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1. 发明授权

US5227535A Process for the preparation of 2-nitro-5-fluoro- or -5-chlorophenol 失效
标题翻译： 2-硝基-5-氟或5-氯苯酚的制备方法
公开(公告)号：US5227535A
公开(公告)日：1993-07-13
申请号：US957674
申请日：1992-10-07
申请人： Ralf Pfirmann , Theodor Papenfuhs , Klaus Forstinger
发明人： Ralf Pfirmann , Theodor Papenfuhs , Klaus Forstinger
IPC分类号： C07C201/12 , C07C205/26
CPC分类号： C07C201/12
摘要： The present invention relates to a process for the preparation of isomerically pure 2-nitro-5-fluoro- or -5-chlorophenol, by reacting 2,4-difluoronitrobenzene or 2,4-dichloronitrobenzene with aqueous alkali metal or alkaline earth metal hydroxide solution or suspension in the absence of organic solvents or other solubility promoting substances at temperatures from about 20.degree. C. to about 190.degree. C., adjusting the pH of the reaction mixture to about 1 to about 6 by the addition of acid, steam distilling the resultant product and isolating it from the distillate after cooling.
摘要翻译：本发明涉及通过2,4-二氟硝基苯或2,4-二氯硝基苯与碱金属或碱土金属氢氧化物水溶液的反应来制备异构纯的2-硝基-5-氟 - 或-5-氯苯酚的方法或在约20℃至约190℃的温度下不存在有机溶剂或其它促溶解物质的悬浮液，通过加入酸将反应混合物的pH调节至约1至约6，蒸馏蒸馏冷却后将其与馏出物分离。

2. 发明授权

US5466859A Process for preparing fluorobenzonitriles 失效
标题翻译：氟苯腈的制备方法
公开(公告)号：US5466859A
公开(公告)日：1995-11-14
申请号：US277518
申请日：1994-07-19
申请人： Thomas Schach , Theodor Papenfuhs , Ralf Pfirmann
发明人： Thomas Schach , Theodor Papenfuhs , Ralf Pfirmann
IPC分类号： B01J31/02 , C07B61/00 , C07C253/30 , C07C255/50
CPC分类号： B01J31/0204 , B01J31/0239 , C07C253/30 , B01J2231/40
摘要： Fluorobenzonitriles and chlorofluorobenzonitriles are prepared in an advantageous manner from the corresponding chlorobenzonitriles and an alkali metal fluoride in a chlorine-fluorine exchange reaction, by catalyzing the reaction with a quaternary ammonium compound comprising at least one alkoxypolyoxyalkyl radical.
摘要翻译：通过催化与包含至少一个烷氧基聚氧烷基的季铵化合物的反应，以有利的方式从相应的氯代苯腈和氯 - 氟交换反应中的碱金属氟化物制备氟代苯腈和氯氟苯腈。

3. 发明授权

US5430173A Process for preparing alkyl 3-hydroxy-2, 4, 5-trifluorobenzoates and/or alkyl 3-alkoxy-2, 4, 5-trifluorobenzoates 失效
标题翻译：制备3-羟基-2,4,5-三氟苯甲酸烷基酯和/或3-烷氧基-2,4,5-三氟苯甲酸烷基酯的方法
公开(公告)号：US5430173A
公开(公告)日：1995-07-04
申请号：US306763
申请日：1994-09-15
申请人： Ralf Pfirmann , Theodor Papenfuhs
发明人： Ralf Pfirmann , Theodor Papenfuhs
IPC分类号： B01J31/26 , C07B61/00 , C07C67/10 , C07C69/84 , C07C69/88 , C07C69/92 , C07C69/76
CPC分类号： C07C69/92 , C07C67/11 , C07C67/31 , C07C69/88
摘要： The present invention relates to a process for preparing alkyl 3-hydroxy-2,4,5-trifluorobenzoate and/or alkyl 3-alkoxy-2,4,5-trifluorobenzoate by reacting 3-hydroxy-2,4,5-trifluorobenzoic acid with a dialkyl carbonate at 80.degree. to 200.degree. C.
摘要翻译：本发明涉及3-羟基-2,4,5-三氟苯甲酸和/或3-烷氧基-2,4,5-三氟苯甲酸烷基酯的制备方法，通过3-羟基-2,4,5-三氟苯甲酸与碳酸二烷基酯在80至200℃

