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1. 发明授权

US5378807A .gamma.-poly(glutamic acid) esters 失效
标题翻译： γ-聚（谷氨酸）酯
公开(公告)号：US5378807A
公开(公告)日：1995-01-03
申请号：US832255
申请日：1992-02-07
申请人： Richard A. Gross , Stephen P. McCarthy , Devang T. Shah
发明人： Richard A. Gross , Stephen P. McCarthy , Devang T. Shah
IPC分类号： B60R25/10 , B62J3/00 , G08B3/10 , C07K7/10
CPC分类号： B60R25/1001 , B62J3/00 , G08B3/10
摘要： A method is disclosed for significantly diminishing the rate of degradation of naturally-produced .gamma.-PGA in a .gamma.-PGA-producing cell culture. Also, a method is disclosed for significantly decreasing the water solubility coefficient of naturally-produced .gamma.-PGA by forming derivatives of .gamma.-PGA. In addition, a polymer solution is disclosed which includes a polysaccharide component and a .gamma.-PGA component.
摘要翻译：公开了一种显着降低在产生γ-PGA的细胞培养物中天然产生的γ-PGA降解速率的方法。此外，公开了通过形成γ-PGA的衍生物来显着降低天然产生的γ-PGA的水溶性系数的方法。此外，公开了一种聚合物溶液，其包括多糖组分和γ-PGA组分。

2. 发明授权

US5440007A Composition of and method for forming high molecular weight predominantly syndiotactic substituted-poly (.beta.-propioesters) 失效
标题翻译：高分子量主要间同立构取代聚（β-丙酸酯）的组成和方法
公开(公告)号：US5440007A
公开(公告)日：1995-08-08
申请号：US232870
申请日：1994-04-25
申请人： Richard A. Gross , John E. Kemnitzer , Stephen P. McCarthy
发明人： Richard A. Gross , John E. Kemnitzer , Stephen P. McCarthy
IPC分类号： C08G63/08 , C08G63/82 , C08L67/04
CPC分类号： C08G63/823 , C08G63/08 , C08L67/04
摘要： High molecular weight, biodegradable polymers of substituted-poly(.beta.-propioesters), wherein the repeat unit sequences have a predominantly syndiotactic arrangement and a method of forming such polymers are disclosed. The method includes exposing a substituted-.beta.-propiolactone to a tin-based organometallic catalyst for a sufficient combination of time and temperature to form the predominantly syndiotactic substituted-poly(.beta.-propioester).
摘要翻译：公开了取代聚（β-丙酰酯）的高分子量可生物降解的聚合物，其中重复单元序列具有主要的间同立构排列和形成这种聚合物的方法。该方法包括将取代的β-丙内酯暴露于锡基有机金属催化剂以充分地组合时间和温度以形成主要间同立构取代的聚（β-丙酸酯）。

3. 发明授权

US6093792A Bioresorbable copolymers 失效
标题翻译：生物可吸收共聚物
公开(公告)号：US6093792A
公开(公告)日：2000-07-25
申请号：US154332
申请日：1998-09-16
申请人： Richard A. Gross , Xianhai Chen , Stephen P. McCarthy
发明人： Richard A. Gross , Xianhai Chen , Stephen P. McCarthy
IPC分类号： A61K9/00 , A61K9/70 , A61L17/12 , A61L31/06 , C08G63/64 , C08G63/08
CPC分类号： C08G63/64 , A61K9/70 , A61L17/12 , A61L31/06 , A61K9/0024
摘要： This invention relates to high molecular weight bioresorbable copolymers constructed to be useful for specific applications in the biomedical arts. Also provided is a new cyclic carbonate monomer, and copolymers containing the new monomers.
摘要翻译：本发明涉及构建成可用于生物医学领域的特定应用的高分子量生物可吸收共聚物。还提供了新的环状碳酸酯单体和含有新单体的共聚物。

