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1. 发明申请

US20070093743A1 Iontophoresis Drug Delivery Device Providing Acceptable Depth and Duration of Dermal Anesthesia 审中-公开
标题翻译：离子导入药物递送装置提供可接受的深度和皮肤麻醉的持续时间
公开(公告)号：US20070093743A1
公开(公告)日：2007-04-26
申请号：US11535608
申请日：2006-09-27
申请人： Preston Keusch , Vilambi Reddy , Ashutosh Sharma , George Baskinger
发明人： Preston Keusch , Vilambi Reddy , Ashutosh Sharma , George Baskinger
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/044 , A61N1/0448
摘要： An electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable depth and duration of dermal anesthesia at a treatment site. In certain embodiments, the anesthetic comprises lidocaine and the vasoconstrictor comprises epinephrine.
摘要翻译：用于麻醉剂和血管收缩剂的高效电运输的电辅助透皮药物递送系统，其在治疗部位产生临床可接受的皮肤麻醉深度和持续时间。在某些实施方案中，麻醉剂包含利多卡因，血管收缩剂包含肾上腺素。

2. 发明申请

US20070078434A1 Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices 审中-公开
标题翻译：通过电子运输设备本地运输麻醉剂的适应症
公开(公告)号：US20070078434A1
公开(公告)日：2007-04-05
申请号：US11537182
申请日：2006-09-29
申请人： Preston Keusch , Vilambi Reddy , Richard Greene , George Baskinger , Ashutosh Sharma
发明人： Preston Keusch , Vilambi Reddy , Richard Greene , George Baskinger , Ashutosh Sharma
IPC分类号： A61M31/00
CPC分类号： A61N1/30 , A61N1/044 , A61N1/0448
摘要： The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.
摘要翻译：描述了用于递送药物制剂的离子电渗电极组件的使用。药物制剂包括麻醉剂和血管收缩剂。在手术部分之前产生临床上可接受的皮肤麻醉深度和持续时间的患者施用于患者，以忍受痛苦的过程或减轻或消除疼痛。该方法选自静脉穿刺，IV插管，针吸，身体穿刺，献血，电解，纹身去除，纹身应用，注射，皮肤磨皮，皮肤剥离，高速颗粒消融，起搏器植入，起搏器替代，硬膜外穿刺，腰椎穿刺，局部神经阻滞，皮肤收获，小皮肤切口，皮肤活检，切割或切除。离子电渗电极组件也可用于减少或暂时消除神经性疼痛。

3. 发明申请

US20070078373A1 PULSATILE DELIVERY OF GONADOTROPIN-RELEASING HORMONE FROM A PRE-LOADED INTEGRATED ELECTROTRANSPORT PATCH 审中-公开
标题翻译：从预加载的集成电子邮件传送中释放激肽释放激素的药物
公开(公告)号：US20070078373A1
公开(公告)日：2007-04-05
申请号：US11537308
申请日：2006-09-29
申请人： Ashutosh Sharma , Sonal Patel , Vilambi Reddy , Preston Keusch , Yogeshvar Kalia
发明人： Ashutosh Sharma , Sonal Patel , Vilambi Reddy , Preston Keusch , Yogeshvar Kalia
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition, such as a composition comprising gonadotropin-releasing hormone and/or related analogs through a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements. Methods of administering compositions to patients with integrated electrode devices according to various embodiments described herein are also disclosed.
摘要翻译：提供了集成电极装置，组件和系统的各种实施例，其被构造用于与被配置用于递送组合物的电辅助递送装置结合使用，所述组合物例如包含通过膜的促性腺激素释放激素和/或相关类似物的组合物。集成电极装置，组件和系统包括各种结构，物理，机械，电和机电增强中的一种或多种。还公开了根据本文所述的各种实施方案向具有集成电极装置的患者施用组合物的方法。

4. 发明申请

US20050228335A1 Physical, structural, mechanical, electrical and electromechanical features for use in association with electrically assisted delivery devices and systems 审中-公开
标题翻译：物理，结构，机械，电气和机电特征，用于与电气辅助输送装置和系统相关联
公开(公告)号：US20050228335A1
公开(公告)日：2005-10-13
申请号：US10820346
申请日：2004-04-07
申请人： Vilambi Reddy , Preston Keusch , Robert Strowe , Jeffrey Kapec , Kazuna Tanaka
发明人： Vilambi Reddy , Preston Keusch , Robert Strowe , Jeffrey Kapec , Kazuna Tanaka
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition to a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements.
摘要翻译：提供了集成电极装置，组件和系统的各种实施例，其被构造为与被配置为将组合物递送到膜的电辅助输送装置相关联地使用。集成电极装置，组件和系统包括各种结构，物理，机械，电和机电增强中的一种或多种。

