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1. 发明授权

US08801701B2 Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment 有权
标题翻译：用于在经历热疗治疗的前列腺和其他组织中获得定量温度测量的方法和装置
公开(公告)号：US08801701B2
公开(公告)日：2014-08-12
申请号：US11728778
申请日：2007-03-27
申请人： Rajiv Chopra , Michael Bronskill , Kee Tang
发明人： Rajiv Chopra , Michael Bronskill , Kee Tang
IPC分类号： A61B18/10
CPC分类号： A61N7/022 , A61B5/01 , A61B5/4381 , A61B2017/00274 , A61B2018/00547 , A61B2090/374 , G01R33/4804
摘要： The invention provides a method and apparatus for monitoring a thermal effect of a conformal thermal treatment to diseased tissue in a target volume. The method includes acquiring a reference image of the volume containing the diseased tissue at a first position of the device, determining a baseline temperature distribution of the reference image, acquiring an image of the volume containing the diseased tissue while delivering a treatment to the volume, performing a phase subtraction between the image and the reference image to determine a change in phase between the image and the reference image and determining a current spatial temperature distribution in the volume containing the diseased tissue.
摘要翻译：本发明提供了一种用于监测对目标体积中的病态组织的保形热处理的热效应的方法和装置。该方法包括在装置的第一位置处获取包含患病组织的体积的参考图像，确定参考图像的基线温度分布，在向体积传送治疗的同时获取包含患病组织的体积的图像，执行图像和参考图像之间的相位减除以确定图像和参考图像之间的相位变化，并确定包含患病组织的体积中的当前空间温度分布。

2. 发明申请

US20070239062A1 Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment 有权
标题翻译：用于在经历热疗治疗的前列腺和其他组织中获得定量温度测量的方法和装置
公开(公告)号：US20070239062A1
公开(公告)日：2007-10-11
申请号：US11728778
申请日：2007-03-27
申请人： Rajiv Chopra , Michael Bronskill , Kee Tang
发明人： Rajiv Chopra , Michael Bronskill , Kee Tang
IPC分类号： A61B18/04 , A61B5/00
CPC分类号： A61N7/022 , A61B5/01 , A61B5/4381 , A61B2017/00274 , A61B2018/00547 , A61B2090/374 , G01R33/4804
摘要： The invention provides a method and apparatus for monitoring a thermal effect of a conformal thermal treatment to diseased tissue in a target volume. The method includes acquiring a reference image of the volume containing the diseased tissue at a first position of the device, determining a baseline temperature distribution of the reference image, acquiring an image of the volume containing the diseased tissue while delivering a treatment to the volume, performing a phase subtraction between the image and the reference image to determine a change in phase between the image and the reference image and determining a current spatial temperature distribution in the volume containing the diseased tissue.
摘要翻译：本发明提供了一种用于监测对目标体积中的病态组织的保形热处理的热效应的方法和装置。该方法包括在装置的第一位置处获取包含患病组织的体积的参考图像，确定参考图像的基线温度分布，在向体积传送治疗的同时获取包含患病组织的体积的图像，执行图像和参考图像之间的相位减除以确定图像和参考图像之间的相位变化，并确定包含患病组织的体积中的当前空间温度分布。

3. 发明申请

US20060206105A1 Treatment of diseased tissue using controlled ultrasonic heating 有权
标题翻译：使用受控超声波加热治疗患病组织
公开(公告)号：US20060206105A1
公开(公告)日：2006-09-14
申请号：US11076669
申请日：2005-03-09
申请人： Rajiv Chopra , Michael Bronskill , Mathieu Burtnyk
发明人： Rajiv Chopra , Michael Bronskill , Mathieu Burtnyk
IPC分类号： A61B18/04 , A61F7/00 , A61F7/12 , A61B8/12
CPC分类号： A61B5/055 , A61B2017/00084 , A61B2018/00023 , A61B2090/374 , A61N7/02 , A61N2007/025
摘要： The present invention provides a method and apparatus for delivering and controlling thermal therapy to a volume of diseased tissue. Specifically, the invention includes using thermal imaging and other inputs to determine an acoustic (ultrasonic) treatment regime employing interstitial ultrasound applicators to deliver a required therapeutic temperature or thermal dose to the affected region in a body or organ. Various aspects of the treatment that can be controlled include individual transducer element operating power and frequency, as well as the rate of cooling and rotation of the entire applicator.
摘要翻译：本发明提供了一种用于向一定体积的病变组织递送和控制热治疗的方法和装置。具体地，本发明包括使用热成像和其他输入来确定采用间质超声施加器的声学（超声）处理方案，以将所需的治疗温度或热剂量递送到身体或器官中的受影响区域。可以控制的治疗的各个方面包括各个换能器元件的操作功率和频率，以及整个施用器的冷却和旋转速率。

