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1. 发明授权

US5750399A Isoflavone reductase promoter 失效
标题翻译：异黄酮还原酶启动子
公开(公告)号：US5750399A
公开(公告)日：1998-05-12
申请号：US339129
申请日：1994-11-14
申请人： Richard A. Dixon , Nancy L. Paiva , Abraham Oommen
发明人： Richard A. Dixon , Nancy L. Paiva , Abraham Oommen
IPC分类号： A01H5/00 , C12N5/10 , C12N9/02 , C12N15/00 , C12N15/09 , C12N15/82 , C12R1/91 , C12N5/04 , C12N15/29
CPC分类号： C12N9/001 , C12N15/8239
摘要： The invention relates to a promoter and associated control elements derived from the isoflavone reductase gene. The upstream activating region and portions thereof have been characterized as to their ability to control the transcription of operably linked foreign structural genes in legumes as well as in plants which lack the isoflavonoid pathway.
摘要翻译：本发明涉及由异黄酮还原酶基因衍生的启动子和相关控制元件。上游活化区及其部分已被表征为它们在豆类以及缺乏异黄酮途径的植物中控制可操作连接的外来结构基因转录的能力。

2. 发明授权

US07622638B2 Genetic manipulation of condensed tannins 有权
标题翻译：浓缩单宁的遗传操作
公开(公告)号：US07622638B2
公开(公告)日：2009-11-24
申请号：US10610351
申请日：2003-06-30
申请人： Richard A. Dixon , Nancy L. Paiva , Deyu Xie , Shashi Sharma
发明人： Richard A. Dixon , Nancy L. Paiva , Deyu Xie , Shashi Sharma
IPC分类号： A01H5/00 , A01H5/10 , A01H1/00 , C12N15/82 , C12N15/53
CPC分类号： C12N9/0006 , C12N15/8243 , C12N15/825
摘要： The invention provides method and compositions for the modulation of condensed tannin production in plants. The methods of the invention allow creation of plants having novel phenotypes. Increased expression of condensed tannins in plants may be used to increase the nutritional value of food plants for both human and animal consumption. Increased condensed tannin content also reduces the potential for bloat in animals fed certain forage plants low in condensed tannin content. The invention may also be used to modify plant pigmentation.
摘要翻译：本发明提供用于调节植物中缩合单宁生产的方法和组合物。本发明的方法允许产生具有新表型的植物。植物中浓缩单宁的增加表达可用于增加食用植物对人和动物消费的营养价值。浓缩单宁含量的增加也降低了饲喂低浓缩单宁含量的某些牧草植物的动物的膨胀潜力。本发明也可用于修饰植物色素沉着。

3. 发明申请

US20100064387A1 EPICATECHIN GLUCOSYLTRANSFERASE 有权
公开(公告)号：US20100064387A1
公开(公告)日：2010-03-11
申请号：US12549248
申请日：2009-08-27
申请人： Richard A. Dixon , Yongzhen Pang , Gregory J. Peel
发明人： Richard A. Dixon , Yongzhen Pang , Gregory J. Peel
IPC分类号： A01H1/00 , C07H21/00 , C12N15/74 , C12N9/10 , A01H5/00 , C12N5/04
CPC分类号： C12N15/8243 , C12N9/1051
摘要： The invention provides methods and compositions for the modulation of epicatechin glucosyltransferase activity in plants. Increased expression of epicatechin glucosides, and ultimately anthocyanins and proanthocyanidins, in plants may be used to increase the nutritional value of food plants for both human and animal consumption. Increased proanthocyanidin content also reduces the potential for bloat in animals fed certain forage plants low in condensed tannin content.
摘要翻译：本发明提供了用于调节植物中表儿茶素葡糖基转移酶活性的方法和组合物。植物中表儿茶素葡萄糖苷和最终花青素和原花青素的表达增加可用于增加食用植物对人和动物消费的营养价值。增加的原花青素含量也降低了饲喂某些低浓缩单宁含量的饲料中的动物的膨胀的可能性。

4. 发明授权

US07663023B2 Modification of lignin biosynthesis 有权
标题翻译：木质素生物合成修饰
公开(公告)号：US07663023B2
公开(公告)日：2010-02-16
申请号：US11189109
申请日：2005-07-25
申请人： Richard A. Dixon , M. S. Srinivasa Reddy , Fang Chen
发明人： Richard A. Dixon , M. S. Srinivasa Reddy , Fang Chen
IPC分类号： A01H1/00 , C12N15/82 , C12N15/87
CPC分类号： C12N15/827 , C12N15/8255 , C12N15/8261 , Y02A40/146
摘要： The invention provides methods for decreasing lignin content and improving lignin profiles. Also provided are the plants prepared by the methods of the invention. Such plants may exhibit improved digestibility relative to prior plants.
摘要翻译：本发明提供了降低木质素含量和改善木质素分布的方法。还提供了通过本发明的方法制备的植物。相对于现有植物，这样的植物可以表现出改善的消化率。

