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1. 发明公开

US20240351978A1 METHOD FOR MANUFACTURING AROMATIC NITRILE COMPOUND 审中-公开
公开(公告)号：US20240351978A1
公开(公告)日：2024-10-24
申请号：US18738245
申请日：2024-06-10
申请人： API CORPORATION
发明人： Masaki NAGAHAMA , Hideki OOMIYA , Daiki OKADO , Hirotsugu TANIIKE
IPC分类号： C07C253/20 , C07C51/06 , C07C57/38 , C07C255/33
CPC分类号： C07C253/20 , C07C51/06 , C07C57/38 , C07C255/33 , C07C2602/10
摘要： The present invention provides a method for industrially producing a highly pure aromatic nitrile compound and a highly pure aromatic carboxylic acid compound safely and highly efficiently at low costs. Compound (2) is subjected to Willgerodt reaction in the presence of an additive as necessary, and the obtained amide compound (3) is hydrolyzed and neutralized to give carboxylic acid compound (4). Carboxylic acid compound (4) is reacted with a halogenating agent in the presence of a catalyst as necessary in an organic solvent, and further reacted with an amidating agent, and the obtained amide compound (5) or (6) is reacted with a dehydrating agent to give nitrile compound (1). Alternatively, carboxylic acid compound (4) is reacted with a halogenating agent and a compound represented by the formula R6SO2R7 in the presence of a catalyst as necessary in an organic solvent to give nitrile compound (1). Np is a naphthyl group optionally having substituent(s), R5 is an alkylene group having 1-3 carbon atoms, and other symbols are as described in the DESCRIPTION.

2. 发明授权

US10829439B2 Method for producing adipamide as intermediate for production of raw material for bio-based nylon 有权
公开(公告)号：US10829439B2
公开(公告)日：2020-11-10
申请号：US16197659
申请日：2018-11-21
申请人： Hyundai Motor Company , Kia Motors Corporation
发明人： Chae-Hwan Hong , Na-Kyong Yun , Ha-Eun Jeong , Sung-Wan Jeon
IPC分类号： C07C231/12 , B01J23/656 , B01J23/42 , B01J23/10 , C07C51/06 , B01J35/00 , C08G69/26 , C07C231/02 , B01J21/08
摘要： Disclosed is a method for producing adipamide, which may include the steps of: (a) reacting glucose, nitric acid (HNO3), sodium nitrite (NaNO2) and potassium hydroxide (KOH) to produce a glucaric acid potassium salt, (b) producing glucamide by reacting the glucaric acid potassium salt, with an acidic solution and removing a potassium ion from the glucaric acid potassium salt, (c) preparing an reaction admixture by adding the glucamide and a catalyst to hydrogen halide and acetic acid, and (d) treating the reaction admixture with hydrogen gas in a reactor thereby producing the adipamide.

3. 发明授权

US10239821B2 Process for the co-production of long chain amino acids and dibasic acids 有权
公开(公告)号：US10239821B2
公开(公告)日：2019-03-26
申请号：US15601556
申请日：2015-12-17
申请人： XIRUI TECHNOLOGY (BEIJING) CO., LTD
发明人： Songzhou Hu
IPC分类号： C07C227/06 , C07C227/18 , C07C51/06 , C07C231/10 , C07C249/08
摘要： There is disclosed a process for the co-production of long chain ω-amino acid and long chain dibasic acid, comprising: (1) reacting long chain ketoacid derivative with hydroxylamine or subjecting ketoacid derivative to an ammoximation to yield oxime derivative; (2) subjecting oxime derivative to Beckmann rearrangement to yield a mixture of mixed amide derivatives; (3) hydrolyzing the mixed amide derivatives to produce long chain ω-amino acid and long chain dibasic acid.

