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    • 6. 发明授权
    • Raman signal-enhancing structures and devices
    • 拉曼信号增强结构和器件
    • US07359048B2
    • 2008-04-15
    • US11413910
    • 2006-04-28
    • Shih-Yuan WangR. Stanley WilliamsRaymond G. BeausoleilTheodore I. KaminsZhiyong LiWei Wu
    • Shih-Yuan WangR. Stanley WilliamsRaymond G. BeausoleilTheodore I. KaminsZhiyong LiWei Wu
    • G01J3/44G01N21/65
    • G01N21/658G01J3/44
    • Raman systems include a radiation source, a radiation detector, and a Raman device or signal-enhancing structure. Raman devices include a tunable resonant cavity and a Raman signal-enhancing structure coupled to the cavity. The cavity includes a first reflective member, a second reflective member, and an electro-optic material disposed between the reflective members. The electro-optic material exhibits a refractive index that varies in response to an applied electrical field. Raman signal-enhancing structures include a substantially planar layer of Raman signal-enhancing material having a major surface, a support structure extending from the major surface, and a substantially planar member comprising a Raman signal-enhancing material disposed on an end of the support structure opposite the layer of Raman signal-enhancing material. The support structure separates at least a portion of the planar member from the layer of Raman signal-enhancing material by a selected distance of less than about fifty nanometers.
    • 拉曼系统包括辐射源,辐射检测器和拉曼器件或信号增强结构。 拉曼器件包括耦合到空腔的可调谐谐振腔和拉曼信号增强结构。 空腔包括第一反射构件,第二反射构件和设置在反射构件之间的电光材料。 电光材料表现出响应于所施加的电场而变化的折射率。 拉曼信号增强结构包括具有主表面的基本平坦的拉曼信号增强材料层,从主表面延伸的支撑结构和包括设置在支撑结构的端部上的拉曼信号增强材料的基本上平面的构件 与拉曼信号增强材料层相对。 支撑结构将平面构件的至少一部分与拉曼信号增强材料层分开小于约五十纳米的选定距离。
    • 7. 发明授权
    • Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
    • 用于纳米增强拉曼光谱(NERS)分子感测的纳米颗粒之间的动态变化分离
    • US07342656B2
    • 2008-03-11
    • US11252134
    • 2005-10-17
    • M. Saif IslamShih-Yuan WangR. Stanley WilliamsPhilip J. KuekesWei WuZhiyong Li
    • M. Saif IslamShih-Yuan WangR. Stanley WilliamsPhilip J. KuekesWei WuZhiyong Li
    • G01J3/44G01N21/65
    • G01N21/658
    • A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle. The nanoparticles each comprise a NERS-active material. The deformable, active nanoparticle support structure is configured to vary the distance between the first nanoparticle and the second nanoparticle while performing NERS. Various active nanoparticle support structures are disclosed. A NERS system includes such a NERS-active structure, a radiation source for generating radiation scatterable by an analyte located proximate the NERS-active structure, and a radiation detector for detecting Raman scattered radiation scattered by the analyte. A method for performing NERS includes providing such a NERS-active structure, providing an analyte at a location proximate the NERS-active structure, irradiating the NERS-active structure and the analyte with radiation, varying the distance between the nanoparticles, and detecting Raman scattered radiation scattered by the analyte.
    • NERS活性结构包括用于支撑第一纳米颗粒的可变形的活性纳米颗粒支撑结构和邻近第一纳米颗粒设置的第二纳米颗粒。 纳米颗粒各自包含NERS-活性材料。 可变形的活性纳米颗粒支撑结构被配置为在执行NERS的同时改变第一纳米颗粒和第二纳米颗粒之间的距离。 公开了各种活性纳米颗粒载体结构。 NERS系统包括这样的NERS-活性结构,用于产生由位于NERS-活性结构附近的分析物可散射的辐射的辐射源,以及用于检测被分析物散射的拉曼散射辐射的辐射检测器。 执行NERS的方法包括提供这样的NERS活性结构,在靠近NERS-活性结构的位置提供分析物,用辐射照射NERS-活性结构和分析物,改变纳米颗粒之间的距离并检测拉曼散射 被分析物散射的辐射。