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1. 发明授权

US6090955A Liposome-encapsulated taxol, its preparation and its use 失效
标题翻译：脂质体包裹的紫杉醇，其制备及其用途
公开(公告)号：US6090955A
公开(公告)日：2000-07-18
申请号：US793238
申请日：1997-06-19
申请人： Regine Reszka , Martin Brandl , Iduna Fichtner , Gernot Warnke
发明人： Regine Reszka , Martin Brandl , Iduna Fichtner , Gernot Warnke
IPC分类号： A61K9/00 , A61K9/127 , A61K31/335 , A61K31/337 , A61K31/555 , C07D493/00
CPC分类号： A61K9/0078 , A61K31/337 , A61K31/555 , A61K9/1277
摘要： The aim of the invention is to produce liposome-encapsulated taxol with a high taxol concentration and high stability and hence a high therapeutic effect. The invention involves the development of specific forms of taxol encapsulation and the use of these, optionally in combination with other substances, in the treatment of various types of tumor. The liposome-encapsulated taxol is characterized in that it is prepared by high-pressure homogenization or by aerosol formulation.
摘要翻译： PCT No.PCT / DE95 / 01163 Sec。 371日期：1997年6月19日 102（e）日期1997年6月19日PCT 1995年8月18日PCT PCT。公开号WO96 / 05821 日期1996年2月29日本发明的目的是制备具有高紫杉醇浓度和高稳定性的脂质体包裹的紫杉醇，因此具有高治疗效果。本发明涉及特定形式的紫杉醇包封的开发，以及它们的使用，任选地与其他物质组合用于治疗各种类型的肿瘤。脂质体包裹的紫杉醇的特征在于其通过高压均化或通过气溶胶制剂制备。

2. 发明授权

US06399094B1 Unilamellar liposomal preparations with high active substance content 失效
标题翻译：具有高活性物质含量的单层脂质体制剂
公开(公告)号：US06399094B1
公开(公告)日：2002-06-04
申请号：US08803435
申请日：1997-02-20
申请人： Martin Brandl , Dieter Bachmann , Regine Reszka , Markus Drechsler
发明人： Martin Brandl , Dieter Bachmann , Regine Reszka , Markus Drechsler
IPC分类号： A61K9127
CPC分类号： A61K9/1277 , Y10T428/2984
摘要： A liposomal vesicular preparation with good encapsulation efficiency for active ingredients, based on homogeneous unilamellar liposomal vesicular lipids, has a substantially tightly packed vesicular structure and forms carriers of active ingredients. At least 20% by weight relative to the total weight of the liposomal vesicular preparation of the active ingredient (drug substances, vaccines, diagnostics, vectors) are present in encapsulated form inside the homogeneous unilamellar liposomal vesicular lipids. The liposomal vesicular preparation is a semi-solid liposomal vesicular lipid gel. The membrane forming amphiphiles can be members of from the group consisting of lipids, phospholipids and synthetic amphiphiles.
摘要翻译：基于均匀的单层脂质体囊泡脂质的活性成分具有良好包封效率的脂质体囊泡制剂具有基本上紧密包装的囊泡结构并形成活性成分的载体。相对于活性成分的脂质体水泡制剂（药物，疫苗，诊断剂，载体）的总重量，至少20重量％以包封形式存在于均匀的单层脂质体囊泡脂质内。脂质体囊泡制剂是半固体脂质体囊泡脂质凝胶。形成两亲物的膜可以是由脂质，磷脂和合成两亲物组成的组的成员。

3. 发明申请

US20140168988A1 OPTICAL ELEMENT, OPTOELECTRONIC COMPONENT AND METHOD FOR THE PRODUCTION THEREOF 有权
标题翻译：光学元件，光电元件及其生产方法
公开(公告)号：US20140168988A1
公开(公告)日：2014-06-19
申请号：US14119711
申请日：2012-05-23
申请人： Kirstin Petersen , Stephan Preuss , Markus Pindl , Markus Boss , Martin Brandl
发明人： Kirstin Petersen , Stephan Preuss , Markus Pindl , Markus Boss , Martin Brandl
IPC分类号： F21K99/00 , H01L33/58 , H01L33/50
CPC分类号： F21K9/50 , B29C43/021 , B29C43/20 , B29D11/0073 , B29D11/00807 , F21K9/60 , H01L24/97 , H01L25/0753 , H01L33/50 , H01L33/505 , H01L33/507 , H01L33/58 , H01L2924/12036 , H01L2924/12041 , H01L2924/12042 , H01L2924/15787 , H01L2924/181 , H01L2924/1815 , H01L2933/0041 , H01L2933/0058 , H01L2933/0091 , H01L2924/00
摘要： An optical element for light outcoupling and/or conversion of light includes a light-emitting semiconductor chip with at least one layer selected from a wavelength conversion layer, a scattering layer, a light outcoupling layer and a lens layer, which each includes a plastics material processable in a compression molding method.
摘要翻译：用于光输出耦合和/或转换光的光学元件包括具有选自波长转换层，散射层，光输出耦合层和透镜层中的至少一个层的发光半导体芯片，每个包括塑料材料可在压缩成型方法中加工。