4. 发明授权

US09931523B2 RF power controller for ultrasound therapy system 有权
公开(公告)号：US09931523B2
公开(公告)日：2018-04-03
申请号：US12932923
申请日：2011-03-09
申请人： Cameron Mahon , Nicolas Yak , Rajiv Chopra , Mathew Asselin , Michael Bronskill
发明人： Cameron Mahon , Nicolas Yak , Rajiv Chopra , Mathew Asselin , Michael Bronskill
IPC分类号： A61H1/00 , A61H1/02 , A61H5/00 , A61N7/00 , A61B17/225 , A61N7/02
CPC分类号： A61N7/00 , A61B17/225 , A61N7/022 , A61N2007/0095
摘要： An apparatus for driving and controlling ultrasonic elements includes a computer-based host unit that determines driving characteristics with which to drive the ultrasonic elements; a microprocessor-based controller that receives an output from the host and provides signals representing a frequency and/or an amplitude characteristic; a frequency control circuit receiving the frequency characteristic signal; an amplitude control circuit receiving the amplitude characteristic signal; an RF amplifier acting on an output from the frequency and/or the amplitude control circuits to provide an amplified output signal corresponding to the frequency and/or amplitude characteristic; a coupling circuit that couples the amplified output signal to the ultrasonic elements and provides a forward output signal to a first RF detector circuit and a reverse output signal to a second RF detector circuit; and an analog-to-digital converter that receives an output of the RF detector circuits and provides a corresponding converted output to the controller.

5. 发明授权

US08989838B2 System for treatment of diseased tissue using controlled ultrasonic heating 有权
标题翻译：使用受控超声波加热治疗患病组织的系统
公开(公告)号：US08989838B2
公开(公告)日：2015-03-24
申请号：US12830648
申请日：2010-07-06
申请人： Rajiv Chopra , Michael Bronskill , Mathieu Burtnyk
发明人： Rajiv Chopra , Michael Bronskill , Mathieu Burtnyk
IPC分类号： A61B5/055 , A61N7/02 , A61B17/00 , A61B18/00 , A61B19/00
CPC分类号： A61B5/055 , A61B2017/00084 , A61B2018/00023 , A61B2090/374 , A61N7/02 , A61N2007/025
摘要： The present invention provides a method and apparatus for delivering and controlling thermal therapy to a volume of diseased tissue. Specifically, the invention includes using thermal imaging and other inputs to determine an acoustic (ultrasonic) treatment regime employing interstitial ultrasound applicators to deliver a required therapeutic temperature or thermal dose to the affected region in a body or organ. Various aspects of the treatment that can be controlled include individual transducer element operating power and frequency, as well as the rate of cooling and rotation of the entire applicator.
摘要翻译：本发明提供了一种用于向一定体积的病变组织递送和控制热治疗的方法和装置。具体地，本发明包括使用热成像和其他输入来确定采用间质超声施加器的声学（超声）处理方案，以将所需的治疗温度或热剂量递送到身体或器官中的受影响区域。可以控制的治疗的各个方面包括各个换能器元件的操作功率和频率，以及整个施用器的冷却和旋转速率。

