：本发明涉及一种可压缩瓣膜置换假体的设计和功能，其可以使用经导管输送系统部署到无心脏循环的搏动心脏中。所讨论的设计重点是通过微创方式部署装置，并且作为一个例子考虑了一种微创外科手术，优选利用用于瓣膜引入的肋间或副脊柱空间。为了实现这一点，阀以这样的方式形成，使得其可以被压缩以配合在输送系统内，并且二次从输送系统喷射到诸如二尖瓣或三尖瓣的目标瓣膜的环中。

8. 发明申请

US20110319988A1 Device and System for Transcatheter Mitral Valve Replacement 审中-公开
标题翻译：用于经导管二尖瓣置换的装置和系统
公开(公告)号：US20110319988A1
公开(公告)日：2011-12-29
申请号：US12963596
申请日：2010-12-08
申请人： Kemal Schankereli , E. Christopher Orton
发明人： Kemal Schankereli , E. Christopher Orton
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2457 , A61F2/848 , A61F2002/9522 , A61F2210/0014 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0069 , A61F2310/00023
摘要： This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
摘要翻译：本发明涉及一种可压缩瓣膜置换假体的设计和功能，其可以使用经导管输送系统部署到无心脏循环的搏动心脏中。所讨论的设计重点是通过微创方式部署装置，并且作为一个例子考虑了一种微创外科手术，优选利用用于瓣膜引入的肋间或副脊柱空间。为了实现这一点，阀以这样的方式形成，使得其可以被压缩以配合在输送系统内，并且二次从输送系统喷射到诸如二尖瓣或三尖瓣的目标瓣膜的环中。

9. 再颁专利

USRE40863E1 Apparatus and method for sealing vascular punctures 失效
标题翻译：用于密封血管穿刺的装置和方法
公开(公告)号：USRE40863E1
公开(公告)日：2009-07-21
申请号：US10150878
申请日：1993-10-22
申请人： Sew Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
发明人： Sew Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
IPC分类号： A61B18/18 , A61B17/00 , A61B17/34 , A61B18/04 , A61B18/14 , A61B18/08 , A61B19/00
CPC分类号： A61B17/0057 , A61B17/3403 , A61B18/082 , A61B18/14 , A61B18/1402 , A61B2017/00504 , A61B2017/00637 , A61B2017/0065 , A61B2090/062 , A61B2090/3937 , A61M2025/0183
摘要： An apparatus for closing and sealing a vascular puncture is connected to an energy supply such that heat is generated in, or thermally conducted to, the tissue, thereby thermally fusing the vascular tissue together. The method for closing and sealing a vascular puncture comprises applying radio frequency or other energy to the tissue, the energy being sufficient to thermally fuse the tissue together, thus sealing the puncture. Embodiments of depth finding and guiding devices, as well as blood vessel occluders, are also disclosed.
摘要翻译：用于关闭和密封血管穿刺的装置连接到能量供应器，使得在组织中产生热量或热传导到组织中，从而将血管组织热熔合在一起。关闭和密封血管穿刺的方法包括向组织施加射频或其他能量，该能量足以将组织热熔融在一起，从而密封穿刺。还公开了深度发现和引导装置以及血管封堵器的实施例。

10. 发明申请

US20070055357A1 Prosthetic heart valve housing 失效
标题翻译：假体心脏瓣膜外壳
公开(公告)号：US20070055357A1
公开(公告)日：2007-03-08
申请号：US11514792
申请日：2006-09-01
申请人： James Pokorney , Kemal Schankereli
发明人： James Pokorney , Kemal Schankereli
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/06 , A61F2/064
摘要： This invention relates to an implant and an implant technique for the interposition of an extracardiac conduit between a ventricle of a beating heart and a nearby blood vessel to form an alternative one-way blood pathway thereby bypassing a native diseased heart valve. More specifically, the present invention provides a prosthetic heart valve housing adopted to allow blood flow. The prosthetic heart valve housing comprises an inlet conduit element, an inlet valve housing element, an outlet valve housing element, and an outlet conduit element. To allow only one-way blood flow through the prosthetic heart valve housing, the inlet and outlet valve housing elements of the prosthetic heart valve housing are adopting to hold a surgeon selected prosthetic heart valve. One element common to many of these valve designs is an annular cuff or sealing gasket located around the periphery of the working valve. When a prosthetic valve having such a cuff element is installed by the surgeon into the prosthetic heart valve housing, the cuff element provides a seal between the valve housing elements to prevent leaks around the prosthetic valve, thereby maintaining the one-way function of the valve within the prosthetic heart valve housing. To maximize flow through the prosthetic heart valve housing, the major internal diameters of the valve housing elements are larger than the minor internal diameters of both the outlet conduit element and the inlet conduit element. To minimize adverse tissue healing response or adverse blood interaction, the blood contacting surfaces are all composed of a common material.
摘要翻译：本发明涉及用于在跳动心脏的心室和附近血管之间插入心外导管的植入物和植入技术，以形成替代的单向血液通路，从而绕过天然患病的心脏瓣膜。更具体地，本发明提供了一种用于允许血液流动的假体心脏瓣膜壳体。假体心脏瓣膜壳体包括入口导管元件，入口阀壳体元件，出口阀壳体元件和出口导管元件。为了仅允许单向血液流过假体心脏瓣膜壳体，假体心脏瓣膜壳体的入口和出口阀壳体元件采用保持外科医生选择的假体心脏瓣膜。许多这些阀设计通用的一个元件是位于工作阀周边周围的环形箍或密封垫圈。当具有这种袖带元件的假体瓣膜由外科医生安装到假体心脏瓣膜壳体中时，袖带元件在阀壳体元件之间提供密封，以防止假肢瓣周围的泄漏，从而保持阀的单向功能在假体心脏瓣膜内。为了最大化通过假体心脏瓣膜的流动，阀壳体元件的主要内径大于出口导管元件和入口导管元件的次内径。为了最小化不良组织愈合反应或不利的血液相互作用，血液接触表面都由普通材料组成。

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