4. 发明授权

US5200556A Process for the preparation of 3,4,6-trifluorophthalic acid and the anhydride thereof 失效
标题翻译：制备3,4,6-三氟乙酸及其无水物的方法
公开(公告)号：US5200556A
公开(公告)日：1993-04-06
申请号：US887182
申请日：1992-05-21
申请人： Theodor Papenfuhs , Ralf Pfirmann
发明人： Theodor Papenfuhs , Ralf Pfirmann
IPC分类号： C07C51/083 , C07C51/377 , C07C51/567 , C07C63/68 , C07D307/89
CPC分类号： C07C51/377 , C07C51/567
摘要： Process for the preparation of 3,4,6-tetrafluorophthalic acid of the formula (1) ##STR1## or the anhydride thereof in good yields and in an advantageous manner, by dehalogenating tetrafluorophthalic anhydride of the formula (2) ##STR2## or tetrafluorophthalic acid in aqueous-alkaline medium using zinc at temperatures of approximately 20.degree. C. to approximately 160.degree. C. and, if appropriate, converting the resulting 3,4,6-trifluorophthalic acid into the anhydride in a known manner by dehydrating it.
摘要翻译：通过使式（2）的四氟邻苯二甲酸脱卤，以良好的产率和有利的方式制备式（1）的3,4,6-四氟邻苯二甲酸（1）或其酸酐的方法

5. 发明授权

US5478963A 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile-(2,3-difluoro-6-chlorobenzonitrile), process for their preparation and their use for the preparation of 2,3,6-trifluorobenzoic acid 失效
标题翻译： 2,3-二氟-6-硝基苄腈和2-氯-5,6-二氟苄腈 - （2,3-二氟-6-氯苄腈）的制备方法及其用于制备2,3,6-三氟苯甲腈酸
公开(公告)号：US5478963A
公开(公告)日：1995-12-26
申请号：US184039
申请日：1994-01-21
申请人： Ralf Pfirmann , Theodor Papenfuhs
发明人： Ralf Pfirmann , Theodor Papenfuhs
IPC分类号： C07C51/08 , C07C63/70 , C07C253/14 , C07C253/30 , C07C255/50
CPC分类号： C07C255/50
摘要： The present invention describes the novel intermediates 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile, a process for their preparation and their advantageous use for the preparation of 2,3,6-trifluorobenzoic acid, which in turn is a valuable intermediate for the preparation of insecticides and antibacterial agents. The intermediates according to the invention are prepared from 2,3,4-trifluoronitrobenzene by fluorine/cyanide exchange and subsequent denitrating chlorination. 2,3,6-Trifluorobenzoic acid can be prepared from the novel intermediates, in a manner known per se in the literature, by simple chlorine/fluorine exchange and subsequent hydrolysis in a process which overall is industrially advantageous and economically favorable.
摘要翻译：本发明描述了新的中间体2,3-二氟-6-硝基苄腈和2-氯-5,6-二氟苯甲腈，其制备方法及其有利于制备2,3,6-三氟苯甲酸，其中这又是制备杀虫剂和抗菌剂的有价值的中间体。根据本发明的中间体通过氟/氰化物交换和随后的脱硝氯化从2,3,4-三氟硝基苯制备。 2,3,6-三氟苯甲酸可以通过简单的氯/氟交换和随后在整体上在工业上有利和经济上有利的方法中的水解，以本文已知的方式从新型中间体制备。

6. 发明授权

US5473095A Process for the preparation of chlorinated 4,5-difluorobenzoic acids, -benzoic acid derivatives and -benzaldehydes 失效
标题翻译：氯代4,5-二氟苯甲酸，苯甲酸衍生物和苯甲醛的制备方法
公开(公告)号：US5473095A
公开(公告)日：1995-12-05
申请号：US187622
申请日：1994-01-27
申请人： Ralf Pfirmann , Theodor Papenfuhs , Georg Weichselbaumer
发明人： Ralf Pfirmann , Theodor Papenfuhs , Georg Weichselbaumer
IPC分类号： C07B61/00 , C07C45/63 , C07C47/55 , C07C51/363 , C07C63/70 , C07C67/307 , C07C69/78 , C07C231/12 , C07C233/65 , C07C253/30 , C07C255/50 , C07C51/60
CPC分类号： C07C51/363 , C07C45/63 , C07C51/567 , C07C67/307
摘要： The present invention relates to a process for the preparation of compounds of the formula ##STR1## in which R.sup.1 is --CN, --COOH, --COOR', R' being an organic radical having 1 to 6 carbon atoms, --CONH.sub.2, --COCl or --CHO and R.sup.2 is H or Cl, which comprises reacting a compound of the formula ##STR2## in which R.sup.1 is as defined above and R.sup.3 is H or Cl, with a chlorinating agent in the presence of a chlorination catalyst at -10.degree. to 200.degree. C.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中R 1是-CN，-COOH，-COOR'，R'是具有1至6个碳原子的有机基团，-CONH 2 ，-COCl或-CHO，并且R 2是H或Cl，其包括使其中R 1如上定义并且R 3是H或Cl的通式为其的化合物（II）与氯化剂在氯化催化剂在-10〜200℃

