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1. 发明授权

US07700827B2 Metal resistant plants and phytoremediation of environmental contamination 失效
标题翻译：金属抗性植物和植物修复环境污染
公开(公告)号：US07700827B2
公开(公告)日：2010-04-20
申请号：US10450731
申请日：2001-12-13
申请人： Richard B. Meagher , Yujing Li , Om P. Dhankher
发明人： Richard B. Meagher , Yujing Li , Om P. Dhankher
IPC分类号： A01H5/00 , C12N15/09 , C12N15/82 , C12N15/31
CPC分类号： C12N9/93 , B09C1/105 , C07K16/40 , C12N9/0004 , C12N9/104 , C12N15/8259 , C12N15/8271 , C12Y120/04001 , C12Y203/02015 , C12Y603/02003
摘要： The present disclosure provides a method of producing transgenic plants which are resistant to at least one metal ion by transforming the plant with a recombinant DNA comprising a nucleic acid encoding a bacterial arsenic reductase under the control of a plant expressible promoter, and a nucleic acid encoding a nucleotide sequence encoding a phytochelatin biosynthetic enzyme under the control of a plant expressible promoter. The invention also relates a method of phytoremediation of a contaminated site by growing in the site a transgenic plant expressing a nucleic acid encoding a bacterial arsenate reductase and a nucleic acid encoding a phytochelatin biosynthetic enzyme.
摘要翻译：本公开提供了通过用包含在植物可表达启动子控制下的编码细菌砷还原酶的核酸的重组DNA转化植物来生产对至少一种金属离子具有抗性的转基因植物的方法，以及编码在植物表达启动子控制下编码植物螯合素生物合成酶的核苷酸序列。本发明还涉及通过在该位点生长表达编码细菌砷酸盐还原酶的核酸和编码植物螯合素生物合成酶的核酸的转基因植物，对污染部位进行植物修复的方法。

2. 发明授权

US07148040B2 Method of rapid production of hybridomas expressing monoclonal antibodies on the cell surface 有权
标题翻译：在细胞表面上快速产生表达单克隆抗体的杂交瘤的方法
公开(公告)号：US07148040B2
公开(公告)日：2006-12-12
申请号：US10079130
申请日：2002-02-20
申请人： Richard B. Meagher , Vince Laterza
发明人： Richard B. Meagher , Vince Laterza
IPC分类号： C12P21/04 , C12N5/06 , C12N15/02 , C12N15/63
CPC分类号： C12N5/163 , C07K16/40 , C12N2510/02 , C12N2517/02 , G01N33/5052 , G01N2800/52
摘要： The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal antibody of interest.
摘要翻译：本发明涉及遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还涉及在制备单克隆抗体的方法中利用遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还提供可用于制备感兴趣的单克隆抗体的杂交瘤和B细胞群体。

3. 发明授权

US08912385B2 Rapid production of monoclonal antibodies 有权
标题翻译：快速生产单克隆抗体
公开(公告)号：US08912385B2
公开(公告)日：2014-12-16
申请号：US12620209
申请日：2009-11-17
申请人： Richard B. Meagher
发明人： Richard B. Meagher
IPC分类号： A01K67/00 , A01K67/033 , C12N5/00 , C12N5/02 , G01N33/574 , C12N5/16 , C07K16/40 , G01N33/50
CPC分类号： C12N5/163 , C07K16/40 , C12N2510/02 , C12N2517/02 , G01N33/5052 , G01N2800/52
摘要： The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal antibody of interest.
摘要翻译：本发明涉及遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还涉及在制备单克隆抗体的方法中利用遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还提供可用于制备感兴趣的单克隆抗体的杂交瘤和B细胞群体。

4. 发明授权

US07491811B2 Repressor-mediated tissue-specific gene expression in plants 失效
标题翻译：抑制因子介导的组织特异性基因表达在植物中
公开(公告)号：US07491811B2
公开(公告)日：2009-02-17
申请号：US11038900
申请日：2005-01-18
申请人： Richard B. Meagher , Rebecca S. Balish , Kim Tehryung , Elizabeth C. McKinney
发明人： Richard B. Meagher , Rebecca S. Balish , Kim Tehryung , Elizabeth C. McKinney
IPC分类号： C12N15/82 , C07H21/04 , A01H5/00
CPC分类号： C12N15/8227 , C12N15/8216 , C12N15/8217 , C12N15/8222 , C12N15/8231 , C12N15/8259 , C12N15/8263 , C12N15/8289
摘要： Plant tissue specific gene expression by way of repressor-operator complexes, has enabled outcomes including, without limitation, male sterility and engineered plants having root-specific gene expression of relevant proteins to clean environmental pollutants from soil and water. A mercury hyperaccumulation strategy requires that mercuric ion reductase coding sequence is strongly expressed. The actin promoter vector, A2pot, engineered to contain bacterial lac operator sequences, directed strong expression in all plant vegetative organs and tissues. In contrast, the expression from the A2pot construct was restricted primarily to root tissues when a modified bacterial repressor (LacIn) was coexpressed from the light-regulated rubisco small subunit promoter in above-ground tissues. Also provided are analogous repressor operator complexes for selective expression in other plant tissues, for example, to produce male sterile plants.
摘要翻译：通过阻遏物 - 操作复合物的植物组织特异性基因表达，已经实现了包括但不限于雄性不育和具有相关蛋白质的根特异性基因表达的工程植物从而清除土壤和水中的环境污染物的结果。水银超累积策略要求汞强反应酶编码序列强烈表达。肌动蛋白启动子载体，A2pot，被设计成含有细菌lac操纵子序列，在所有植物营养器官和组织中指示强表达。相比之下，当修饰的细菌阻遏物（LacIn）从地上组织中的光调节的rubisco小亚基启动子共表达时，来自A2pot构建体的表达主要限于根组织。还提供了用于在其他植物组织中选择性表达的类似的阻遏物操纵子复合物，例如产生雄性不育植物。

