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1. 发明授权

US4305876A Process for the manufacture of tertiary, optically active aliphatic compounds 失效
标题翻译：制备叔，光学活性脂族化合物的方法
公开(公告)号：US4305876A
公开(公告)日：1981-12-15
申请号：US963613
申请日：1978-11-24
申请人： Richard Barner , Walter Boguth , Hans G. W. Leuenberger , Max Schmid , Reinhard Zell
发明人： Richard Barner , Walter Boguth , Hans G. W. Leuenberger , Max Schmid , Reinhard Zell
IPC分类号： C07C17/26 , C07C29/10 , C07C47/14 , C07D309/12 , C07D311/72 , C07D315/00 , C07F9/54 , C12P7/02 , C12P7/62 , C07D307/32 , C07C43/10 , C07C69/66
CPC分类号： C07D315/00 , C07C17/263 , C07C17/2635 , C07C29/10 , C07C45/41 , C07D309/12 , C07D311/72 , C07F9/5456 , C12P7/02 , C12P7/62
摘要： A process for asymmetrically hydrogenating through the use of microorganisms a double bond connected to tertiary carbon atom in an olefinic aliphatic compound to produce a tertiary, optically active aliphatic compound useful as an intermediate for optically active Vitamins E and K.
摘要翻译：通过使用微生物将烯键式脂族化合物中与叔碳原子连接的双键不对称氢化的方法，以产生用作光学活性维生素E和K的中间体的叔，光学活性脂族化合物。

2. 发明授权

US4138289A Process for the manufacture of tertiary, optically active aliphatic compounds 失效
标题翻译：制备叔，光学活性脂族化合物的方法
公开(公告)号：US4138289A
公开(公告)日：1979-02-06
申请号：US793093
申请日：1977-05-02
申请人： Richard Barner , Walter Boguth , Hans G. W. Leuenberger , Max Schmid , Reinhard Zell
发明人： Richard Barner , Walter Boguth , Hans G. W. Leuenberger , Max Schmid , Reinhard Zell
IPC分类号： C07D317/18 , C07C17/20 , C07C17/26 , C07C17/354 , C07C29/09 , C07C29/10 , C07C29/124 , C07C31/125 , C07C43/12 , C07C45/67 , C07C47/14 , C07C49/04 , C07C55/02 , C07C69/74 , C07D307/02 , C07D307/33 , C07D309/12 , C07D311/72 , C07D315/00 , C07F9/54 , C12P7/02 , C12P7/04 , C12P7/40 , C12P7/62 , C12P7/64 , C12R1/04 , C12R1/07 , C12R1/11 , C12R1/285 , C12R1/32 , C12R1/365 , C12R1/38 , C12R1/39 , C12R1/425 , C12R1/46 , C12R1/465 , C12R1/47 , C12R1/54 , C12R1/56 , C12R1/61 , C12R1/65 , C12R1/66 , C12R1/67 , C12R1/68 , C12R1/685 , C12R1/725 , C12R1/785 , C12R1/80 , C12R1/825 , C12R1/845 , C12R1/86 , C12R1/865 , C12R1/88 , C12D13/02
CPC分类号： C07D315/00 , C07C17/208 , C07C17/263 , C07C17/2635 , C07C17/354 , C07C29/095 , C07C29/10 , C07C29/124 , C07C45/673 , C07C47/14 , C07C49/04 , C07D309/12 , C07D311/72 , C07F9/5456 , C12P7/02 , C12P7/62 , C07B2200/07 , Y10S435/822 , Y10S435/839 , Y10S435/862 , Y10S435/866 , Y10S435/872 , Y10S435/876 , Y10S435/881 , Y10S435/882 , Y10S435/885 , Y10S435/887 , Y10S435/896 , Y10S435/899 , Y10S435/904 , Y10S435/906 , Y10S435/909 , Y10S435/911 , Y10S435/912 , Y10S435/917 , Y10S435/921 , Y10S435/931 , Y10S435/933 , Y10S435/936 , Y10S435/939 , Y10S435/94 , Y10S435/941 , Y10S435/942 , Y10S435/944
摘要： A process for asymmetrically hydrogenating through the use of microorganisms a double bond connected to tertiary carbon atom in an olefinic aliphatic compound to produce a tertiary, optically active aliphatic compound useful as an intermediate for optically active Vitamins E and K.
摘要翻译：通过使用微生物将烯键式脂族化合物中与叔碳原子连接的双键不对称氢化的方法，以产生用作光学活性维生素E和K的中间体的叔，光学活性脂族化合物。