4. 发明授权

US09944533B2 Installation and process for the preparation of hydrogen cyanide 有权
公开(公告)号：US09944533B2
公开(公告)日：2018-04-17
申请号：US14905435
申请日：2014-07-18
申请人： Arkema France
发明人： Yves Bernardin , Xavier Marcarian , Romain Billon
IPC分类号： C01C3/02 , C07C67/20 , C07C231/06 , C07C231/12 , C07C253/04 , C07C51/06
CPC分类号： C01C3/0212 , C01C3/022 , C07C51/06 , C07C67/20 , C07C231/06 , C07C231/12 , C07C253/04 , Y02P20/129
摘要： Present invention relates to a process and an installation (100) for the preparation of hydrogen cyanide by the Andrussow process, and more precisely for improving the conditions of mixing the reactant gases before feeding the Andrussow type reactor (60), in order to improve safety, to avoid any risk of explosion and to produce HCN in safe and efficient manner. The installation is configured in such a manner that oxygen is pre-mixed with air with a ratio comprised between 20.95% and 32.5% by volume, preferably between 25% and 30.5% by volume; methane containing gas and ammonia are simultaneously added in the pre-mixture of oxygen-enriched air in such a manner that the volumic ratio of methane to ammonia is comprised between 1.35 and 1.02 depending on the content of oxygen into air; said obtained reactant gases mixture having a temperature comprised between 80° C. and 120° C., preferably between 95° C. and 115° C. for feeding the Andrussow type reactor (60).

5. 发明申请

US20170247328A1 IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE 审中-公开
公开(公告)号：US20170247328A1
公开(公告)日：2017-08-31
申请号：US15509786
申请日：2015-09-08
申请人： MSN LABORATORIES PRIVATE LIMITED
发明人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Komati SATYANARAYANA
IPC分类号： C07D211/22 , C07C51/367 , C07D263/24 , C07C51/06
CPC分类号： C07D211/22 , C07B2200/07 , C07C51/02 , C07C51/06 , C07C51/09 , C07C51/367 , C07C51/412 , C07D263/24 , C07C59/48
摘要： The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate, represented by the following structural formula (I).

6. 发明授权

US09024028B2 Methods and compositions for the synthesis of multimerizing agents 有权
标题翻译：用于合成多聚化剂的方法和组合物
公开(公告)号：US09024028B2
公开(公告)日：2015-05-05
申请号：US13981051
申请日：2012-01-26
申请人： Feng Li , Yihan Wang
发明人： Feng Li , Yihan Wang
IPC分类号： C07D211/60 , C07C51/06 , C07C209/08 , C07C231/02 , C07C235/34 , C07D205/04 , C07D319/06 , C07D319/04 , C07B53/00 , C07C209/62 , C07C209/74 , C07C231/18
CPC分类号： C07D401/12 , C07B53/00 , C07B2200/07 , C07C51/06 , C07C209/08 , C07C209/62 , C07C209/74 , C07C231/02 , C07C231/18 , C07C235/34 , C07D205/04 , C07D211/60 , C07D319/04 , C07D319/06 , C07C211/15 , C07C211/13 , C07C235/20 , C07C59/64
摘要： The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.
摘要翻译：本发明的特征在于用于合成多聚化剂的方法和组合物。制备AP20187的示例性方法可以包括：（a）将2-N，N-二甲基氨基甲基-1,3-二氨基丙烷与AP20792偶联以产生二聚醇AP20793; 和（b）将如此生产的AP20793与API7362耦合以产生AP20187。在具体实施方案中，该方法还包括通过将API7360与甲基-L-哌啶酸或其盐偶联制备API7362的步骤。

7. 发明授权

US08975438B2 Process for the preparation of cyclohexanecarboxylic acid derivatives 有权
标题翻译：环己烷羧酸衍生物的制备方法
公开(公告)号：US08975438B2
公开(公告)日：2015-03-10
申请号：US13541795
申请日：2012-07-05
申请人： Beat Birrer , Leo Clarke , Walter Deichtmann , John Hayes , Julius Jeisy , Christian Lautz , Rainer E. Martin , Michael Meade , Joaquim Pintao , Michelangelo Scalone , Juergen Schaefer , Dennis Smith , Andreas Staempfli , Joachim Veits , Christian Walch , Andrew Walsh , Andreas Zogg
发明人： Beat Birrer , Leo Clarke , Walter Deichtmann , John Hayes , Julius Jeisy , Christian Lautz , Rainer E. Martin , Michael Meade , Joaquim Pintao , Michelangelo Scalone , Juergen Schaefer , Dennis Smith , Andreas Staempfli , Joachim Veits , Christian Walch , Andrew Walsh , Andreas Zogg
IPC分类号： C07C259/04 , C07C319/20 , C07C51/06 , C07C51/08 , C07C319/06 , C07C327/30 , C07C51/02
CPC分类号： C07C319/20 , C07C51/02 , C07C51/06 , C07C51/08 , C07C319/06 , C07C327/30 , C07C2601/14 , C07C323/40 , C07C61/08
摘要： A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.
摘要翻译：制备式（I）化合物的方法：其可用作药物活性化合物的制备中的中间体。

