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1. 发明申请

US20120184503A1 NUTRITIONAL COMPOSITIONS COMPRISING HUMAN MILK OLIGOSACCHARIDES AND NUCLEOTIDES AND USES THEREOF FOR TREATING AND/OR PREVENTING ENTERIC VIRAL INFECTION 有权
标题翻译：包含人乳酪寡糖和核苷酸的营养成分及其用于治疗和/或预防肠道病毒感染的用途
公开(公告)号：US20120184503A1
公开(公告)日：2012-07-19
申请号：US13335404
申请日：2011-12-22
申请人： Rachael Buck , Debra L. Thomas , Joseph P. Schaller
发明人： Rachael Buck , Debra L. Thomas , Joseph P. Schaller
IPC分类号： A61K31/7068 , A61P31/14 , A61K31/708 , A61P31/12 , A61K31/7072 , A61K31/7076
CPC分类号： A61K31/702 , A23L33/13 , A23L33/40 , A23V2002/00 , A23V2200/32 , A23V2200/3202 , A23V2200/324 , A23V2250/284 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K2300/00
摘要： Disclosed are nutritional compositions including human milk oligosaccharides and nucleotides that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
摘要翻译：公开了包括人乳寡糖和可以对早产儿，婴儿，幼儿和儿童施用以减少炎症和发炎的疾病的营养组合物。

2. 发明授权

US09763970B2 Nutritional compositions comprising human milk oligosaccharides and nucleotides and uses thereof for treating and/or preventing enteric viral infection 有权
公开(公告)号：US09763970B2
公开(公告)日：2017-09-19
申请号：US13335404
申请日：2011-12-22
申请人： Rachael Buck , Debra L. Thomas , Joseph P. Schaller
发明人： Rachael Buck , Debra L. Thomas , Joseph P. Schaller
IPC分类号： A61K31/702 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A23L33/00 , A23L33/13
CPC分类号： A61K31/702 , A23L33/13 , A23L33/40 , A23V2002/00 , A23V2200/32 , A23V2200/3202 , A23V2200/324 , A23V2250/284 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K2300/00
摘要： Disclosed are nutritional compositions including human milk oligosaccharides and nucleotides that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

3. 发明申请

US20110177044A1 Nutritional Formulas Containing Synbiotics 审中-公开
标题翻译：含有合生素的营养配方
公开(公告)号：US20110177044A1
公开(公告)日：2011-07-21
申请号：US13009816
申请日：2011-01-19
申请人： Debra L. Thomas , Rachael H. Buck
发明人： Debra L. Thomas , Rachael H. Buck
IPC分类号： A61K35/74 , A61P11/06 , A61P37/08 , A61P17/00
CPC分类号： A61K31/702 , A23L33/135 , A23L33/21 , A23L33/30 , A23V2002/00 , A61K35/74 , A61K2035/11 , C12N1/20 , A61K2300/00 , A23V2200/3204 , A23V2200/3202
摘要： The present disclosure relates to a synbiotic composition comprising the probiotic Lactobacillus rhamnosus HN001 and a carbohydrate-based prebiotic such as fructooligosaccharides, galactooligosaccharides, human milk oligosaccharides, or combinations thereof, and the use of the composition for the prevention and/or treatment of allergic disease. In one embodiment, the symbiotic composition comprising the probiotic and prebiotic may be included in a nutritional composition or infant formula.
摘要翻译：本公开涉及包含益生菌鼠李糖乳杆菌HN001和基于碳水化合物的益生元如果寡糖，低聚半乳糖，人乳低聚糖或其组合的合生物组合物，以及该组合物用于预防和/或治疗过敏性疾病的用途。在一个实施方案中，包含益生菌和益生元的共生组合物可以包含在营养组合物或婴儿配方食品中。

4. 发明授权

US08796333B2 Method of using β-hydroxy-β-methylbutyrate to treat a condition 有权
标题翻译：使用β-羟基 - 甲基丁酸酯治疗病症的方法
公开(公告)号：US08796333B2
公开(公告)日：2014-08-05
申请号：US13347750
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/191 , A61K31/19
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

5. 发明申请

US20120189709A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE TO TREAT A CONDITION 有权
标题翻译：使用β-羟基 - 甲基丁酸酯处理条件的方法
公开(公告)号：US20120189709A1
公开(公告)日：2012-07-26
申请号：US13347750
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/19 , A61K38/02 , A61K31/23 , A61K33/06 , A61K33/42 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K33/00 , A61K33/24 , A61K33/20 , A61P37/08 , A61P17/00 , A61P11/06 , A61P3/02 , A61K31/70
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

6. 发明申请

US20120177744A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：使用β-羟基-β-甲基丁酸钠治疗癌症的方法
公开(公告)号：US20120177744A1
公开(公告)日：2012-07-12
申请号：US13347774
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/19 , A61K31/70 , A61K31/23 , A61K31/59 , A61K31/355 , A61K31/714 , A61K31/51 , A61K31/525 , A61K31/4415 , A61K31/455 , A61K31/519 , A61K31/197 , A61K31/375 , A61K31/4188 , A61K33/06 , A61K33/42 , A61K33/34 , A61K33/00 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/20 , A61K33/24 , A61P35/00 , A61P3/02 , A61K38/02
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会引起1型与2型细胞因子的比例增加，包括1型与2型细胞因子的比例增加，而2型细胞因子水平相应增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

7. 发明授权

US08778992B2 Method of using beta-hydroxy-beta-methylbutyrate to treat allergies and asthma 失效
标题翻译：使用β-羟基-β-甲基丁酸酯治疗过敏和哮喘的方法
公开(公告)号：US08778992B2
公开(公告)日：2014-07-15
申请号：US11641978
申请日：2006-12-19
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/191
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

8. 发明申请

US20120178811A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE TO REDUCE THE RISK OF INFECTION IN AN ELDERLY INDIVIDUAL 审中-公开
标题翻译：使用β-羟基-β-甲基丁酸钠降低感染在高龄个体中的风险的方法
公开(公告)号：US20120178811A1
公开(公告)日：2012-07-12
申请号：US13347757
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/19 , A61P25/00 , A61P11/00 , A61P31/00
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

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