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1. 发明授权

US07201917B2 Porous delivery scaffold and method 有权
标题翻译：多孔递送支架和方法
公开(公告)号：US07201917B2
公开(公告)日：2007-04-10
申请号：US10195633
申请日：2002-07-15
申请人： Prasanna Malaviya , Herbert E. Schwartz , Pamela L. Plouhar , Janine M. Orban
发明人： Prasanna Malaviya , Herbert E. Schwartz , Pamela L. Plouhar , Janine M. Orban
IPC分类号： A61K45/00 , C12N5/02
CPC分类号： A61L27/3843 , A61B17/064 , A61B17/0642 , A61B2017/0646 , A61F2/0063 , A61F2/0811 , A61F2/30749 , A61F2/3872 , A61F2002/30294 , A61F2002/30751 , A61F2002/30766 , A61F2230/0091 , A61L27/18 , A61L27/3604 , A61L27/3633 , A61L27/3687 , A61L27/3691 , A61L27/54 , A61L27/56 , A61L31/005 , A61L2300/252 , A61L2300/412 , A61L2300/602 , A61L2300/64 , A61L2430/06 , C08L67/04
摘要： A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.
摘要翻译：制造用于修复受损或患病组织的可植入支架的方法包括将细胞外基质材料块悬浮在液体中的步骤。细胞外基质材料和液体形成质量。随后将液体排出，以便在质量块中形成空隙。支架还可包含促进组织修复和愈合的生物制剂。还公开了通过这种方法制造的多孔可植入支架。

2. 发明授权

US07569233B2 Hybrid biologic-synthetic bioabsorbable scaffolds 有权
标题翻译：混合生物合成生物可吸收支架
公开(公告)号：US07569233B2
公开(公告)日：2009-08-04
申请号：US11110169
申请日：2005-04-20
申请人： Prasanna Malaviya , Janine M. Orban , Philip J. Jenks , Terrence D. Whalen
发明人： Prasanna Malaviya , Janine M. Orban , Philip J. Jenks , Terrence D. Whalen
IPC分类号： B27N3/00 , A61F2/00 , A61F2/02 , C12N9/10
CPC分类号： A61L27/3691 , A61L27/3629 , A61L27/3633
摘要： A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion.
摘要翻译：提供了用于软组织附着，加强和/或重建的生物假体装置。该装置包括天然存在的细胞外基质部分和合成部分。

3. 发明授权

US07666230B2 Implant device for cartilage regeneration in load bearing articulation regions 失效
标题翻译：用于承载关节区域软骨再生的植入装置
公开(公告)号：US07666230B2
公开(公告)日：2010-02-23
申请号：US10730423
申请日：2003-12-08
申请人： Janine M. Orban , Herbert E. Schwartz , Nathaniel W. Grobe
发明人： Janine M. Orban , Herbert E. Schwartz , Nathaniel W. Grobe
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61F2/30749 , A61F2002/30062 , A61F2002/30116 , A61F2002/30153 , A61F2002/30156 , A61F2002/30158 , A61F2002/30224 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30265 , A61F2002/3028 , A61F2002/30327 , A61F2002/30329 , A61F2002/30332 , A61F2002/30403 , A61F2002/30429 , A61F2002/305 , A61F2002/30504 , A61F2002/30599 , A61F2002/30604 , A61F2002/30751 , A61F2002/30766 , A61F2002/30785 , A61F2002/30878 , A61F2002/30884 , A61F2002/30896 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0006 , A61F2230/0019 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0039 , A61F2250/0063
摘要： An implant device for cartilage regeneration in loading-bearing regions uses the osteochondral defect model. The implant is formed of resorbable polymeric materials. The implant is designed such that load is transmitted from the articulating surface of the bone platform through the implant to the entire area of subchondral bone of the bone platform. Application of load in this manner results in reduced subchondral bone resorption, leading to joint stabilization and maintenance of normal joint biomechanics. The implant allows for the incorporation therein of a resorbable scaffold or matrix material. The present implant solves the current inability to regenerate cartilage in load-bearing articulating surfaces using engineered scaffold devices.
摘要翻译：用于承载区域软骨再生的植入装置使用骨软骨缺损模型。植入物由可再吸收的聚合材料形成。植入物被设计成使得负荷从骨平台的关节表面通过植入物传递到骨平台的软骨下骨的整个区域。以这种方式施加负荷导致软骨下骨吸收减少，导致正常关节生物力学的联合稳定和维持。植入物允许在其中掺入可再吸收的支架或基质材料。本植入物解决了目前无法使用工程支架装置在承载关节表面再生软骨。

4. 发明授权

US06936298B2 Antithrombogenic membrane mimetic compositions and methods 失效
标题翻译：抗血栓形成膜模拟组合物和方法
公开(公告)号：US06936298B2
公开(公告)日：2005-08-30
申请号：US10257805
申请日：2001-04-13
申请人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue-Long Sun
发明人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue-Long Sun
IPC分类号： A61L15/32 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/12 , C07F9/10 , C07F9/655 , A61L27/00
CPC分类号： B82Y30/00 , A61L15/32 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/507 , A61L33/0082 , A61L33/12 , C07F9/10 , C07F9/65525 , C08L89/00
摘要： The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.
摘要翻译：本说明书描述了提供医疗假体的改进性能的材料和方法，包括血管移植材料，人造心脏瓣膜和其他植入材料。包含结合血栓调节蛋白或功能等同衍生蛋白的材料提供较少的不良副作用，包括炎症，血栓形成和新生内膜增生。

5. 发明授权

US07713544B2 Biological component comprising artificial membrane 有权
标题翻译：包含人造膜的生物成分
公开(公告)号：US07713544B2
公开(公告)日：2010-05-11
申请号：US10343408
申请日：2001-07-30
申请人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
发明人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
IPC分类号： A61L27/00 , A61F13/00 , A61K9/127
CPC分类号： C07F9/6552 , A61K9/1273 , A61K9/5031 , A61K9/5073 , A61L15/32 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/507 , A61L33/0082 , B82Y5/00 , B82Y30/00 , C08F220/28 , C08F220/36 , C12N1/00
摘要： A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e.g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present. To facilitate binding, the substrate may optionally be treated with a polyelectrolyte or alternating layers of oppositely-charged polyelectrolytes to facilitate charged binding of the membrane-mimetic film or alkylated layer beneath the membrane-mimetic film to the substrate. The membrane-mimetic film is preferably made by in situ polymerization of phospholipid vesicles.
摘要翻译：提供生物相容的生物组分，其包含覆盖基质的膜模拟表面膜。合适的底物包括水合底物，例如水凝胶，其可以含有通过膜模拟膜递送到患者的药物，或者可以由用于移植的细胞如胰岛细胞组成。表面可以在体内呈现暴露的生物活性分子或结合靶向分子的部分，用于当植入患者时调节宿主反应（例如表面可能是抗血栓形成或抗炎性的），并且该表面可以具有选定尺寸的孔以促进物质的运输通过。衬底和膜模拟表面之间的可选的亲水垫或间隔物允许跨膜蛋白从表面延伸穿过亲水垫，模仿天然存在的细胞的结构。直接在膜 - 模拟表面下面的烷基化层促进了表面与生物组分的其余部分的结合。当存在时，烷基链可以完全延伸穿过亲水性垫。为了便于结合，底物可以任选地用聚电解质或交替的相反电荷的聚电解质层处理，以促进膜 - 模拟膜下面的膜模拟膜或烷基化层与底物的带电结合。膜模拟膜优选通过磷脂囊泡的原位聚合来制备。

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