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1. 发明授权

US07824672B2 Method for coating living cells 有权
标题翻译：活细胞涂层方法
公开(公告)号：US07824672B2
公开(公告)日：2010-11-02
申请号：US11091939
申请日：2005-03-28
申请人： Elliot L. Chaikof , Wanxing Cui , Zhifei Dai
发明人： Elliot L. Chaikof , Wanxing Cui , Zhifei Dai
IPC分类号： A01N63/00
CPC分类号： A61K9/5052 , A61K9/5036 , A61K9/5073 , A61K45/06
摘要： The invention comprises anti-inflammatory conformal barriers with controllable permeability properties that can be applied to living cells prior to transplant, and methods for coating living cells with conformal barriers. The coatings comprise polymer layers deposited on a cell surface by layer-by-layer polymer assembly, wherein each layer contains a positive and a negative polymer pair. The barriers can be actively anti-inflammatory through incorporation of anticoagulant and/or anti-inflammatory agents into the barrier.
摘要翻译：本发明包括可移植前可应用于活细胞的具有可控渗透性的抗炎保形屏障，以及用保形屏障涂覆活细胞的方法。涂层包括通过逐层聚合物组合物沉积在电池表面上的聚合物层，其中每个层包含正和负的聚合物对。障碍物可以通过将抗凝血剂和/或抗炎剂并入阻隔物中来积极地消炎。

2. 发明授权

US07713544B2 Biological component comprising artificial membrane 有权
标题翻译：包含人造膜的生物成分
公开(公告)号：US07713544B2
公开(公告)日：2010-05-11
申请号：US10343408
申请日：2001-07-30
申请人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
发明人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue Long Sun , Keith M. Faucher
IPC分类号： A61L27/00 , A61F13/00 , A61K9/127
CPC分类号： C07F9/6552 , A61K9/1273 , A61K9/5031 , A61K9/5073 , A61L15/32 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/507 , A61L33/0082 , B82Y5/00 , B82Y30/00 , C08F220/28 , C08F220/36 , C12N1/00
摘要： A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e.g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present. To facilitate binding, the substrate may optionally be treated with a polyelectrolyte or alternating layers of oppositely-charged polyelectrolytes to facilitate charged binding of the membrane-mimetic film or alkylated layer beneath the membrane-mimetic film to the substrate. The membrane-mimetic film is preferably made by in situ polymerization of phospholipid vesicles.
摘要翻译：提供生物相容的生物组分，其包含覆盖基质的膜模拟表面膜。合适的底物包括水合底物，例如水凝胶，其可以含有通过膜模拟膜递送到患者的药物，或者可以由用于移植的细胞如胰岛细胞组成。表面可以在体内呈现暴露的生物活性分子或结合靶向分子的部分，用于当植入患者时调节宿主反应（例如表面可能是抗血栓形成或抗炎性的），并且该表面可以具有选定尺寸的孔以促进物质的运输通过。衬底和膜模拟表面之间的可选的亲水垫或间隔物允许跨膜蛋白从表面延伸穿过亲水垫，模仿天然存在的细胞的结构。直接在膜 - 模拟表面下面的烷基化层促进了表面与生物组分的其余部分的结合。当存在时，烷基链可以完全延伸穿过亲水性垫。为了便于结合，底物可以任选地用聚电解质或交替的相反电荷的聚电解质层处理，以促进膜 - 模拟膜下面的膜模拟膜或烷基化层与底物的带电结合。膜模拟膜优选通过磷脂囊泡的原位聚合来制备。

3. 发明授权

US06171614B2 Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof 失效
标题翻译：糖磷脂和肽 - 磷脂缀合物的合成及其用途
公开(公告)号：US06171614B2
公开(公告)日：2001-01-09
申请号：US09514348
申请日：2000-02-28
申请人： Elliot L. Chaikof , Lijun Sun
发明人： Elliot L. Chaikof , Lijun Sun
IPC分类号： A61K9127
CPC分类号： B82Y30/00 , A61K9/1271 , A61K47/544 , C07H15/10 , C07K1/1077 , C07K9/001 , Y10S436/829 , Y10S530/81 , Y10T428/2984
摘要： The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the invention comprises a flexible spacer arm between the phospholipid and saccharide or peptide moieties which, being variable in length, serves to optimize saccharide or peptide bioactivity. This invention further provides a method for the synthesis of such conjugates comprising the step of reductive amination. The method is efficient, economical and provides a high yield of product. Glycophospholipid and peptide-phospholipid conjugates of the invention can be incorporated and, optionally, chemically polymerized in self-assembling systems such as membranes, bilayers, films, liposomes and the like, and find utility diagnostically and therapeutically in medical and immuno-biological applications.
摘要翻译：本发明提供了包含磷脂部分和通过包含仲胺或叔胺的醚键连接的糖或肽部分的糖磷脂和肽 - 磷脂缀合物。本发明的共轭结构包括在磷脂和糖或肽部分之间的柔性间隔臂，其长度可变地用于优化糖或肽的生物活性。本发明还提供了一种合成这种共轭物的方法，其包括还原胺化的步骤。该方法效率高，经济实惠，产品成品率高。本发明的糖尿病和肽 - 磷脂缀合物可以并入并任选地在诸如膜，双层，膜，脂质体等的自组装系统中化学聚合，并且在医学和免疫生物应用中在诊断和治疗上发现。

