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1. 发明授权

US6060138A Material for flexible medical products 有权
标题翻译：灵活医疗产品的材料
公开(公告)号：US6060138A
公开(公告)日：2000-05-09
申请号：US361250
申请日：1999-07-27
申请人： Raleigh A. Carmen , Ronald H. Bauman
发明人： Raleigh A. Carmen , Ronald H. Bauman
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08K5/12 , C08F114/06 , A61B19/00 , B29D22/00
CPC分类号： A61L31/048 , A61J1/10 , A61L29/041 , A61L29/141 , A61L31/141 , C08K5/12 , Y10T428/1334 , Y10T428/1341 , Y10T428/1345 , Y10T428/1352 , Y10T428/1379 , Y10T428/139
摘要： Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).
摘要翻译：改进的由PVC化合物制造的医疗产品的柔性膜和管道，其包含一定量的特性粘度范围为约1.25至约2.00，最优选约1.71和约43至约57的超高分子量（UHMW）PVC树脂重量百分比的医药上可接受的增塑剂，最优选约53％，如偏苯三酸三（2-乙基己基）酯（TOTM）。

2. 发明授权

US5769839A Long-term blood components storage system and method 失效
标题翻译：长期血液成分储存系统及方法
公开(公告)号：US5769839A
公开(公告)日：1998-06-23
申请号：US708899
申请日：1996-09-05
申请人： Raleigh A. Carmen , Chi Yong Chong , Randy B. Garcez
发明人： Raleigh A. Carmen , Chi Yong Chong , Randy B. Garcez
IPC分类号： A01N1/02 , A61K35/18 , A61L31/04 , A61L31/06 , A61L31/14 , A61M1/02 , A61B19/00
CPC分类号： A01N1/0263 , A01N1/02 , A01N1/0226 , A61K35/18 , A61L31/048 , A61L31/06 , A61L31/141 , A61M1/0209 , A61M1/0218 , A61M1/0236
摘要： System and method for storing packed red blood cells (RBCs) long-term in a non-extractable plastic blood storage bag in a hypotonic cell preservation solution, for subsequent human parenteral introduction of the stored red blood cells. In addition, a blood storage bag that contains a volume of blood product, such as packed red blood cells, that have hemolyzed less than 1% during at least 42 days storage in a non-extractable plastic storage bag containing a volume of hypotonic cell preservation solution.
摘要翻译：用于在低渗细胞保存溶液中的不可提取的塑料储血袋中长期储存包装的红细胞（RBC）的系统和方法，用于随后的人肠胃外引入所储存的红细胞。另外，在含有一定体积的低渗细胞保存物的不可萃取的塑料储存袋中，含有一定量的血液制品例如包装的红细胞的血液储存袋在至少42天内溶血至少少于1％解。

3. 发明授权

US5236716A Platelets concentrate with low white blood cells content 失效
标题翻译：血小板浓度低，白细胞含量低
公开(公告)号：US5236716A
公开(公告)日：1993-08-17
申请号：US836631
申请日：1992-02-14
申请人： Raleigh A. Carmen , Edward J. Nelson
发明人： Raleigh A. Carmen , Edward J. Nelson
IPC分类号： A61M1/02
CPC分类号： A61M1/0209 , A61M1/0218 , A61M2202/0415 , A61M2202/0427 , A61M2202/0439
摘要： Platelet concentrate containing less then 10.sup.6 white blood cells and prepared from a unit of whole blood sample in a closed multiple blood bag system within less than about eight hours after the whole blood is removed from a human. The concentrate is contained in a platelet storage bag made from polyvinyl chloride plasticized with either trioctyltrimellitate or ethylene vinyl acetate.
摘要翻译：血小板浓缩物含有少于106个白血球，并且在全血从人中除去之后的大约八小时内，在封闭的多个血液袋系统中由全血样品单元制备。浓缩物包含在由聚氯乙烯制成的血小板储存袋中，所述聚氯乙烯用三辛基偏苯三酸酯或乙烯乙酸乙烯酯增塑。