5. 发明申请

US20110263487A1 Plant Production and Delivery System for Recombinant Proteins as Protein-Flour or Protein-Oil Compositions 审中-公开
标题翻译：重组蛋白作为蛋白质 - 面粉或蛋白油组合物的植物生产和递送系统
公开(公告)号：US20110263487A1
公开(公告)日：2011-10-27
申请号：US12809470
申请日：2008-12-22
申请人： Richard B. Meagher
发明人： Richard B. Meagher
IPC分类号： A01N37/18 , C12N9/96 , A01P7/04 , C07K19/00
CPC分类号： C12N15/8286 , A01N63/02 , C07K14/325 , C07K14/415 , C07K2319/50 , Y02A40/162 , A01N25/08 , A01N2300/00
摘要： The present invention relates to a plant flour material comprising a ground, dried plant material, wherein the plant material contains a recombinant protein comprises a bactericidal or an insecticidal protein toxin, or combinations thereof. The present invention further relates to a seed oil body composition comprising a seed oil body fusion, said oil body fusion comprising an oil body protein fused to a recombinant protein comprising a bactericidal or an insecticidal protein toxin. The present invention provides for a method of abating or controlling the population of mosquitoes comprising administering to a water source suspected of containing mosquito larvae an effective amount of seed oil body preparation comprising one or more Bti toxins, optionally in combination with one or more BtBs. Additionally, the present invention provides for a method of controlling or abating a pathogenic microbial population comprising administering to an insect population, which serves as a host for the pathogenic microbial population, a recombinant plant material containing a recombinant protein comprising an bactericidal protein toxin.
摘要翻译：本发明涉及包含研磨的干燥植物材料的植物面粉材料，其中植物材料含有重组蛋白质，其包含杀菌或杀虫蛋白毒素或其组合。本发明还涉及包含种子油体融合物的种子油体组合物，所述油体融合物包含与包含杀菌或杀虫蛋白毒素的重组蛋白质融合的油体蛋白质。本发明提供减轻或控制蚊子群体的方法，包括对怀疑含有蚊子幼虫的水源施用有效量的含有一种或多种Bti毒素的种子油体制剂，任选地与一种或多种BtB组合。另外，本发明提供了一种控制或减轻致病微生物群体的方法，其包括向作为致病微生物群体宿主的昆虫群体施用含有包含杀菌蛋白毒素的重组蛋白质的重组植物材料。

6. 发明授权

US07667096B2 Conditional sterility in plants 失效
标题翻译：植物条件不育
公开(公告)号：US07667096B2
公开(公告)日：2010-02-23
申请号：US10559301
申请日：2004-06-03
申请人： Richard B. Meagher , Elizabeth McKinney , Tehryung Kim
发明人： Richard B. Meagher , Elizabeth McKinney , Tehryung Kim
IPC分类号： C12N15/82 , C12N15/54 , A01H1/02 , A01H5/00
CPC分类号： C12N15/8218 , C12N15/8287 , C12N15/8289 , C12N15/829
摘要： The present disclosure provides methods, recombinant DNA molecules, recombinant host cells containing the DNA molecules, and transgenic plant cells, plant tissue and plants which contain and express at least one antisense or interference RNA specific for a thiamine biosynthetic coding sequence or a thiamine binding protein or a thiamine-degrading protein, wherein the RNA or thiamine binding protein is expressed under the regulatory control of a transcription regulatory sequence which directs expression in male and/or female reproductive tissue. These transgenic plants are conditionally sterile; i.e., they are fertile only in the presence of exogenous thiamine. Such plants are especially appropriate for use in the seed industry or in the environment, for example, for use in revegetation of contaminated soils or phytoremediation, especially when those transgenic plants also contain and express one or more chimeric genes which confer resistance to contaminants.
摘要翻译：本公开提供了方法，重组DNA分子，含有DNA分子的重组宿主细胞和转基因植物细胞，植物组织和植物，其含有和表达至少一种对硫胺素生物合成编码序列或硫胺素结合蛋白特异性的反义或干扰RNA 或硫胺素降解蛋白，其中所述RNA或硫胺素结合蛋白在引导雄性和/或雌性生殖组织中的表达的转录调控序列的调节控制下表达。这些转基因植物是无条件的; 即只有在存在外源性硫胺素的情况下它们是肥沃的。这样的植物特别适用于种子工业或环境中，例如用于植被污染土壤或植物修复，尤其是当这些转基因植物还含有和表达一种或多种赋予对污染物的抗性的嵌合基因时。

