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1. 发明申请

US20100311753A1 C5aR ANTAGONISTS 审中-公开
公开(公告)号：US20100311753A1
公开(公告)日：2010-12-09
申请号：US12823039
申请日：2010-06-24
申请人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： A61K31/5377 , C07D211/32 , C07D401/06 , C07D401/12 , C07D413/14 , A61K31/451 , A61K31/4545 , A61K31/454 , A61P9/00 , A61P9/10 , A61P7/02 , A61P25/00 , A61P37/00 , A61P29/00 , A61P3/10 , A61P25/28
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

2. 发明申请

US20110275639A1 C5aR ANTAGONISTS 审中-公开
公开(公告)号：US20110275639A1
公开(公告)日：2011-11-10
申请号：US13072616
申请日：2011-03-25
申请人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： A61K31/445 , C07D401/06 , C07D401/12 , C07D413/14 , A61K31/4545 , A61K31/454 , A61K31/5377 , A61P29/00 , A61P7/00 , A61P31/00 , A61P25/28 , A61P1/00 , A61P27/02 , A61P11/00 , A61P19/02 , A61P17/00 , A61P9/10 , A61P37/06 , A61P35/00 , A61P9/00 , A61P25/00 , A61P37/00 , A61P19/04 , A61P17/06 , A61P11/06 , A61P3/10 , C07D211/60
CPC分类号： A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译：提供了作为C5a受体调节剂的化合物。化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。

3. 发明授权

US09126939B2 C5AR antagonists 有权
标题翻译： C5AR拮抗剂
公开(公告)号：US09126939B2
公开(公告)日：2015-09-08
申请号：US13806339
申请日：2011-06-24
申请人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： A61K31/445 , C07D211/60 , C07D401/14 , C07D413/14 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/10 , C07D413/12 , C07D405/12
CPC分类号： C07D211/60 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译：提供了作为C5a受体调节剂的化合物。化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。

4. 发明申请

US20130172347A1 C5AR ANTAGONISTS 有权
公开(公告)号：US20130172347A1
公开(公告)日：2013-07-04
申请号：US13806339
申请日：2011-06-24
申请人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： C07D211/60 , C07D401/10 , C07D405/12 , C07D401/06 , C07D401/12
CPC分类号： C07D211/60 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译：提供了作为C5a受体调节剂的化合物。化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。

5. 发明授权

US08445515B2 C5aR antagonists 有权
标题翻译： C5aR拮抗剂
公开(公告)号：US08445515B2
公开(公告)日：2013-05-21
申请号：US12643229
申请日：2009-12-21
申请人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： A61K31/445 , C07D401/06 , C07D413/12 , C07D211/36
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译：提供了作为C5a受体调节剂的化合物。化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。

6. 发明申请

US20100160320A1 C5aR ANTAGONISTS 有权
公开(公告)号：US20100160320A1
公开(公告)日：2010-06-24
申请号：US12643229
申请日：2009-12-21
申请人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： A61K31/445 , C07D211/36 , C07D401/06 , C07D413/12 , A61K31/4545 , A61K31/5377 , A61P37/00 , A61P9/00 , A61P25/00
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译：提供了作为C5a受体调节剂的化合物。化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。

7. 发明申请

US20060211702A1 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as Raf kinase inhibitors 失效
标题翻译：吡啶基嘧啶酮，二氢嘧啶并嘧啶酮和可用作Raf激酶抑制剂的蝶啶酮
公开(公告)号：US20060211702A1
公开(公告)日：2006-09-21
申请号：US11301311
申请日：2005-12-12
申请人： Johan Oslob , Jiang Zhu , Kenneth Barr , Jennifer Cossrow , Brian Raimundo , Hiroko Tanaka
发明人： Johan Oslob , Jiang Zhu , Kenneth Barr , Jennifer Cossrow , Brian Raimundo , Hiroko Tanaka
IPC分类号： A61K31/525 , A61K31/519 , C07D487/02 , C07D475/02
CPC分类号： C07D471/04 , C07D475/00 , C07D475/06 , C07D487/04
摘要： The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.
摘要翻译：本发明提供具有下式的化合物：其中AB一起表示以下结构之一：n，R 1，R 2，R 3， R 4，L 1，L 2，Y和Z如本文中的类别和亚类所定义，及其药物组合物，如所述通常和在本文中的亚类中，哪些化合物可用作蛋白激酶（例如RAF）的抑制剂，因此可用于例如治疗RAF介导的疾病。

