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1. 发明授权

US4855063A Red blood cell filtering system 失效
标题翻译：红细胞过滤系统
公开(公告)号：US4855063A
公开(公告)日：1989-08-08
申请号：US854287
申请日：1986-04-21
申请人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
发明人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
IPC分类号： A61M1/02 , A61M1/36
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M2202/0439
摘要： Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with perservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
摘要翻译：用于从红细胞混合物中相对快速有效地除去白细胞的封闭过滤系统。系统包括通过中间过滤器组件彼此密封连通的至少两个血袋，所述中间过滤器组件包括含有连续过滤纤维的壳体。优选的外壳是锥形的，并且纤维优选地具有大致Y形的横截面积，并且其适合于允许从红血细胞混合物中显着除去白细胞，当混合物用维生素溶液稀释时，红细胞溶血少并以相对高的流量从一个袋子传递到另一个袋子。过滤在全血献血的24小时内，最好在6小时内完成。

2. 发明授权

US4810378A Red blood cell filtering system 失效
标题翻译：红细胞过滤系统
公开(公告)号：US4810378A
公开(公告)日：1989-03-07
申请号：US53884
申请日：1987-05-26
申请人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
发明人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , B01D29/08 , B01D36/00
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0439
摘要： Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
摘要翻译：用于从红细胞混合物中相对快速有效地除去白细胞的封闭过滤系统。系统包括通过中间过滤器组件彼此密封连通的至少两个血袋，所述中间过滤器组件包括含有连续过滤纤维的壳体。优选的外壳是锥形的，并且纤维优选地具有大致Y形的横截面积，并且其适于允许当用防腐剂溶液稀释混合物时从红细胞混合物中显着除去白细胞，红细胞溶血最小并以相对高的流量从一个袋子传递到另一个袋子。过滤在全血献血的24小时内，最好在6小时内完成。

3. 发明授权

US4915848A Red blood cell filtering system 失效
标题翻译：红细胞过滤系统
公开(公告)号：US4915848A
公开(公告)日：1990-04-10
申请号：US304133
申请日：1989-01-31
申请人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
发明人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
IPC分类号： A61M1/02 , A61M1/36
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0439
摘要： Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
摘要翻译：用于从红细胞混合物中相对快速有效地除去白细胞的封闭过滤系统。系统包括通过中间过滤器组件彼此密封连通的至少两个血袋，所述中间过滤器组件包括含有连续过滤纤维的壳体。优选的壳体是锥形的并且纤维优选地具有大致Y形的横截面积，并且其适于允许当用防腐剂溶液稀释混合物时从红细胞混合物中显着除去白细胞，同时具有最小的红细胞溶血并以相对高的流量从一个袋子传递到另一个袋子。过滤在全血献血的24小时内，最好在6小时内完成。

4. 发明授权

US4609372A Heat sterilizable storage solution for red blood cells 失效
标题翻译：用于红细胞的热灭菌储存溶液
公开(公告)号：US4609372A
公开(公告)日：1986-09-02
申请号：US541813
申请日：1983-10-13
申请人： Raleigh A. Carmen , Chiyong Chong , Barry Leng
发明人： Raleigh A. Carmen , Chiyong Chong , Barry Leng
IPC分类号： A01N1/02 , A61M1/02
CPC分类号： A01N1/02 , A01N1/0263 , A61M1/0209
摘要： Aqueous storage solution for red blood cells comprising a stabilized ascorbate derivative and having a pH sufficient to maintain substantially all of the initial concentration of ascorbate derivative and avoid formation of ascorbate degradation products during heat sterilization. A preferred solution includes at least about 90% of the pre-sterilization ascorbate and adenine but is free of dextrose.
摘要翻译：含有稳定的抗坏血酸盐衍生物的红细胞水溶液，其PH值足以维持基本上全部的抗坏血酸盐衍生物的初始浓度，并避免在加热灭菌过程中形成抗坏血酸降解产物。优选的溶液包括至少约90％的灭菌前抗坏血酸和腺嘌呤但不含葡萄糖。

5. 发明授权

US4969882A Bag for separation and isolation of blood components 失效
标题翻译：用于分离和分离血液成分的袋子
公开(公告)号：US4969882A
公开(公告)日：1990-11-13
申请号：US879745
申请日：1986-06-27
申请人： Raleigh A. Carmen , Barry S. Leng , Willie J. Lewis , Edward J. Nelson
发明人： Raleigh A. Carmen , Barry S. Leng , Willie J. Lewis , Edward J. Nelson
IPC分类号： A61M1/02
CPC分类号： A61M1/0209
摘要： A generally flat, elongated edge-sealed polymeric blood bag having a length to width ratio of at least 2 to 1 and one end portion in tapering communication with a connected tubing. When the bag is filled with a mixture of blood components which are then separated, the tapering end portion expands to form a funnel-like guide for directing a separated component from the bag through the tubing in a substantially unobstructed manner. Bag is especially useful for separating and isolating the components of a neocyte/gerocyte red blood cell mixture.
摘要翻译：一种长度与宽度比至少为2比1的一般扁平细长的边缘密封聚合血袋，以及与连接的管子呈锥形连通的一个端部。当袋子充满血液成分的混合物然后分离时，锥形端部膨胀以形成漏斗状引导件，用于以基本无阻碍的方式将分离的部件从袋子引导通过管道。袋对于分离和分离新生细胞/巨细胞红细胞混合物的组分特别有用。

