专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09410123B2 Hemangio colony forming cells and non-engrafting hemangio cells 有权
标题翻译：血管瘤集落形成细胞和非移植血管瘤细胞
公开(公告)号：US09410123B2
公开(公告)日：2016-08-09
申请号：US12991096
申请日：2009-05-06
申请人： Robert Lanza , Shi-Jiang Lu
发明人： Robert Lanza , Shi-Jiang Lu
IPC分类号： C12N5/00 , C12N5/0789
CPC分类号： C12N5/0647 , A61K35/12 , A61K35/28 , A61K35/44 , A61K38/13 , A61K45/06 , A61K2035/124 , A61N5/10 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/26 , C12N2506/02 , C12N2506/45
摘要： Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom. The compositions, preparations, and solutions include cryopreserved preparations and substantially purified preparations, as well as mixed compositions formulated in combination with related hemangioblast progenitor cell types that can engraft into the bone marrow.
摘要翻译：公开了在体外产生和扩大人血管瘤集落形成细胞和非移植血管瘤细胞的方法以及扩增和使用这些细胞的方法。该方法允许生产大量的血管瘤集落形成细胞，非移植血管瘤细胞以及衍生细胞，如造血细胞和内皮细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。人类非移植血管瘤细胞是与成血管细胞和人类血管瘤集落形成细胞相关但不同的新型祖细胞群。本发明还提供包含血管瘤集落形成细胞，非移植血管瘤细胞或与其分化的细胞的组合物，制剂和溶液。组合物，制剂和溶液包括冷冻保存的制剂和基本纯化的制剂，以及与可以移入骨髓的相关成血管细胞祖细胞类型组合配制的混合组合物。

2. 发明申请

US20110286978A1 Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof 审中-公开
标题翻译：基因完整诱导多能细胞或转分化细胞及其生产方法
公开(公告)号：US20110286978A1
公开(公告)日：2011-11-24
申请号：US12787175
申请日：2010-05-25
申请人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
IPC分类号： A61K35/12 , C12N5/00 , C12N15/01
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译：本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。这些方法使不希望的基因组序列改变的风险最小化。这些方法采用重编程因子，其可以单独使用或以某种组合使用。这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。

3. 发明申请

US20120315338A1 LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER STROMAL-FREE CONDITIONS 有权
标题翻译：在无条件条件下从人类胚胎干细胞中大量生成功能性大分子和片段
公开(公告)号：US20120315338A1
公开(公告)日：2012-12-13
申请号：US13512827
申请日：2010-12-03
申请人： Feng Li , Shi-Jiang Lu
发明人： Feng Li , Shi-Jiang Lu
IPC分类号： C12N5/078 , A61K35/14 , A61P7/04 , G01N33/566
CPC分类号： C12N5/0644 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/2311 , C12N2501/26 , C12N2501/91 , C12N2502/1394 , C12N2506/02 , C12N2506/45
摘要： The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.
摘要翻译：本发明提供了产生巨核细胞和血小板的方法。在各种实施方案中，方法涉及在血清和无基质条件下使用人胚胎干细胞衍生的成血成血管细胞分化成巨核细胞和血小板。在该系统中，hESCs通过胚状体形成和成血管细胞分化来针对巨核细胞。还提供了治疗需要血小板输注的受试者的方法。

4. 发明授权

US08017393B2 Hemangio-colony forming cells 有权
标题翻译：血管瘤集落形成细胞
公开(公告)号：US08017393B2
公开(公告)日：2011-09-13
申请号：US11787262
申请日：2007-04-13
申请人： Robert Lanza , Shi-Jiang Lu
发明人： Robert Lanza , Shi-Jiang Lu
IPC分类号： C12N5/02
CPC分类号： C12N5/0647 , A61K35/44 , A61K2035/124 , C12N2500/90 , C12N2500/99 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/20 , C12N2501/26 , C12N2501/998 , C12N2506/02
摘要： Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
摘要翻译：公开了在体外产生和扩大人血管瘤集落形成细胞的方法以及扩增和使用这些细胞的方法。该方法允许生产大量的血管瘤集落形成细胞以及衍生细胞，如造血细胞和内皮细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。

5. 发明申请

US20110086424A1 METHODS FOR PRODUCING ENUCLEATED ERYTHROID CELLS DERIVED FROM PLURIPOTENT STEM CELLS 审中-公开
标题翻译：用于生产从PLUIPOTETIC STEM CELLS衍生的已知的乳清细胞的方法
公开(公告)号：US20110086424A1
公开(公告)日：2011-04-14
申请号：US12991111
申请日：2009-05-06
申请人： Robert Lanza , Shi-Jiang Lu
发明人： Robert Lanza , Shi-Jiang Lu
IPC分类号： C12N5/0797
CPC分类号： C12N5/0641 , A61K35/12 , C12N5/0644 , C12N5/0647 , C12N5/0692 , C12N2500/25 , C12N2500/38 , C12N2501/115 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/23 , C12N2501/26 , C12N2501/60 , C12N2502/1358 , C12N2502/1394 , C12N2506/02 , C12N2506/45 , C12N2533/78
摘要： Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Methods for generating megakaryocyte and platelets are also provided.
摘要翻译：提供了使用多能干细胞产生去核的红细胞的方法。该方法允许生产大量的细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。还提供了产生巨核细胞和血小板的方法。