4. 发明授权

US5883199A Polyactic acid-based blends 失效
标题翻译：聚乳酸基共混物
公开(公告)号：US5883199A
公开(公告)日：1999-03-16
申请号：US825810
申请日：1997-04-03
申请人： Stephen P. McCarthy , Richard A. Gross , Wenguang Ma
发明人： Stephen P. McCarthy , Richard A. Gross , Wenguang Ma
IPC分类号： A61L15/26 , A61L15/62 , B65D65/46 , C08J5/18 , C08L67/02 , C08L67/04 , C08F20/00 , B29D22/00
CPC分类号： C08J5/18 , A61L15/26 , A61L15/62 , B65D65/466 , C08L67/02 , C08L67/04 , C08J2367/04 , Y02W90/12 , Y02W90/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/1397
摘要： Biodegradable blends including a first, polylactic acid-based polymer or copolymer, and a second polymer or copolymer including one or more polyesters, e.g., an aliphatic polyester or a polyester of one aliphatic C.sub.2 to C.sub.20 diacid or of a combination of two more different aliphatic C.sub.2 to C.sub.20 diacids, wherein the first and second polymers are present in a ratio of 9:1 to 1:9, are described.
摘要翻译：包括第一聚乳酸类聚合物或共聚物的生物可降解共混物以及包含一种或多种聚酯的第二聚合物或共聚物，例如一种脂肪族聚酯或一种脂族C 2 -C 20二酸的聚酯或两种更不同的脂族描述了C2至C20二酸，其中第一和第二聚合物以9:1至1:9的比率存在。

5. 发明授权

US5439985A Biodegradable and hydrodegradable diblock copolymers composed of poly(.beta . 失效
标题翻译：由聚（β-羟基链烷酸酯）和聚（内酯）或聚（丙交酯）链段组成的可生物降解和可降解的二嵌段共聚物
公开(公告)号：US5439985A
公开(公告)日：1995-08-08
申请号：US98709
申请日：1993-07-28
申请人： Richard A. Gross , Stephen P. McCarthy , Michael S. Reeve
发明人： Richard A. Gross , Stephen P. McCarthy , Michael S. Reeve
IPC分类号： C08G63/08 , C08G63/84
CPC分类号： C08G63/08
摘要： A biodegradable and hydrodegradable diblock copolymer includes a naturally-occurring poly(.beta.-alkanoate) component and a chemically synthesized polyester component formed by ring-opening polymerization. A method of forming the biodegradable and hydrodegradable diblock copolymer having a poly(.beta.-hydroxyalkanoate) component and a chemically synthesized polyester component includes exposing a naturally-occurring poly(.beta.-hydroxyalkanoate) to alcoholysis and then to a trialkyl metal to form a dialkyl metal poly(.beta.-hydroxyalkanoate) macroinitiator. The macroinitiator is then reacted with a lactone or lactide reactant to form the biodegradable and hydrodegradable diblock copolymer.
摘要翻译：可生物降解和可降解的二嵌段共聚物包括天然存在的聚（β-链烷酸酯）组分和通过开环聚合形成的化学合成的聚酯组分。形成具有聚（β-羟基链烷酸酯）组分和化学合成的聚酯组分的可生物降解和可降解的二嵌段共聚物的方法包括将天然存在的聚（β-羟基链烷酸酯）暴露于醇解，然后暴露于三烷基金属以形成二烷基金属聚（β-羟基链烷酸酯）大分子引发剂。然后将大引发剂与内酯或丙交酯反应物反应以形成可生物降解和可降解的二嵌段共聚物。

6. 发明申请

US20110020227A1 POLYSACCHARIDE-CONTAINING BLOCK COPOLMER PARTICLES AND USES THEREOF 审中-公开
标题翻译：含多糖嵌段共聚物颗粒及其用途
公开(公告)号：US20110020227A1
公开(公告)日：2011-01-27
申请号：US12820887
申请日：2010-06-22
申请人： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
发明人： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
IPC分类号： A61K49/00 , A61K9/14 , A61K47/36 , A61K38/02 , A61K31/7088 , A61P35/04 , A61P31/04 , A61P31/12 , A61P7/00 , A61P35/00 , A61P9/10 , A61P29/00 , A61P15/00 , A61P25/24 , A61P3/10 , A61K38/28
CPC分类号： A61K47/36 , A61K9/1075 , A61K9/5153 , A61K38/28 , A61K51/1244 , G01N33/5088 , Y10T428/2991 , Y10T436/144444
摘要： The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.
摘要翻译：本发明涉及多糖和聚合物的新型两亲线性嵌段共聚物。两亲性线性嵌段共聚物在水中不形成真正的溶液，并且能够在选择性溶剂中形成胶束。还公开了通过使用这些颗粒，每个颗粒具有壳和芯，直径约为1-1000纳米，以及通过使用这些颗粒从受试者或环境中递送物质或除去物质，例如不需要的物质的方法。

