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1. 发明授权

US08916154B2 Antibodies against delta-5 desaturase and uses thereof 有权
标题翻译：针对δ-5去饱和酶的抗体及其用途
公开(公告)号：US08916154B2
公开(公告)日：2014-12-23
申请号：US12686781
申请日：2010-01-13
申请人： Tapas Das , Suzette L. Pereira , Pradip Mukerji , Padmavathy Krishnan
发明人： Tapas Das , Suzette L. Pereira , Pradip Mukerji , Padmavathy Krishnan
IPC分类号： A61K39/395 , C07K16/40 , C07K16/14
CPC分类号： C07K16/14 , C07K16/40 , C07K2319/23
摘要： Disclosed are antibodies that specifically recognize Δ5-desaturase, methods of producing the antibodies, nucleotides and polypeptides for producing the antibodies, and methods of using the antibodies. The Δ5-desaturase-specific antibodies provide improved methods of detecting Δ5-desaturase in a sample.
摘要翻译：公开了特异性识别和/或去除饱和酶的抗体，产生抗体的方法，用于产生抗体的核苷酸和多肽，以及使用抗体的方法。＆Dgr。5-去饱和酶特异性抗体提供了一种检测样品中Dgr。5-去饱和酶的改进方法。

2. 发明授权

US08778994B2 Method of using beta-hydroxy-beta-methylbutyrate and fatty acids for treating disease-associated wasting 有权
标题翻译：使用β-羟基-β-甲基丁酸酯和脂肪酸治疗疾病相关性消耗的方法
公开(公告)号：US08778994B2
公开(公告)日：2014-07-15
申请号：US13348035
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji , Michael J. Tisdale
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且游离氨基酸不足的食品中。

3. 发明授权

US08778993B2 Method of using β-hydroxy-β-methylbutyrate for the treatment of disease conditions 有权
标题翻译：用于治疗疾病的方法 - 用于治疗疾病的方法 - 羟基 - 甲基丁酸酯
公开(公告)号：US08778993B2
公开(公告)日：2014-07-15
申请号：US13347877
申请日：2012-01-11
申请人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
发明人： Jeffrey H. Baxter , Anne C. Voss , Pradip Mukerji
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者单独或者与二十碳五烯酸（20:5ω-3），FOS，肉碱及其混合物联合给予HMB。 HMB可以添加到包含富含大的中性氨基酸的氨基氮源的食品中，所述大型中性氨基酸例如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸，并且基本上不含游离氨基酸。

4. 发明授权

US08722384B2 Methods and compositions for synthesis of long chain polyunsaturated fatty acids 失效
标题翻译：用于合成长链多不饱和脂肪酸的方法和组合物
公开(公告)号：US08722384B2
公开(公告)日：2014-05-13
申请号：US12414274
申请日：2009-03-30
申请人： Deborah Knutzon , Pradip Mukerji , Yung-Sheng Huang , Jennifer Thurmond , Sunita Chaudhary , Amanda Eun-Yeong Leonard
发明人： Deborah Knutzon , Pradip Mukerji , Yung-Sheng Huang , Jennifer Thurmond , Sunita Chaudhary , Amanda Eun-Yeong Leonard
IPC分类号： C12N1/20 , C07H21/04
CPC分类号： C12N9/0083 , A01K2217/05 , A23D9/00 , A23K20/158 , A23L33/12 , A23L33/40 , A61K38/00 , C12N15/81 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to γ-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.
摘要翻译：本发明涉及能够催化油酸转化为亚油酸，亚油酸至γ-亚麻酸或α-亚麻酸转化为十八碳四烯酸的脂肪酸去饱和酶。描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主微生物或动物。公开了通过表达增加的去饱和酶水平使脂肪酸去饱和并产生去饱和脂肪酸的方法。提供了通过由重组宿主微生物或动物产生的去饱和酶已经去饱和的含有它们的脂肪酸和油。还描述了通过由重组宿主微生物或动物产生的去饱和酶已经去饱和的含有脂肪酸的药物组合物，婴儿配方食品或膳食补充剂。

5. 发明申请

US20120177744A1 METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：使用β-羟基-β-甲基丁酸钠治疗癌症的方法
公开(公告)号：US20120177744A1
公开(公告)日：2012-07-12
申请号：US13347774
申请日：2012-01-11
申请人： Debra L. Thomas , Pradip Mukerji
发明人： Debra L. Thomas , Pradip Mukerji
IPC分类号： A61K31/19 , A61K31/70 , A61K31/23 , A61K31/59 , A61K31/355 , A61K31/714 , A61K31/51 , A61K31/525 , A61K31/4415 , A61K31/455 , A61K31/519 , A61K31/197 , A61K31/375 , A61K31/4188 , A61K33/06 , A61K33/42 , A61K33/34 , A61K33/00 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/20 , A61K33/24 , A61P35/00 , A61P3/02 , A61K38/02
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
摘要翻译：公开了治疗具有以1型和2型细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效调节的β-羟基 - 甲基丁酸酯（HMB）否则会引起1型与2型细胞因子的比例增加，包括1型与2型细胞因子的比例增加，而2型细胞因子水平相应增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于HMB调节细胞因子产生的发现，最典型地通过增加1型细胞因子而没有相应增加的2型细胞因子。

