会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • Biosensory layers
    • 生物传感层
    • US5986066A
    • 1999-11-16
    • US878105
    • 1997-06-18
    • Richard BarnerWalter HuberJosef HubscherJurg HurstDaniel Schlatter
    • Richard BarnerWalter HuberJosef HubscherJurg HurstDaniel Schlatter
    • G01N33/53G01N33/543C07K16/00G01N33/547
    • G01N33/5438G01N33/54353Y10S436/823Y10S436/828Y10S977/714Y10S977/795Y10S977/92
    • A biologically recognizing layer on a solid phase consisting of biologically recognizing molecules comprising regions which recognize a substance to be analyzed and regions which do not recognize a substance to be analyzed.The biologically recognizing molecules are aligned on a suitably modified surface by means of molecular regions which do not recognize the substance to be analyzed. The biologically recognizing molecules are cross-linked with the aligning surface and are consequently covalently altered. The molecular regions recognizing the substance to be analyzed are not altered by the covalent bonding and retain their bonding activity.The layer is produced in a novel two-stage method. In the first step, the biologically recognizing molecules, the aligning molecules and carrier molecules are adsorbed. In the second step, the molecules are covalently anchored by cross-linking. Cross-linking is brought about by photolytic activation of a water soluble reagent bonded to the carrier molecules.
    • 由包含识别待分析物质的区域和不能识别被分析物质的区域的生物识别分子组成的固相上的生物识别层。 生物识别分子通过不识别待分析物质的分子区域在适当修饰的表面上排列。 生物识别分子与对准表面交联并因此共价改变。 识别待分析物质的分子区域不会因共价键而改变,并保持其结合活性。 该层以新颖的两阶段方法生产。 在第一步中,生物识别分子,对准分子和​​载体分子被吸附。 在第二步中,分子通过交联共价锚定。 交联是通过与载体分子结合的水溶性试剂的光解活化引起的。