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1. 发明授权

US06063085A Apparatus and method for sealing vascular punctures 失效
标题翻译：用于密封血管穿刺的装置和方法
公开(公告)号：US06063085A
公开(公告)日：2000-05-16
申请号：US537902
申请日：1995-10-23
申请人： Sew Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
发明人： Sew Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
IPC分类号： A61B17/00 , A61B17/34 , A61B18/08 , A61B18/14 , A61B19/00 , A61B18/18
CPC分类号： A61B17/0057 , A61B17/3403 , A61B18/082 , A61B18/14 , A61B18/1402 , A61B2017/00504 , A61B2017/00637 , A61B2017/0065 , A61B2090/062 , A61B2090/3937 , A61M2025/0183
摘要： An apparatus for closing and sealing a vascular puncture is connected to an energy supply such that heat is generated in, or thermally conducted to, the tissue, thereby thermally fusing the vascular tissue together. The method for closing and sealing a vascular puncture comprises applying radio frequency or other energy to the tissue, the energy being sufficient to thermally fuse the tissue together, thus sealing the puncture. Embodiments of depth finding and guiding devices, as well as blood vessel occluders, are also disclosed.
摘要翻译： PCT No.PCT / US93 / 10202 Sec。 371日期1995年10月23日第 102（e）日期1995年10月23日PCT 1993年10月22日PCT公布。 WO94 / 24948 PCT公开号日期1994年11月10日用于关闭和密封血管穿刺的装置连接到能量供应，使得在组织中产生热量或热传导到组织中，从而将血管组织热熔在一起。关闭和密封血管穿刺的方法包括向组织施加射频或其他能量，该能量足以将组织热熔融在一起，从而密封穿刺。还公开了深度发现和引导装置以及血管封堵器的实施例。

2. 再颁专利

USRE40863E1 Apparatus and method for sealing vascular punctures 失效
标题翻译：用于密封血管穿刺的装置和方法
公开(公告)号：USRE40863E1
公开(公告)日：2009-07-21
申请号：US10150878
申请日：1993-10-22
申请人： Sew Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
发明人： Sew Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
IPC分类号： A61B18/18 , A61B17/00 , A61B17/34 , A61B18/04 , A61B18/14 , A61B18/08 , A61B19/00
CPC分类号： A61B17/0057 , A61B17/3403 , A61B18/082 , A61B18/14 , A61B18/1402 , A61B2017/00504 , A61B2017/00637 , A61B2017/0065 , A61B2090/062 , A61B2090/3937 , A61M2025/0183
摘要： An apparatus for closing and sealing a vascular puncture is connected to an energy supply such that heat is generated in, or thermally conducted to, the tissue, thereby thermally fusing the vascular tissue together. The method for closing and sealing a vascular puncture comprises applying radio frequency or other energy to the tissue, the energy being sufficient to thermally fuse the tissue together, thus sealing the puncture. Embodiments of depth finding and guiding devices, as well as blood vessel occluders, are also disclosed.
摘要翻译：用于关闭和密封血管穿刺的装置连接到能量供应器，使得在组织中产生热量或热传导到组织中，从而将血管组织热熔合在一起。关闭和密封血管穿刺的方法包括向组织施加射频或其他能量，该能量足以将组织热熔融在一起，从而密封穿刺。还公开了深度发现和引导装置以及血管封堵器的实施例。

3. 发明授权

US5810810A Apparatus and method for sealing vascular punctures 失效
公开(公告)号：US5810810A
公开(公告)日：1998-09-22
申请号：US472717
申请日：1995-06-06
申请人： Sew-Wah Tay , Kemal Schankereli , Hans Mische , Thomas Holman
发明人： Sew-Wah Tay , Kemal Schankereli , Hans Mische , Thomas Holman
IPC分类号： A61B17/00 , A61B17/34 , A61B18/08 , A61B18/14 , A61B19/00 , A61B17/36
CPC分类号： A61B17/0057 , A61B17/3403 , A61B18/082 , A61B18/14 , A61B18/1402 , A61B2017/00504 , A61B2017/00637 , A61B2017/0065 , A61B2090/062 , A61B2090/3937 , A61M2025/0183
摘要： An apparatus for closing and sealing a vascular puncture is connected to an energy supply such that heat is generated in, or thermally conducted to, the tissue, thereby thermally fusing the vascular tissue together. The method for closing and sealing a vascular puncture comprises applying radio frequency or other energy to the tissue, the energy being sufficient to thermally fuse the tissue together, thus sealing the puncture. Embodiments of depth finding and guiding devices, as well as blood vessel occluders, are also disclosed.

4. 发明授权

US5507744A Apparatus and method for sealing vascular punctures 失效
公开(公告)号：US5507744A
公开(公告)日：1996-04-16
申请号：US55634
申请日：1993-04-30
申请人： Sew-Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
发明人： Sew-Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
IPC分类号： A61B18/12 , A61B17/00 , A61B17/34 , A61B18/08 , A61B18/14 , A61B19/00 , A61B17/36
CPC分类号： A61B17/0057 , A61B17/3403 , A61B18/082 , A61B18/14 , A61B18/1402 , A61B2090/062 , A61B2090/3937 , A61M2025/0183
摘要： An apparatus for closing and sealing a vascular puncture is connected to an energy supply such that heat is generated in, or thermally conducted to, the tissue, thereby thermally fusing the vascular tissue together. The method for closing and sealing a vascular puncture comprises applying radio frequency or other energy to the tissue, the energy being sufficient to thermally fuse the tissue together, thus sealing the puncture. Embodiments of depth finding and guiding devices, as well as blood vessel occluders, are also disclosed.

