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1. 发明申请

US20130104993A1 SYSTEMS AND METHODS FOR VARIABLE INJECTION FLOW 审中-公开
公开(公告)号：US20130104993A1
公开(公告)日：2013-05-02
申请号：US13409875
申请日：2012-03-01
申请人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud KABIR-SERAJ
发明人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud KABIR-SERAJ
IPC分类号： F17D3/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

2. 发明申请

US20130110100A1 SYSTEMS AND METHODS FOR VARIABLE INJECTION FLOW 有权
公开(公告)号：US20130110100A1
公开(公告)日：2013-05-02
申请号：US13409646
申请日：2012-03-01
申请人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud KABIR-SERAJ
发明人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud KABIR-SERAJ
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

3. 发明申请

US20130110099A1 SYSTEMS AND METHODS FOR VARIABLE INJECTION FLOW 有权
标题翻译：可变注射流量的系统和方法
公开(公告)号：US20130110099A1
公开(公告)日：2013-05-02
申请号：US13300931
申请日：2011-11-21
申请人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud Kabir SERAJ
发明人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud Kabir SERAJ
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.
摘要翻译：公开了用于可控地变化的流体流动的系统和方法，其提供修改可用于流体流动的流体输送导管的有效横截面面积的能力。因此，选择性地控制这些构造允许在流体输送压力保持相同时根据需要调节流体流动。本文提供的其它配置允许选择性地操纵在单个过程期间用医疗装置实现的足迹或治疗模式，否定了去除和插入多个装置以实现治疗几何形状或特征的相同变化的需要。

4. 发明申请

US20130197498A1 LARGE AREA CRYOABLATION CATHETER WITH MULTI-GEOMETRY TIP ECG/CRYO MAPPING CAPABILITIES 有权
标题翻译：具有多特征提示的大面积CRYOABLATION导管ECG / CRYO MAPPING能力
公开(公告)号：US20130197498A1
公开(公告)日：2013-08-01
申请号：US13360379
申请日：2012-01-27
申请人： Timothy G. LASKE , Claudia LUECKGE , Réal STE-MARIE
发明人： Timothy G. LASKE , Claudia LUECKGE , Réal STE-MARIE
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B17/320068 , A61B18/1492 , A61B18/1815 , A61B2018/00101 , A61B2018/00196 , A61B2018/00357 , A61B2018/00577 , A61B2018/00613 , A61B2018/0212 , A61B2018/0262 , A61B2018/1407 , A61B2090/0463 , F04C2270/041
摘要： A medical device including an ablation element. A thermally insulative sheath is included disposed within the ablation element. A fluid injection tube is disposed within a portion of the thermally insulative sheath. The ablation element passively transitions from a substantially linear geometric configuration to a substantially circular geometric configuration as the sheath is retracted proximally from a first position in which the sheath substantially encloses the fluid injection tube to a second position in which a portion of the fluid injection tube extends a distance away from the sheath.
摘要翻译：包括消融元件的医疗装置。包括设置在消融元件内的绝热护套。流体注入管设置在绝热护套的一部分内。当护套从第一位置向近侧缩回时，消融元件从基本线性的几何构型被无源地过渡到基本上圆形的几何构型，其中鞘基本上包围流体注入管到第二位置，在第二位置，一部分流体注入管距离护套延伸一段距离。