6. 发明申请

US20110295161A1 Ultrasonic therapy applicator 有权
标题翻译：超声波治疗仪
公开(公告)号：US20110295161A1
公开(公告)日：2011-12-01
申请号：US12932920
申请日：2011-03-09
申请人： Rajiv Chopra , Michael Bronskill , Sean Donaldson , Cameron Mahon
发明人： Rajiv Chopra , Michael Bronskill , Sean Donaldson , Cameron Mahon
IPC分类号： A61N7/02
CPC分类号： A61N7/022 , A61B18/1485 , A61B18/1815 , A61B2017/00274 , A61B2018/00011 , A61B2018/00023 , A61B2018/00517 , A61B2018/00547 , A61B2090/374 , A61B2090/378 , A61F7/12 , A61N7/02 , A61N2007/0078 , A61N2007/0091
摘要： An apparatus is disclosed for thermal therapy in a male prostate patient. The apparatus includes, in preferred embodiments, a long tubular element that is to be inserted into a patient's urethra so that a first tip end of it reaches up into the patient's diseased prostate. The elongated portion includes a narrow cylindrical tube within which an ultrasonic array is disposed along the long axis of the cylinder. Fluid is pumped into and out of a treatment zone of said patient as needed to control a temperature of a region in said treatment zone. A motorized driver is used to controllably rotate said elongated portion and the ultrasound array therein about the long axis of the apparatus so as to deliver acoustic energy to said diseased tissue. Various control and monitoring components may be used in conjunction with the present apparatus to design, control, and terminate the therapy.
摘要翻译：公开了一种用于男性前列腺患者的热疗的装置。在优选实施例中，该装置包括待插入患者尿道的长管状元件，使得其第一末端到达患者的患病前列腺。细长部分包括窄圆柱形管，超声波阵列沿着圆柱体的长轴设置在该圆柱形管内。根据需要将流体泵入和流出所述患者的治疗区域以控制所述治疗区域中的区域的温度。电动驾驶员用于围绕设备的长轴可控地旋转所述细长部分和超声阵列，以将声能递送到所述患病组织。可以结合本装置使用各种控制和监测部件来设计，控制和终止治疗。

7. 发明授权

US07771418B2 Treatment of diseased tissue using controlled ultrasonic heating 有权
标题翻译：使用受控超声波加热治疗患病组织
公开(公告)号：US07771418B2
公开(公告)日：2010-08-10
申请号：US11076669
申请日：2005-03-09
申请人： Rajiv Chopra , Michael Bronskill , Mathieu Burtnyk
发明人： Rajiv Chopra , Michael Bronskill , Mathieu Burtnyk
IPC分类号： A61B18/04
CPC分类号： A61B5/055 , A61B2017/00084 , A61B2018/00023 , A61B2090/374 , A61N7/02 , A61N2007/025
摘要： The present invention provides a method and apparatus for delivering and controlling thermal therapy to a volume of diseased tissue. Specifically, the invention includes using thermal imaging and other inputs to determine an acoustic (ultrasonic) treatment regime employing interstitial ultrasound applicators to deliver a required therapeutic temperature or thermal dose to the affected region in a body or organ. Various aspects of the treatment that can be controlled include individual transducer element operating power and frequency, as well as the rate of cooling and rotation of the entire applicator.
摘要翻译：本发明提供了一种用于向一定体积的病变组织递送和控制热治疗的方法和装置。具体地，本发明包括使用热成像和其他输入来确定采用间质超声施加器的声学（超声）处理方案，以将所需的治疗温度或热剂量递送到身体或器官中的受影响区域。可以控制的治疗的各个方面包括各个换能器元件的操作功率和频率，以及整个施用器的冷却和旋转速率。

8. 发明申请

US20110270366A1 RF power controller for ultrasound therapy system 有权
标题翻译：射频功率控制器用于超声治疗系统
公开(公告)号：US20110270366A1
公开(公告)日：2011-11-03
申请号：US12932923
申请日：2011-03-09
申请人： Cameron Mahon , Nicolas Yak , Rajiv Chopra , Mathew Asselin , Michael Bronskill
发明人： Cameron Mahon , Nicolas Yak , Rajiv Chopra , Mathew Asselin , Michael Bronskill
IPC分类号： A61F7/00
CPC分类号： A61N7/00 , A61B17/225 , A61N7/022 , A61N2007/0095
摘要： A system and method for fluid control in a thermal therapy system is disclosed. A fluid circuit permits passage of a fluid through a fluid circuit, including into and out of a treatment zone so as to cool or heat or maintain a temperature in said treatment zone at or near a desired temperature. The desired temperature may be programmably set to a given value or within a band of values using a processor and a temperature controller. In some aspects, leakage of fluid from a patient or from the fluid control system is captured by a leak-proof member to protect imaging and treatment equipment from damage.
摘要翻译：公开了一种用于热疗系统中的流体控制的系统和方法。流体回路允许流体通过流体回路，包括进入和离开处理区域，以便冷却或加热或维持处于或接近所需温度的处理区域的温度。可以使用处理器和温度控制器将期望的温度可编程地设置为给定值或在值带内。在一些方面，来自患者或流体控制系统的流体泄漏由防漏构件捕获以保护成像和治疗设备免受损坏。