3. 发明授权

US4072715A Optically active cyclohexane derivatives 失效
标题翻译：光学活性环己烷衍生物
公开(公告)号：US4072715A
公开(公告)日：1978-02-07
申请号：US707123
申请日：1976-07-20
申请人： Walter Boguth , Hans G. W. Leuenberger , Hans J. Mayer , Erich Widmer , Reinhard Zell
发明人： Walter Boguth , Hans G. W. Leuenberger , Hans J. Mayer , Erich Widmer , Reinhard Zell
IPC分类号： C07C49/403 , C07C403/00 , C07F9/54 , C12P7/26 , C07C49/30
CPC分类号： C12P7/26 , C07C403/02 , C07C403/08 , C07C403/12 , C07C403/14 , C07C403/16 , C07C403/24 , C07C45/64 , C07F9/5428 , C07B2200/07 , C07C2101/16
摘要： A process for fermentatively hydrogenating and reducing ketoisophorone to produce optically active [4R,6R]-4-hydroxy-2,6,6-trimethyl-cyclohexanone useful as an intermediate in the production of optically active carotenoids and intermediates in the production of these carotenoids.
摘要翻译：一种用于发酵氢化和还原酮异二酮以制备光学活性的[4R，6R] -4-羟基-2,6,6-三甲基 - 环己酮的方法，其用作制备光学活性类胡萝卜素的中间体和这些类胡萝卜素生产中的中间体。

4. 发明授权

US4156100A Optically active cyclohexane derivatives 失效
公开(公告)号：US4156100A
公开(公告)日：1979-05-22
申请号：US849138
申请日：1977-11-07
申请人： Walter Boguth , Hans G. W. Leuenberger , Hans J. Mayer , Erich Widmer , Reinhard Zell
发明人： Walter Boguth , Hans G. W. Leuenberger , Hans J. Mayer , Erich Widmer , Reinhard Zell
IPC分类号： C07C49/403 , C07C403/00 , C07F9/54 , C12P7/26 , C07C35/18
CPC分类号： C12P7/26 , C07C403/02 , C07C403/08 , C07C403/12 , C07C403/14 , C07C403/16 , C07C403/24 , C07C45/64 , C07F9/5428 , C07B2200/07 , C07C2101/16
摘要： A process for fermentatively hydrogenating and reducing ketoisophorone to produce optically active [4R,6R]-4-hydroxy-2,6,6-trimethyl-cyclohexanone useful as an intermediate in the production of optically active carotenoids and intermediates in the production of these carotenoids.

5. 发明授权

US4095038A Optically active cyclohexane derivatives 失效
标题翻译：光学活性环己烷衍生物
公开(公告)号：US4095038A
公开(公告)日：1978-06-13
申请号：US707146
申请日：1976-07-20
申请人： Walter Boguth , Hans Georg Wilhelm Leuenberger , Hans Johann Mayer , Erich Widmer , Reinhard Zell
发明人： Walter Boguth , Hans Georg Wilhelm Leuenberger , Hans Johann Mayer , Erich Widmer , Reinhard Zell
IPC分类号： C07C49/403 , C07C403/00 , C07F9/54 , C12P7/26 , C07C175/00
CPC分类号： C12P7/26 , C07C403/02 , C07C403/08 , C07C403/12 , C07C403/14 , C07C403/16 , C07C403/24 , C07C45/64 , C07F9/5428 , C07B2200/07 , C07C2101/16
摘要： A process for fermentatively hydrogenating and reducing ketoisophorone to produce optically active [4R,6R]-4-hydroxy-2,6,6-trimethyl-cyclohexanone useful as an intermediate in the production of optically active carotenoids and intermediates in the production of these carotenoids.

6. 发明授权

US4026949A Optically active cyclohexane derivatives 失效
标题翻译：光学活性环己烷衍生物
公开(公告)号：US4026949A
公开(公告)日：1977-05-31
申请号：US707128
申请日：1976-07-20
申请人： Walter Boguth , Hans Georg Wilhelm Leuenberger , Hans Johann Mayer , Erich Widmer , Reinhard Zell
发明人： Walter Boguth , Hans Georg Wilhelm Leuenberger , Hans Johann Mayer , Erich Widmer , Reinhard Zell
IPC分类号： C07F9/54 , C07C47/46
CPC分类号： C07F9/5428 , Y10S435/822
摘要： A process for fermentatively hydrogenating and reducing ketoisophorone to produce optically active [4R,6R]-4-hydroxy-2,6,6-trimethyl-cyclohexanone useful as an intermediate in the production of optically active carotenoids and intermediates in the production of these carotenoids.
摘要翻译：一种用于发酵氢化和还原酮异二酮以制备光学活性的[4R，6R] -4-羟基-2,6,6-三甲基 - 环己酮的方法，其用作制备光学活性类胡萝卜素的中间体和这些类胡萝卜素生产中的中间体。

