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1. 发明申请

US20110286978A1 Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof 审中-公开
标题翻译：基因完整诱导多能细胞或转分化细胞及其生产方法
公开(公告)号：US20110286978A1
公开(公告)日：2011-11-24
申请号：US12787175
申请日：2010-05-25
申请人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
IPC分类号： A61K35/12 , C12N5/00 , C12N15/01
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译：本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。这些方法使不希望的基因组序列改变的风险最小化。这些方法采用重编程因子，其可以单独使用或以某种组合使用。这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。

2. 发明申请

US20100120079A1 Trans-Differentiation And Re-Differentiation Of Somatic Cells And Production Of Cells For Cell Therapies 审中-公开
标题翻译：体细胞细胞的转分化和再分化以及细胞治疗细胞的产生
公开(公告)号：US20100120079A1
公开(公告)日：2010-05-13
申请号：US12609439
申请日：2009-10-30
申请人： Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Raymond Page , Tanja Dominko , Christopher Malcuit
IPC分类号： C12N5/071 , C12N5/00 , C12Q1/02
CPC分类号： C12N5/0618 , A61K35/12 , C12N2501/70 , C12N2501/999 , C12N2506/1307
摘要： The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.
摘要翻译：本发明提供了一种用于实现体细胞的转分化的方法，即将一种细胞类型的体细胞转化成不同细胞类型的体细胞。所述方法是通过在至少一种选自（a）细胞骨架抑制剂和（b）乙酰化抑制剂）的药剂存在下培养体细胞来实施的，和（c）甲基化抑制剂，并且还将细胞培养诱导分化成不同细胞类型的药剂或病症的存在。该方法可用于生产用于细胞治疗的组织相容性细胞。

3. 发明授权

US07621606B2 Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies 有权
标题翻译：体细胞的转分化和再分化以及用于细胞治疗的细胞的产生
公开(公告)号：US07621606B2
公开(公告)日：2009-11-24
申请号：US10228296
申请日：2002-08-27
申请人： Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Raymond Page , Tanja Dominko , Christopher Malcuit
IPC分类号： C12N5/00 , C12N5/02 , C12N5/08 , C12N5/16
CPC分类号： C12N5/0618 , A61K35/12 , C12N2501/70 , C12N2501/999 , C12N2506/1307
摘要： The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy.
摘要翻译：本发明提供了一种用于实现体细胞的转分化的方法，即将一种细胞类型的体细胞转化成不同细胞类型的体细胞。所述方法是通过在至少一种选自（a）细胞骨架抑制剂和（b）乙酰化抑制剂）的药剂存在下培养体细胞来实施的，和（c）甲基化抑制剂，并且还将细胞培养诱导分化成不同细胞类型的药剂或病症的存在。该方法可用于生产用于细胞治疗的组织相容性细胞。

4. 发明申请

US20080076176A1 De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies 审中-公开
标题翻译：体细胞的分化和再分化以及用于细胞治疗的细胞的产生
公开(公告)号：US20080076176A1
公开(公告)日：2008-03-27
申请号：US11842074
申请日：2007-08-20
申请人： Tanja Dominko , Raymond Page
发明人： Tanja Dominko , Raymond Page
IPC分类号： C12N5/00 , C12N5/08
CPC分类号： C12N5/0618 , C12N5/16 , C12N2500/25 , C12N2500/80 , C12N2500/90 , C12N2501/13 , C12N2502/13 , C12N2506/1307
摘要： The invention provides a method for effecting the de-differentiation of a somatic cell by culturing the cell in the absence of growth factors, cytokines, or other differentiation-inducing agents, and introducing components of cytoplasm of plutipotent cells into the somatic cell and allowing the cell to de-differentiate. The method can be used with somatic cells of any type, from any species of animal. The pluripotent cells may be oocytes, blastomeres, inner cell mass cells, embryonic stem cells, embryonic germ cells, embryos consisting of one or more cells, embryoid body (embryoid) cells, moruia-derived cells, teratoma (teratocarcinoma) cells, as well as multipotent partially differentiated embryonic stem cells taken from later in the embryonic development process. After being de-differentiated, the cell can be induced to re-differentiate into a different somatic cell type. A method for de-differentiating a somatic cell and inducing it to re-differentiate into a cell of neural lineage is disclosed.
摘要翻译：本发明提供了一种通过在不存在生长因子，细胞因子或其它分化诱导剂的情况下培养细胞来实现体细胞去分化的方法，并将多能细胞的细胞质成分引入体细胞，并允许细胞去分化。该方法可以与来自任何动物种类的任何类型的体细胞一起使用。多能细胞可以是卵母细胞，卵裂球细胞，内细胞大量细胞，胚胎干细胞，胚胎生殖细胞，由一种或多种细胞组成的胚胎，胚状体（胚状体）细胞，蚕源性细胞，畸胎瘤（畸胎癌）细胞，以及作为从胚胎发育过程后期获取的多能部分分化胚胎干细胞。在被分化后，可诱导细胞重新分化成不同的体细胞类型。公开了一种使体细胞去分化并诱导其重新分化成神经谱系的细胞的方法。

