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1. 发明申请

US20120177744A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：使用β-羟基-β-甲基丁酸钠治疗癌症的方法
公开(公告)号：US20120177744A1
公开(公告)日：2012-07-12
申请号：US13347774
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/19 , A61K31/70 , A61K31/23 , A61K31/59 , A61K31/355 , A61K31/714 , A61K31/51 , A61K31/525 , A61K31/4415 , A61K31/455 , A61K31/519 , A61K31/197 , A61K31/375 , A61K31/4188 , A61K33/06 , A61K33/42 , A61K33/34 , A61K33/00 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/20 , A61K33/24 , A61P35/00 , A61P3/02 , A61K38/02
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会引起1型与2型细胞因子的比例增加，包括1型与2型细胞因子的比例增加，而2型细胞因子水平相应增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

2. 发明授权

US08778992B2 Method of using beta-hydroxy-beta-methylbutyrate to treat allergies and asthma 失效
标题翻译：使用β-羟基-β-甲基丁酸酯治疗过敏和哮喘的方法
公开(公告)号：US08778992B2
公开(公告)日：2014-07-15
申请号：US11641978
申请日：2006-12-19
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/191
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

3. 发明申请

US20120178811A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE TO REDUCE THE RISK OF INFECTION IN AN ELDERLY INDIVIDUAL 审中-公开
标题翻译：使用β-羟基-β-甲基丁酸钠降低感染在高龄个体中的风险的方法
公开(公告)号：US20120178811A1
公开(公告)日：2012-07-12
申请号：US13347757
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/19 , A61P25/00 , A61P11/00 , A61P31/00
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

4. 发明授权

US08796333B2 Method of using β-hydroxy-β-methylbutyrate to treat a condition 有权
标题翻译：使用β-羟基 - 甲基丁酸酯治疗病症的方法
公开(公告)号：US08796333B2
公开(公告)日：2014-08-05
申请号：US13347750
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/191 , A61K31/19
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

5. 发明申请

US20120189709A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE TO TREAT A CONDITION 有权
标题翻译：使用β-羟基 - 甲基丁酸酯处理条件的方法
公开(公告)号：US20120189709A1
公开(公告)日：2012-07-26
申请号：US13347750
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/19 , A61K38/02 , A61K31/23 , A61K33/06 , A61K33/42 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K33/00 , A61K33/24 , A61K33/20 , A61P37/08 , A61P17/00 , A61P11/06 , A61P3/02 , A61K31/70
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会导致1型与2型细胞因子的比例增加，包括1型与2型细胞因子比例的增加，而2型细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

6. 发明申请

US20120189717A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE AND FATTY ACIDS FOR TREATING DISEASE-ASSOCIATED WASTING 有权
标题翻译：使用β-羟基 - 甲基丁酸酯与脂肪酸处理疾病相关的废物的方法
公开(公告)号：US20120189717A1
公开(公告)日：2012-07-26
申请号：US13348035
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
IPC分类号： A61K31/202 , A61K31/205 , A61P21/00 , A61K31/355 , A61K31/375 , A61K33/04 , A61K31/201 , A61K31/702
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。

7. 发明申请

US20120189715A1 COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE AND USES THEREOF 审中-公开
标题翻译：包括β-羟基-β-甲基丁酸酯的组合物及其用途
公开(公告)号：US20120189715A1
公开(公告)日：2012-07-26
申请号：US13347978
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/702 , A61K31/375 , A61K33/04 , A61K31/717 , A61P35/00 , A61P11/00 , A61P31/18 , A61P19/02 , A61P1/16 , A61P1/00 , A61P13/12 , A61K31/355 , A61P3/00
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

8. 发明申请

US20120189714A1 COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE 有权
标题翻译：包括β-羟基 - 甲基丁酸酯的组合物
公开(公告)号：US20120189714A1
公开(公告)日：2012-07-26
申请号：US13347956
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/205 , A61K31/355 , A61P3/00 , A61K33/04 , A61P29/00 , A61P35/00 , A61K31/702 , A61K31/375
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

9. 发明申请

US20120177752A1 NUTRITIONAL COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE 审中-公开
标题翻译：包含β-羟基 - 甲基丁酸酯的营养组合物
公开(公告)号：US20120177752A1
公开(公告)日：2012-07-12
申请号：US13347985
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/702 , A61P3/04 , A61P29/00 , A61P35/00 , A61K31/70 , A61K33/04
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

10. 发明授权

US08188335B2 Δ9-elongase for production of polyunsaturated fatty acid-enriched oils 有权
标题翻译：＆Dgr; 9-延伸酶用于生产多不饱和脂肪酸富集油
公开(公告)号：US08188335B2
公开(公告)日：2012-05-29
申请号：US12505293
申请日：2009-07-17
申请人： Suzette Pereira , Tapas Das , Padmavathy Krishnan , Pradip Mukerji
发明人： Suzette Pereira , Tapas Das , Padmavathy Krishnan , Pradip Mukerji
IPC分类号： A01H1/00 , A01H5/00 , C12N5/14 , C12N5/16 , C07H21/04
CPC分类号： C12N9/0071 , C12N9/93 , C12N15/8247
摘要： The present disclosure relates to isolated polynucleotides encoding a delta 9-elongase, delta 9-elongases encoded by the isolated polynucleotides, expression vectors comprising the isolated polynucleotides, host cells comprising the expression vectors, and methods for producing delta 9-elongase and polyunsaturated fatty acids.
摘要翻译：本公开涉及编码由分离的多核苷酸编码的δ9-延伸酶，δ9-延伸酶，包含分离的多核苷酸的表达载体，包含表达载体的宿主细胞和用于产生δ9-延伸酶和多不饱和脂肪酸的方法的分离的多核苷酸。

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