6. 发明申请

US20110064705A1 HEMANGIO COLONY FORMING CELLS AND NON-ENGRAFTING HEMANGIO CELLS 有权
标题翻译： HEMANGIO COLONY成形细胞和非恒定HEMANGIO细胞
公开(公告)号：US20110064705A1
公开(公告)日：2011-03-17
申请号：US12991096
申请日：2009-05-06
申请人： Robert Lanza , Shi-Jiang Lu
发明人： Robert Lanza , Shi-Jiang Lu
IPC分类号： A61K35/12 , C12N5/071 , C40B50/06 , C12N5/078 , C40B40/02 , A61P37/06 , A61P9/10
CPC分类号： C12N5/0647 , A61K35/12 , A61K35/28 , A61K35/44 , A61K38/13 , A61K45/06 , A61K2035/124 , A61N5/10 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/26 , C12N2506/02 , C12N2506/45
摘要： Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom. The compositions, preparations, and solutions include cryopreserved preparations and substantially purified preparations, as well as mixed compositions formulated in combination with related hemangioblast progenitor cell types that can engraft into the bone marrow.
摘要翻译：公开了在体外产生和扩大人血管瘤集落形成细胞和非移植血管瘤细胞的方法以及扩增和使用这些细胞的方法。该方法允许生产大量的血管瘤集落形成细胞，非移植血管瘤细胞以及衍生细胞，如造血细胞和内皮细胞。通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。人类非移植血管瘤细胞是与成血管细胞和人类血管瘤集落形成细胞相关但不同的新型祖细胞群。本发明还提供包含血管瘤集落形成细胞，非移植血管瘤细胞或与其分化的细胞的组合物，制剂和溶液。组合物，制剂和溶液包括冷冻保存的制剂和基本纯化的制剂，以及与可以移入骨髓的相关成血管细胞祖细胞类型组合配制的混合组合物。

7. 发明授权

US09988603B2 Large scale generation of functional megakaryocytes and platelets from human embryonic stem cells under stromal-free conditions 有权
公开(公告)号：US09988603B2
公开(公告)日：2018-06-05
申请号：US13512827
申请日：2010-12-03
申请人： Feng Li , Shi-Jiang Lu
发明人： Feng Li , Shi-Jiang Lu
IPC分类号： C12N5/078
CPC分类号： C12N5/0644 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/2311 , C12N2501/26 , C12N2501/91 , C12N2502/1394 , C12N2506/02 , C12N2506/45
摘要： The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.

8. 发明申请

US20120282693A1 METHOD OF GENERATING NATURAL KILLER CELLS AND DENDRITIC CELLS FROM HUMAN EMBRYONIC STEM CELL-DERIVED HEMANGIOBLASTS 有权
标题翻译：从人胚胎干细胞衍生的HEMANGIOBLASTS产生天然杀伤细胞和细胞的方法
公开(公告)号：US20120282693A1
公开(公告)日：2012-11-08
申请号：US13512795
申请日：2010-12-01
申请人： Erin Kimbrel , Shi-Jiang Lu
发明人： Erin Kimbrel , Shi-Jiang Lu
IPC分类号： C12N5/0783 , C12N5/0784
CPC分类号： C12N5/0639 , A61K35/15 , A61K2035/124 , C12N5/0646 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/2303 , C12N2501/2304 , C12N2501/26 , C12N2506/02
摘要： This invention provides methods of generating natural killer (NK) cells and dendritic cells (DCs). The methods utilize human hemangioblasts as intermediate cells to generate the NK cells and DCs. In various embodiments, the methods do not require the use of stromal feeder layers.
摘要翻译：本发明提供了产生自然杀伤（NK）细胞和树突状细胞（DC）的方法。该方法利用人类成血成血管细胞作为中间细胞产生NK细胞和DC。在各种实施方案中，所述方法不需要使用基质饲养层。

9. 发明申请

US20110171185A1 Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof 审中-公开
标题翻译：遗传完整的诱导多能细胞或转分化细胞及其生产方法
公开(公告)号：US20110171185A1
公开(公告)日：2011-07-14
申请号：US12700545
申请日：2010-02-04
申请人： IRINA V. KLIMANSKAYA , SHI-JIANG LU , ROBERT LANZA , MICHAEL D. WEST , KAREN B. CHAPMAN , ROY GEOFFREY SARGENT , RAYMOND PAGE , TANJA DOMINKO , CHRISTOPHER MALCUIT
发明人： IRINA V. KLIMANSKAYA , SHI-JIANG LU , ROBERT LANZA , MICHAEL D. WEST , KAREN B. CHAPMAN , ROY GEOFFREY SARGENT , RAYMOND PAGE , TANJA DOMINKO , CHRISTOPHER MALCUIT
IPC分类号： A61K35/12 , C12N15/01 , A61P43/00
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译：本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。这些方法使不希望的基因组序列改变的风险最小化。这些方法采用重编程因子，其可以单独使用或以某种组合使用。这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。

10. 发明授权

US08822218B2 Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts 有权
标题翻译：从人胚胎干细胞衍生的成血成血管细胞产生天然杀伤细胞和树突状细胞的方法
公开(公告)号：US08822218B2
公开(公告)日：2014-09-02
申请号：US13512795
申请日：2010-12-01
申请人： Erin Kimbrel , Shi-Jiang Lu
发明人： Erin Kimbrel , Shi-Jiang Lu
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0639 , A61K35/15 , A61K2035/124 , C12N5/0646 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/2303 , C12N2501/2304 , C12N2501/26 , C12N2506/02
摘要： This invention provides methods of generating natural killer (NK) cells and dendritic cells (DCs). The methods utilize human hemangioblasts as intermediate cells to generate the NK cells and DCs. In various embodiments, the methods do not require the use of stromal feeder layers.
摘要翻译：本发明提供了产生自然杀伤（NK）细胞和树突状细胞（DC）的方法。该方法利用人类成血成血管细胞作为中间细胞产生NK细胞和DC。在各种实施方案中，所述方法不需要使用基质饲养层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式