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1. 发明授权

US08495084B2 Molecular level similarity search and computer aided drug discovery process 有权
标题翻译：分子水平相似性检索和计算机辅助药物发现过程
公开(公告)号：US08495084B2
公开(公告)日：2013-07-23
申请号：US12560748
申请日：2009-09-16
申请人： Richard D. Dettinger , Barry Robson
发明人： Richard D. Dettinger , Barry Robson
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30017 , G06F19/705
摘要： Systems, methods and articles of manufacture are disclosed for searching chemical compounds referenced in chemical literature. References to chemical compounds in the documents may be transformed to corresponding references using a standard notation for representing chemical compounds. Criteria specifying desired molecular characteristics may be received. A regular expression may be generated based on the received criteria. The chemical documents may be searched using the regular expression. Based on the search, a chemical document may be determined that references a chemical compound satisfying the received criteria. Further, the regular expression may be generated based on the received criteria and a received mutation rule. Based on the generated regular expression and the chemical documents, one or more chemical compounds may be discovered that satisfy both the received criteria and the received mutation rule, but that is are not referenced in the chemical documents.
摘要翻译：公开了用于搜索化学文献中引用的化合物的系统，方法和制品。文献中化学化合物的引用可以使用表示化合物的标准符号转化为相应的参考文献。可以接收指定所需分子特征的标准。可以基于接收的标准生成正则表达式。可以使用正则表达式搜索化学文档。基于搜索，可以确定参考符合接收标准的化合物的化学文献。此外，可以基于接收到的标准和接收到的突变规则来生成正则表达式。基于生成的正则表达式和化学文献，可以发现满足接收标准和接收到的突变规则的一种或多种化学化合物，但化学文献中没有参考。

2. 发明授权

US07158892B2 Genomic messaging system 失效
标题翻译：基因组消息系统
公开(公告)号：US07158892B2
公开(公告)日：2007-01-02
申请号：US10185657
申请日：2002-06-28
申请人： Barry Robson , Richard Alan Mushlin
发明人： Barry Robson , Richard Alan Mushlin
IPC分类号： G06F19/00 , G05B15/00 , G11C17/00
CPC分类号： G06F19/22
摘要： A computer-based method is provided for transferring data that includes a genomic sequence. The method includes identifying at least one genomic base in an input data stream comprising said genomic sequence; assigning a base-specific binary code to the at least one genomic base; grouping the base-specific binary code to form a genomic data stream representative of the genomic sequence; assigning a command binary code to at least one command for selectively processing said genomic data stream; and integrating said genomic data stream and said command binary code to form an output binary data stream.
摘要翻译：提供了一种基于计算机的方法来传送包括基因组序列的数据。该方法包括在包含所述基因组序列的输入数据流中鉴定至少一个基因组碱基; 将基因特异性二进制代码分配给所述至少一个基因组基因; 分组基本特定二进制代码以形成代表基因组序列的基因组数据流; 将命令二进制代码分配给用于选择性处理所述基因组数据流的至少一个命令; 并整合所述基因组数据流和所述命令二进制代码以形成输出二进制数据流。

3. 发明授权

US5773572A Fragments of prion proteins 失效
标题翻译：朊蛋白片段
公开(公告)号：US5773572A
公开(公告)日：1998-06-30
申请号：US244701
申请日：1994-06-02
申请人： Robert Vincent Fishleigh , Barry Robson , Roger Paul Mee
发明人： Robert Vincent Fishleigh , Barry Robson , Roger Paul Mee
IPC分类号： A61K39/00 , A61K38/00 , C07K7/08 , C07K14/005 , C07K14/47 , C07K16/00 , C07K16/18 , G01N33/53 , C07K14/435 , C07H21/04
CPC分类号： C07K16/18 , C07K14/47 , A61K38/00 , A61K39/00
摘要： Synthetic polypeptides having at least one antigenic site of a prion protein are disclosed together methods for their use and manufacture and antibodies raised against such polypeptides. Diagnostic kits using the polypeptides and/or antibodies are also disclosed.
摘要翻译： PCT No.PCT / GB92 / 02246 Sec。 371日期：1994年6月2日 102（e）日期1994年6月2日PCT提交1992年12月3日PCT公布。公开号WO93 / 11155 日期1993年6月10日具有朊病毒蛋白的至少一个抗原位点的合成多肽一起公开其用于和制备的方法以及针对这些多肽产生的抗体。还公开了使用多肽和/或抗体的诊断试剂盒。

4. 发明申请

US20170185729A1 METHODS AND SYSTEMS OF A HYPERBOLIC-DIRAC-NET-BASED BIOINGINE PLATFORM AND ENSEMBLE OF APPLICATIONS 审中-公开
公开(公告)号：US20170185729A1
公开(公告)日：2017-06-29
申请号：US15356533
申请日：2016-11-18
申请人： Srinidhi Boray , Barry Robson
发明人： Srinidhi Boray , Barry Robson
IPC分类号： G06F19/00 , G06N7/00 , G06N99/00
CPC分类号： G06N7/005 , G06N5/02 , G06N20/00 , G16H50/20
摘要： In one example aspect, a method obtains a file system of a virtual machine. The virtual machine comprises a plurality of applications. The plurality of applications are started through an initialization system when the virtual machine is initialized. The method captures a set of contents of the file system of the virtual machine. The method captures a metadata of the file system of the virtual machine. The method captures a state of file system of virtual machine. The method converts the plurality of applications deployed in the virtual machine into a set of containers by creating a separate container image for each application of the plurality of applications deployed in the virtual machine. Each container comprises an application packaging medium and is built based on a container specification. The container specification is derived from the set of contents of the file system of the virtual machine, metadata of the file system of the virtual machine, and the state of file system of virtual machine. The method includes using the container specification to generate a second virtual machine.