7. 发明申请

US20100287632A1 Rapid Production of Monoclonal Antibodies 有权
标题翻译：快速生产单克隆抗体
公开(公告)号：US20100287632A1
公开(公告)日：2010-11-11
申请号：US12620209
申请日：2009-11-17
申请人： Richard B. Meagher
发明人： Richard B. Meagher
IPC分类号： A01K67/00 , G01N33/53 , C12N5/00 , C12N15/63
CPC分类号： C12N5/163 , C07K16/40 , C12N2510/02 , C12N2517/02 , G01N33/5052 , G01N2800/52
摘要： The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal antibody of interest.
摘要翻译：本发明涉及遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还涉及在制备单克隆抗体的方法中利用遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还提供可用于制备感兴趣的单克隆抗体的杂交瘤和B细胞群体。

8. 发明授权

US07629171B2 Genetically altered hybridomas, myelomas and B cells that facilitate the rapid production of monoclonal antibodies 有权
标题翻译：遗传改变的杂交瘤，骨髓瘤和B细胞，促进单克隆抗体的快速生产
公开(公告)号：US07629171B2
公开(公告)日：2009-12-08
申请号：US11600595
申请日：2006-11-16
申请人： Richard B. Meagher , Vince Laterza
发明人： Richard B. Meagher , Vince Laterza
IPC分类号： C12N15/00
CPC分类号： C12N5/163 , C07K16/40 , C12N2510/02 , C12N2517/02 , G01N33/5052 , G01N2800/52
摘要： The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal antibody of interest.
摘要翻译：本发明涉及遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还涉及在制备单克隆抗体的方法中利用遗传改变的杂交瘤，骨髓瘤和B细胞。本发明还提供可用于制备感兴趣的单克隆抗体的杂交瘤和B细胞群体。

9. 发明授权

US5668294A Metal resistance sequences and transgenic plants 失效
标题翻译：金属抗性序列和转基因植物
公开(公告)号：US5668294A
公开(公告)日：1997-09-16
申请号：US427097
申请日：1995-04-21
申请人： Richard B. Meagher , Anne O. Summers
发明人： Richard B. Meagher , Anne O. Summers
IPC分类号： B09C1/10 , C12N9/02 , C12N9/88 , C12N15/29 , C12N15/31 , C12N15/52 , C12N15/82 , A01H5/00
CPC分类号： C12N9/0091 , B09C1/105 , C12N15/52 , C12N15/8259 , C12N15/8271 , C12N15/8274 , C12N9/88
摘要： The present invention provides nucleic acid sequences encoding a metal ion resistance protein, which are expressible in plant cells. The metal resistance protein provides for the enzymatic reduction of metal ions including by not limited to divalent Cu, divalent mercury, trivalent gold, divalent cadmium, lead ions and monovalent silver ions. Transgenic plants which express these coding sequences exhibit increased resistance to metal ions in the environment as compared with plants which have not been so genetically modified. Transgenic plants which are resistant to organomercurials including alkylmercury compounds, among others, are provided by the further inclusion of plant-expressible organomercurial lyase coding sequences. Furthermore, these transgenic plants which have been genetically modified to express the metal resistance coding sequences of the present invention can participate in the bioremediation of metal contamination via the enzymatic reduction of metal ions. Transgenic plants resistant to organomercurials can further mediate remediation of alkylmercury compounds in the environment by causing the freeing of mercuric ions and the reduction of the ionic mercury to the less toxic elemental mercury.
摘要翻译：本发明提供编码金属离子电阻蛋白的核酸序列，其可在植物细胞中表达。金属电阻蛋白提供金属离子的酶还原，包括不限于二价Cu，二价汞，三价金，二价镉，铅离子和一价银离子。与未经遗传修饰的植物相比，表达这些编码序列的转基因植物表现出对环境中金属离子的增加的抗性。通过进一步包含植物可表达的有机体裂解酶编码序列，提供对包括烷基汞化合物在内的有机体活性物质具有抗性的转基因植物。此外，经遗传修饰以表达本发明的金属电阻编码序列的这些转基因植物可以通过金属离子的酶还原来参与金属污染物的生物修复。通过使汞离子释放和将离子汞还原成毒性较小的元素汞，可以进一步介导对有机体药物有抗性的转基因植物来调节环境中烷基汞化合物的修复。

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