4. 发明申请

US20130034552A1 TEMPERATURE SENSITIVE CONJUGATE COMPOSITIONS, AND USES RELATED THERETO 有权
标题翻译：温度敏感的结合组合物及其相关用途
公开(公告)号：US20130034552A1
公开(公告)日：2013-02-07
申请号：US13583055
申请日：2011-03-08
申请人： Elliot L. Chaikof , Karlheinz Peter , Danijal Topcic , Carolyn A. Haller , Wookhyun Kim
发明人： Elliot L. Chaikof , Karlheinz Peter , Danijal Topcic , Carolyn A. Haller , Wookhyun Kim
IPC分类号： C07K19/00 , A61P7/02 , C12N15/63 , A61K39/395 , C07H21/04
CPC分类号： A61K47/48246 , A61K47/64 , C07K14/78 , C07K16/2848 , C07K2317/622 , C07K2319/00
摘要： This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.
摘要翻译：本公开涉及温度敏感性缀合物，组合物和与其相关的用途。在某些实施方案中，本公开涉及包含a）温度敏感聚合物和b）抗体的缀合物聚合物。通常抗体具有血小板受体的表位。抗体可以是单链抗体，其中血小板受体是GPIIb / IIIa，例如抗GPIIb / IIIa抗体。在某些实施方案中，抗体特异性结合GPIIb / IIIa的活化构象，即活化特异性GPIIb / IIIa抗体。

5. 发明授权

US06936298B2 Antithrombogenic membrane mimetic compositions and methods 失效
标题翻译：抗血栓形成膜模拟组合物和方法
公开(公告)号：US06936298B2
公开(公告)日：2005-08-30
申请号：US10257805
申请日：2001-04-13
申请人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue-Long Sun
发明人： Elliot L. Chaikof , June Feng , Janine M. Orban , Hongbo Liu , Xue-Long Sun
IPC分类号： A61L15/32 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/12 , C07F9/10 , C07F9/655 , A61L27/00
CPC分类号： B82Y30/00 , A61L15/32 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/507 , A61L33/0082 , A61L33/12 , C07F9/10 , C07F9/65525 , C08L89/00
摘要： The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.
摘要翻译：本说明书描述了提供医疗假体的改进性能的材料和方法，包括血管移植材料，人造心脏瓣膜和其他植入材料。包含结合血栓调节蛋白或功能等同衍生蛋白的材料提供较少的不良副作用，包括炎症，血栓形成和新生内膜增生。

6. 发明授权

US6071532A Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof 失效
标题翻译：糖磷脂和肽 - 磷脂缀合物的合成及其用途
公开(公告)号：US6071532A
公开(公告)日：2000-06-06
申请号：US729928
申请日：1996-10-15
申请人： Elliot L. Chaikof , Lijun Sun
发明人： Elliot L. Chaikof , Lijun Sun
IPC分类号： A61K9/127 , C07H15/10 , C07K1/107 , C07K9/00 , A61K38/00 , C07F9/02 , C07H19/04
CPC分类号： B82Y30/00 , A61K47/48053 , A61K9/1271 , C07H15/10 , C07K1/1077 , C07K9/001 , Y10S436/829 , Y10S530/81 , Y10T428/2984
摘要： The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the invention comprises a flexible spacer arm between the phospholipid and saccharide or peptide moieties which, being variable in length, serves to optimize saccharide or peptide bioactivity. This invention further provides a method for the synthesis of such conjugates comprising the step of reductive amination. The method is efficient, economical and provides a high yield of product. Glycophospholipid and peptide-phospholipid conjugates of the invention can be incorporated and, optionally, chemically polymerized in self-assembling systems such as membranes, bilayers, films, liposomes and the like, and find utility diagnostically and therapeutically in medical and immuno-biological applications.
摘要翻译：本发明提供了包含磷脂部分和通过包含仲胺或叔胺的醚键连接的糖或肽部分的糖磷脂和肽 - 磷脂缀合物。本发明的共轭结构包括在磷脂和糖或肽部分之间的柔性间隔臂，其长度可变地用于优化糖或肽的生物活性。本发明还提供了一种合成这种共轭物的方法，其包括还原胺化的步骤。该方法效率高，经济实惠，产品成品率高。本发明的糖尿病和肽 - 磷脂缀合物可以并入并任选地在诸如膜，双层，膜，脂质体等的自组装系统中化学聚合，并且在医学和免疫生物应用中在诊断和治疗上发现。

