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1. 发明授权

US09623184B2 Cartridge for containing and dispensing a medicament 有权
公开(公告)号：US09623184B2
公开(公告)日：2017-04-18
申请号：US13513087
申请日：2010-12-03
申请人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
发明人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
IPC分类号： A61M5/24 , A61M5/31 , A61M5/28 , A61J1/06 , A61M5/315 , A61M5/34
CPC分类号： A61M5/24 , A61J1/062 , A61M5/2448 , A61M5/2466 , A61M5/28 , A61M5/284 , A61M5/3134 , A61M5/3135 , A61M5/31525 , A61M5/31533 , A61M5/347 , A61M2005/2488 , A61M2005/2492 , A61M2005/3123 , A61M2005/3126 , A61M2005/3132 , A61M2005/31516 , A61M2207/00 , B65B3/003 , B65B3/022 , B65B7/2821 , B65B63/08 , Y10T29/494
摘要： A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.

2. 发明申请

US20120277684A1 CARTRIDGE FOR CONTAINING AND DISPENSING A MEDICAMENT 有权
标题翻译：用于包含和分配药物的药盒
公开(公告)号：US20120277684A1
公开(公告)日：2012-11-01
申请号：US13513087
申请日：2010-12-03
申请人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
发明人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
IPC分类号： A61M5/31 , B21D51/16 , A61M5/34
CPC分类号： A61M5/24 , A61J1/062 , A61M5/2448 , A61M5/2466 , A61M5/28 , A61M5/284 , A61M5/3134 , A61M5/3135 , A61M5/31525 , A61M5/31533 , A61M5/347 , A61M2005/2488 , A61M2005/2492 , A61M2005/3123 , A61M2005/3126 , A61M2005/3132 , A61M2005/31516 , A61M2207/00 , B65B3/003 , B65B3/022 , B65B7/2821 , B65B63/08 , Y10T29/494
摘要： A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.
摘要翻译：一种用于容纳和分配药物的药筒（100），所述药筒（100）包括其中具有内腔（10B）的药筒本体（104），可移动地设置在所述内腔（108）内的止动件（112）所述隔膜（116,148）设置在所述内部空腔（108）的与所述止动件（112）的相对的端部处，用于将所述药物容纳在所述内腔（108）内。盒（100）还包括整体形成为盒体（104）的整体结构的连接螺纹（120），螺纹（120）设置在药筒主体（104）的第一端，用于连接笔针直接到药筒体（104）刺穿隔膜（116,148），并提供药物与笔针的患者端之间的连通。

3. 发明授权

US09381136B2 Fixturing member and device for permitting mixing in a pen injector 有权
标题翻译：固定构件和装置，用于允许在笔式注射器中混合
公开(公告)号：US09381136B2
公开(公告)日：2016-07-05
申请号：US13262033
申请日：2010-04-15
申请人： Richard Cronenberg , Lionel Vedrine
发明人： Richard Cronenberg , Lionel Vedrine
IPC分类号： A61M37/00 , A61J1/20 , A61J1/06
CPC分类号： A61J1/2096 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2037 , A61J1/2072
摘要： In one aspect, a fixturing member for fixing a source of flowable material relative to a pen injector so as to permit introduction of the flowable material into the pen injector is provided herein. The fixturing member includes a body having a web with opposing proximal and distal faces. A distal wall extends distally from the distal face of the web, with the distal wall at least partially encompassing a distal chamber. Features are formed on the body for removable mounting onto a pen injector. Also, features are formed on the body for mounting onto a source of flowable material, A cannula extends through the web the cannula having proximal and distal ends with a lumen extending therebetween. The distal end of the cannula is located in the distal chamber and positioned such that, with the member being mounted to a pen injector, the distal end is located to be in the pen injector. The proximal end of the cannula is located proximally of the proximally face of the web such that, with the member being mounted to a source of flowable material, the proximal end of the cannula is located to be in communication with the flowable material. Advantageously, with the subject invention, a fixturing member is provided which facilitates mixing of substances in a pen injector in preparing a pen injector for injection.
摘要翻译：一方面，提供了一种用于固定可流动材料源相对于笔式注射器以便允许将可流动材料引入笔式注射器的固定构件。固定构件包括具有相对的近侧和远侧面的腹板的主体。远端壁从腹板的远端远端延伸，远端壁至少部分地包围远侧腔室。特征形成在主体上用于可拆卸地安装到笔式注射器上。此外，在身体上形成用于安装到可流动材料源上的特征。套管延伸穿过腹板，套管具有近端和远端，其间延伸有内腔。套管的远端位于远侧腔室中并且定位成使得当该构件安装到笔式注射器时，该远端位于笔式注射器中。套管的近端位于腹板近端面的近侧，使得在该构件被安装到可流动的材料源上时，套管的近端被定位成与可流动材料连通。有利地，在本发明中，提供了一种在制备注射用笔式注射器的同时便于在笔式注射器中混合物质的固定构件。