6. 发明授权

US4892537A Bag for separation and isolation of blood components 失效
公开(公告)号：US4892537A
公开(公告)日：1990-01-09
申请号：US700793
申请日：1985-02-11
申请人： Raleigh A. Carmen , Barry S. Leng , Willie J. Lewis , Edward J. Nelson
发明人： Raleigh A. Carmen , Barry S. Leng , Willie J. Lewis , Edward J. Nelson
IPC分类号： A61J1/05 , A61J1/00 , A61J1/10 , A61K35/14 , A61M1/02 , A61M1/36
CPC分类号： A61M1/0209
摘要： A generally flat, elongated edge-sealed polymeric blood bag having a length to width ratio of at least 2 to 1 and one end portion in tapering communication with a connected tubing. When the bag is filled with a mixture of blood components which are then separated, the tapering end portion expands to form a funnel-like guide for directing a separated component from the bag through the tubing in a substantially unobstructed manner. Bag is especially useful for separating and isolating the components of a neocyte/gerocyte red blood cell mixture.

7. 发明授权

US5968619A Material for flexible medical products 失效
公开(公告)号：US5968619A
公开(公告)日：1999-10-19
申请号：US978441
申请日：1997-11-25
申请人： Raleigh A. Carmen , Ronald H. Bauman
发明人： Raleigh A. Carmen , Ronald H. Bauman
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08K5/12 , C08F114/06 , A61B19/00 , B29D22/00
CPC分类号： A61L31/048 , A61J1/10 , A61L29/041 , A61L29/141 , A61L31/141 , C08K5/12 , Y10T428/1334 , Y10T428/1341 , Y10T428/1345 , Y10T428/1352 , Y10T428/1379 , Y10T428/139
摘要： Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).

8. 发明授权

US5089146A Pre-storage filtration of platelets 失效
标题翻译：板坯的预储存过滤
公开(公告)号：US5089146A
公开(公告)日：1992-02-18
申请号：US478853
申请日：1990-02-12
申请人： Raleigh A. Carmen , Edward J. Nelson
发明人： Raleigh A. Carmen , Edward J. Nelson
IPC分类号： A61M1/02
CPC分类号： A61M1/0209 , A61M1/0218 , A61M2202/0415 , A61M2202/0427 , A61M2202/0439
摘要： Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter disposed between a first blood bag and at least two empty secondary bags. A fourth bag may be included in the closed system to contain a platelet additive solution. System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.

9. 发明授权

US6060138A Material for flexible medical products 有权
标题翻译：灵活医疗产品的材料
公开(公告)号：US6060138A
公开(公告)日：2000-05-09
申请号：US361250
申请日：1999-07-27
申请人： Raleigh A. Carmen , Ronald H. Bauman
发明人： Raleigh A. Carmen , Ronald H. Bauman
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08K5/12 , C08F114/06 , A61B19/00 , B29D22/00
CPC分类号： A61L31/048 , A61J1/10 , A61L29/041 , A61L29/141 , A61L31/141 , C08K5/12 , Y10T428/1334 , Y10T428/1341 , Y10T428/1345 , Y10T428/1352 , Y10T428/1379 , Y10T428/139
摘要： Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).
摘要翻译：改进的由PVC化合物制造的医疗产品的柔性膜和管道，其包含一定量的特性粘度范围为约1.25至约2.00，最优选约1.71和约43至约57的超高分子量（UHMW）PVC树脂重量百分比的医药上可接受的增塑剂，最优选约53％，如偏苯三酸三（2-乙基己基）酯（TOTM）。

10. 发明授权

US5769839A Long-term blood components storage system and method 失效
标题翻译：长期血液成分储存系统及方法
公开(公告)号：US5769839A
公开(公告)日：1998-06-23
申请号：US708899
申请日：1996-09-05
申请人： Raleigh A. Carmen , Chi Yong Chong , Randy B. Garcez
发明人： Raleigh A. Carmen , Chi Yong Chong , Randy B. Garcez
IPC分类号： A01N1/02 , A61K35/18 , A61L31/04 , A61L31/06 , A61L31/14 , A61M1/02 , A61B19/00
CPC分类号： A01N1/0263 , A01N1/02 , A01N1/0226 , A61K35/18 , A61L31/048 , A61L31/06 , A61L31/141 , A61M1/0209 , A61M1/0218 , A61M1/0236
摘要： System and method for storing packed red blood cells (RBCs) long-term in a non-extractable plastic blood storage bag in a hypotonic cell preservation solution, for subsequent human parenteral introduction of the stored red blood cells. In addition, a blood storage bag that contains a volume of blood product, such as packed red blood cells, that have hemolyzed less than 1% during at least 42 days storage in a non-extractable plastic storage bag containing a volume of hypotonic cell preservation solution.
摘要翻译：用于在低渗细胞保存溶液中的不可提取的塑料储血袋中长期储存包装的红细胞（RBC）的系统和方法，用于随后的人肠胃外引入所储存的红细胞。另外，在含有一定体积的低渗细胞保存物的不可萃取的塑料储存袋中，含有一定量的血液制品例如包装的红细胞的血液储存袋在至少42天内溶血至少少于1％解。

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