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    • 8. 发明授权
    • Use of short chain fatty acid containing lipids to maintain
gastrointestinal integrity and function in patients
    • 使用短链脂肪酸含脂质维持胃肠道完整性和功能
    • US5919822A
    • 1999-07-06
    • US831627
    • 1992-02-06
    • Richard CotterHugh Tucker
    • Richard CotterHugh Tucker
    • A61K9/107A61K31/19A61K31/22A61P1/00A61K31/20A61K9/10A61K31/23A61K47/44
    • A61K31/22A61K31/19Y10S514/937Y10S514/943
    • A method for the use of short chain fatty acids containing lipids in clinical nutrition to maintain gastrointestinal integrity and function in conditions where normal short chain fatty acid substrates, provided by bacterial fermentation of carbohydrates, is inadequate due to the clinical condition of the patient. By providing the short chain fatty acid in a lipid form of free fatty acid, triglyceride, diglyceride, monoglyceride, phospholipid, or cholesterol ester one is able to avoid the clinical defect and allow the gastrointestinal tract to continue to maintain its integrity and function. The short chain fatty acids of the present invention can be provided either in enteral preparations or parenteral preparations.The short chain fatty acids can be provided by hydrolysis of a structure such as: ##STR1## wherein R--COO--, R'--COO--, and R"--COO-- represent either the same or different short chain fatty acids.
    • 在临床营养中使用含有脂质的短链脂肪酸的方法,用于在通过碳水化合物的细菌发酵提供的正常短链脂肪酸底物由于患者的临床状况而不足的条件下维持胃肠完整性和功能。 通过提供游离脂肪酸的脂质形式的短链脂肪酸,甘油三酯,甘油二酯,甘油单酯,磷脂或胆固醇酯,能够避免临床缺陷,并允许胃肠道继续保持其完整性和功能。 本发明的短链脂肪酸可以在肠内制剂或肠胃外制剂中提供。 短链脂肪酸可以通过以下结构的水解提供:其中R-COO-,R'-COO-和R“ - COO-代表相同或不同的短链脂肪酸。