4. 发明申请

US20120172793A1 FIXTURING MEMBER AND DEVICE FOR PERMITTING MIXING IN A PEN INJECTOR 有权
标题翻译：用于在笔式注射器中进行混合的装配构件和装置
公开(公告)号：US20120172793A1
公开(公告)日：2012-07-05
申请号：US13262033
申请日：2010-04-15
申请人： Richard Cronenberg , Lionel Vedrine
发明人： Richard Cronenberg , Lionel Vedrine
IPC分类号： A61M5/31 , B65B3/04
CPC分类号： A61J1/2096 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2037 , A61J1/2072
摘要： In one aspect, a fixturing member for fixing a source of flowable material relative to a pen injector so as to permit introduction of the flowable material into the pen injector is provided herein. The fixturing member includes a body having a web with opposing proximal and distal faces. A distal wall extends distally from the distal face of the web, with the distal wall at least partially encompassing a distal chamber. Features are formed on the body for removable mounting onto a pen injector. Also, features are formed on the body for mounting onto a source of flowable material, A cannula extends through the web the cannula having proximal and distal ends with a lumen extending therebetween. The distal end of the cannula is located in the distal chamber and positioned such that, with the member being mounted to a pen injector, the distal end is located to be in the pen injector. The proximal end of the cannula is located proximally of the proximally face of the web such that, with the member being mounted to a source of flowable material, the proximal end of the cannula is located to be in communication with the flowable material. Advantageously, with the subject invention, a fixturing member is provided which facilitates mixing of substances in a pen injector in preparing a pen injector for injection.
摘要翻译：一方面，提供了一种用于固定可流动材料源相对于笔式注射器以便允许将可流动材料引入笔式注射器的固定构件。固定构件包括具有相对的近侧和远侧面的腹板的主体。远端壁从腹板的远端远端延伸，远端壁至少部分地包围远侧腔室。特征形成在主体上用于可拆卸地安装到笔式注射器上。此外，在身体上形成用于安装到可流动材料源上的特征。套管延伸穿过腹板，套管具有近端和远端，其间延伸有内腔。套管的远端位于远侧腔室中并且定位成使得当该构件安装到笔式注射器时，该远端位于笔式注射器中。套管的近端位于腹板近端面的近侧，使得在该构件被安装到可流动的材料源上时，套管的近端被定位成与可流动材料连通。有利地，在本发明中，提供了一种在制备注射用笔式注射器的同时便于在笔式注射器中混合物质的固定构件。

5. 发明授权

US10195340B2 Self-injection device 有权
公开(公告)号：US10195340B2
公开(公告)日：2019-02-05
申请号：US13516547
申请日：2009-12-16
申请人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
发明人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
IPC分类号： A61M5/145 , A61M5/142
摘要： A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).