4. 发明申请

US20130309788A1 Leadframe for Optoelectronic Components and Method for Producing Optoelectronic Components 有权
标题翻译：光电元件的引线框架和光电子元件的制造方法
公开(公告)号：US20130309788A1
公开(公告)日：2013-11-21
申请号：US13885912
申请日：2012-01-31
申请人： Martin Brandl , Tobias Gebuhr , Markus Pindl , Albert Schneider
发明人： Martin Brandl , Tobias Gebuhr , Markus Pindl , Albert Schneider
IPC分类号： H01L33/62
CPC分类号： H01L33/62 , H01L21/561 , H01L23/49541 , H01L23/49548 , H01L24/29 , H01L24/83 , H01L24/97 , H01L33/0095 , H01L2224/29191 , H01L2224/32245 , H01L2224/83192 , H01L2924/00013 , H01L2924/12041 , H01L2924/12042 , H01L2224/13099 , H01L2224/13599 , H01L2224/05599 , H01L2224/05099 , H01L2224/29099 , H01L2224/29599 , H01L2924/00
摘要： A leadframe for producing a number of optoelectronic components is specified. At least one mounting region includes a number of chip mounting areas for a number of semiconductor chips. Alongside the mounting region at at least one main area of the leadframe one or more of grooves for reducing mechanical stresses in the leadframe are formed. The groove(s) do not completely penetrate through the leadframe. A method for producing a number of optoelectronic components on a leadframe of this type is furthermore specified.
摘要翻译：指定了用于生产多个光电子部件的引线框架。至少一个安装区域包括用于多个半导体芯片的多个芯片安装区域。在引线框架的至少一个主要区域上的安装区域之外，形成用于减小引线框架中的机械应力的一个或多个凹槽。凹槽不完全穿透引线框架。进一步规定了在这种类型的引线框上产生多个光电子部件的方法。

5. 发明申请

US20140167303A1 PRESSING TOOL AND METHOD FOR PRODUCING A SILICONE ELEMENT 审中-公开
标题翻译：压制工具和生产硅胶元件的方法
公开(公告)号：US20140167303A1
公开(公告)日：2014-06-19
申请号：US14238218
申请日：2012-08-31
申请人： Markus Boss , Martin Brandl , Markus Pindl
发明人： Markus Boss , Martin Brandl , Markus Pindl
IPC分类号： B29C43/58 , B29C43/20
CPC分类号： B29C43/58 , B29C43/18 , B29C43/203 , H01L21/565 , H01L2924/0002 , H01L2933/0041 , H01L2924/00
摘要： A pressing tool for pressing a silicone element may include: an upper pressing tool half and a lower pressing tool half, which in the closed state of the pressing tool form a cavity for pressing a silicone element, and a carrier foil, which bears on one of the pressing tool halves, for the silicone element to be pressed, wherein at least the upper pressing tool half or the lower pressing tool half has at least one clamping element for aligning the two pressing tool halves with respect to one another, and wherein the clamping element is arranged between the pressing tool halves and outside the region covered by the carrier foil.
摘要翻译：用于按压硅树脂元件的压制工具可以包括：在按压工具的关闭状态下形成用于挤压硅树脂元件的空腔的上压制工具半部和下压制工具半部以及承载在一个上的载体箔对于待挤压的硅树脂元件，其中至少上压制工具半部或下压制工具半部具有至少一个夹紧元件，用于使两个按压工具半部相对于彼此对准，并且其中，夹紧元件布置在挤压工具半部之间以及由载体箔覆盖的区域之外。