6. 发明授权

US07745694B1 Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants 失效
标题翻译：在植物中合成长链多不饱和脂肪酸的方法和组合物
公开(公告)号：US07745694B1
公开(公告)日：2010-06-29
申请号：US09355903
申请日：1998-04-10
申请人： Deborah Knutzon , Pradip Mukerji , Yung-Sheng Huang , Jennifer Thurmond , Sunita Chaudhary , Amanda Eun-Yeong Leonard
发明人： Deborah Knutzon , Pradip Mukerji , Yung-Sheng Huang , Jennifer Thurmond , Sunita Chaudhary , Amanda Eun-Yeong Leonard
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N9/0083 , A01K2217/05 , A23D9/00 , A23K20/158 , A23L33/12 , A23L33/21 , A23L33/40 , A23V2002/00 , A61K38/00 , C12N15/81 , C12N15/8247 , C12P7/64 , C12P7/6427 , C12P7/6472 , A23V2250/54246 , A23V2250/5488 , A23V2250/1882 , A23V2250/187 , A23V2250/1874
摘要： The present invention relates to compositions and methods for preparing polyunsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding fatty acid desaturases, including Δ5-desaturases, Δ6-desaturases and Δ12-desaturases, are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more desaturases. Expression of the desaturases with different substrate specificities in the plant system permit the large scale production of polyunsaturated long chain fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, α-linolenic acid, gamma-linolenic acid, arachidonic acid and the like for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.
摘要翻译：本发明涉及用于在植物，植物部分和植物细胞如叶，根，果实和种子中制备多不饱和长链脂肪酸的组合物和方法。编码脂肪酸去饱和酶的核酸序列和构建体，包括Dgr。5-脱饱和酶，Dgr。6去饱和酶和Dgr。12去饱和酶，用于产生转基因植物，植物部分和细胞，其含有并表达编码一个或多个转基因的一个或多个转基因或更多的去饱和酶。在植物系统中具有不同底物特异性的去饱和酶的表达允许大规模生产多不饱和长链脂肪酸如二十二碳六烯酸，二十碳五烯酸，α-亚麻酸，γ-亚麻酸，花生四烯酸等，用于改性植物，植物部分和组织的脂肪酸分布。脂肪酸分布的操作允许生产商业数量的新型植物油和产品。

7. 发明申请

US20090226987A1 Desaturase Genes, Enzymes Encoded Thereby, and Uses Thereof 有权
标题翻译：去饱和酶基因，由此编码的酶及其用途
公开(公告)号：US20090226987A1
公开(公告)日：2009-09-10
申请号：US12409211
申请日：2009-03-23
申请人： Pradip Mukerji , Suzette L. Pereira , Yung-Sheng Huang
发明人： Pradip Mukerji , Suzette L. Pereira , Yung-Sheng Huang
IPC分类号： C12P7/64 , C12N15/53 , C12N9/04 , C12N15/82 , C12N5/10 , A01H5/00 , C12N15/80 , C12N15/85 , C12N1/15
CPC分类号： C12N9/0083 , C12P7/6427 , C12P7/6472
摘要： Disclosed are isolated polynucleotides encoding an omega-3 desaturase and a delta-12 desaturase, the enzymes encoded by the isolated polynucleotides, vectors containing the isolated polynucleotides, transgenic hosts that contain the isolated polynucleotides that express the enzymes encoded thereby, methods for producing the desaturase enzymes, and method of using the enzymes to make polyunsaturated fatty acids. The isolated polynucleotides are derived from a fungus, Saprolegnia diclina (ATCC 56851). In particular, omega-3-desaturase may be utilized, for example, in the conversion of arachidonic acid (AA) to eicosapentaenoic acid (EPA). Delta-12 desaturase may be used, for example, in the conversion of oleic acid (OA) to linoleic (LA). EPA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：公开了编码ω-3去饱和酶和δ-12去饱和酶的分离的多核苷酸，由分离的多核苷酸编码的酶，含有分离的多核苷酸的载体，含有表达由其编码的酶的分离的多核苷酸的转基因宿主，用于产生去饱和酶的方法酶和使用酶制备多不饱和脂肪酸的方法。分离的多核苷酸衍生自真菌Saprolegnia diclina（ATCC 56851）。特别地，ω-3-去饱和酶可用于例如花生四烯酸（AA）转化为二十碳五烯酸（EPA）。 Δ-12去饱和酶可以用于例如将油酸（OA）转化为亚油酸（LA）。由此产生的EPA或多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

