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    • 2. 发明授权
    • Method of using beta-hydroxy-beta-methylbutyrate to treat allergies and asthma
    • 使用β-羟基-β-甲基丁酸酯治疗过敏和哮喘的方法
    • US08778992B2
    • 2014-07-15
    • US11641978
    • 2006-12-19
    • Debra L. ThomasPradip Mukerji
    • Debra L. ThomasPradip Mukerji
    • A61K31/191
    • A61K31/19A23L33/10A23L33/40Y10S514/826Y10S514/885
    • Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
    • 公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法,其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯(HMB) 否则会导致1型与2型细胞因子的比例增加,包括1型与2型细胞因子比例的增加,而2型细胞因子水平没有相应的增加。 还公开了使用HMB治疗哮喘和过敏的方法。 本发明的方法基于HMB调节细胞因子产生的发现,最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。
    • 4. 发明授权
    • Method of using β-hydroxy-β-methylbutyrate to treat a condition
    • 使用β-羟基 - 甲基丁酸酯治疗病症的方法
    • US08796333B2
    • 2014-08-05
    • US13347750
    • 2012-01-11
    • Debra L. ThomasPradip Mukerji
    • Debra L. ThomasPradip Mukerji
    • A61K31/191A61K31/19
    • A61K31/19A23L33/10A23L33/40Y10S514/826Y10S514/885
    • Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
    • 公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法,其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯(HMB) 否则会导致1型与2型细胞因子的比例增加,包括1型与2型细胞因子比例的增加,而2型细胞因子水平没有相应的增加。 还公开了使用HMB治疗哮喘和过敏的方法。 本发明的方法基于HMB调节细胞因子产生的发现,最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。