5. 发明申请

US20120029493A1 DUAL INJECTION TUBE CRYOCATHETER AND METHOD FOR USING SAME 有权
标题翻译：双注射管结晶器及其使用方法
公开(公告)号：US20120029493A1
公开(公告)日：2012-02-02
申请号：US12844388
申请日：2010-07-27
申请人： Dan WITTENBERGER , Claudia LUECKGE , Miriam LANE
发明人： Dan WITTENBERGER , Claudia LUECKGE , Miriam LANE
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00166 , A61B2018/0022 , A61B2018/00642 , A61B2018/0212 , A61B2090/064
摘要： A medical device includes a catheter body having a first injection lumen, a second injection lumen, and an exhaust lumen, where the first injection lumen provides a fluid flow rate greater than a fluid flow rate provided by the second injection lumen; an expandable element coupled to the catheter body in fluid communication with the first and second injection lumens; a cryogenic fluid source in fluid communication with the first and second injection lumens; a valve in fluid communication with the first and second injection lumens to selectively allow fluid flow to at least one of the first and second injection lumens; a pressure sensor in fluid communication with an interior defined by the expandable element; and a controller in communication with the pressure sensor programmed to regulate fluid flow through the first injection lumen based at least in part on a signal from the pressure sensor.
摘要翻译：医疗装置包括具有第一注射腔，第二注射内腔和排气腔的导管主体，其中第一注射腔提供大于由第二注射腔提供的流体流速的流体流速; 耦合到所述导管主体的可扩张元件，其与所述第一和第二注射腔流体连通; 与所述第一和第二注射腔流体连通的低温流体源; 与所述第一和第二注射腔流体连通的阀，以选择性地允许流体流向所述第一和第二注射腔中的至少一个; 与由可膨胀元件限定的内部流体连通的压力传感器; 以及与所述压力传感器通信的控制器，其被编程为至少部分地基于来自所述压力传感器的信号来调节通过所述第一喷射腔的流体流动。

6. 发明申请

US20130197497A1 BALLOON CATHETER 有权
标题翻译：气球导管
公开(公告)号：US20130197497A1
公开(公告)日：2013-08-01
申请号：US13360092
申请日：2012-01-27
申请人： Dan WITTENBERGER , Claudia LUECKGE , Réal STE-MARIE
发明人： Dan WITTENBERGER , Claudia LUECKGE , Réal STE-MARIE
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0016 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device including a catheter body defining a proximal portion and a distal portion. An expandable element is included defining a proximal end and a distal end, the proximal end being coupled to the distal portion of the catheter body. A tip element coupled to the distal end of the expandable element is included, the tip element including a shaft slideably receivable within a portion of the catheter body. A tensioning element coupled to the shaft and disposed within the expandable element is included, the tensioning element being engageable with the distal end of the catheter body and biasing the expandable element toward a pre-determined longitudinal position. An electrode array defining a substantially closed loop affixed to and extending from the tip element is also included.
摘要翻译：一种医疗装置，包括限定近端部分和远端部分的导管主体。包括可扩张元件，其限定近端和远端，近端联接到导管主体的远端部分。包括联接到可扩张元件的远端的尖端元件，末端元件包括可滑动地容纳在导管主体的一部分内的轴。包括联接到轴并且设置在可扩张元件内的张紧元件，张紧元件可与导管主体的远端接合并且朝向预定的纵向位置偏压可扩张元件。还包括限定固定到尖端元件并从尖端元件延伸的基本上闭合回路的电极阵列。

7. 发明申请

US20130197496A1 CRYO SENSITIZING AGENTS FOR THE ENHANCEMENT OF CRYOTHERAPY 有权
标题翻译： CRYO敏感剂用于增强结实性
公开(公告)号：US20130197496A1
公开(公告)日：2013-08-01
申请号：US13555221
申请日：2012-07-23
申请人： Claudia LUECKGE , Ethel RUBIN
发明人： Claudia LUECKGE , Ethel RUBIN
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/148 , A61B2018/0293
摘要： A method and device for treating tissue with temperature-sensitizing adjuvants to enhance the effects of ablation therapy. The method may comprise identifying tissue to receive ablation therapy, treating the tissue with a temperature-sensitizing agent, and activating an ablation therapy device proximate the treated tissue. The device may comprise a cryo-sensitizing adjuvant operable in association with a cryotherapy device, the cryo-sensitizing adjuvant enhancing the effectiveness of tissue destruction upon application of temperatures below 0° C.
摘要翻译：一种用温度敏化佐剂处理组织以增强消融治疗效果的方法和装置。该方法可以包括识别组织以接受消融治疗，用温度敏化剂处理组织，以及激活靠近治疗组织的消融治疗装置。该装置可以包括与冷冻治疗装置相关联的可操作的低温敏化佐剂，该低温敏化佐剂在施加低于0℃的温度时增强组织破坏的有效性。

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