专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050159700A1 Iontophoretic drug delivery device and reservoir and method of making same 审中-公开
公开(公告)号：US20050159700A1
公开(公告)日：2005-07-21
申请号：US11039520
申请日：2005-01-19
申请人： Preston Keusch , Nrk Vilambi , Bruce Eliash
发明人： Preston Keusch , Nrk Vilambi , Bruce Eliash
IPC分类号： A61N1/30 , A61B17/20
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

2. 发明申请

US20050159699A1 Iontophoretic drug delivery device and reservoir and method of making same 审中-公开
公开(公告)号：US20050159699A1
公开(公告)日：2005-07-21
申请号：US11039519
申请日：2005-01-19
申请人： Preston Keusch , Nrk Vilambi , Bruce Eliash
发明人： Preston Keusch , Nrk Vilambi , Bruce Eliash
IPC分类号： A61N1/30 , A61B17/20
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

3. 发明申请

US20050159698A1 Iontophoretic drug delivery device and reservoir and method of making same 审中-公开
标题翻译：离子电渗药物输送装置和储存器及其制作方法
公开(公告)号：US20050159698A1
公开(公告)日：2005-07-21
申请号：US11039514
申请日：2005-01-19
申请人： Preston Keusch , Nrk Vilambi , Bruce Eliash
发明人： Preston Keusch , Nrk Vilambi , Bruce Eliash
IPC分类号： A61N1/30 , A61B17/20
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic crosslinked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.
摘要翻译：用于离子电渗药物递送装置的本发明的储存器电极组件包括位于与电极导电关系的电极和亲水性储存器。亲水性储存器由具有粘附到电极的第一表面和第二表面的吸水性亲水性交联聚合物材料形成。当应用于患者皮肤区域时，聚合物材料的第一表面可剥离地粘附。聚合物材料具有内聚强度，其形成粘合剂粘合，聚合物材料的第二表面与电极之间的粘合强度大于聚合物材料的内聚强度。此外，聚合物材料的第一表面与患者的施用区域的粘合粘合强度小于聚合材料的内聚强度，使得当从患者的施用区域移除本发明的储器组件时，基本上没有聚合物材料保留在施加的区域上，并且亲水性储存器保持基本上完整且粘附到电极上。

4. 发明授权

US06394994B1 Method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament 失效
标题翻译：用于测试离子电渗储器电极递送药物的能力的方法
公开(公告)号：US06394994B1
公开(公告)日：2002-05-28
申请号：US09384765
申请日：1999-08-27
申请人： Nrk Vilambi , Bruce M. Eliash , Preston Keusch , Lue Huai Li , Elena N. Chabala , Uday K. Jain , Louis J. Mestichelli
发明人： Nrk Vilambi , Bruce M. Eliash , Preston Keusch , Lue Huai Li , Elena N. Chabala , Uday K. Jain , Louis J. Mestichelli
IPC分类号： A61M3100
CPC分类号： A61N1/0428
摘要： A method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament includes providing an iontophoretic reservoir-electrode with a contact surface having a shape, a suitable electrical connection and a hydrated bibulous reservoir containing an ionized medicament. The method further includes providing another electrode operating a at preselected polarity opposite to the preselected polarity of the medicament reservoir-electrode. The method further includes providing a separation medium having the property of allowing passage therein to of ions of one charge. The separation medium is positioned between the reservoir electrode with the ionized medicament and the another electrode. The method also includes applying a sufficient electrical potential between the iontophoretic reservoir-electrode containing the ionized medicament and the another iontophoretic reservoir-electrode so that a current flows through the separation medium for a preselected time thereby transporting a quantity of the ionized medicament into the separation medium. The method then includes determining an amount of the ionizable medicament in the separation medium.
摘要翻译：用于测试离子电渗储存器电极递送药物的能力的方法包括提供具有形状，合适的电连接的接触表面和含有电离药物的水合吸水性储存器的离子电渗储器电极。该方法还包括提供另外的电极，其操作的预选极性与药物储存器电极的预选极性相反。该方法还包括提供一种分离介质，该分离介质具有允许通过一次电荷的离子的性质。分离介质位于储存器电极与电离药物和另一电极之间。该方法还包括在包含电离药物的离子电渗储存器电极和另一离子电渗储存器电极之间施加足够的电势，使得电流流过分离介质预选的时间，从而将一定量的离子化药物输送到分离中。该方法然后包括确定分离介质中的可离子化药物的量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式