4. 发明授权

US4902287A Sterilizable system for blood storage 失效
标题翻译：血液储存无菌系统
公开(公告)号：US4902287A
公开(公告)日：1990-02-20
申请号：US100647
申请日：1987-09-24
申请人： Raleigh A. Carmen , Chi-Yong Chong
发明人： Raleigh A. Carmen , Chi-Yong Chong
IPC分类号： A61J1/05 , A61J1/00 , A61J1/10 , A61J1/20 , A61L2/07 , A61L2/10
CPC分类号： A61L2/07 , A61J1/067 , A61J1/10 , A61J1/2089 , A61J1/2027 , A61J1/2037
摘要： An improved heat sterilizable blood bag system adapted for containing and mixing of different materials originally placed in separate but potentially communicating compartments. The improvement comprises of having a smaller squeezable compartment for one material attached to and capable of communicating with a larger compartment for the other material. The material in the smaller compartment is separated from the interior of the larger compartment by means of an externally manipulatable closure means which, when opened, permits mixture of the contents in the first compartment and contents of the second compartment when the smaller compartment is repeatedly squeezed.

5. 发明授权

US4810378A Red blood cell filtering system 失效
标题翻译：红细胞过滤系统
公开(公告)号：US4810378A
公开(公告)日：1989-03-07
申请号：US53884
申请日：1987-05-26
申请人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
发明人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , B01D29/08 , B01D36/00
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0439
摘要： Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
摘要翻译：用于从红细胞混合物中相对快速有效地除去白细胞的封闭过滤系统。系统包括通过中间过滤器组件彼此密封连通的至少两个血袋，所述中间过滤器组件包括含有连续过滤纤维的壳体。优选的外壳是锥形的，并且纤维优选地具有大致Y形的横截面积，并且其适于允许当用防腐剂溶液稀释混合物时从红细胞混合物中显着除去白细胞，红细胞溶血最小并以相对高的流量从一个袋子传递到另一个袋子。过滤在全血献血的24小时内，最好在6小时内完成。

6. 发明授权

US5721024A Material for flexible medical products 失效
公开(公告)号：US5721024A
公开(公告)日：1998-02-24
申请号：US487493
申请日：1995-06-07
申请人： Raleigh A. Carmen , Ronald H. Bauman
发明人： Raleigh A. Carmen , Ronald H. Bauman
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08K5/12
CPC分类号： A61L31/048 , A61J1/10 , A61L29/041 , A61L29/141 , A61L31/141 , C08K5/12 , Y10T428/1334 , Y10T428/1341 , Y10T428/1345 , Y10T428/1352 , Y10T428/1379 , Y10T428/139
摘要： Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).

7. 发明授权

US5102407A Blood separation system 失效
标题翻译：血液分离系统
公开(公告)号：US5102407A
公开(公告)日：1992-04-07
申请号：US493024
申请日：1990-03-13
申请人： Raleigh A. Carmen , Willie J. Lewis , Eva Sajan
发明人： Raleigh A. Carmen , Willie J. Lewis , Eva Sajan
IPC分类号： A61J1/10 , A61M1/02
CPC分类号： A61M1/0209
摘要： Blood bag system for separating whole blood into upper, middle, and lower components which can then be isolated from each other in an automated manner. The system comprises a primary or main blood bag having first and second outlet ports. The first outlet port communicates via tubing with a first satellite bag. The second outlet port communicates via tubing with a second satellite bag at one end and at the other end communicates with a tubular member extending into and toward the bottom of the main bag. In use whole blood is drawn into the main bag through an inlet port and centrifuged to form an upper, less dense plasma portion, a lower, more dense red blood cell (RBC) portion and an intermediate portion of buffy coat (including platelets). Pressure is then applied to the bag with the first outlet open and the second outlet closed to express all of the upper plasma through the first outlet port after which the first outlet port is closed and the second outlet is opened. The lower RBCs are expressed by pressure through the tubular member and second outlet, leaving only the intermediate buffy coat in the main bag. The system may be automated with sensors to monitor and control the flow of fluids through each outlet and from the main bag.