5. 发明申请

US20070078372A1 Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia 审中-公开
标题翻译：离子导入药物递送配方提供可接受的感觉和皮肤麻醉
公开(公告)号：US20070078372A1
公开(公告)日：2007-04-05
申请号：US11537141
申请日：2006-09-29
申请人： Vilambi Reddy , Preston Keusch
发明人： Vilambi Reddy , Preston Keusch
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/044 , A61N1/325 , A61N1/36021
摘要： A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.
摘要翻译：提供了一种用于产生临床可接受的皮肤麻醉和感觉的麻醉剂和血管收缩剂的高效电运输的稳定的电辅助透皮药物递送系统。在某些实施方案中，麻醉剂包括利多卡因，血管收缩剂包括肾上腺素。如通过各种指标测试所测量，药物输送受影响以在输送期间提供很少或没有感觉的皮肤麻醉。还提供了在患者体内产生真皮麻醉的方法。

6. 发明申请

US20050228336A1 Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability 审中-公开
标题翻译：具有延长储存稳定性的电辅助利多卡因和肾上腺素递送装置
公开(公告)号：US20050228336A1
公开(公告)日：2005-10-13
申请号：US10821151
申请日：2004-04-07
申请人： Preston Keusch , Vilambi Reddy , Philip Green , Uday Jain
发明人： Preston Keusch , Vilambi Reddy , Philip Green , Uday Jain
IPC分类号： A61K31/137 , A61K31/167 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61N1/30 , A61P9/00 , A61P11/08 , A61P23/02
CPC分类号： A61N1/0448 , A61N1/044
摘要： Highly shelf-stable electrically assisted transdermal drug delivery systems for delivering epinephrine, typically with an anesthetic such as lidocaine, are provided along with methods for making the highly shelf-stable epinephrine-containing transdermal delivery device. Highly shelf-stable packaged electrode assemblies for transdermal delivery of epinephrine also are provided.
摘要翻译：提供用于递送肾上腺素（通常用麻醉剂如利多卡因）的高度稳定的电子辅助透皮药物递送系统以及用于制备高度稳定的含肾上腺素的透皮递送装置的方法。还提供了用于透皮递送肾上腺素的高度稳定的包装电极组件。

7. 发明申请

US20100191216A1 INDICATIONS FOR LOCAL TRANSPORT OF ANAESTHETIC AGENTS BY ELECTROTRANSPORT DEVICES 审中-公开
标题翻译：电气设备本地运输麻醉剂的适用症状
公开(公告)号：US20100191216A1
公开(公告)日：2010-07-29
申请号：US12492361
申请日：2009-06-26
申请人： Preston Keusch , Vilambi Nrk Reddy , Richard Greene , George M. Baskinger , Ashutosh Sharma
发明人： Preston Keusch , Vilambi Nrk Reddy , Richard Greene , George M. Baskinger , Ashutosh Sharma
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/044 , A61N1/0448
摘要： The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.
摘要翻译：描述了用于递送药物制剂的离子电渗电极组件的使用。药物制剂包括麻醉剂和血管收缩剂。在手术部分之前产生临床上可接受的皮肤麻醉深度和持续时间的患者施用于患者，以忍受痛苦的过程或减轻或消除疼痛。该方法选自静脉穿刺，IV插管，针吸，身体穿刺，献血，电解，纹身去除，纹身应用，注射，皮肤磨皮，皮肤剥离，高速颗粒消融，起搏器植入，起搏器替代，硬膜外穿刺，腰椎穿刺，局部神经阻滞，皮肤收获，小皮肤切口，皮肤活检，切割或切除。离子电渗电极组件也可用于减少或暂时消除神经性疼痛。

