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1. 发明申请

US20070237685A1 Closed flow-through microplate and methods for using and manufacturing same 有权
标题翻译：封闭流通微孔板及其使用和制造方法
公开(公告)号：US20070237685A1
公开(公告)日：2007-10-11
申请号：US11784130
申请日：2007-04-05
申请人： Richard Bergman , William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
发明人： Richard Bergman , William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/5025 , B01L3/502738 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0829 , B01L2300/0864 , B01L2300/0887
摘要： A closed flow-through microplate is described herein that can be used to perform high-throughput kinetic flow-through assays to detect biomolecular interactions like material bindings, adsorptions etc. . . . that is helpful for example with testing new drugs. A method for manufacturing the closed flow-through microplate is also described herein.
摘要翻译：本文描述了一种封闭的流通微孔板，其可用于执行高通量动力学流通测定以检测生物分子相互作用，如材料结合，吸附等。。。这有助于检测新药。本文还描述了用于制造封闭流通微孔板的方法。

2. 发明授权

US07824624B2 Closed flow-through microplate and methods for using and manufacturing same 有权
标题翻译：封闭流通微孔板及其使用和制造方法
公开(公告)号：US07824624B2
公开(公告)日：2010-11-02
申请号：US11784130
申请日：2007-04-05
申请人： Richard Bergman , William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
发明人： Richard Bergman , William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/5025 , B01L3/502738 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0829 , B01L2300/0864 , B01L2300/0887
摘要： A closed flow-through microplate is described herein that can be used to perform high-throughput kinetic flow-through assays to detect biomolecular interactions like material bindings, adsorptions etc. . . that is helpful for example with testing new drugs. A method for manufacturing the closed flow-through microplate is also described herein.
摘要翻译：本文描述了一种封闭的流通微孔板，其可用于执行高通量动力学流通测定以检测生物分子相互作用，如材料结合，吸附等。。这有助于检测新药。本文还描述了用于制造封闭流通微孔板的方法。

3. 发明申请

US20080003147A1 Fluid handling system for flow-through assay 审中-公开
标题翻译：用于流通测定的流体处理系统
公开(公告)号：US20080003147A1
公开(公告)日：2008-01-03
申请号：US11824420
申请日：2007-06-29
申请人： William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
发明人： William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
IPC分类号： B01L3/02
CPC分类号： G01N35/1072 , B01L3/5027 , G01N35/1074
摘要： A fluid handling system for transferring fluids is disclosed. The fluid handling system incorporates a plurality of transfer units for dispensing and/or collecting fluids as part of a closed analytical system. The plurality of transfer units are capable of functioning independently and/or collectively when assembled in a unitary array format. Methods of making and using the fluid handling system are also disclosed. The fluid handling system allows a sub-array of transfer units to shift in a vertical direction independent from a position of another sub-array of transfer units that are assembled within the same fluid head. Therefore, the fluid handling system facilitates multi-port fluid delivery and collection in an array format. Further, the fluid handling system aligned with a sensing surface enables label-free detection assays to be performed in an analytical system.
摘要翻译：公开了一种用于输送流体的流体处理系统。流体处理系统包括用于分配和/或收集流体作为封闭分析系统的一部分的多个转运单元。当以单一阵列格式组装时，多个传送单元能够独立地和/或共同地起作用。还公开了制造和使用流体处理系统的方法。流体处理系统允许传送单元的子阵列在垂直方向上移动，独立于组装在同一流体头内的另一传送单元子阵列的位置。因此，流体处理系统便于以端口流体输送和以阵列格式收集。此外，与感测表面对准的流体处理系统使得能够在分析系统中进行无标记检测分析。