7. 发明授权

US06440593B2 Molded article 失效
标题翻译：成型品
公开(公告)号：US06440593B2
公开(公告)日：2002-08-27
申请号：US09775416
申请日：2001-02-01
申请人： Thomas M. Ellison , Arthur K. Delusky , Robert Lucke , Stephen P. McCarthy
发明人： Thomas M. Ellison , Arthur K. Delusky , Robert Lucke , Stephen P. McCarthy
IPC分类号： H01B510
CPC分类号： B32B27/20 , Y10S428/923 , Y10S428/925 , Y10S428/931 , Y10T428/249924 , Y10T428/24993 , Y10T428/26 , Y10T428/2931 , Y10T428/294
摘要： A molded plastic article having improved electromagnetic interference (EMI) shielding properties. The article includes a plastic layer and an outer film layer over the plastic layer. The outer film layer has an inner surface adjacent to and bonded to the plastic layer and an outer surface opposed to the inner surface. The plastic layer and outer layer are electrically conductive. Preferably the outer layer has higher conductivity than the plastic layer.
摘要翻译：具有改进的电磁干扰（EMI）屏蔽性能的模制塑料制品。该制品包括塑料层和塑料层上的外部薄膜层。外膜层具有与塑料层相邻并与其结合的内表面和与内表面相对的外表面。塑料层和外层是导电的。优选地，外层具有比塑料层更高的导电性。

8. 发明授权

US07763663B2 Polysaccharide-containing block copolymer particles and uses thereof 有权
标题翻译：含多糖嵌段共聚物颗粒及其用途
公开(公告)号：US07763663B2
公开(公告)日：2010-07-27
申请号：US10324825
申请日：2002-12-19
申请人： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
发明人： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
IPC分类号： A61K47/00
CPC分类号： A61K47/36 , A61K9/1075 , A61K9/5153 , A61K38/28 , A61K51/1244 , G01N33/5088 , Y10T428/2991 , Y10T436/144444
摘要： The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.
摘要翻译：本发明涉及多糖和聚合物的新型两亲线性嵌段共聚物。两亲性线性嵌段共聚物在水中不形成真正的溶液，并且能够在选择性溶剂中形成胶束。还公开了通过使用这些颗粒，每个颗粒具有壳和芯，直径约为1-1000纳米，以及通过使用这些颗粒从受试者或环境中递送物质或除去物质，例如不需要的物质的方法。

9. 发明授权

US06670028B2 Molded article and process for preparing same 失效
标题翻译：成型制品及其制备方法
公开(公告)号：US06670028B2
公开(公告)日：2003-12-30
申请号：US09881751
申请日：2001-06-15
申请人： Thomas M. Ellison , Stephen P. McCarthy , Arthur K. Delusky , Qing Guan
发明人： Thomas M. Ellison , Stephen P. McCarthy , Arthur K. Delusky , Qing Guan
IPC分类号： B32B3300
CPC分类号： B32B27/00 , B29C70/086 , B29C70/467 , B32B27/12 , B32B2038/0076 , B32B2305/08 , B44C1/10 , B44C3/02 , Y10T428/24994 , Y10T428/249949 , Y10T428/24995 , Y10T428/249951 , Y10T428/2904 , Y10T428/2907
摘要： A molded article including a plastic layer and an outer film over the plastic layer forming a composite laminate with the plastic layer and a process for preparing same. The outer film has an inner surface adjacent and bonded to the plastic layer and an outer surface opposed to the inner surface. The molded article also includes a reinforcing material adhered to the inner surface of the outer film layer and preferably at least partly embedded in the inner surface of the outer film layer.
摘要翻译：一种模塑制品，包括塑料层上的塑料层和外膜，与塑料层形成复合层压材料及其制备方法。外部薄膜具有与塑料层相邻并接合的内表面和与内表面相对的外表面。成型品还包括附着在外膜层的内表面上的增强材料，优选至少部分地嵌入外膜层的内表面。

10. 发明申请

US20100040883A1 POLYSACCHARIDE-CONTAINING BLOCK COPOLYMER PARTICLES AND USES THEREOF 有权
标题翻译：含多糖嵌段共聚物颗粒及其用途
公开(公告)号：US20100040883A1
公开(公告)日：2010-02-18
申请号：US10324825
申请日：2002-12-19
申请人： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
发明人： Stephen P. McCarthy , Balint Koroskenyi , Robert J. Nicolosi
IPC分类号： B32B1/00 , C07H3/00
CPC分类号： A61K47/36 , A61K9/1075 , A61K9/5153 , A61K38/28 , A61K51/1244 , G01N33/5088 , Y10T428/2991 , Y10T436/144444
摘要： The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.
摘要翻译：本发明涉及多糖和聚合物的新型两亲线性嵌段共聚物。两亲性线性嵌段共聚物在水中不形成真正的溶液，并且能够在选择性溶剂中形成胶束。还公开了通过使用这些颗粒，每个颗粒具有壳和芯，直径约为1-1000纳米，以及通过使用这些颗粒从受试者或环境中递送物质或除去物质，例如不需要的物质的方法。

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