5. 发明授权

US07038113B1 Genetic manipulation of isoflavonoids 失效
标题翻译：异黄酮的遗传操作
公开(公告)号：US07038113B1
公开(公告)日：2006-05-02
申请号：US09936190
申请日：2000-03-08
申请人： Richard A. Dixon , Christopher L. Steele
发明人： Richard A. Dixon , Christopher L. Steele
IPC分类号： C12N15/29 , C12N15/63 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N9/0077 , C12N15/8243 , C12N15/825 , C12N15/8261 , Y02A40/146
摘要： Soybean and Medicago truncatula CYP93C genes have been isolated which encode a cytochrome P450 that can catalyze the aryl migration of a flavanone to yield an isoflavanone intermediate or an isoflavone. Plants can now be genetically engineered to produce isoflavones that provide potential human health benefits and increase disease resistance in plants. Isoflavones can now be produced in transgenic plants species in which isoflavones do not naturally occur, i.e., in species other than legumes. Alternatively, introducing infection-inducible isoflavonoid biosynthesis into non-legumes qualitatively complements these plants phytoalexin defenses against microbial pathogens, whereas over-expression of the isoflavonoid pathway in legumes quantitatively increases this defense response. Finally, modifying the extend of production of isoflavonoids in legume roots positively impacts nodulation efficiency and therefore plant yield.
摘要翻译：已经分离出大豆和苜蓿Truncatula CYP93C基因，其编码细胞色素P450，其可以催化黄烷酮的芳基迁移以产生异黄酮中间体或异黄酮。植物现在可以进行基因工程，以生产提供潜在的人类健康益处并增加植物抗病性的异黄酮。异黄酮现在可以在其中不是天然存在异黄酮的转基因植物物种中生产，即在除豆类之外的物种中。或者，将感染诱导型异黄酮生物合成引入非豆科植物定性补充这些植物对微生物病原体的植物抗毒素抗性，而豆类中异黄酮途径的过表达量则定量增加了这种防御反应。最后，修改豆科植物中异黄酮生产的延伸对结瘤效率和植株产量产生积极影响。

6. 发明授权

US06447462B1 Urodynamic catheter and methods of fabrication and use 有权
标题翻译：尿动力导管及其制造和使用方法
公开(公告)号：US06447462B1
公开(公告)日：2002-09-10
申请号：US09504972
申请日：2000-02-15
申请人： Wm. Dean Wallace , Christopher A. Cutler , Steven R. Smith , Richard A. Dixon
发明人： Wm. Dean Wallace , Christopher A. Cutler , Steven R. Smith , Richard A. Dixon
IPC分类号： A61B500
CPC分类号： A61M25/1011 , A61B5/02156 , A61B5/202 , A61B5/205 , A61M25/10 , A61M2025/0003 , A61M2025/1061 , A61M2205/3344 , A61M2210/1085
摘要： A urodynamic catheter incorporating at least one balloon adjacent a distal end thereof and associated with a pressure lumen extending to a proximal end to be placed external to the body of a patient and usable with a transducer housing including a pressure transducer and a mechanism for alternatively venting an air column defined by the assembled pressure lumen and transducer housing to the ambient environment and closing the air column and charging it with air while reducing volume of the air column. One embodiment includes two, separately-chargeable balloons and a bladder fill tube, another embodiment includes a single balloon and a fill tube, and yet another embodiment, suitable for use as a reference catheter to measure abdominal pressure, includes only a single balloon and omits the fill tube. A novel catheter architecture and assembly technique are also disclosed, as are methods of using the inventive catheter.
摘要翻译：一种尿动力导管，其包括邻近其远端的至少一个气囊，并且与延伸到近端的压力腔相关联，以放置在患者身体外部并且可用于包括压力换能器和换气器的机构的换能器壳体空气柱由组装的压力腔和换能器壳体限定到周围环境，并关闭空气塔并且用空气充电，同时减少空气柱的体积。一个实施例包括两个可分开充电的气囊和气囊填充管，另一个实施例包括单个球囊和填充管，并且适于用作测量腹压的参考导管的又一个实施例仅包括单个球囊并省略填充管。还公开了新颖的导管结构和装配技术，以及使用本发明的导管的方法。

