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1. 发明授权

US09314588B2 Systems and methods for variable injection flow 有权
标题翻译：可变注射流量的系统和方法
公开(公告)号：US09314588B2
公开(公告)日：2016-04-19
申请号：US13300931
申请日：2011-11-21
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.
摘要翻译：公开了用于可控地变化的流体流动的系统和方法，其提供修改可用于流体流动的流体输送导管的有效横截面面积的能力。因此，选择性地控制这些构造允许在流体输送压力保持相同时根据需要调节流体流动。本文提供的其它配置允许选择性地操纵在单个过程期间用医疗装置实现的足迹或治疗模式，否定了去除和插入多个装置以实现治疗几何形状或特征的相同变化的需要。

2. 发明授权

US09320871B2 Systems and methods for variable injection flow 有权
公开(公告)号：US09320871B2
公开(公告)日：2016-04-26
申请号：US13409875
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

3. 发明授权

US09352121B2 Systems and methods for variable injection flow 有权
公开(公告)号：US09352121B2
公开(公告)日：2016-05-31
申请号：US13409646
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

4. 发明授权

US09050069B2 Thermocouple-controlled catheter cooling system 有权
标题翻译：热电偶控制导管冷却系统
公开(公告)号：US09050069B2
公开(公告)日：2015-06-09
申请号：US12122436
申请日：2008-05-16
申请人： Jean-Pierre Lalonde , Dan Wittenberger , Marwan Abboud , Constantin Bogdan Ciobotaru , Ramin Sabbaghe-Kermani
发明人： Jean-Pierre Lalonde , Dan Wittenberger , Marwan Abboud , Constantin Bogdan Ciobotaru , Ramin Sabbaghe-Kermani
IPC分类号： A61B18/02 , A61B18/00 , A61M25/01
CPC分类号： A61B18/02 , A61B2018/00023 , A61B2018/0022 , A61B2018/00797 , A61B2018/00821 , A61B2018/0212 , A61B2018/0262 , A61M25/0136
摘要： The present invention provides a medical system, including a catheter defining an injection lumen, a chamber in fluid communication with the injection lumen, and an exhaust lumen in fluid communication with the chamber; a first temperature sensor positioned in the exhaust lumen proximal to the chamber; a second temperature sensor positioned in the chamber; and a console in electrical communication with the first and second temperature sensors, the controller modifying coolant flow through the medical device based at least in part upon a signal received from the first and second temperature sensor. The system may further include a thermally-conductive element circumscribing a substantial portion of the exhaust lumen proximal to the chamber, where the first temperature sensor is mounted to the thermally-conductive element, and the thermally-conductive element may include at least one of a braid, coil, and band.
摘要翻译：本发明提供了一种医疗系统，其包括限定注射腔的导管，与注射腔流体连通的腔室和与腔室流体连通的排气腔; 定位在靠近所述腔室的所述排气腔内的第一温度传感器; 位于所述室中的第二温度传感器; 以及与所述第一和第二温度传感器电连通的控制台，所述控制器至少部分地基于从所述第一和第二温度传感器接收的信号来改变通过所述医疗设备的冷却剂流动。该系统还可以包括限定靠近腔室的排气腔的主要部分的导热元件，其中第一温度传感器安装到导热元件，并且导热元件可以包括以下中的至少一个：辫子，线圈和乐队。

5. 发明授权

US06270493B1 Cryoablation structure 有权
标题翻译：冷冻消融结构
公开(公告)号：US06270493B1
公开(公告)日：2001-08-07
申请号：US09356433
申请日：1999-07-19
申请人： Jean-Pierre Lalonde , Cristian Petre , Robert Martin , Claudia Lueckge , Sean Carroll , Dan Wittenberger , George Klein
发明人： Jean-Pierre Lalonde , Cristian Petre , Robert Martin , Claudia Lueckge , Sean Carroll , Dan Wittenberger , George Klein
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2017/00084 , A61B2018/00041 , A61B2018/0022 , A61B2018/0212 , A61B2018/0268
摘要： A cryocatheter for treatment of tissue includes a coolant line communicating with a cryochamber having a coolant receiving interior and a thermally conductive wall for contacting and conductively treating tissue. A return line returns spent coolant, and an insert or partition in the cryochamber conditions flow or channels fluid from the coolant line to the return line to enhance the rate or uniformity of cooling. The partition may extend axially to define an elongated sub-chamber which is preferentially cooled, or it may isolate one side to define an uncooled side of the cryochamber. The partition may extend axially to define a sub-chamber extending along a segmented length around a partial circumference of the catheter tip, or may channel the coolant from a central region outwardly against the peripheral wall of the cryochamber. The return line may be a vacuum return line. The catheter may include a means for warming the catheter tip to warm up or accelerate thawing of treated tissue, and the heating may be implemented by a heater in thermal contact with a fluid supply line, which may, moreover, be the coolant supply line. Alternatively, the warming fluid supply line may be distinct from the coolant line. In one embodiment, the device may connect the warming line as an additional coolant return line during cryotreatment, and switch its connection to supply warming fluid after the tissue has been cooled. The catheter may further include sensors such as thermal or impedance sensors for sensing contact orientation of the catheter against adjacent tissue. Electrodes may apply signals of two different frequencies to the two sides, and a processor may determine frequency, impedance or a differential temperature to indicate the tip contact orientation.
摘要翻译：用于治疗组织的低温灭菌器包括与具有冷却剂接收内部的冷冻箱和用于接触和导电地处理组织的导热壁连通的冷却剂管线。返回管路返回耗尽的冷却剂，冷冻箱条件中的插入物或分隔件将流体从冷却剂管路流向或返回管路，以提高冷却速度或均匀性。分隔件可以轴向延伸以限定优选冷却的细长子室，或者可以隔离一侧以限定冷冻箱的未冷却侧。分隔件可以轴向延伸以限定围绕导管尖端的部分圆周的分段长度延伸的子室，或者可以将冷却剂从中心区域向外引导抵靠冷冻箱的周壁。返回管线可以是真空回流管线。导管可以包括用于加温导管尖端以加热或加速经处理的组织的解冻的装置，并且加热可以通过与流体供应管线热接触的加热器来实现，流体供应管线还可以是冷却剂供应管线。或者，加温流体供应管线可以不同于冷却剂管线。在一个实施例中，该装置可以在冷冻处理期间将加热管线作为另外的冷却剂返回管线连接，并且在组织冷却之后将其连接切换到供应加热流体。导管还可以包括传感器，例如用于感测导管相对于相邻组织的接触取向的热传感器或阻抗传感器。电极可以将两个不同频率的信号施加到两侧，并且处理器可以确定频率，阻抗或差分温度以指示尖端接触取向。