7. 发明授权

US5274115A N'-substituted N-amino-3,4,5,6-tetrafluorophthalimides 失效
标题翻译： N-取代的N-氨基-3,4,5,6-四氟邻苯二酰亚胺
公开(公告)号：US5274115A
公开(公告)日：1993-12-28
申请号：US872058
申请日：1992-04-23
申请人： Theodor Papenfuhs , Ralf Pfirmann
发明人： Theodor Papenfuhs , Ralf Pfirmann
IPC分类号： C07D209/48 , C07D403/04 , C07D209/34
CPC分类号： C07D209/48
摘要： Compounds of the formula ##STR1## in which X is the radical ##STR2## where R.sub.1 and R.sub.2 are in each case a hydrogen atom, an alkyl-(C.sub.1 -C.sub.10) group, aryl group, alkyl(C.sub.1 -C.sub.6)-CO group or aryl-CO group, where the aryl or aryl-CO group in the case of R.sub.1 and R.sub.2 can be substituted on the aromatic ring by fluorine and/or chlorine atoms and/or alkyl(C.sub.1 -C.sub.4) groups, or R.sub.1 and R.sub.2 together are a phthaloyl radical which can be substituted on the aromatic ring by 4 chlorine atoms or 4 fluorine atoms, or where X is the radical ##STR3## which can be substituted on the aromatic ring by fluorine and/or chlorine atoms and/or alkyl(C.sub.1 -C.sub.4) groups, and processes for their preparation.
摘要翻译：式（1）的化合物，其中X是基团，其中R 1和R 2各自为氢原子，烷基 - （C 1 -C 10）基团，芳基，烷基（C 1 -C 6） -CO基或芳基-CO基，其中在R1和R2的情况下的芳基或芳基-CO基可以在芳环上被氟和/或氯原子和/或烷基（C1-C4）基团取代，或 R1和R2一起是可以在芳环上被4个氯原子或4个氟原子取代的邻苯二甲酰基，或其中X是可以在芳环上被氟和/或氯原子取代的基团， /或烷基（C 1 -C 4）基团，及其制备方法。

8. 发明授权

US5179230A Process for the preparation of 2,3,4,5-tetrafluorobenzoic acid 失效
标题翻译：制备2,3,4,5-四氢叶酸的方法
公开(公告)号：US5179230A
公开(公告)日：1993-01-12
申请号：US872059
申请日：1992-04-23
申请人： Theodor Papenfuhs , Ralf Pfirmann
发明人： Theodor Papenfuhs , Ralf Pfirmann
IPC分类号： C07C51/00 , C07C51/06 , C07C63/70
CPC分类号： C07C51/44 , C07C51/38
摘要： A process for the preparation of 2,3,4,5,-tetrafluorobenzoic acid of the formula (1) ##STR1## by heating N'-substituted N-aminotetrafluorophthalimides of the formula (2) ##STR2## in which X is the radical ##STR3## where R.sub.1, R.sub.2 are a hydrogen atom, an alkyl-(C.sub.1 -C.sub.10)- group, aryl group, alkyl-(C.sub.1 -C.sub.6)-Co- group or aryl-CO- group, it being possible for the aryl or aryl-CO- group in the case of R.sub.1 and R.sub.2 to be substituted on the aromatic ring by fluorine and/or chlorine atoms and/or alkyl-(C.sub.1 -C.sub.4)-groups, or R.sub.1 and R.sub.2 together are a phthaloyl radical which can be substituted on the aromatic ring by 4 chlorine atoms or 4 fluorine atoms, or where X is the radical ##STR4## which can be substituted on the aromatic ring by fluorine and/or chlorine atoms and/or alkyl-(C.sub.1 -C.sub.4)- groups, in an aqueous medium at pH values of approximately -1 to approximately +1 at temperatures of approximately 160 to approximately 220.degree. C.
摘要翻译：通过加热式（2）的N-取代的N-氨基四氟邻苯二甲酰亚胺（2）制备式（1）的2,3,4,5-四氟苯甲酸的方法（1）其中X是基团，其中R 1，R 2是氢原子，烷基 - （C 1 -C 10） - 基，芳基，烷基 - （C 1 -C 6） - 基或芳基-CO-基团， R 1和R 2在芳环上被氟和/或氯原子和/或烷基 - （C 1 -C 4） - 基团取代时，芳基或芳基-CO-基团是有可能的，或者R1和R2 一起是可以在芳环上被4个氯原子或4个氟原子取代的邻苯二甲酰基，或其中X是可以在芳环上被氟和/或氯原子和/或烷基取代的基团 - （C1-C4） - 基团，在约160至约220℃的温度下，pH值约为-1至约+ 1的水性介质中。