8. 发明申请

US20090148919A1 Delta 6-Desaturase Genes and Uses Thereof 失效
标题翻译： Delta 6脱氢酶基因及其用途
公开(公告)号：US20090148919A1
公开(公告)日：2009-06-11
申请号：US12256611
申请日：2008-10-23
申请人： Pradip Mukerji , Yung-Sheng Huang , Amanda E. Leonard , Suzette L. Pereira , Jennifer M. Thurmond
发明人： Pradip Mukerji , Yung-Sheng Huang , Amanda E. Leonard , Suzette L. Pereira , Jennifer M. Thurmond
IPC分类号： C12P7/64
CPC分类号： C12N15/8247 , C12N9/0083
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 6 (i.e., “Δ6-desaturase”). In particular, Δ6-desaturase may be utilized, for example, in the conversion of linoleic acid to γ-linolenic acid and in the conversion of α-linolenic acid stearidonic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：本发明涉及鉴定参与碳6多不饱和脂肪酸脱饱和基因（即“Δ6-去饱和酶”）的基因。特别地，可以使用Δ6-去饱和酶，例如，将亚油酸转化为γ-亚麻酸和在α-亚麻酸十八碳四烯酸的转化中。通过使用酶产生的多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

9. 发明申请

US20080214667A1 Elongase Gene and Uses Thereof 有权
标题翻译：延长酶基因及其用途
公开(公告)号：US20080214667A1
公开(公告)日：2008-09-04
申请号：US11939641
申请日：2007-11-14
申请人： Tapas Das , Pradip Mukerji , Padmavathy Krishnan , Amanda E. Leonard , Suzette L. Pereira
发明人： Tapas Das , Pradip Mukerji , Padmavathy Krishnan , Amanda E. Leonard , Suzette L. Pereira
IPC分类号： A61K31/20 , C07H21/04 , C12N15/00 , C12N5/00 , C12N1/20 , C12N1/12 , C12N1/00 , C12N5/06 , A01H5/00 , A01K67/00 , C12P7/64
CPC分类号： C12N9/1029 , C12N15/8247
摘要： The subject invention relates to the identification of a gene involved in the elongation of polyunsaturated fatty acids containing unsaturation at the carbon 9 position (i.e., “Δ9-elongase”) and to uses thereof. In particular, Δ9-elongase may be utilized, for example, in the conversion of linoleic acid (LA, 18:2n-6) to eicosadienoic acid (EDA, 20:2n-6). The production of dihomo-γ-linolenic acid (DGLA, 20:3n-6) from eicosadienoic acid (EDA, 20:2n-6), and arachidonic acid (AA, 20:4n-6) from dihomo-γ-linolenic acid (DGLA, 20:3n-6) is then catalyzed by Δ8-desaturase and Δ5-desaturase, respectively. AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：本发明涉及鉴定参与碳9位上含有不饱和键的多不饱和脂肪酸（即“Δ9-延伸酶”）的伸长的基因及其用途。特别地，可以使用Δ9-延伸酶，例如将亚油酸（LA，18：2n-6）转化成二十碳烯酸（EDA，20：2n-6）。来自二十碳-7-烯亚油酸（EDA，20：2n-6）的二氧化γ-亚麻酸（DGLA，20：3n-6）和花生四烯酸（AA，20：4n-6）（DGLA，20：3n-6）分别由Delta8-去饱和酶和Δ5-去饱和酶催化。由其制备的AA或多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

10. 发明授权

US07241619B2 Desaturase genes and uses thereof 有权
标题翻译：去饱和酶基因及其用途
公开(公告)号：US07241619B2
公开(公告)日：2007-07-10
申请号：US10431952
申请日：2003-05-08
申请人： Pradip Mukerji , Yung-Sheng Huang , Tapas Das , Jennifer Thurmond , Suzette L. Pereira
发明人： Pradip Mukerji , Yung-Sheng Huang , Tapas Das , Jennifer Thurmond , Suzette L. Pereira
IPC分类号： C12N5/14 , C12N15/74 , C07H21/04 , C12P21/02
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：本发明涉及鉴定参与碳5（即“Δ5-去饱和酶”）和碳6（即“Δ6-去饱和酶”）的多不饱和脂肪酸的去饱和的基因及其用途。特别地，可以使用Δ5-去饱和酶，例如将dihomo-γ-亚麻酸（DGLA）转化为花生四烯酸（AA）和将20:4n-3转化成二十碳五烯酸（EPA）。 Δ-6去饱和酶可用于例如亚油酸（LA）转化为γ-亚麻酸（GLA）。由其制备的AA或多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

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