6. 发明申请

US20110208105A1 METHOD FOR DETECTING THE ION CONCENTRATIONS OF CITRATE ANTI-COAGULATED EXTRACORPOREAL BLOOD PURIFICATION 有权
标题翻译：检测CITRATE抗凝血提取物血液净化的离子浓度的方法
公开(公告)号：US20110208105A1
公开(公告)日：2011-08-25
申请号：US12675605
申请日：2008-08-28
申请人： Martin Brandl , Jens Hartmann , Karin Strobl , Dieter Falkenhagen
发明人： Martin Brandl , Jens Hartmann , Karin Strobl , Dieter Falkenhagen
IPC分类号： A61M1/14
CPC分类号： A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3458 , A61M1/3672 , A61M1/3675 , A61M2205/33
摘要： The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising: an extracorporeal blood purification system comprising an extracorporeal blood circuit (202), which comprises a dialysis unit (205), a blood inflow (203) and a blood discharge (204), a citrate metering device (212) for supplying citrate at a citrate supply point (213) upstream of the dialysis unit (205), a substitution medium metering device (214) for supplying a substitution medium at a substitution medium supply point (215) downstream from the dialysis unit (205), at least one ion concentration measuring means (224) for measuring bivalent cations and a controller (225), wherein the controller (225) is adapted to regulate the metering of the substitution medium as a function of a comparison between a setpoint value range and the ion concentration measured by means of the ion concentration measuring means (224), wherein the ion concentration measuring means (224) is adapted for the continuous generation of measuring values and is arranged upstream of the citrate supply point (213) and the controller (225) is adapted to continuously carry out a regulation of the metering of the citrate and of the substitution medium in consideration of a target value or target value range, which can be predetermined in the controller (225) downstream from the citrate supply point (213). The invention further relates to a method for detecting the ion concentration.
摘要翻译：本发明涉及一种用于柠檬酸盐抗凝血体外血液净化的装置，包括：体外血液净化系统，其包括体外血液回路（202），其包括透析单元（205），血液流入物（203）和血液放电（204），用于在所述透析单元（205）上游的柠檬酸盐供应点（213）处供应柠檬酸盐的柠檬酸盐计量装置（212），用于在置换介质供应点处供应置换介质的置换介质计量装置（215），用于测量二价阳离子的至少一个离子浓度测量装置（224）和控制器（225），其中所述控制器（225）适于将所述替代介质的计量调节为通过离子浓度测量装置（224）测定的设定点值范围和离子浓度之间的比较的功能，其中离子浓度测量装置（224）适于f 或连续产生测量值，并且设置在柠檬酸盐供应点（213）的上游，并且控制器（225）适于连续地执行柠檬酸盐和替代介质的计量的调节，以考虑目标值或目标值范围，其可以在柠檬酸盐供应点（213）下游的控制器（225）中预先确定。本发明还涉及一种用于检测离子浓度的方法。

7. 发明授权

US09366395B2 Optical element, optoelectronic component and method for the production thereof 有权
标题翻译：光学元件，光电元件及其制造方法
公开(公告)号：US09366395B2
公开(公告)日：2016-06-14
申请号：US14119711
申请日：2012-05-23
申请人： Kirstin Petersen , Stephan Preuss , Markus Pindl , Markus Boss , Martin Brandl
发明人： Kirstin Petersen , Stephan Preuss , Markus Pindl , Markus Boss , Martin Brandl
IPC分类号： F21V9/16 , F21K99/00 , H01L33/50 , B29D11/00 , B29C43/02 , H01L33/58 , H01L23/00 , H01L25/075 , B29C43/20
CPC分类号： F21K9/50 , B29C43/021 , B29C43/20 , B29D11/0073 , B29D11/00807 , F21K9/60 , H01L24/97 , H01L25/0753 , H01L33/50 , H01L33/505 , H01L33/507 , H01L33/58 , H01L2924/12036 , H01L2924/12041 , H01L2924/12042 , H01L2924/15787 , H01L2924/181 , H01L2924/1815 , H01L2933/0041 , H01L2933/0058 , H01L2933/0091 , H01L2924/00
摘要： An optical element for light outcoupling and/or conversion of light includes a light-emitting semiconductor chip with at least one layer selected from a wavelength conversion layer, a scattering layer, a light outcoupling layer and a lens layer, which each includes a plastics material processable in a compression molding method.
摘要翻译：用于光输出耦合和/或转换光的光学元件包括具有选自波长转换层，散射层，光输出耦合层和透镜层中的至少一个层的发光半导体芯片，每个包括塑料材料可在压缩成型方法中加工。