9. 发明授权

US5723658A Process for the preparation of salts of substituted or unsubstituted phthalic acids 失效
标题翻译：用于制备取代或未取代的邻苯二甲酸的盐的方法
公开(公告)号：US5723658A
公开(公告)日：1998-03-03
申请号：US641757
申请日：1996-05-02
申请人： Ralf Pfirmann , Theodor Papenfuhs
发明人： Ralf Pfirmann , Theodor Papenfuhs
IPC分类号： C07C51/06 , C07C51/00 , C07C51/41 , C07C63/72 , C07C65/03 , C07C63/16 , C07C63/17
CPC分类号： C07C51/00 , C07C51/41
摘要： The present invention relates to a process for the preparation of salts of substituted or unsubstituted phthalic acids, by reacting a compound of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and are H, F, Cl, Br, CF.sub.3, OH, an alkoxy or alkyl radical in each case having 1 to 4 carbon atoms, or a radical --NR.sup.7 R.sup.8, in which R.sup.7 and R.sup.8 are identical or different and are H, an alkyl radical having 1 to 4 carbon atoms, or a phenyl radical, R.sup.5 and R.sup.6 are identical or different and are H, a --CO-- alkyl group having 1 to 6 carbon atoms in the alkyl radical, or a benzoyl group, or R.sup.5 and R.sup.6 together form a radical of the formula ##STR2## in which R.sup.9, R.sup.10, R.sup.11 and R.sup.12 are identical or different and are H, F, Cl, Br, CF.sub.3, OH, an alkoxy or alkyl radical in each case having 1 to 4 carbon atoms, or a radical --NR.sup.7 R.sup.8, in which R.sup.7 and R.sup.8 are identical or different and are H, an alkyl radical having 1 to 4 carbon atoms, or a phenyl radical, with water, a water-soluble base, and an oxidizing agent at a temperature of -10.degree. to 150.degree. C. in the presence or absence of a water-insoluble solvent inert under the reaction conditions.
摘要翻译：本发明涉及一种制备取代或未取代的邻苯二甲酸的盐的方法，其中R1，R2，R3和R4相同或不同，为H，F ，Cl，Br，CF 3，OH，每种情况下具有1至4个碳原子的烷氧基或烷基，或基团-NR 7 R 8，其中R 7和R 8相同或不同，为H，具有1至4个碳原子或苯基，R 5和R 6相同或不同，为H，烷基中具有1至6个碳原子的-CO-烷基或苯甲酰基，或者R 5和R 6一起形成其中R 9，R 10，R 11和R 12相同或不同，为每个情况具有1至4个碳原子的H，F，Cl，Br，CF 3，OH，烷氧基或烷基的式（II）或基团-NR 7 R 8，其中R 7和R 8相同或不同，为H，具有1至4个碳原子的烷基或苯基，与水，水溶性碱，和在-10℃〜150℃的温度下，在反应条件下在水不溶性溶剂存在或不存在下为惰性的氧化剂。

10. 发明授权

US5384413A Process for the preparation of tetrafluorophthalic acid and/or tetrafluorophthalic anhydride 失效
标题翻译：制备四氟邻苯二甲酸和/或四氟邻苯二甲酸酐的方法
公开(公告)号：US5384413A
公开(公告)日：1995-01-24
申请号：US90794
申请日：1993-07-12
申请人： Ralf Pfirmann , Theodor Papenfuhs
发明人： Ralf Pfirmann , Theodor Papenfuhs
IPC分类号： C07C51/06 , C07C51/00 , C07C51/083 , C07C51/38 , C07C51/54 , C07C63/70 , C07C63/72 , C07D209/48 , C07D307/89 , C07D307/83
CPC分类号： C07C51/00 , C07C51/44 , C07D209/48
摘要： The present invention relates to a process for the preparation of tetrafluorophthalic acid and/or tetrafluorophthalic anhydride by reacting a compound of the formula ##STR1## in which X is a radical ##STR2## which is optionally mono- or polysubstituted on the aromatic nucleus by fluorine and/or chlorine and/or alkyl groups having 1 to 4 carbon atoms, or is a radical ##STR3## in which R.sub.1, R.sub.2 and R.sub.3 are as defined, with water, and subsequently removing the water still present by azeotropic distillation or extracting the tetrafluorophthalic acid and/or its anhydride with a water-insoluble solvent or solvent mixture.
摘要翻译：本发明涉及一种制备四氟邻苯二甲酸和/或四氟邻苯二甲酸酐的方法，该方法通过使式（IMAGE）的化合物与其中X是一个基团（IMAGE）反应，该基团在芳香核上任选被一个或多个取代在氟原子上和/或具有1至4个碳原子的氯和/或烷基，或者是其中R 1，R 2和R 3如上定义的基团，与水反应，随后通过共沸蒸馏除去仍然存在的水或提取四氟邻苯二甲酸和/或其酸酐与水不溶性溶剂或溶剂混合物。

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