9. 发明申请

US20080182895A1 IDENTIFICATION AND CHARACTERIZATION OF HCV REPLICON VARIANTS WITH REDUCED SUSCEPTIBILITY TO HCV-796, AND METHODS RELATED THERETO 审中-公开
标题翻译：具有降低HCV-796易感性的HCV REPLICON变体的鉴定和表征及其相关方法
公开(公告)号：US20080182895A1
公开(公告)日：2008-07-31
申请号：US11842312
申请日：2007-08-21
申请人： Anita Y.M. Howe , Rajiv Chopra
发明人： Anita Y.M. Howe , Rajiv Chopra
IPC分类号： A61K31/343 , C12Q1/00 , A61P31/12
CPC分类号： G01N33/5767 , A61K31/343 , A61K31/7056 , A61K45/06 , G01N2333/18 , A61K2300/00
摘要： The present invention provides methods of decreasing the frequency of emergence, decreasing the level of resistance, and delaying the emergence of a treatment-resistant Hepatitis C viral infection, by administering to a subject, either in combination or in series, an inhibitor of the Hepatitis C RNA-dependent RNA polymerase NS5B, e.g., a benzofuran, such as 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide (HCV-796), and at least one additional anti-Hepatitis C agent, e.g., a ribavirin product or an immunomodulator, such as an interferon product. Additionally, the invention relates to methods of monitoring the course of treatment of a Hepatitis C viral infection, methods of monitoring and prognosing a Hepatitis C viral infection, and methods of identifying an individual with a decreased likelihood of responding to an anti-Hepatitis C viral therapy. These methods use the sequence and/or structure of the Hepatitis C RNA-dependent RNA polymerase NS5B to identify the emergence of a treatment-resistant Hepatitis C viral infection, particularly a benzofuran (e.g., HCV-796) treatment-resistant Hepatitis C viral infection.
摘要翻译：本发明提供降低出血频率，降低耐药水平并延缓出现治疗抗性丙型肝炎病毒感染的方法，通过给予受试者，组合或串联地将肝炎抑制剂 C RNA依赖性RNA聚合酶NS5B，例如苯并呋喃，如5-环丙基-2-（4-氟苯基）-6 - [（2-羟乙基）（甲基磺酰基）氨基] -N-甲基-1-苯并呋喃-3 （HCV-796）和至少一种另外的抗丙型肝炎药物，例如利巴韦林产品或免疫调节剂，例如干扰素产物。此外，本发明涉及监测丙型肝炎病毒感染的治疗过程，监测和预测丙型肝炎病毒感染的方法的方法，以及鉴定具有降低的抗丙型肝炎病毒反应可能性的个体的方法治疗。这些方法使用丙型肝炎病毒RNA依赖性RNA聚合酶NS5B的序列和/或结构来鉴定治疗抗性丙型肝炎病毒感染，特别是苯并呋喃（例如HCV-796）治疗抗性丙型肝炎病毒感染的出现。

10. 发明授权

US09707413B2 Controllable rotating ultrasound therapy applicator 有权
公开(公告)号：US09707413B2
公开(公告)日：2017-07-18
申请号：US12932920
申请日：2011-03-09
申请人： Rajiv Chopra , Sean Donaldson , Cameron Mahon
发明人： Rajiv Chopra , Sean Donaldson , Cameron Mahon
IPC分类号： A61N7/02 , A61B18/18 , A61B18/14 , A61F7/12 , A61B18/00 , A61B90/00 , A61B17/00 , A61N7/00
CPC分类号： A61N7/022 , A61B18/1485 , A61B18/1815 , A61B2017/00274 , A61B2018/00011 , A61B2018/00023 , A61B2018/00517 , A61B2018/00547 , A61B2090/374 , A61B2090/378 , A61F7/12 , A61N7/02 , A61N2007/0078 , A61N2007/0091
摘要： An apparatus is disclosed for thermal therapy in a male prostate patient. The apparatus includes, in preferred embodiments, a long tubular element that is to be inserted into a patient's urethra so that a first tip end of it reaches up into the patient's diseased prostate. The elongated portion includes a narrow cylindrical tube within which an ultrasonic array is disposed along the long axis of the cylinder. Fluid is pumped into and out of a treatment zone of said patient as needed to control a temperature of a region in said treatment zone. A motorized driver is used to controllably rotate said elongated portion and the ultrasound array therein about the long axis of the apparatus so as to deliver acoustic energy to said diseased tissue. Various control and monitoring components may be used in conjunction with the present apparatus to design, control, and terminate the therapy.

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