8. 发明授权

US09278171B2 Method for detecting the ion concentrations of citrate anti-coagulated extracorporeal blood purification 有权
标题翻译：用于检测柠檬酸盐抗凝血体外血液纯化离子浓度的方法
公开(公告)号：US09278171B2
公开(公告)日：2016-03-08
申请号：US12675605
申请日：2008-08-28
申请人： Martin Brandl , Jens Hartmann , Karin Strobl , Dieter Falkenhagen
发明人： Martin Brandl , Jens Hartmann , Karin Strobl , Dieter Falkenhagen
IPC分类号： A61M1/34 , A61M1/36 , A61M37/00
CPC分类号： A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3458 , A61M1/3672 , A61M1/3675 , A61M2205/33
摘要： The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising: an extracorporeal blood purification system comprising an extracorporeal blood circuit (202), which comprises a dialysis unit (205), a blood inflow (203) and a blood discharge (204), a citrate metering device (212) for supplying citrate at a citrate supply point (213) upstream of the dialysis unit (205), a substitution medium metering device (214) for supplying a substitution medium at a substitution medium supply point (215) downstream from the dialysis unit (205), at least one ion concentration measuring means (224) for measuring bivalent cations and a controller (225), wherein the controller (225) is adapted to regulate the metering of the substitution medium as a function of a comparison between a setpoint value range and the ion concentration measured by means of the ion concentration measuring means (224), wherein the ion concentration measuring means (224) is adapted for the continuous generation of measuring values and is arranged upstream of the citrate supply point (213) and the controller (225) is adapted to continuously carry out a regulation of the metering of the citrate and of the substitution medium in consideration of a target value or target value range, which can be predetermined in the controller (225) downstream from the citrate supply point (213). The invention further relates to a method for detecting the ion concentration.
摘要翻译：本发明涉及一种用于柠檬酸盐抗凝血体外血液净化的装置，包括：体外血液净化系统，其包括体外血液回路（202），其包括透析单元（205），血液流入物（203）和血液放电（204），用于在所述透析单元（205）上游的柠檬酸盐供应点（213）处供应柠檬酸盐的柠檬酸盐计量装置（212），用于在置换介质供应点处供应置换介质的置换介质计量装置（215），用于测量二价阳离子的至少一个离子浓度测量装置（224）和控制器（225），其中所述控制器（225）适于将所述替代介质的计量调节为通过离子浓度测量装置（224）测定的设定点值范围和离子浓度之间的比较的功能，其中离子浓度测量装置（224）适于f 或连续产生测量值，并且设置在柠檬酸盐供应点（213）的上游，并且控制器（225）适于连续地执行柠檬酸盐和替代介质的计量的调节，以考虑目标值或目标值范围，其可以在柠檬酸盐供应点（213）下游的控制器（225）中预先确定。本发明还涉及一种用于检测离子浓度的方法。

9. 发明授权

US09130136B2 Leadframe for optoelectronic components and method for producing optoelectronic components 有权
标题翻译：光电元件引线框架及光电元件生产方法
公开(公告)号：US09130136B2
公开(公告)日：2015-09-08
申请号：US13885912
申请日：2012-01-31
申请人： Martin Brandl , Tobias Gebuhr , Markus Pindl , Albert Schneider
发明人： Martin Brandl , Tobias Gebuhr , Markus Pindl , Albert Schneider
IPC分类号： H01L23/495 , H01L33/62 , H01L21/56 , H01L33/00 , H01L23/00
CPC分类号： H01L33/62 , H01L21/561 , H01L23/49541 , H01L23/49548 , H01L24/29 , H01L24/83 , H01L24/97 , H01L33/0095 , H01L2224/29191 , H01L2224/32245 , H01L2224/83192 , H01L2924/00013 , H01L2924/12041 , H01L2924/12042 , H01L2224/13099 , H01L2224/13599 , H01L2224/05599 , H01L2224/05099 , H01L2224/29099 , H01L2224/29599 , H01L2924/00
摘要： A leadframe for producing a number of optoelectronic components is specified. At least one mounting region includes a number of chip mounting areas for a number of semiconductor chips. Alongside the mounting region at at least one main area of the leadframe one or more of grooves for reducing mechanical stresses in the leadframe are formed. The groove(s) do not completely penetrate through the leadframe. A method for producing a number of optoelectronic components on a leadframe of this type is furthermore specified.
摘要翻译：指定了用于生产多个光电子部件的引线框架。至少一个安装区域包括用于多个半导体芯片的多个芯片安装区域。在引线框架的至少一个主要区域上的安装区域之外，形成用于减小引线框架中的机械应力的一个或多个凹槽。凹槽不完全穿透引线框架。进一步规定了在这种类型的引线框上产生多个光电子部件的方法。

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