8. 发明授权

US4994057A Sterilizable system for blood storage 失效
标题翻译：血液储存无菌系统
公开(公告)号：US4994057A
公开(公告)日：1991-02-19
申请号：US432431
申请日：1989-11-06
申请人： Raleigh A. Carmen , Chi-Yong Chong
发明人： Raleigh A. Carmen , Chi-Yong Chong
IPC分类号： A61J1/05 , A61J1/00 , A61J1/10 , A61J1/20 , A61L2/07 , A61L2/10
CPC分类号： A61L2/07 , A61J1/067 , A61J1/10 , A61J1/2089 , A61J1/2027 , A61J1/2037
摘要： An improved heat sterilizable blood bag system adapted for containing and mixing of different materials originally placed in separate but potentially communicating compartments. The improvement comprises of having a smaller squeezable compartment for one material attached to and capable of communicating with a larger compartment for the other material. The material in the smaller compartment is separated from the interior of the larger compartment by means of an externally manipulatable closure means which, when opened, permits mixture of the contents in the first compartment and contents of the second compartment when the smaller compartment is repeatedly squeezed.
摘要翻译：一种改进的可热灭菌血袋系统，适用于容纳和混合最初放置在单独但潜在连通的隔室中的不同材料。该改进包括具有较小的可挤压隔间，用于连接到并能够与用于其它材料的较大隔间连通的一种材料。较小隔间的材料通过外部可操纵的封闭装置从较大隔间的内部分离，当封闭装置打开时，当较小的隔室被重复挤压时，允许混合第一隔室中的内容物和第二隔室的内容物。

9. 发明授权

US4943287A Red blood cell storage system 失效
标题翻译：红细胞储存系统
公开(公告)号：US4943287A
公开(公告)日：1990-07-24
申请号：US380949
申请日：1989-07-17
申请人： Raleigh A. Carmen
发明人： Raleigh A. Carmen
IPC分类号： A61J1/10 , A61K35/18 , A61M1/02 , A61M39/22
CPC分类号： A61K35/18 , A61M1/0209 , A61M1/0218 , A61M2039/222 , A61M2202/0429 , A61M2202/0439
摘要： Closed blood bag system for long term storage of red blood cells (RBCs) without contamination due to storage. System comprises the combination of a white blood cell (WBC) filter in sterile communication with a plastic bag made from a film substantially free of blood extractable plasticizers. In use, an RBC preservative solution (preferably from within the closed system) is added to a mixture of RBCs and WBCs and the mixture is then passed through the filter to remove at least 98% of the WBCs. The filtered RBCs and preservative solution pass into the attached bag and can then be stored in the attached bag for up to 42 days.
摘要翻译：封闭式血袋系统可长期储存红血球（RBC），不会因储存而受到污染。系统包括与由基本上不含可提取血液的增塑剂的薄膜制成的塑料袋无菌连通的白血球（WBC）过滤器的组合。在使用中，将RBC防腐剂溶液（优选从封闭系统内）加入到RBC和WBC的混合物中，然后使混合物通过过滤器以除去至少98％的WBC。过滤的红细胞和防腐剂溶液进入附着的袋子中，然后可以存放在附着的袋子中长达42天。

10. 发明授权

US4915848A Red blood cell filtering system 失效
标题翻译：红细胞过滤系统
公开(公告)号：US4915848A
公开(公告)日：1990-04-10
申请号：US304133
申请日：1989-01-31
申请人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
发明人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
IPC分类号： A61M1/02 , A61M1/36
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0439
摘要： Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
摘要翻译：用于从红细胞混合物中相对快速有效地除去白细胞的封闭过滤系统。系统包括通过中间过滤器组件彼此密封连通的至少两个血袋，所述中间过滤器组件包括含有连续过滤纤维的壳体。优选的壳体是锥形的并且纤维优选地具有大致Y形的横截面积，并且其适于允许当用防腐剂溶液稀释混合物时从红细胞混合物中显着除去白细胞，同时具有最小的红细胞溶血并以相对高的流量从一个袋子传递到另一个袋子。过滤在全血献血的24小时内，最好在6小时内完成。

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