8. 发明授权

US6140428A Simultaneous production of dicarboxylic acids and diamines by splitting polyamides into their monomeric constituents 失效
标题翻译：通过将聚酰胺分解成其单体组分同时生产二羧酸和二胺
公开(公告)号：US6140428A
公开(公告)日：2000-10-31
申请号：US711995
申请日：1996-09-10
申请人： Ursula Seeliger , Wolfgang F. Mueller , Frank Heimann , Guenther Huber , Wolfgang Habermann , Hartwig Voss , Hardo Siegel
发明人： Ursula Seeliger , Wolfgang F. Mueller , Frank Heimann , Guenther Huber , Wolfgang Habermann , Hartwig Voss , Hardo Siegel
IPC分类号： B01D61/44 , C07C51/06 , C07C51/43 , C07C209/62 , C07C211/12 , C08G69/48 , C25B3/00
CPC分类号： C08G69/48 , B01D61/44 , B01D61/445 , C07C209/62 , C07C51/06 , C07C51/43
摘要： A process for the simultaneous production of dicarboxylic acids and diamines from a) polymers based on polyamides of dicarboxylic acids or their derivatives with diamines, orb) compositions containing essentially such polymers, by splitting these polymers into their monomeric constituents, comprises treating these polymers or compounds with a base in alcoholic medium, and subsequently converting the resulting dicarboxylate salts electrochemically into the corresponding dicarboxylic acids and bases.
摘要翻译：一种从二羧酸或二胺同时制备二羧酸和二胺的方法，其中基于二羧酸或其衍生物与二胺的聚酰胺的聚合物，或b）通过将这些聚合物分解成其单体组分，基本上含有这些聚合物的组合物包括处理这些聚合物或在醇介质中具有碱的化合物，随后将所得的二羧酸盐电化学转化成相应的二羧酸和碱。

9. 发明授权

US5900490A Preparation of perylene-3, 4-Dicarboxylic acid anhydrides 失效
标题翻译：苝-3,4-二羧酸酐的制备
公开(公告)号：US5900490A
公开(公告)日：1999-05-04
申请号：US7193
申请日：1998-01-14
申请人： Leonhard Feiler
发明人： Leonhard Feiler
IPC分类号： C07D221/18 , C07C50/36 , C07C51/00 , C07C51/06 , C07C51/54 , C07D311/78 , C07D311/96 , C09B5/62 , C09D11/00
CPC分类号： C09B5/62 , C07C51/54 , C07D311/78
摘要： Preparation of perylene-3,4-dicarboxylic acid anhydrides of the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 can each be independently of one another hydrogen, halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl, C.sub.1 -C.sub.20 alkoxy, phenyl, phenyloxy or phenylthio, where phenyl can in each case be mono- or polysubstituted by halogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.14 cycloalkyl and/or C.sub.1 -C.sub.20 alkoxy; --NR.sup.5.sub.2 or --OR.sup.5, wherein R.sup.5 is hydrogen or C.sub.1 -C.sub.20 alkyl, or one of the pairs R.sup.1 /R.sup.2 and R.sup.3 /R.sup.4 each in 6,7- or 1,12-position is a bridge having the bridge atoms or bridge atom groups --O--, --S--, S.dbd.O, SO.sub.2 or --NR.sup.6, wherein R.sup.6 is hydrogen, C.sub.1 -C.sub.20 alkyl or C.sub.3 -C.sub.14 cycloalkyl, by treating a perylene-3,4-dicarboximide of formula II ##STR2## (a) in a first step with a base and, (b) in a second step, reacting the resultant anion with an alkylation agent R.sup.7 --X, X being halogen and R.sup.7 being unsubstituted or phenyl-substituted C.sub.1 -C.sub.20 alkyl, to the corresponding carboximide and,(c) in a third step, treating the alkylated carboximide first with a base and, after the treatment with a base, obtaining the perylene-3,4-dicarboxylic acid anhydride I by acidifying the reaction mixture, andnovel perylene-3,4-dicarboxylic acid anhydrides, novel N-alkylperylene-3,4-dicarboxylic acid imides and possibilities for the application of the compounds prepared according to this invention.
摘要翻译：制备通式Ⅰ的苝-3,4-二羧酸酐，其中R 1，R 2，R 3和R 4各自各自独立地为氢，卤素，C 1 -C 20烷基，C 3 -C 14环烷基，C 1 -C 20烷氧基，苯基，苯氧基或苯硫基，其中每种情况下苯基可被卤素，C 1 -C 20烷基，C 3 -C 14环烷基和/或C 1 -C 20烷氧基单取代或多取代; -NR 52或-OR 5，其中R 5是氢或C 1 -C 20烷基，或者每个6,7或1,12位中的一对R 1 / R 2和R 3 / R 4是具有桥原子或桥原子基团的桥 -O-，-S-，S = O，SO 2或-NR 6，其中R 6是氢，C 1 -C 20烷基或C 3 -C 14环烷基，通过在第一步中处理式II（a）的苝-3,4-二甲酰亚胺与碱反应，（b）在第二步中，使所得阴离子与烷基化试剂R7-X，X为卤素，R7为未取代的或苯基取代的C1-C20烷基反应至相应的甲酰亚胺，和（c）第三步，首先用碱处理烷基化的酰亚胺化物，在用碱处理后，通过酸化反应混合物得到苝-3,4-二羧酸酐I，并加入新的苝-3,4-二羧酸酐，新型N-烷基亚丙基-3,4-二羧酸酰亚胺以及应用根据本发明制备的化合物的可能性。