5. 发明申请

US20110066632A1 MOLECULAR LEVEL SIMILARITY SEARCH AND COMPUTER AIDED DRUG DISCOVERY PROCESS 有权
标题翻译：分子水平相似性搜索和计算机辅助药物发现过程
公开(公告)号：US20110066632A1
公开(公告)日：2011-03-17
申请号：US12560748
申请日：2009-09-16
申请人： Barry Robson , Richard Dettinger
发明人： Barry Robson , Richard Dettinger
IPC分类号： G06F7/10 , G06F17/30
CPC分类号： G06F17/30864 , G06F17/30017 , G06F19/705
摘要： Systems, methods and articles of manufacture are disclosed for searching chemical compounds referenced in chemical literature. References to chemical compounds in the documents may be transformed to corresponding references using a standard notation for representing chemical compounds. Criteria specifying desired molecular characteristics may be received. A regular expression may be generated based on the received criteria. The chemical documents may be searched using the regular expression. Based on the search, a chemical document may be determined that references a chemical compound satisfying the received criteria. Further, the regular expression may be generated based on the received criteria and a received mutation rule. Based on the generated regular expression and the chemical documents, one or more chemical compounds may be discovered that satisfy both the received criteria and the received mutation rule, but that is are not referenced in the chemical documents.
摘要翻译：公开了用于搜索化学文献中引用的化合物的系统，方法和制品。文献中化学化合物的引用可以使用表示化合物的标准符号转化为相应的参考文献。可以接收指定所需分子特征的标准。可以基于接收的标准生成正则表达式。可以使用正则表达式搜索化学文档。基于搜索，可以确定参考符合接收标准的化合物的化学文献。此外，可以基于接收到的标准和接收到的突变规则来生成正则表达式。基于生成的正则表达式和化学文献，可以发现满足接收标准和接收到的突变规则的一种或多种化学化合物，但化学文献中没有参考。

6. 发明授权

US07043476B2 Method and apparatus for data mining to discover associations and covariances associated with data 有权
标题翻译：用于数据挖掘的方法和装置，用于发现与数据相关联的关联和协方差
公开(公告)号：US07043476B2
公开(公告)日：2006-05-09
申请号：US10269375
申请日：2002-10-11
申请人： Barry Robson
发明人： Barry Robson
IPC分类号： G06F17/30
CPC分类号： G06F17/30595 , G06F19/22 , G06F19/28 , G16H10/60 , Y10S707/99937 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： Data mining techniques are provided which are effective and efficient for discovering useful information from an amorphous collection or data set of records. For example, the present invention provides for the mining of data, e.g., of several or many records, to discover interesting associations between entries of qualitative text, and covariances between data of quantitative numerical types, in records. Although not limited thereto, the invention has particular application and advantage when the data is of a type such as clinical, pharmacogenomic, forensic, police and financial records, which are characterized by many varied entries, since the problem is then said to be one of “high dimensionality” which has posed mathematical and technical difficulties for researchers. This is especially true when considering strong negative associations and negative covariance, i.e., between items of data which may so rarely come together that their concurrence is never seen in any record, yet the fact that this is not expected is of potential great interest.
摘要翻译：提供了数据挖掘技术，这些技术对于从无定形集合或记录数据集中发现有用的信息是有效和高效的。例如，本发明提供数据挖掘，例如几个或多个记录，以发现定性文本的条目之间的有趣的关联以及定量数值类型的数据之间的协整。虽然不限于此，但是当数据是诸如临床，药物基因组，法医，警察和财务记录的类型时，本发明具有特别的应用和优点，其特征在于许多变化的条目，因为该问题然后被认为是 “高维度”，为研究人员带来了数学和技术上的困难。当考虑强烈的负面协会和负协方差时，尤其是这样的情况，即在可能很少汇集的数据项之间，他们的同意在任何记录中都是从来没有见过的，但事实并非如此，这是非常有意义的。