5. 发明申请

US20050210537A1 Pluripotent mammalian cells 审中-公开
标题翻译：多能哺乳动物细胞
公开(公告)号：US20050210537A1
公开(公告)日：2005-09-22
申请号：US11131703
申请日：2005-05-18
申请人： Tanja Dominko , Raymond Page , Alan Colman , Todd Vaught , Vivienne Marshall
发明人： Tanja Dominko , Raymond Page , Alan Colman , Todd Vaught , Vivienne Marshall
IPC分类号： A61K48/00 , C12N5/16 , C12N15/873 , A01K67/027 , C12N5/06 , C12N5/08
CPC分类号： C12N15/873 , A61K48/00 , C12N5/16 , C12N2506/04 , C12N2517/04 , C12N2517/10
摘要： The invention relates to a method of making pluripotent stem cells that does not involve the formation of early preimplantation embryos or fetal tissue. The method has general utility in the production of pluripotent stem cells from many mammalian species but has particular application in man where pluripotent stem cell production can be customized to particular human individual. The method involves the fusion of donor somatic or stem cells (or their karyoplasts) with cytoplasmic, membrane-delimited fragments of mammalian oocytes or zygotes. After the initial genomic reprogramming occurs, the cells can proliferate and thus multiply in vitro yielding a large number of autologous cells for cell therapy application. The result of this process is a cell population genomically identical to the somatic, differentiated cells derived from an individual patient. However, these cells are pluripotent in that upon application of specific growth factors, the cells are capable of differentiating into specific cell types as required by the sought clinical indication.
摘要翻译：本发明涉及一种制造不涉及早期植入前胚胎或胎儿组织的形成的多能干细胞的方法。该方法在许多哺乳动物物种的多能干细胞的生产中具有普遍的用途，但在人类中具有特殊应用，其中多能干细胞的生产可以根据具体的个体进行定制。该方法涉及供体体细胞或干细胞（或它们的核型）与哺乳动物卵母细胞或合子的细胞质膜分离的片段的融合。在初始基因组重编程发生后，细胞可以增殖并因此在体外繁殖产生大量用于细胞治疗应用的自体细胞。该过程的结果是与来自个体患者的体细胞分化细胞基因相同的细胞群体。然而，这些细胞是多能的，因为在应用特定生长因子时，细胞能够根据寻求的临床适应症的要求将其分化成特定的细胞类型。