6. 发明授权

US08043284B2 Cryosurgical catheter 有权
公开(公告)号：US08043284B2
公开(公告)日：2011-10-25
申请号：US12792376
申请日：2010-06-02
申请人： John W. Lehmann , Dan Wittenberger , Claudia Luckge , Jean-Pierre Lalonde , Cristian Petre , Domenic Santoianni
发明人： John W. Lehmann , Dan Wittenberger , Claudia Luckge , Jean-Pierre Lalonde , Cristian Petre , Domenic Santoianni
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/00292 , A61B2017/00973 , A61B2018/00095 , A61B2018/0212 , A61F2007/0298 , A61M25/0029 , A61M2025/0039 , Y10S977/906
摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

7. 发明授权

US06635053B1 Cooling system 有权
标题翻译：冷却系统
公开(公告)号：US06635053B1
公开(公告)日：2003-10-21
申请号：US09638208
申请日：2000-08-11
申请人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00119 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.
摘要翻译：低温医疗系统包括在连接点处可连接到医疗装置的医疗装置和控制台。控制台控制医疗设备的温度。所述控制台包括第一冷却系统，所述第一冷却系统沿着冷却剂供应管线在第一温度下将冷却剂引导至所述医疗设备;以及第二冷却系统，在所述冷却剂到达所述连接点之前将所述冷却剂供应管线内的冷却剂冷却至低于所述第一温度的温

8. 发明授权

US09220556B2 Balloon design to enhance cooling uniformity 有权
标题翻译：气球设计，以提高冷却均匀性
公开(公告)号：US09220556B2
公开(公告)日：2015-12-29
申请号：US13360430
申请日：2012-01-27
申请人： Jean-Pierre Lalonde , Scott W. Davie , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Scott W. Davie , Dan Wittenberger
IPC分类号： A61B18/00 , A61B18/02 , A61B18/14 , A61B19/00
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0022 , A61B2018/00255 , A61B2018/00375 , A61B2018/00577 , A61B2018/00648 , A61B2018/00791 , A61B2018/00994 , A61B2018/0212 , A61B2018/0268 , A61B2018/0275 , A61B2090/064
摘要： A device, system, and method for enhancing cooling uniformity and efficiency of cryogenic fluids and providing a treatment element the shape of which can be adjusted for multiple purposes. The device may include a balloon catheter and fluid dispersion element, the fluid dispersion element directing the flow of coolant from a fluid injection element the interior wall of the balloon. The method of changing the shape of the treatment element may include retracting and extending a shaft to which the distal neck of a balloon is coupled, so that the balloon goes from a first shape to a second shape.
摘要翻译：一种用于增强低温流体的冷却均匀性和效率的装置，系统和方法，并提供一种处理元件，其形状可以被调整用于多种目的。该装置可以包括球囊导管和流体分散元件，流体分散元件将来自流体注射元件的冷却剂流引导到气囊的内壁。改变处理元件的形状的方法可以包括缩回和延伸气球的远端颈部所连接的轴，使得气球从第一形状变为第二形状。

9. 发明授权

US07914524B2 Surgical clamp having trasmurality assessment capabilities 有权
标题翻译：手术夹具具有纹理评估能力
公开(公告)号：US07914524B2
公开(公告)日：2011-03-29
申请号：US11709040
申请日：2007-02-21
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/1465
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融机构连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

10. 发明授权

US07819860B2 Surgical clamp having trasmurality assessment capabilities 有权
标题翻译：手术夹具具有纹理评估能力
公开(公告)号：US07819860B2
公开(公告)日：2010-10-26
申请号：US10841955
申请日：2004-05-07
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
IPC分类号： A61B18/02
CPC分类号： A61B17/2812 , A61B5/0408 , A61B17/122 , A61B17/282 , A61B17/29 , A61B18/02 , A61B18/0218 , A61B2017/00026 , A61B2017/00084 , A61B2017/00243 , A61B2017/00738 , A61B2017/2905 , A61B2017/2931 , A61B2017/2944 , A61B2018/00011 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00839 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/145
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融机构连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

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