7. 发明授权

US5530187A Transgenic plants containing multiple disease resistance genes 失效
标题翻译：含有多种抗病性基因的转基因植物
公开(公告)号：US5530187A
公开(公告)日：1996-06-25
申请号：US93372
申请日：1993-07-16
申请人： Christopher J. Lamb , Qun Zhu , Eileen A. Maher , Richard A. Dixon
发明人： Christopher J. Lamb , Qun Zhu , Eileen A. Maher , Richard A. Dixon
IPC分类号： A01H5/00 , C12N5/10 , C12N9/24 , C12N15/09 , C12N15/82 , C12N9/42 , C12N15/29 , C12N15/56
CPC分类号： C12Y302/01014 , C12N15/8282 , C12N9/2408 , C12Y302/01059
摘要： In accordance with the present invention, there are provided transgenic plants comprising a plurality of plant-defense-associated proteins that are expressed to produce such proteins in an amount sufficient to increase the plants resistance to plant pathogens, relative to non-transgenic plants of the same species. The transgenic plants are useful to study patterns of development, and to provide increased resistance to plant pathogens when grown in crops as a food source, and the like. Nucleic acid constructs are also provided that are useful in methods for producing the invention transgenic plants.
摘要翻译：根据本发明，提供转基因植物，其包含多个植物防御相关蛋白，其表达以相对于植物病原体的非转基因植物产生足以增加植物对植物病原体的抗性的量的蛋白质同一物种转基因植物可用于研究发育模式，并且在作物作为食物来源生长时提供对植物病原体的增加的抗性。还提供了可用于制备本发明转基因植物的方法的核酸构建体。

8. 发明授权

US09309528B2 Biofuel production methods and compositions 有权
标题翻译：生物燃料生产方法和组成
公开(公告)号：US09309528B2
公开(公告)日：2016-04-12
申请号：US11944217
申请日：2007-11-21
申请人： Richard A. Dixon , Fang Chen , Zengyu Wang
发明人： Richard A. Dixon , Fang Chen , Zengyu Wang
IPC分类号： A01H5/00 , A01H5/10 , C12N15/82 , C12P7/06
CPC分类号： C12N15/8245 , C12N15/8255 , Y02E50/17
摘要： The invention provides methods for increasing the level of fermentable carbohydrates in a biofuel crop plant such as alfalfa or switchgrass, by modification of the lignin biosynthetic pathway. Also provided are plants prepared by the methods of the invention. Methods for processing plant tissue and for producing ethanol by utilizing such plants are also provided.
摘要翻译：本发明提供了通过修饰木质素生物合成途径来增加生物燃料作物植物如苜蓿或柳枝稷中可发酵碳水化合物的水平的方法。还提供了通过本发明的方法制备的植物。还提供了利用这些植物处理植物组织和生产乙醇的方法。

9. 发明授权

US09121031B2 Methods and compositions for regulating production of proanthocyanidins 有权
标题翻译：用于调节原花青素生产的方法和组合物
公开(公告)号：US09121031B2
公开(公告)日：2015-09-01
申请号：US13444507
申请日：2012-04-11
申请人： Jerome A. Verdier , Jian Zhao , Richard A. Dixon , Michael K. Udvardi
发明人： Jerome A. Verdier , Jian Zhao , Richard A. Dixon , Michael K. Udvardi
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/825 , C07K14/415
摘要： The invention provides methods and compositions for the modulation of proanthocynidin (“PA;” condensed tannin) production in plants. The methods of the invention allow creation of plants having novel phenotypes, such as alterations in levels of PA or in the types of tissues in which PAs are produced. Altered expression of PA in plants may be achieved, for instance without significantly affecting anthocyanin content or overall secondary metabolite profiles. Alternatively, expression of PA in plants may be achieved while also affecting anthocyanin content.
摘要翻译：本发明提供用于调节植物中原花色素（“PA”，“缩合鞣酸”）生产的方法和组合物。本发明的方法允许产生具有新表型的植物，例如PA水平的改变或其中产生PA的组织类型。可以实现植物中PA的改变的表达，例如不显着影响花青素含量或总体次级代谢物分布。或者，可以在植物中表达PA，同时也影响花青素含量。

10. 发明授权

US08420889B2 Epicatechin glucosyltransferase 有权
标题翻译：表儿茶素葡糖基转移酶
公开(公告)号：US08420889B2
公开(公告)日：2013-04-16
申请号：US12549248
申请日：2009-08-27
申请人： Richard A. Dixon , Yongzhen Pang , Gregory J. Peel
发明人： Richard A. Dixon , Yongzhen Pang , Gregory J. Peel
IPC分类号： A01H5/00 , C12N15/52 , C12N15/85 , C12N9/10
CPC分类号： C12N15/8243 , C12N9/1051
摘要： The invention provides methods and compositions for the modulation of epicatechin glucosyltransferase activity in plants. Increased expression of epicatechin glucosides, and ultimately anthocyanins and proanthocyanidins, in plants may be used to increase the nutritional value of food plants for both human and animal consumption. Increased proanthocyanidin content also reduces the potential for bloat in animals fed certain forage plants low in condensed tannin content.
摘要翻译：本发明提供了用于调节植物中表儿茶素葡糖基转移酶活性的方法和组合物。植物中表儿茶素葡萄糖苷和最终花青素和原花青素的表达增加可用于增加食用植物对人和动物消费的营养价值。增加的原花青素含量也降低了饲喂某些低浓缩单宁含量的饲料中的动物的膨胀的可能性。

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