4. 发明授权

US06701057B2 Method and apparatus for separating two optical fibers 有权
标题翻译：用于分离两根光纤的方法和装置
公开(公告)号：US06701057B2
公开(公告)日：2004-03-02
申请号：US10153234
申请日：2002-05-21
申请人： Patrick J. Burke , William J. Miller , Mark L. Morrell
发明人： Patrick J. Burke , William J. Miller , Mark L. Morrell
IPC分类号： G02B600
CPC分类号： G02B6/245 , G02B6/2835
摘要： A method and apparatus for separating a first and second optical fibers including a fiber feed mechanism adapted to feed the first optical fiber and the second optical fiber, and a nozzle adapted to provide a displacing force on the second optical fiber, where the second optical fiber is displaced away from the first optical fiber to thereby separate the second optical fiber from the first optical fiber. In one embodiment, the displacing force is provided by a gas stream directed away from the nozzle while in another embodiment, the displacing force is directed towards the nozzle. In another embodiment, the apparatus includes a separation mechanism with a first guide, a second guide, a guide separator, and a deflector plate. In another embodiment, the apparatus includes a clamp mechanism with a first clamping pad having an offset extension that extends beyond an edge of a second clamp pad.
摘要翻译：一种用于分离第一和第二光纤的方法和装置，包括适于馈送第一光纤和第二光纤的光纤馈送机构，以及适于在第二光纤上提供移位力的喷嘴，其中第二光纤离开第一光纤，从而将第二光纤与第一光纤分离。在一个实施例中，位移力由远离喷嘴的气流提供，而在另一个实施例中，移位力指向喷嘴。在另一个实施例中，该装置包括具有第一引导件，第二引导件，引导件分离器和偏转板的分离机构。在另一个实施例中，该装置包括具有第一夹持垫的夹紧机构，该第一夹持垫具有延伸超过第二夹紧垫的边缘的偏移延伸部。

5. 发明授权

US06278821B1 Segmented cane mach-zehnder interferometer 失效
标题翻译：分段甘蔗马歇尔干涉仪
公开(公告)号：US06278821B1
公开(公告)日：2001-08-21
申请号：US09374738
申请日：1999-08-13
申请人： Joel P. Carberry , Mark F. Krol , William J. Miller , Mark L. Morrell
发明人： Joel P. Carberry , Mark F. Krol , William J. Miller , Mark L. Morrell
IPC分类号： G02B626
CPC分类号： G02B6/29353 , G02B6/0218 , G02B6/02204 , G02B6/2835 , G02B6/29383 , G02B6/29398 , G02F1/3136 , G02F2201/307 , G02F2203/055 , G02F2203/585
摘要： A Mach-Zehnder interferometer for performing an optical function on a plurality of optical fibers is provided. The interferometer includes a first cane segment surrounding the optical fibers. The first cane segment forms a first optical coupling region. The interferometer also includes a second cane segment surrounding the optical fibers. The second cane segment forms a second optical coupling region. A phase shift region is formed by a discontinuity between the first and second cane segments for exposing the optical fibers. The optical fibers are suspended between the first and second cane segments within the phase shift region. A substrate is provided for supporting the optical fibers within the phase shift region.
摘要翻译：提供了一种用于在多根光纤上执行光学功能的马赫 - 曾德干涉仪。干涉仪包括围绕光纤的第一拐杖段。第一甘蔗段形成第一光耦合区域。干涉仪还包括围绕光纤的第二甘蔗段。第二甘蔗段形成第二光耦合区域。相移区域由第一和第二拐点部分之间的不连续部分形成，用于露出光纤。光纤悬浮在相移区域内的第一和第二拐点段之间。提供了用于在相移区域内支撑光纤的基板。

6. 发明授权

US08257665B2 Dual inlet microchannel device and method for using same 有权
标题翻译：双入口微通道装置及其使用方法
公开(公告)号：US08257665B2
公开(公告)日：2012-09-04
申请号：US13038005
申请日：2011-03-01
申请人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
发明人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
IPC分类号： B01L3/00
CPC分类号： G01N33/557 , B01L3/5025 , B01L3/502746 , B01L3/565 , B01L2200/027 , B01L2200/0621 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B01L2400/084 , B01L2400/086
摘要： A dual inlet microchannel device and a method for using the device to perform a flow-through kinetic assay are described. A microplate having an array of the dual inlet microchannel devices and in particular their specially configured flow chambers is also described. Several embodiments of the dual inlet microchannel devices and specially configured flow chambers are also described.
摘要翻译：描述了双入口微通道装置和使用该装置进行流通动力学测定的方法。还描述了具有双入口微通道装置的阵列，特别是其特别构造的流动室的微孔板。还描述了双入口微通道装置和特别构造的流动室的几个实施例。