7. 发明授权

US3988205A Optically active cyclohexane derivatives 失效
公开(公告)号：US3988205A
公开(公告)日：1976-10-26
申请号：US601770
申请日：1975-08-04
申请人： Walter Boguth , Hans Georg Wilhelm Leuenberger , Hans Johann Mayer , Erich Widmer , Reinhard Zell
发明人： Walter Boguth , Hans Georg Wilhelm Leuenberger , Hans Johann Mayer , Erich Widmer , Reinhard Zell
IPC分类号： C07C45/64 , C07C49/403 , C07C49/497 , C07F9/54 , C12P7/26 , C12D13/00
CPC分类号： C07C403/24 , C07C403/08 , C07C403/12 , C07C403/14 , C07C45/64 , C07C49/403 , C07C49/497 , C07F9/5428 , C12P7/26 , C07B2200/07 , C07C2101/14 , C07C2101/16 , Y10S435/822 , Y10S435/823 , Y10S435/828 , Y10S435/83 , Y10S435/831 , Y10S435/832 , Y10S435/848 , Y10S435/85 , Y10S435/853 , Y10S435/872 , Y10S435/873 , Y10S435/874 , Y10S435/882 , Y10S435/885 , Y10S435/886 , Y10S435/913 , Y10S435/921 , Y10S435/929 , Y10S435/931 , Y10S435/933 , Y10S435/939 , Y10S435/94 , Y10S435/944
摘要： A process for fermentatively hydrogenating and reducing ketoisophorone to produce optically active [4R,6R]-4-hydroxy-2,6,6-trimethyl-cyclohexanone useful as an intermediate in the production of optically active carotenoids and intermediates in the production of these carotenoids.

8. 发明授权

US4070450A Sunscreening compound and method 失效
标题翻译：防晒化合物及方法
公开(公告)号：US4070450A
公开(公告)日：1978-01-24
申请号：US643427
申请日：1975-12-22
申请人： Richard Barner , Walter Boguth
发明人： Richard Barner , Walter Boguth
IPC分类号： C07D213/66 , C07D213/79 , A61K7/42 , C07D471/00
CPC分类号： C07D213/66 , C07D213/79
摘要： Radiation screening preparations comprising a cosmetically acceptable carrier and, as the active ingredient, one or more compounds represented by the formula ##STR1## WHEREIN N IS 1, R.sub.1 is hydrogen, alkyl, alkali metal, ammonium or ammonium substituted with one or more alkyl or hydroxyalkyl residues, R.sub.2 is hydroxymethyl or alkoxymethyl and R.sub.3 is hydrogen; or R.sub.1 and R.sub.2 together constitute a methylene group and R.sub.3 is hydrogen, methyl or ethyl; and wherein n is 2, R.sub.1 is an alkaline earth metal, R.sub.2 is hydroxymethyl or alkoxymethyl and R.sub.3 is hydrogenAnd pharmaceutically acceptable acid addition salts thereof. The preparations may additionally contain other agents which are characterized by a maximum light absorption in the erythemal range. Certain novel compounds are disclosed.
摘要翻译：包含美容上可接受的载体和作为活性成分的一种或多种由下式表示的化合物的辐射筛选制剂，R1是氢，被一个或多个烷基取代的烷基，碱金属，铵或铵，或羟烷基残基，R2是羟甲基或烷氧基甲基，R3是氢; 或R 1和R 2一起构成亚甲基，R 3为氢，甲基或乙基; 并且其中n为2，R 1为碱土金属，R 2为羟甲基或烷氧基甲基，R 3为氢，并且其药学上可接受的酸添加量为。制剂可以另外含有特征在于红斑范围内最大光吸收的其它药剂。公开了某些新型化合物。

9. 发明授权

US4307074A Novel reagent 失效
标题翻译：新型试剂
公开(公告)号：US4307074A
公开(公告)日：1981-12-22
申请号：US75300
申请日：1979-09-13
申请人： Richard Barner , Walter Boguth
发明人： Richard Barner , Walter Boguth
IPC分类号： C07F9/09 , C07F9/10 , G01N33/571 , G01N33/48 , C12Q1/04 , G01N33/50
CPC分类号： G01N33/571 , C07F9/094 , C07F9/10
摘要： Novel reagents for the determination of Wassermann antibodies comprising a compound selected from those represented by the formula ##STR1## wherein n is a whole number from 12 to 16 inclusive andR is phenyl or substituted phenyl and salts thereof.
摘要翻译：用于测定Wassermann抗体的新型试剂，其包含选自由下式表示的化合物的化合物：其中n为12至16的整数，并且R为苯基或取代的苯基及其盐。

10. 发明授权

US4393073A Pharmaceutical preparations 失效
公开(公告)号：US4393073A
公开(公告)日：1983-07-12
申请号：US371621
申请日：1982-04-26
申请人： Walter Boguth , Georges Hirth
发明人： Walter Boguth , Georges Hirth
IPC分类号： A61K9/00 , A61K31/635 , A61K47/10
CPC分类号： A61K9/0019 , A61K31/635 , A61K47/10 , Y10S514/97
摘要： Pharmaceutical preparations containing glycerol alkyl ethers as the solvent.

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