7. 发明授权

US5897863A LHRH hormones 失效
标题翻译： LHRH激素
公开(公告)号：US5897863A
公开(公告)日：1999-04-27
申请号：US484839
申请日：1995-06-07
申请人： Barry Robson , Robert V. Fishleigh
发明人： Barry Robson , Robert V. Fishleigh
IPC分类号： A61K39/00 , C07K7/23 , A61K38/09 , A61K38/24 , A61K39/385 , C07K14/00
CPC分类号： C07K7/23 , A61K39/00
摘要： An analogue of lutenising hormone-releasing hormone (LHRH) having the amino acid sequence: pGlg-His-Trp-Ser-Tyr-X-Len-Arg-Pro-Gly-Y-Zwherein X represents Gly or a D-amino acid, Y represents one or more amino acid residues, which may be the same or different, and Z represents Cys or Tyr, such that the solution conformation of said analogue is substantially similar to that of native LHRH. The analogues may be used to prepare vaccines for reducing fertility in mammals.
摘要翻译：具有氨基酸序列：pGlg-His-Trp-Ser-Tyr-X-Len-Arg-Pro-Gly-YZ的促黄体激素释放激素（LHRH）的类似物，其中X表示Gly或D-氨基酸，Y 表示一个或多个氨基酸残基，其可以相同或不同，Z表示Cys或Tyr，使得所述类似物的溶液构象基本上与天然LHRH相似。类似物可用于制备用于降低哺乳动物的生殖力的疫苗。

8. 发明申请

US20080125978A1 Method and apparatus for deriving the genome of an individual 审中-公开
标题翻译：用于导出个体基因组的方法和装置
公开(公告)号：US20080125978A1
公开(公告)日：2008-05-29
申请号：US10269150
申请日：2002-10-11
申请人： Barry Robson , Richard Mushlin
发明人： Barry Robson , Richard Mushlin
IPC分类号： G06F19/00
CPC分类号： G16B20/00
摘要： A computer-based method is provided for deriving a genome of an individual. The method comprises the steps of accessing a selector for an individual and a reference template for a group genome, the selector comprising a locus value and a base value; and processing the selector and the reference template to derive a sequence representative of the genome of the individual. The reference template preferably comprises data components representing a probability of occurrence of a base value. The probability of occurrence is based on base value occurrences at corresponding locus values in the group genome. The method of the present invention further comprises computing a base value from the data component in the reference template, for base values not in the selector.
摘要翻译：提供基于计算机的方法来获得个体的基因组。该方法包括以下步骤：访问个体的选择器和组基因组的参考模板，所述选择器包括基因座值和基本值; 并且处理选择器和参考模板以导出代表个体基因组的序列。参考模板优选地包括表示基本值的出现概率的数据组件。发生概率基于组基因组中相应基因座值的基础值出现。本发明的方法还包括从参考模板中的数据分量计算基值，对于不在选择器中的基值。

9. 发明授权

US06434488B1 Alignment free methodology for rapid determination of differences between a test data set and known data sets 失效
标题翻译：用于快速确定测试数据集和已知数据集之间差异的无对准方法
公开(公告)号：US06434488B1
公开(公告)日：2002-08-13
申请号：US09454379
申请日：1999-12-03
申请人： Barry Robson
发明人： Barry Robson
IPC分类号： G01N3348
CPC分类号： G06F19/22 , G06F17/18 , G06F19/24
摘要： A method for generating data characterizing an item described by an ordered string of characters, comprises the steps of: (i) for a set of separation metrics each representing a unique number of positions of separation between arbitrary characters in a character group in the ordered string of characters, associating first with each separation metric; generating a set of character groups, wherein each character group comprises at least two characters contained within the ordered string of characters; and (ii) for at least one given character group in the set of character groups, for each given separation metric in the set of separation metrics, generating second data representing number of occurrences that the given character group satisfies the given separation metric; generating third data associated with the given character group, wherein the third data is based upon the second data and the first data; and storing the third data in memory for subsequent use.
摘要翻译：一种用于产生表征由有序字符串字符串描述的项目的数据的方法，包括以下步骤：（i）对于一组分离度量，每个表示在有序字符串中的字符组中的任意字符之间的分离位置的唯一数量的字符，首先与每个分离度量相关联; 生成一组字符组，其中每个字符组包括包含在有序字符串中的至少两个字符; 以及（ii）对于所述一组字符组中的至少一个给定字符组，对于所述一组分离度量中的每个给定的分离度量，生成表示给定字符组满足给定分离度量的出现次数的第二数据; 产生与所述给定字符组相关联的第三数据，其中所述第三数据基于所述第二数据和所述第一数据; 并将第三数据存储在存储器中以供后续使用。

10. 发明授权

US07777011B2 Prion-specific polyclonal antibodies 失效
标题翻译：朊病毒特异性多克隆抗体
公开(公告)号：US07777011B2
公开(公告)日：2010-08-17
申请号：US10116061
申请日：2002-04-05
申请人： Robert Vincent Fishleigh , Barry Robson , Roger Paul Mee
发明人： Robert Vincent Fishleigh , Barry Robson , Roger Paul Mee
IPC分类号： C07K16/00 , A61K39/00 , B01L3/00
CPC分类号： C07K16/18 , A61K38/00 , A61K39/00 , C07K14/47
摘要： Synthetic polypeptides having at least one antigenic site of a prior protein, methods for their use and manufacture, antibodies raised against such polypeptides and diagnostic kits containing these polypeptides or antibodies.
摘要翻译：具有至少一个先前蛋白质的抗原位点的合成多肽，其使用和制备方法，针对这种多肽产生的抗体以及含有这些多肽或抗体的诊断试剂盒。

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