6. 发明授权

US09480804B2 Monodose nasal drug delivery system 有权
标题翻译： Monodose鼻给药系统
公开(公告)号：US09480804B2
公开(公告)日：2016-11-01
申请号：US13517496
申请日：2010-12-23
申请人： Lionel Vedrine
发明人： Lionel Vedrine
IPC分类号： A61M11/00 , A61M15/08 , A61M5/28 , B05B11/02
CPC分类号： A61M11/007 , A61M5/282 , A61M15/08 , B05B11/02
摘要： A delivery device for delivery of a medicament to a user including a container defining a reservoir storing the medicament, a body in which the container is received, a spray nozzle arranged on one of the body and the container for receiving medicament expelled from the container, and a pusher actuatable for pushing the medicament from the container reservoir through the nozzle, said pusher being movable from a rest position to a fully activated position relative to said body in response to an actuating force. The assembly is particularly applicable to nasal syringes where it is desirable to deliver the medicament in the form of a spray.
摘要翻译：一种用于将药物输送给使用者的输送装置，包括限定储存药剂的容器的容器，容纳容器的容器，布置在主体和容器中的一个上的喷嘴，用于接收从容器中排出的药物，以及推动器，其可致动以将药物从容器储存器推动通过喷嘴，所述推动器可响应于致动力而从静止位置相对于所述主体移动到完全启动位置。该组件特别适用于需要以喷雾形式输送药物的鼻注射器。

7. 发明授权

US09375529B2 Extended use medical device 有权
标题翻译：延长使用医疗器械
公开(公告)号：US09375529B2
公开(公告)日：2016-06-28
申请号：US12585061
申请日：2009-09-02
申请人： Gary Searle , Keith N Knapp , Roman Tunkel , Peter Skutnik , Lionel Vedrine
发明人： Gary Searle , Keith N Knapp , Roman Tunkel , Peter Skutnik , Lionel Vedrine
IPC分类号： A61M5/168 , A61M5/142 , A61M5/172 , A61M5/31 , A61M5/14 , A61M5/38 , A61M5/46 , A61M5/158
CPC分类号： A61M5/158 , A61M5/1413 , A61M5/14212 , A61M5/14224 , A61M5/14248 , A61M5/16886 , A61M5/1723 , A61M5/3134 , A61M5/385 , A61M5/46 , A61M2005/14208 , A61M2005/14268 , A61M2005/1585 , A61M2005/16872 , A61M2205/16 , A61M2205/702 , A61M2209/045 , A61M2230/005 , A61M2230/201
摘要： Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device. Another embodiment comprises a partially reusable and partially disposable medical device implementing the above features.
摘要翻译：提供了一种扩展使用的独立的，可穿戴的医疗设备。该装置优选地配置有输注展开机构，用于将输注针可变地插入和缩回到不同的深度，或者将输注针从输注部位完全缩回，然后在整个输注期间在预定时间段之后重新插入输注针循环，以延长输注部位的生存能力。另一个实施例包括双针展开机构，其也可以可变地插入和缩回输注针。优选地提供流量传感器用于检测通过输注套管的流动的停止并且发出针部署机构以尝试在不同深度输注或部署第二输注针。优选地，可重新填充的储存器组件用于通过扩展使用该装置来供应药物。另一实施例包括实现上述特征的部分可再利用和部分一次性医疗装置。

8. 发明授权

US08323238B2 Medical injector with rotatable body portions 有权
标题翻译：具有旋转体部分的医用注射器
公开(公告)号：US08323238B2
公开(公告)日：2012-12-04
申请号：US13063829
申请日：2009-09-18
申请人： Richard A. Cronenberg , Asif Fayyaz , Atul Patel , Lionel Vedrine
发明人： Richard A. Cronenberg , Asif Fayyaz , Atul Patel , Lionel Vedrine
IPC分类号： A61M37/00
CPC分类号： A61M5/2033 , A61M5/2448 , A61M5/3129 , A61M5/31553 , A61M5/3156 , A61M2005/2073
摘要： A medical injector is provided herein which includes first and second body portions rotatably coupled together; a displaceable plunger disposed in at least one of the first and second body portions; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first portion against force of the spring. The releasable retainer releases the plunger upon a predetermined extent of relative rotation between the first and second body portions, thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon rotation of injector body portions, thereby minimizing premature or failed activations.
摘要翻译：本文提供了一种医疗注射器，其包括可旋转地联接在一起的第一和第二主体部分; 设置在所述第一和第二主体部分中的至少一个中的可移位柱塞; 设置成使柱塞前进的弹簧; 以及用于抵抗弹簧的力而将柱塞保持在第一部分中的可释放保持器。可释放的保持器在第一和第二主体部分之间的预定的相对旋转程度上释放柱塞，从而允许弹簧推进柱塞。有利地，本发明提供一种具有自动柱塞驱动器的医用注射器，其在喷射器主体部分的旋转时被触发，由此最小化过早或失败的激活。