5. 发明申请

US20080050462A1 Process and Apparatus for Forming Medical Device Balloons 有权
标题翻译：用于形成医疗器械气球的过程和装置
公开(公告)号：US20080050462A1
公开(公告)日：2008-02-28
申请号：US11849913
申请日：2007-09-04
申请人： Thomas Holman , Nam Hoang , Jeffrey Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Zhang , Afsar Ali
发明人： Thomas Holman , Nam Hoang , Jeffrey Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Zhang , Afsar Ali
IPC分类号： B29C45/78
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

6. 发明授权

US07216154B1 Apparatus and method for facilitating access to network resources 有权
标题翻译：便于访问网络资源的装置和方法
公开(公告)号：US07216154B1
公开(公告)日：2007-05-08
申请号：US09724336
申请日：2000-11-28
申请人： Kingsum Chow , Colin Cunningham , Thomas Holman
发明人： Kingsum Chow , Colin Cunningham , Thomas Holman
IPC分类号： G06F15/16
CPC分类号： H04L67/1002 , H04L67/02 , H04L67/1008
摘要： For a client seeking network resources from a network site, such as a web page, audio, visual, or other data, where the network site's desired network resources are also provided by mirroring network hosts, measurements are made to determine a communication efficiency between the client and the network site and mirroring network hosts. The client is then directed to communicate with the network site or a mirroring network host according to which had the highest measured communication efficiency with the client. In such fashion, real time adjustments can be made so as to more optimally distribute client network resource requests across all available sources of the desired network resources, and provide for real time load balancing and fail over of disabled hosts.
摘要翻译：对于从网站（例如网页，音频，视觉或其他数据）寻求网络资源的客户端，其中也通过镜像网络主机提供网络站点所需的网络资源，进行测量以确定网络资源之间的通信效率客户端和网络站点以及镜像网络主机。然后，客户端被指示与网络站点或镜像网络主机通信，根据该主机与客户端具有最高的测量通信效率。以这种方式，可以进行实时调整，以便更好地将客户端网络资源请求分配到所需可用网络资源的所有可用源上，并提供实时的负载平衡和故障切换的禁用主机。

7. 发明申请

US20060129179A1 Medical devices formed with a sacrificial structure and processes of forming the same 有权
标题翻译：用牺牲结构形成的医疗器械及其形成方法
公开(公告)号：US20060129179A1
公开(公告)日：2006-06-15
申请号：US11010810
申请日：2004-12-13
申请人： Jan Weber , Scott Schewe , Thomas Holman
发明人： Jan Weber , Scott Schewe , Thomas Holman
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61M25/0009 , A61M25/0045 , A61M25/1036 , A61M25/104 , A61M2025/1075 , A61M2025/1086
摘要： Medical devices formed using a sacrificial structure, and processes of forming the devices therefrom.
摘要翻译：使用牺牲结构形成的医疗器械，以及由其形成器件的工艺。

8. 发明申请

US20060079836A1 Reinforced and drug-eluting balloon catheters and methods for making same 有权
公开(公告)号：US20060079836A1
公开(公告)日：2006-04-13
申请号：US10963272
申请日：2004-10-12
申请人： Thomas Holman , Jan Weber , Scott Schewe
发明人： Thomas Holman , Jan Weber , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61M25/10 , A61M25/1002 , A61M25/1034 , A61M25/1038 , A61M2025/0058 , A61M2025/1031 , A61M2025/105 , A61M2025/1084
摘要： The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.

9. 发明申请

US20050182478A1 Laser shock peening of medical devices 失效
标题翻译：医疗器械的激光冲击硬化
公开(公告)号：US20050182478A1
公开(公告)日：2005-08-18
申请号：US10778841
申请日：2004-02-13
申请人： Thomas Holman , Jan Weber
发明人： Thomas Holman , Jan Weber
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90 , C21D10/00
CPC分类号： C21D10/005 , A61F2/91 , A61F2250/0068
摘要： A laser shock peening process for producing one or more compressive residual stress regions in a medical device is disclosed. A high-energy laser apparatus can be utilized to direct an intense laser beam through a confining medium and onto the target surface of a workpiece. An absorption overlay disposed on the target surface of the workpiece absorbs the laser beam, inducing a pressure shock wave that forms a compressive residual stress region deep within the workpiece. Medical devices such as stents and guidewires having one or more of these compressive residual stress regions are also disclosed.
摘要翻译：公开了一种用于在医疗装置中产生一个或多个压缩残余应力区域的激光冲击硬化方法。可以使用高能激光装置将强激光束引导通过约束介质和工件的目标表面。设置在工件的目标表面上的吸收层吸收激光束，引起在工件内部形成压缩残余应力区域的压力冲击波。还公开了具有这些压缩残余应力区域中的一个或多个的支架和导线的医疗装置。

10. 发明申请

US20050131445A1 Balloon catheter tip design 有权
标题翻译：气球导管尖端设计
公开(公告)号：US20050131445A1
公开(公告)日：2005-06-16
申请号：US10732983
申请日：2003-12-10
申请人： Thomas Holman , Daniel Tomaschko , Leo Klisch , Richard Olson , Joseph Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas Holman , Daniel Tomaschko , Leo Klisch , Richard Olson , Joseph Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

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