7. 发明申请

US20110151585A1 DUAL INLET MICROCHANNEL DEVICE AND METHOD FOR USING SAME 有权
标题翻译：双通道微通道器件及其使用方法
公开(公告)号：US20110151585A1
公开(公告)日：2011-06-23
申请号：US13038005
申请日：2011-03-01
申请人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
发明人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
IPC分类号： G01N33/557 , B01L3/00
CPC分类号： G01N33/557 , B01L3/5025 , B01L3/502746 , B01L3/565 , B01L2200/027 , B01L2200/0621 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B01L2400/084 , B01L2400/086
摘要： A dual inlet microchannel device and a method for using the device to perform a flow-through kinetic assay are described. A microplate having an array of the dual inlet microchannel devices and in particular their specially configured flow chambers is also described. Several embodiments of the dual inlet microchannel devices and specially configured flow chambers are also described.
摘要翻译：描述了双入口微通道装置和使用该装置进行流通动力学测定的方法。还描述了具有双入口微通道装置的阵列，特别是其特别构造的流动室的微孔板。还描述了双入口微通道装置和特别构造的流动室的几个实施例。

8. 发明授权

US08974748B2 Dual inlet microchannel device and method for using same 有权
标题翻译：双入口微通道装置及其使用方法
公开(公告)号：US08974748B2
公开(公告)日：2015-03-10
申请号：US11983327
申请日：2007-11-08
申请人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
发明人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
IPC分类号： B01L3/00 , B01L99/00 , G01N33/557
CPC分类号： G01N33/557 , B01L3/5025 , B01L3/502746 , B01L3/565 , B01L2200/027 , B01L2200/0621 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B01L2400/084 , B01L2400/086
摘要： A dual inlet microchannel device and a method for using the device to perform a flow-through kinetic assay are described. A microplate having an array of the dual inlet microchannel devices and in particular their specially configured flow chambers is also described. Several embodiments of the dual inlet microchannel devices and specially configured flow chambers are also described.
摘要翻译：描述了双入口微通道装置和使用该装置进行流通动力学测定的方法。还描述了具有双入口微通道装置的阵列，特别是其特别构造的流动室的微孔板。还描述了双入口微通道装置和特别构造的流动室的几个实施例。

9. 发明申请

US20080247907A1 Dual inlet microchannel device and method for using same 有权
标题翻译：双入口微通道装置及其使用方法
公开(公告)号：US20080247907A1
公开(公告)日：2008-10-09
申请号：US11983327
申请日：2007-11-08
申请人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
发明人： Richard Bergman , Mark A. Lewis , Cheng-Chung Li , William J. Miller
IPC分类号： B01J19/00 , G01F1/37
CPC分类号： G01N33/557 , B01L3/5025 , B01L3/502746 , B01L3/565 , B01L2200/027 , B01L2200/0621 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B01L2400/084 , B01L2400/086
摘要： A dual inlet microchannel device and a method for using the device to perform a flow-through kinetic assay are described. A microplate having an array of the dual inlet microchannel devices and in particular their specially configured flow chambers is also described. Several embodiments of the dual inlet microchannel devices and specially configured flow chambers are also described.
摘要翻译：描述了双入口微通道装置和使用该装置进行流通动力学测定的方法。还描述了具有双入口微通道装置的阵列，特别是其特别构造的流动室的微孔板。还描述了双入口微通道装置和特别构造的流动室的几个实施例。

10. 发明授权

US08887901B2 Conveyor sprocket assembly 有权
标题翻译：输送链轮总成
公开(公告)号：US08887901B2
公开(公告)日：2014-11-18
申请号：US13561682
申请日：2012-07-30
申请人： Michael S. Cox , William J. Miller
发明人： Michael S. Cox , William J. Miller
IPC分类号： B65G23/06 , F16H55/12
CPC分类号： B65G23/06
摘要： A conveyor sprocket assembly generally includes a support shaft, at least one conveyor sprocket slidably engaging the support shaft, and an abutment stop positioned adjacent the conveyor sprocket. The abutment stop is configured to be removed to allow the conveyor sprocket to slide axially along the support shaft.
摘要翻译：传送链轮组件通常包括支撑轴，至少一个可滑动地接合支撑轴的传送链轮以及邻近输送链轮定位的邻接止动件。抵靠止挡被构造成被移除以允许输送链轮沿着支撑轴轴向滑动。

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