9. 发明授权

US07967010B2 Spray or injection device allowing at least two preset doses of product to be delivered 有权
标题翻译：喷雾或注射装置允许至少两个预设剂量的产品被输送
公开(公告)号：US07967010B2
公开(公告)日：2011-06-28
申请号：US12690159
申请日：2010-01-20
申请人： Lionel Vedrine , Frederic Perot , Laurent Barrelle
发明人： Lionel Vedrine , Frederic Perot , Laurent Barrelle
IPC分类号： B05B7/00 , B05B11/00
CPC分类号： A61M5/2429 , A61M5/2459 , A61M5/315 , A61M5/31595 , A61M11/007 , A61M11/06 , A61M15/0065 , A61M15/08 , B05B11/02 , B05B11/025
摘要： A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.
摘要翻译：一种喷雾或注射装置，其包括外壳或推动器，其包括至少一个突出部，其可在第一径向位置和第二径向位置之间径向移动，所述突片在第一径向位置之间，其中突片不阻碍推动器相对于外壳的移动，该卡舌反对推动器的移动。推动器或壳体分别包括至少一个斜面形突起，其被构造成使突片进入第二径向位置，然后允许其返回到第一径向位置。推动器或套管还包括推动器和套管之间的至少一个止动件，以描绘对应于第一剂量的药物的第一冲程的结束，以及对应于第二剂量的药物的第二冲程的开始。

10. 发明授权

US07875007B2 Syringe accessory 有权
标题翻译：注射器配件
公开(公告)号：US07875007B2
公开(公告)日：2011-01-25
申请号：US10520980
申请日：2003-07-10
申请人： Frederic Perot , Lionel Vedrine
发明人： Frederic Perot , Lionel Vedrine
IPC分类号： A61M5/00 , A61M5/31
CPC分类号： A61M5/344 , A61F9/0017 , A61M2005/3139
摘要： According to the invention, the accessory (1) comprises a body (15) of roughly semi-tubular shape, first means of holding the syringe comprising a distal transverse wall (20) connected to one end of said body (15), and pierced with a hole (22) for the passage of the needle (7) through it, and second means of holding the syringe comprising a bearing zone (61) against which the proximal flange (10) or the lateral lugs that the syringe body (5) comprises is or are intended to bear so as to provide support for the user's fingers; the distance between said distal transverse wall (20) and said bearing zone (61) is such that the adapter (8) connecting the needle (7) to the syringe body (5) is kept bearing against said distal transverse wall (20) when said flange (10) or said lateral lugs are bearing against said bearing zone (61).
摘要翻译：根据本发明，附件（1）包括大致半管形的主体（15），第一装置保持注射器，其包括连接到所述主体（15）的一端的远侧横向壁（20）具有用于针（7）通过其的通孔（22），以及保持注射器的第二装置，其包括轴承区（61），近侧凸缘（10）或侧向凸耳与注射器主体（5））包括或旨在承担以便为用户的手指提供支持; 所述远端横向壁（20）和所述支承区域（61）之间的距离使得将针（7）连接到注射器主体（5）的适配器（8）保持抵靠所述远侧横向壁（20）所述凸缘（10）或所述侧向凸耳与所述轴承区（61）相对。

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