6. 发明申请

US20060110830A1 De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies 审中-公开
公开(公告)号：US20060110830A1
公开(公告)日：2006-05-25
申请号：US11055454
申请日：2005-02-09
申请人： Tanja Dominko , Raymond Page
发明人： Tanja Dominko , Raymond Page
IPC分类号： C12N5/06 , C12N15/87
CPC分类号： C12N5/0618 , C12N5/16 , C12N2500/25 , C12N2500/80 , C12N2500/90 , C12N2501/13 , C12N2502/13 , C12N2506/1307
摘要： The invention provides a method for effecting the de-differentiation of a somatic cell by culturing the cell in the absence of growth factors, cytokines, or other differentiation-inducing agents, and introducing components of cytoplasm of plutipotent cells into the somatic cell and allowing the cell to de-differentiate. The method can be used with somatic cells of any type, from any species of animal. The pluripotent cells may be oocytes, blastomeres, inner cell mass cells, embryonic stem cells, embryonic germ cells, embryos consisting of one or more cells, embryoid body (embryoid) cells, morula-derived cells, teratoma (teratocarcinoma) cells, as well as multipotent partially differentiated embryonic stem cells taken from later in the embryonic development process. After being de-differentiated, the cell can be induced to re-differentiate into a different somatic cell type. A method for de-differentiating a somatic cell and inducing it to re-differentiate into a cell of neural lineage is disclosed.

7. 发明申请

US20090253588A1 Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy 有权
标题翻译：用于鉴定分化诱导剂的筛选测定和用于细胞治疗的分化细胞的产生
公开(公告)号：US20090253588A1
公开(公告)日：2009-10-08
申请号：US12322612
申请日：2009-02-03
申请人： Michael D. West , Raymond Page , Hans Scholer , Karen B. Chapman
发明人： Michael D. West , Raymond Page , Hans Scholer , Karen B. Chapman
IPC分类号： C40B30/06 , C12Q1/68 , C12Q1/02 , G01N33/53 , C12Q1/37 , C40B40/02 , C12N5/06
CPC分类号： G01N33/5023 , C12N5/0652 , C12N5/0657 , C12N5/069 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/23 , C12N2501/998 , C12N2506/02 , C12N2506/03 , C12N2506/04 , C12Q1/6888 , C12Q2600/158 , G01N33/5011 , G01N33/5061 , G01N33/5073 , G01N33/5091 , G01N2333/475 , G01N2333/52
摘要： The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.
摘要翻译：本发明涉及同时或临时地筛选生长因子，粘附分子，免疫刺激分子，细胞外基质组分和其它材料，用于诱导多能干细胞和多能干细胞的定向分化的能力。

8. 发明授权

US08531476B1 Enhanced monochromatic display 有权
标题翻译：增强单色显示
公开(公告)号：US08531476B1
公开(公告)日：2013-09-10
申请号：US12877095
申请日：2010-09-07
申请人： Simon Jiang , Raymond Page
发明人： Simon Jiang , Raymond Page
IPC分类号： G09G5/02
CPC分类号： G09G3/204 , G09G3/2022 , G09G3/2044 , G09G5/026 , G09G2340/0457
摘要： A method includes receiving a desired output shade of a pixel for display to a user. The pixel has a first, second, and third sub-pixel, each of which have associated a luminosity, a plurality of private color bits, and a plurality of common color bits. The method selects a plurality of intermediate shades based on the desired output shade and maps the plurality of intermediate shades to a plurality of frame colors, including a first and second frame color. The method sets a first display frame, setting the luminosity, private color bits, and common color bits of each sub-pixel based on the first frame color. The method sets a second display frame, setting the luminosity, private color bits, and common color bits of each sub-pixel based on the second frame color. The method includes sending a first and second display signal to an output device, the first display signal being based on the first display frame, and the second display signal being based on the second display frame. The output device displays the pixel to the user based on the first display signal and the second display signal.
摘要翻译：一种方法包括：向用户接收用于显示的像素的期望输出色调。像素具有第一，第二和第三子像素，每个子像素具有与亮度相关联的多个私有色彩位和多个公共色彩位。该方法基于期望的输出色调选择多个中间色调，并将多个中间色调映射到包括第一和第二帧颜色的多个帧颜色。该方法基于第一帧颜色设置第一显示帧，设置每个子像素的亮度，专色比特和公共颜色比特。该方法基于第二帧颜色设置第二显示帧，设置每个子像素的亮度，私有颜色位和公共颜色位。该方法包括向输出设备发送第一和第二显示信号，第一显示信号基于第一显示帧，第二显示信号基于第二显示帧。输出设备基于第一显示信号和第二显示信号向用户显示像素。

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