8. 发明申请

US20120040951A1 HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS 审中-公开
标题翻译：异氟醚化合物有效用作RAF激酶抑制剂
公开(公告)号：US20120040951A1
公开(公告)日：2012-02-16
申请号：US13142603
申请日：2009-12-30
申请人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
发明人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
IPC分类号： A61K31/437 , A61K31/5377 , C07D417/14 , A61P35/00 , A61P9/00 , A61P25/28 , A61P37/00 , A61P37/06 , A61P29/00 , A61P31/12 , A61P19/08 , A61P1/16 , A61P7/00 , A61P3/10 , C12N9/99 , C07D471/04
CPC分类号： C07D261/08 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译：本发明提供了可用作Raf蛋白激酶抑制剂的式（I）化合物。本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。

9. 发明授权

US07967917B2 Method of cleaning storage case 有权
标题翻译：储存盒清洗方法
公开(公告)号：US07967917B2
公开(公告)日：2011-06-28
申请号：US11839626
申请日：2007-08-16
申请人： Shu Shimada , Noriyuki Takahashi , Hiroyuki Nakajima , Hiroko Tanaka , Nobuyuki Kanda
发明人： Shu Shimada , Noriyuki Takahashi , Hiroyuki Nakajima , Hiroko Tanaka , Nobuyuki Kanda
IPC分类号： B08B5/02 , B08B9/093
CPC分类号： B08B7/0071 , G03F1/66 , G03F1/82
摘要： The present invention provides a method of cleaning a storage case to be used for storing or transporting mask substrates such as photomasks and photomask blanks, semiconductor substrates such as semiconductor wafers, pellicles, or the like. The present invention: facilitates a regular cleaning operation, can be used also for a storage case of a complicated shape, does not require a large scale equipment or an expensive equipment to facilitate an environmental countermeasure, and provides high cleaning effect. The method of cleaning a storage case polluted by adhesion of a foreign substance of an organic material, an ionic foreign substances or an ionic crystal foreign substance physically absorbed, comprises a step of placing the storage case still in air flow of cleaned air or an inert gas in a temperature range from room temperature to 80° C. for desorbing and removing the foreign substance adhered to the storage case.
摘要翻译：本发明提供了一种清洁用于存放或传送诸如光掩模和光掩模坯料的掩模基板，诸如半导体晶片，薄膜等半导体基板的存储盒的方法。本发明：便于定期的清洁操作，也可以用于复杂形状的储存盒，不需要大型设备或昂贵的设备来促进环境对策，并且提供高清洁效果。清洁被有机材料的异物，物理吸收的离子性异物或离子性异物的附着物污染的储存箱的方法包括将储存箱放置在清洁空气的空气流中或惰性气体的步骤气体在室温至80℃的温度范围内，用于解吸和除去粘附到储存盒的异物。

10. 发明授权

US07718008B2 Method for cleaning photo mask 有权
标题翻译：清洁光罩的方法
公开(公告)号：US07718008B2
公开(公告)日：2010-05-18
申请号：US11839655
申请日：2007-08-16
申请人： Shu Shimada , Noriyuki Takahashi , Hiroko Tanaka , Hiroyuki Ishii , Yusuke Shoji , Masashi Ohtsuki
发明人： Shu Shimada , Noriyuki Takahashi , Hiroko Tanaka , Hiroyuki Ishii , Yusuke Shoji , Masashi Ohtsuki
IPC分类号： B08B7/00 , G01N21/00
CPC分类号： G03F7/70925 , G03F1/64 , G03F1/82
摘要： The present invention provides a method for cleaning a photo mask without the need for removal of the pellicle mounted on the photo mask, without the large scale equipment for washing with a solution, with a small number of steps for cleaning and inspection, and without the increase of the production cost. The method for cleaning a photo mask with a pellicle mounted, in which the pellicle frame has a gas introducing hole and a gas discharging hole, comprises: a step of introducing a gaseous substituting substance from the gas introducing hole in a pellicle inner space surrounded by the photo mask and the pellicle, substituting foreign substances on the photo mask, and discharging the foreign substances from the gas discharging hole; and a step of irradiating an ultraviolet ray to the photo mask, while an air or a nitrogen gas or a rare gas is introduced from the gas introducing hole, for degrading the substituted substituting substance so as to be gaseous, and discharging the same from the gas discharging hole.
摘要翻译：本发明提供了一种清洁光掩模的方法，而不需要除去安装在光掩模上的防护薄膜组件，而不需要用溶液洗涤的大规模设备，具有少量用于清洁和检查的步骤，并且没有增加生产成本。用防护薄膜组件清洁光罩的方法，其中防护薄膜组件框架具有气体导入孔和气体排出孔，包括：将气体取代物质从气体导入孔引入防护薄膜组件内部空间的步骤，光掩模和防护薄膜组件，在光掩模上代替异物，并从排气孔排出异物; 以及从气体导入孔导入空气或氮气或稀有气体而将紫外线照射到光掩模的步骤，使取代的取代物质降解成气态，并将其从气体排放孔。

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