10. 发明授权

US5179230A Process for the preparation of 2,3,4,5-tetrafluorobenzoic acid 失效
标题翻译：制备2,3,4,5-四氢叶酸的方法
公开(公告)号：US5179230A
公开(公告)日：1993-01-12
申请号：US872059
申请日：1992-04-23
申请人： Theodor Papenfuhs , Ralf Pfirmann
发明人： Theodor Papenfuhs , Ralf Pfirmann
IPC分类号： C07C51/00 , C07C51/06 , C07C63/70
CPC分类号： C07C51/44 , C07C51/38
摘要： A process for the preparation of 2,3,4,5,-tetrafluorobenzoic acid of the formula (1) ##STR1## by heating N'-substituted N-aminotetrafluorophthalimides of the formula (2) ##STR2## in which X is the radical ##STR3## where R.sub.1, R.sub.2 are a hydrogen atom, an alkyl-(C.sub.1 -C.sub.10)- group, aryl group, alkyl-(C.sub.1 -C.sub.6)-Co- group or aryl-CO- group, it being possible for the aryl or aryl-CO- group in the case of R.sub.1 and R.sub.2 to be substituted on the aromatic ring by fluorine and/or chlorine atoms and/or alkyl-(C.sub.1 -C.sub.4)-groups, or R.sub.1 and R.sub.2 together are a phthaloyl radical which can be substituted on the aromatic ring by 4 chlorine atoms or 4 fluorine atoms, or where X is the radical ##STR4## which can be substituted on the aromatic ring by fluorine and/or chlorine atoms and/or alkyl-(C.sub.1 -C.sub.4)- groups, in an aqueous medium at pH values of approximately -1 to approximately +1 at temperatures of approximately 160 to approximately 220.degree. C.
摘要翻译：通过加热式（2）的N-取代的N-氨基四氟邻苯二甲酰亚胺（2）制备式（1）的2,3,4,5-四氟苯甲酸的方法（1）其中X是基团，其中R 1，R 2是氢原子，烷基 - （C 1 -C 10） - 基，芳基，烷基 - （C 1 -C 6） - 基或芳基-CO-基团， R 1和R 2在芳环上被氟和/或氯原子和/或烷基 - （C 1 -C 4） - 基团取代时，芳基或芳基-CO-基团是有可能的，或者R1和R2 一起是可以在芳环上被4个氯原子或4个氟原子取代的邻苯二甲酰基，或其中X是可以在芳环上被氟和/或氯原子和/或烷基取代的基团 - （C1-C4） - 基团，在约160至约220℃的温度下，pH值约为-1至约+ 1的水性介质中。

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