8. 发明申请

US20090312688A1 IONTOPHORESIS DRUG DELIVERY FORMULATION PROVIDING ACCEPTABLE SENSATION AND DERMAL ANESTHESIA 审中-公开
标题翻译： IOPOPHORESIS药物递送配方提供可接受的感染和牙齿麻醉
公开(公告)号：US20090312688A1
公开(公告)日：2009-12-17
申请号：US12355521
申请日：2009-01-16
申请人： Vilambi NRK Reddy , Preston Keusch
发明人： Vilambi NRK Reddy , Preston Keusch
IPC分类号： A61N1/30 , A61M19/00
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/044 , A61N1/325 , A61N1/36021
摘要： A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.
摘要翻译：提供了一种用于产生临床可接受的皮肤麻醉和感觉的麻醉剂和血管收缩剂的高效电运输的稳定的电辅助透皮药物递送系统。在某些实施方案中，麻醉剂包括利多卡因，血管收缩剂包括肾上腺素。如通过各种指标测试所测量，药物输送受影响以在输送期间提供很少或没有感觉的皮肤麻醉。还提供了在患者体内产生真皮麻醉的方法。

9. 发明授权

US06387325B1 Assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample 失效
标题翻译：用于将复合生物流体样品中的成分成分与液体成分分离的装置
公开(公告)号：US06387325B1
公开(公告)日：2002-05-14
申请号：US09414803
申请日：1999-10-08
申请人： Preston Keusch , Stephen C. Wardlaw
发明人： Preston Keusch , Stephen C. Wardlaw
IPC分类号： G01N3300
CPC分类号： G01N1/4077 , G01N1/38 , G01N15/1456 , G01N2001/302 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G02B21/34
摘要： Formed constituents in an aqueous based fluid biologic material sample are separated from the aqueous constituent of the sample, and are concentrated in an examining instrument's focal plane where they can be examined under magnification. Examples of fluids that can be analyzed in this fashion include urine; cerebrospinal fluid; pleural fluid; ascites; fluids aspirated from cysts such as thyroid and breast cysts; cytologic specimens which have been placed in an aqueous fluid; platelet-rich plasma; and the like. The sample is placed in a chamber having a layer of a hydrophilic hydrogel covering a surface of the chamber. An opposite surface of the chamber is transparent, and may be formed by a microscope slide cover slip, or the like. The volume of hydrogel in the chamber is sufficient so that, when the hydrogel absorbs essentially all of the aqueous fraction of the sample, the hydrogel will expand and fill the chamber. The capture surface of the expanded hydrogel is preferably planar, and any formed constituents in the sample will be captured on the capture surface of the hydrogel layer, and will not be absorbed into the hydrogel. Formed constituents, such as: cells; bacteria; crystals; protozoa; ova; parasites; and the like, can be differentially highlighted by use of labeled antibodies, selective stains, or the like, so as to enable optical examination and differentiation of various formed constituents which may be in the sample. Formed constituents may be harvested from the capture surface of the expanded hydrogel layer for more detailed examination and analysis. The capture surface of the hydrogel may be provided with a plurality of beads for use in locating the capture surface with an optical scanning instrument, and for re-establishing previously scanned fields of view.
摘要翻译：将含水基流体生物材料样品中的成分与样品的水性成分分离，并浓缩在检查仪的焦平面上，在此可以在放大倍数下进行检查。可以以这种方式分析的流体的实例包括尿液; 脑脊液胸膜液腹水; 从囊肿如甲状腺和乳腺囊肿吸出的液体; 已经置于水性液体中的细胞学标本; 血小板富集血浆等等。将样品放置在具有覆盖室的表面的亲水性水凝胶层的室中。室的相对表面是透明的，并且可以由显微镜滑盖盖等形成。腔室中的水凝胶的体积是足够的，使得当水凝胶基本上吸收样品的所有含水部分时，水凝胶将膨胀并填充室。膨胀的水凝胶的捕获表面优选是平面的，并且样品中的任何形成的成分将被捕获在水凝胶层的捕获表面上，并且不会被吸收到水凝胶中。形成成分，如：细胞; 菌; 晶体原生动物奥娃寄生虫可以通过使用标记的抗体，选择性污渍等差异地突出显示，以便能够对可能在样品中的各种形成的成分进行光学检查和分化。可以从膨胀的水凝胶层的捕获表面收获成形成分，以进行更详细的检查和分析。水凝胶的捕获表面可以设置有多个珠子，用于使用光学扫描仪器来定位捕获表面，并且用于重建先前扫描的视场。

10. 发明申请

US20050159700A1 Iontophoretic drug delivery device and reservoir and method of making same 审中-公开
公开(公告)号：US20050159700A1
公开(公告)日：2005-07-21
申请号：US11039520
申请日：2005-01-19
申请人： Preston Keusch , Nrk Vilambi , Bruce Eliash
发明人： Preston Keusch , Nrk Vilambi , Bruce Eliash
IPC分类号： A61N1/30 , A61B17/20
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

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