7. 发明授权

US07833978B2 Thrombomodulin derivatives and conjugates 有权
标题翻译：血栓调节蛋白衍生物和缀合物
公开(公告)号：US07833978B2
公开(公告)日：2010-11-16
申请号：US10598149
申请日：2005-02-22
申请人： Elliot L. Chaikof , Chrystelle S. Cazalis , Carolyn A. Haller
发明人： Elliot L. Chaikof , Chrystelle S. Cazalis , Carolyn A. Haller
IPC分类号： A61K38/00
CPC分类号： C07K14/7455
摘要： The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured blood vessels under physiologic conditions in vivo. Compositions and methods are disclosed relating to thrombomodulin derivatives and conjugates, including methods for site-specific pegylation and compositions of a truncated thrombomodulin derivative.
摘要翻译：作为蛋白C途径的关键调节剂的跨膜人蛋白质血栓调节蛋白（TM）代表在体内生理条件下在正常和受损的血管中起作用的主要抗凝血机制。公开了关于血栓调节蛋白衍生物和缀合物的组合物和方法，包括用于位点特异性聚乙二醇化的方法和截短的血栓调节蛋白衍生物的组合物。

8. 发明申请

US20100048473A1 Modified Protein Polymers 有权
标题翻译：改性蛋白质聚合物
公开(公告)号：US20100048473A1
公开(公告)日：2010-02-25
申请号：US12440670
申请日：2007-09-11
申请人： Elliot L. Chaikof , Vincent P. Conticello
发明人： Elliot L. Chaikof , Vincent P. Conticello
IPC分类号： A61K38/16 , C07K14/00 , C07H21/00 , A61P7/00 , B29C47/00 , A61L33/00
CPC分类号： A61L31/047 , A61L15/32 , A61L27/227 , A61L2430/36
摘要： In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the synthetic proteins are elastin-mimetic proteins having improved mechanical characteristics and related methods of making the proteins with the capability of providing precise control over the mechanical properties. Provided are proteins used in a number of medical devices such as artificial blood vessels, shunts, stents or as embolic agents in situations where it is desired to stop or reduce blood flow or pressure in a localized region.
摘要翻译：在一个实施方案中，提供了许多合成蛋白质三嵌段共聚物，其包含由中心亲水嵌段分隔的第一和第二末端疏水嵌段。特别地，合成蛋白质是具有改善的机械特性的弹性蛋白模拟蛋白质和使蛋白质具有提供对机械性能的精确控制能力的相关方法。提供了在需要停止或减少局部区域中的血流或压力的情况下，在许多医疗装置中使用的蛋白质，例如人造血管，分流器，支架或栓塞剂。

9. 发明授权

US07244830B2 Glycopolymers and free radical polymerization methods 失效
标题翻译：甘油聚合物和自由基聚合方法
公开(公告)号：US07244830B2
公开(公告)日：2007-07-17
申请号：US10451011
申请日：2002-01-14
申请人： Elliot L. Chaikof , Daniel Grande , Subramanian Baskaran
发明人： Elliot L. Chaikof , Daniel Grande , Subramanian Baskaran
IPC分类号： C07H5/06 , C07H1/00
CPC分类号： C08B37/00 , C08B37/0063
摘要： A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a saccharide moiety connected to said linking group, optionally a second pendent unit; a phenyl ring at a first end of the polymer backbone; and a cyanoxyl group at the second end of the polymer backbone, useful as intermediates for making bioactive glycopolymers which bind to bioactive molecules, viruses, cells and substrates for protein separation, cell culture, ad drug delivery systems, as well as in targeting for treatment of wound healing and other pathological conditions.
摘要翻译：提供了包含具有聚合物主链的聚合物聚合物分子的糖聚合物组合物; 第一悬挂单元，其包含连接到所述聚合物主链的连接基团和连接到所述连接基团的糖部分，任选地是第二侧挂单元; 在聚合物骨架的第一端的苯环; 和在聚合物主链的第二端的氰氧基，其可用作生物活性糖聚合物的中间体，其结合用于蛋白质分离，细胞培养，药物递送系统的生物活性分子，病毒，细胞和底物，以及靶向治疗的伤口愈合等病理状况。

10. 发明授权

US06583251B1 Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof 失效
标题翻译：模块化细胞模拟生物材料，运输研究，其制备和利用
公开(公告)号：US06583251B1
公开(公告)日：2003-06-24
申请号：US09342922
申请日：1999-06-30
申请人： Elliot L. Chaikof , Kacey G. Marra , John H. Chon
发明人： Elliot L. Chaikof , Kacey G. Marra , John H. Chon
IPC分类号： C08F3002
CPC分类号： B82Y30/00 , A61L33/0082 , B82Y5/00 , C07F9/10 , C08F30/02 , Y10T428/1352 , Y10T428/2984
摘要： The present invention provides a biocompatible material, comprising a phospholipid or phospholipid derivative comprising various functional groups having specific chemical properties, which can function as a modular surface design unit to be incorporated or appended to a desired substrate on which it is then polymerized, thereby contributing new or specified biochemical characteristics to the polymerized and stabilized biomaterial.
摘要翻译：本发明提供了一种生物相容性材料，其包含磷脂或磷脂衍生物，其包含具有特定化学性质的各种官能团，其可以作为待结合或附着到其然后被聚合的所需基底上的模块化表面设计单元，从而有助于新的或指定的生物化学特性对聚合和稳定的生物材料。

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